Pub Date : 2002-01-01DOI: 10.1080/10575630290020604
J. Makangara, S. Jonker, M. Nkunya
Two new natural products, the phenanthrenoid puguenolide (6-hydroxy-3-methoxy-4-oxapyren-5-one) and isoangoletin were isolated from the stem bark of the newly described Uvaria species, U. puguensis D.M. Johnson, together with the sesquiterpene guaiol and the usual C-benzyldihydrochalcones previously found in the genus Uvaria , viz . uvaretin, diuvaretin, chamuvaritin and a mixture of triuvaretin and isotriuvaretin. Structural elucidation was achieved through a combination of spectroscopic methods.
{"title":"A Novel Phenanthrenolide and C-Benzyl Dihydrochalcones from Uvaria Puguensis","authors":"J. Makangara, S. Jonker, M. Nkunya","doi":"10.1080/10575630290020604","DOIUrl":"https://doi.org/10.1080/10575630290020604","url":null,"abstract":"Two new natural products, the phenanthrenoid puguenolide (6-hydroxy-3-methoxy-4-oxapyren-5-one) and isoangoletin were isolated from the stem bark of the newly described Uvaria species, U. puguensis D.M. Johnson, together with the sesquiterpene guaiol and the usual C-benzyldihydrochalcones previously found in the genus Uvaria , viz . uvaretin, diuvaretin, chamuvaritin and a mixture of triuvaretin and isotriuvaretin. Structural elucidation was achieved through a combination of spectroscopic methods.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75157649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.1080/10575630290020046
B. Esquivel, Francisco Guerrero, R. Toscano
From the aerial parts of Salvia aspera one new tri-nordammarane named amblyol ( 1 ) was isolated besides amblyone ( 2 ). An X-ray analysis was performed on compound 1 . In addition, three known neoclerodane diterpenoids were also isolated. The structures of these compounds were established by spectral and chemical methods. The presence of dammarane triterpenoids in a Mexican Salvia is described for the first time.
{"title":"Tri-Nordammarane Triterpenoids and Neoclerodane Diterpenoids From Salvia Aspera (Labiatae)","authors":"B. Esquivel, Francisco Guerrero, R. Toscano","doi":"10.1080/10575630290020046","DOIUrl":"https://doi.org/10.1080/10575630290020046","url":null,"abstract":"From the aerial parts of Salvia aspera one new tri-nordammarane named amblyol ( 1 ) was isolated besides amblyone ( 2 ). An X-ray analysis was performed on compound 1 . In addition, three known neoclerodane diterpenoids were also isolated. The structures of these compounds were established by spectral and chemical methods. The presence of dammarane triterpenoids in a Mexican Salvia is described for the first time.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75957637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.1080/10575630290004233
C. Fan, Hai-Fang Sun, Shao-Nong Chen, J. Yue, Zhongwen Lin, Han-Dong Sun
Three saponins, craniosaponin A ( 1 ) and buddlejasaponins Ia ( 2 ) and I ( 3 ) were isolated from the n -butanol soluble fraction of Craniotome furcata for the first time. Among them, craniosaponin A ( 1 ) was identified to be a new compound. The structure of craniosaponin A was assigned mainly by spectral methods. A preliminary assay in vitro was applied to evaluate their cytotoxicity against several tumor cell-lines.
{"title":"Triterpene Saponins from Craniotome Furcata","authors":"C. Fan, Hai-Fang Sun, Shao-Nong Chen, J. Yue, Zhongwen Lin, Han-Dong Sun","doi":"10.1080/10575630290004233","DOIUrl":"https://doi.org/10.1080/10575630290004233","url":null,"abstract":"Three saponins, craniosaponin A ( 1 ) and buddlejasaponins Ia ( 2 ) and I ( 3 ) were isolated from the n -butanol soluble fraction of Craniotome furcata for the first time. Among them, craniosaponin A ( 1 ) was identified to be a new compound. The structure of craniosaponin A was assigned mainly by spectral methods. A preliminary assay in vitro was applied to evaluate their cytotoxicity against several tumor cell-lines.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80052724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.1080/10575630290020460
F. Faini, C. Labbé, R. Torres, G. D. Monache, F. Monache
A chemical study of aerial parts of Haplopappus illinitus afforded five labdane diterpenoids whose structures were elucidated by high field NMR spectroscopy and 2D techniques. Four of them are dicarboxylic acids previously reported as the corresponding dimethyl ester derivatives and the fifth is a new compound.
