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Nefropatía IgA tras tratamiento prolongado con infliximab por enfermedad de Crohn, a propósito de dos casos 2例克罗恩病英夫利昔单抗长期治疗后IgA肾病
IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.02.007
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引用次数: 0
Uno de los pocos casos reportados de glomerulonefritis fibrilar en nefropatía lúpica 狼疮肾病中纤维性肾小球肾炎的少数复发病例之一
IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2022.12.007
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引用次数: 0
Hodgkin lymphoma in a patient with kidney transplantation 肾移植患者的霍奇金淋巴瘤
IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.03.006
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引用次数: 0
Epidemiología, comportamiento clínico y pronóstico de la patología glomerular asociada a infección o vacunación del SARS-CoV-2: nuestra experiencia 与 SARS-CoV-2 感染或接种疫苗相关的肾小球病变的流行病学、临床表现和预后:我们的经验。
IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.10.006
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引用次数: 0
Glomerulonefritis fibrilar: ¿Más frecuente de lo que parece? La importancia de la inmunohistoquímica en el diagnóstico 纤维化肾小球肾炎:比看起来更常见?免疫组化在诊断中的意义
IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.05.003
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引用次数: 0
Hepatitis C virus infection is associated with proteinuria according to a systematic review with meta-analysis 系统回顾与荟萃分析显示丙型肝炎病毒感染与蛋白尿有关
IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2024.01.002

Introduction and aim

Hepatitis C virus infection and chronic kidney disease are major public health issues all over the world. It has been suggested a role of HCV as a risk factor for the development and progression of chronic kidney disease (defined by reduced glomerular filtration rate and/or detectable proteinuria) in the general population but conflicting findings have been given.

Material and methods

A systematic review of the published medical literature was conducted to assess whether positive HCV serologic status is associated with greater rate of proteinuria in the adult general population. We used a random-effect model to generate a summary estimate of the relative risk of proteinuria with HCV across the published studies.

Results

We identified 23 studies (n = 198,967 unique patients) and performed separate meta-analyses according to the study design. Overall effect estimate was significant in cross-sectional (OR, 1.47, 95%CI, 1.3; 1.66) (P < 0.001) and obvious between-study heterogeneity was observed (Q value by Chi-squared [χ2] test 27.3, P = 0.02). The risk of proteinuria after exposure to HCV was also consistent among longitudinal studies (HR, 1.79, 95% CI, 1.17; 2.74) (P < 0.001) and between-study heterogeneity occurred (Q value, 27.82 by X2 test, P = 0.0001). Stratified analysis did not report heterogeneity in several comparisons-pooling studies based on urine protein/creatinine ratio (UACR) showed that the adjusted OR with HCV was 1.64 (95% CI, 1.41; 1.91, P < 0.001) without heterogeneity (Q value by Chi-squared [χ2] test 9.98, P = NS). Meta-regression recorded a link between greater prevalence of proteinuria in males with HCV exposure (P = 0.03). Studies based on univariate analysis (n = 6, n = 72, 551 unique patients) gave similar results, pooled OR 1.54 (95% CI, 1.08; 2.19) (P = 0.0001).

Conclusions

An important relationship between HCV infection and higher risk of proteinuria in the general population exists. Research aimed to understand the biological mechanisms underlying such association is under way. We encourage to screen all patients with HCV exposure for proteinuria.

导言和目的丙型肝炎病毒感染和慢性肾脏病是全世界主要的公共卫生问题。有人认为丙型肝炎病毒是普通人群中慢性肾脏病(定义为肾小球滤过率降低和/或可检测到蛋白尿)发生和发展的风险因素,但研究结果相互矛盾。结果我们确定了 23 项研究(n = 198,967 例患者),并根据研究设计分别进行了荟萃分析。横断面总效应估计值显著(OR, 1.47, 95%CI, 1.3; 1.66)(P <0.001),且观察到明显的研究间异质性(通过Chi-squared [χ2]检验的Q值为27.3,P = 0.02)。在纵向研究中,暴露于 HCV 后出现蛋白尿的风险也是一致的(HR,1.79,95% CI,1.17;2.74)(P <;0.001),并且出现了研究间异质性(通过 X2 检验,Q 值为 27.82,P = 0.0001)。基于尿蛋白/肌酐比值(UACR)的分层分析未显示几项比较的异质性--汇总研究显示,HCV 的调整 OR 为 1.64(95% CI,1.41;1.91,P <;0.001),无异质性(通过 Chi-squared [χ2]检验的 Q 值为 9.98,P = NS)。元回归结果表明,男性蛋白尿发病率较高与接触过丙型肝炎病毒有关(P = 0.03)。基于单变量分析的研究(n = 6,n = 72,551 名患者)得出了相似的结果,汇总 OR 为 1.54(95% CI,1.08; 2.19)(P = 0.0001)。目前正在开展研究,以了解这种关联的生物机制。我们鼓励对所有接触过 HCV 的患者进行蛋白尿筛查。
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引用次数: 0
La orina más allá de los electrolitos: diagnóstico a través de las vesículas extracelulares 电解质以外的尿液:通过细胞外囊泡进行诊断
IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.05.010