{"title":"Labdane Diterpenes from Haplopappus Illinitus","authors":"F. Faini, C. Labbé, R. Torres, G. D. Monache, F. Monache","doi":"10.1080/10575630290020460","DOIUrl":"https://doi.org/10.1080/10575630290020460","url":null,"abstract":"A chemical study of aerial parts of Haplopappus illinitus afforded five labdane diterpenoids whose structures were elucidated by high field NMR spectroscopy and 2D techniques. Four of them are dicarboxylic acids previously reported as the corresponding dimethyl ester derivatives and the fifth is a new compound.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83557060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.1080/10575630290020028
A. Lutz-Röder, Marc Schneider, P. Winterhalter
The 9- O - - d -glucopyranosides of (6 R )-3-oxo-4-hydroxy-7,8-dihydro- -ionol 1 and 3-oxo-5,6-epoxy- -ionol 2 were isolated from quince leaves. The glycosidic extract was obtained by XAD-2 adsorption and MeOH elution. After DCCC separation and flash chromatography, purification by high performance liquid chromatography was carried out. The novel quince leaf constituents were characterized as peracetates 1a and 2a .
从木瓜叶中分离得到(6 R)-3-氧-4-羟基-7,8-二氢-离子醇1和3-氧-5,6-环氧-离子醇2的9- O -d -葡萄糖吡喃苷。通过XAD-2吸附和甲醇洗脱得到糖苷提取物。经DCCC分离、闪蒸色谱后，进行高效液相色谱纯化。木瓜叶的新成分为过乙酸酯1a和过乙酸酯2a。
{"title":"Isolation of Two New Ionone Glucosides from Quince ( Cydonia Oblonga Mill.) Leaves","authors":"A. Lutz-Röder, Marc Schneider, P. Winterhalter","doi":"10.1080/10575630290020028","DOIUrl":"https://doi.org/10.1080/10575630290020028","url":null,"abstract":"The 9- O - - d -glucopyranosides of (6 R )-3-oxo-4-hydroxy-7,8-dihydro- -ionol 1 and 3-oxo-5,6-epoxy- -ionol 2 were isolated from quince leaves. The glycosidic extract was obtained by XAD-2 adsorption and MeOH elution. After DCCC separation and flash chromatography, purification by high performance liquid chromatography was carried out. The novel quince leaf constituents were characterized as peracetates 1a and 2a .","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91427615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.1080/10575630290020578
V. H. Verma, U. Mahmood, Bikram Singh
The whole plant of Ajuga bracteosa afforded five compounds including one new clerodane diterpenoid designated as Bracteonin-A ( 1 ) 6 f -acetoxy, 15 (R&S)-methoxy, 18-(4'-hydroxy, 3'- g -methyl, 3'- f -acetoxy, butyryloxy) neoclerodane. The other compounds identified were 14,15-dihydroajugapitin, 14-hydro-15-hydroxy ajugapitin, g -sitosterol, and stigmasterol. The structural elucidation was carried out by spectroscopic techniques.
在小苞草属植物中发现了5个新化合物，包括一种新的氯烷二萜类化合物，命名为小苞草素-a (1) 6 f -乙酰氧基，15 (R&S)-甲氧基，18-(4'-羟基，3'- g -甲基，3'- f -乙酰氧基，丁基氧基)新氯烷。其他化合物鉴定为14,15-二氢合欢素、14-氢-15-羟基合欢素、g -谷甾醇和豆甾醇。用光谱技术对其结构进行了解析。
{"title":"Clerodane Diterpenoids from Ajuga Bracteosa Wall","authors":"V. H. Verma, U. Mahmood, Bikram Singh","doi":"10.1080/10575630290020578","DOIUrl":"https://doi.org/10.1080/10575630290020578","url":null,"abstract":"The whole plant of Ajuga bracteosa afforded five compounds including one new clerodane diterpenoid designated as Bracteonin-A ( 1 ) 6 f -acetoxy, 15 (R&S)-methoxy, 18-(4'-hydroxy, 3'- g -methyl, 3'- f -acetoxy, butyryloxy) neoclerodane. The other compounds identified were 14,15-dihydroajugapitin, 14-hydro-15-hydroxy ajugapitin, g -sitosterol, and stigmasterol. The structural elucidation was carried out by spectroscopic techniques.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86048539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.1080/10575630290013585
H. Pratsinis, S. Haroutounian
A series of 3-substituted guaiazulene derivatives has been synthesized and their antioxidant properties were evaluated by monitoring their capacity for scavenging the stable free-radical DPPH. 3-Vinylguaiazulene was the most potent, possessing antioxidant activity superior than f -tocopherol. These derivatives were also moderate inhibitors of the proliferation of human promyelocytic leukemia cells.
{"title":"Synthesis and Antioxidant Activity of 3-Substituted Guaiazulene Derivatives","authors":"H. Pratsinis, S. Haroutounian","doi":"10.1080/10575630290013585","DOIUrl":"https://doi.org/10.1080/10575630290013585","url":null,"abstract":"A series of 3-substituted guaiazulene derivatives has been synthesized and their antioxidant properties were evaluated by monitoring their capacity for scavenging the stable free-radical DPPH. 3-Vinylguaiazulene was the most potent, possessing antioxidant activity superior than f -tocopherol. These derivatives were also moderate inhibitors of the proliferation of human promyelocytic leukemia cells.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91011561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.1080/10575630290020541
Wen-ji Sun, Jin-Min Gao, G. Tu, Z. Guo, Yongming Zhang
A new steroidal saponin containing six monosaccharides was obtained from the total plant of Tribulus terrestris and elucidated based on chemical spectroscopic analysis, especially on 2D-NMR technology as 26- O - g - d -glucopyranosyl-22-methoxy-furostane-3- O -{ g - d -xylopyranosyl(1 M 3)-[ g - d -xylopyranosyl(1 M 2)- g - d -glucopyranosyl(1 M 4)]}-[ f - l -rhamnopyranosy(1 M 2)]- g - d -galactopyranoside.
获得了一个新的包含六个单糖甾体皂苷的总植物刺蒺藜,阐明基于化学光谱分析,尤其是在2 d-nmr技术为26 - O g - d -glucopyranosyl-22-methoxy-furostane-3 - O - {g - d -xylopyranosyl(1米3)- (g - d -xylopyranosyl(1米2)- g d -glucopyranosyl(1米4)]}- [f - l -rhamnopyranosy(1米2)]- g d -galactopyranoside。
{"title":"A New Steroidal Saponin from Tribulus Terrestris Linn","authors":"Wen-ji Sun, Jin-Min Gao, G. Tu, Z. Guo, Yongming Zhang","doi":"10.1080/10575630290020541","DOIUrl":"https://doi.org/10.1080/10575630290020541","url":null,"abstract":"A new steroidal saponin containing six monosaccharides was obtained from the total plant of Tribulus terrestris and elucidated based on chemical spectroscopic analysis, especially on 2D-NMR technology as 26- O - g - d -glucopyranosyl-22-methoxy-furostane-3- O -{ g - d -xylopyranosyl(1 M 3)-[ g - d -xylopyranosyl(1 M 2)- g - d -glucopyranosyl(1 M 4)]}-[ f - l -rhamnopyranosy(1 M 2)]- g - d -galactopyranoside.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73498838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Khan, S. Perveen, S. A. M. Ayattollahi, N. Saba, A. Rashid, S. Firdous, Syed Moazzam Haider, Z. Ullah, Shagufta Rahat, Zarrar Khan
Three glycosides and a long chain alcohol were isolated from the bulbs of Polianthes tuberosa , these were identified as 3,29-dihydroxystigmast-5-ene-3- O - g - d -galactopyranoside ( 1 ) 1 , ethyl g - d -galactopyranoside ( 2 ), ethyl- f - d -galactopyranoside ( 3 ), and 1-tricosanol ( 4 ). The structures were determined by extensive spectroscopic and chemical methods. All four isolated compounds were screened for their cytotoxicity, antibacterial and antifungal activities, none of the compounds showed any significant activity.
从牡丹鳞茎中分离到3种糖苷和1种长链醇，分别鉴定为3,29-二羟基柱状体-5-烯-3- O -g -d -半乳糖苷(1)1、乙基g -d -半乳糖苷(2)、乙基- f -d -半乳糖苷(3)和1-三葡萄糖醇(4)。通过广泛的光谱和化学方法确定了其结构。对4个分离得到的化合物进行了细胞毒性、抗菌和抗真菌活性的筛选，均未显示出明显的活性。
{"title":"Isolation and Structure Elucidation of Three Glycosides and a Long Chain Alcohol from Polianthes Tuberosa Linn","authors":"K. Khan, S. Perveen, S. A. M. Ayattollahi, N. Saba, A. Rashid, S. Firdous, Syed Moazzam Haider, Z. Ullah, Shagufta Rahat, Zarrar Khan","doi":"10.1080/713604303","DOIUrl":"https://doi.org/10.1080/713604303","url":null,"abstract":"Three glycosides and a long chain alcohol were isolated from the bulbs of Polianthes tuberosa , these were identified as 3,29-dihydroxystigmast-5-ene-3- O - g - d -galactopyranoside ( 1 ) 1 , ethyl g - d -galactopyranoside ( 2 ), ethyl- f - d -galactopyranoside ( 3 ), and 1-tricosanol ( 4 ). The structures were determined by extensive spectroscopic and chemical methods. All four isolated compounds were screened for their cytotoxicity, antibacterial and antifungal activities, none of the compounds showed any significant activity.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88950105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.1080/1057563029001/4818
S. Sung, W. J. Jung, Y. Kim
A novel flavonol lyxoside was isolated from the aerial part of Orostachys japonicus (Crassulaceae). Its structure was determined as gossypetin 8-O-f-D-lyxopyranoside using several spectral data and chemical methods. Lyxoside of flavonoid was isolated for the first time from nature.
{"title":"A Novel Flavonol Lyxoside of Orostachys Japonicus Herb","authors":"S. Sung, W. J. Jung, Y. Kim","doi":"10.1080/1057563029001/4818","DOIUrl":"https://doi.org/10.1080/1057563029001/4818","url":null,"abstract":"A novel flavonol lyxoside was isolated from the aerial part of Orostachys japonicus (Crassulaceae). Its structure was determined as gossypetin 8-O-f-D-lyxopyranoside using several spectral data and chemical methods. Lyxoside of flavonoid was isolated for the first time from nature.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89420415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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