Background and objective

Extracellular vesicles (EVs) reflect the pathophysiological state of their cells of origin and are a reservoir of renal information accessible in urine. When biopsy is not an option, EVs present themselves as sentinels of function and damage, providing a non-invasive approach. However, the analysis of EVs in urine requires prior isolation, which slows down and hinders translation to clinical practice. The aim of this study is to show the applicability of the “single particle interferometric reflectance imaging sensor” (SP-IRIS) technology through the ExoView® platform for the direct analysis of urine EVs and proteins involved in renal function.

Materials and methods

The ExoView® technology enables the quantification and phenotyping of EVs present in urine and the quantification of their membrane and internal proteins. We have applied this technology to the quantification of urinary EVs and their proteins with renal tubular expression, amnionless (AMN) and secreted frizzled-related protein 1 (SFRP1), using only 5 μl of urine. Tubular expression was confirmed by immunohistochemistry.

Results

The mean size of the EVs analysed was 59 ± 16 nm for those captured by tetraspanin CD63, 61 ± 16 nm for those captured by tetraspanin CD81, and 59 ± 10 nm for tetraspanin CD9, with CD63 being the majority EVs subpopulation in urine (48.92%). The distribution of AMN and SFRP1 in the three capture tetraspanins turned out to be similar for both proteins, being expressed mainly in CD63 (48.23% for AMN and 52.1% for SFRP1).

Conclusions

This work demonstrates the applicability and advantages of the ExoView® technique for the direct analysis of urine EVs and their protein content in relation to the renal tubule. The use of minimum volumes, 5 μl, and the total analysis time not exceeding three hours facilitate the translation of EVs to daily clinical practice as source of diagnostic information.

背景和目的细胞外囊泡(EVs)反映了其来源细胞的病理生理状态,是尿液中可获取的肾脏信息库。当无法进行活组织检查时,EVs 可作为功能和损伤的哨兵,提供一种非侵入性的方法。然而,对尿液中的 EVs 进行分析需要事先进行分离,这就减慢了将 EVs 转化为临床实践的速度。本研究的目的是通过 ExoView® 平台展示 "单颗粒干涉反射成像传感器"(SP-IRIS)技术在直接分析尿液 EVs 和参与肾功能的蛋白质方面的适用性。我们仅用 5 μl 尿液就将该技术应用于尿液 EVs 及其肾小管表达蛋白、无羊膜蛋白 (AMN) 和分泌型皱纹相关蛋白 1 (SFRP1) 的定量分析。结果所分析的 EVs 的平均大小为:被四跨蛋白 CD63 捕获的为 59 ± 16 nm,被四跨蛋白 CD81 捕获的为 61 ± 16 nm,被四跨蛋白 CD9 捕获的为 59 ± 10 nm,其中 CD63 是尿液中最主要的 EVs 亚群(48.92%)。AMN和SFRP1在三种捕获四跨蛋白中的分布情况相似,主要在CD63中表达(AMN为48.23%,SFRP1为52.1%)。使用最小容量(5 μl)和不超过三小时的总分析时间有助于将 EVs 转化为日常临床实践中的诊断信息来源。
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引用次数: 0
Caracterización de la población con fracaso renal agudo durante la hospitalización por COVID-19 en España: tratamiento renal sustitutivo y mortalidad. Datos del Registro FRA-COVID SEN 西班牙 COVID-19 住院期间急性肾衰竭患者的特征:肾替代疗法和死亡率。数据来自 FRA-COVID SEN 登记处。
IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.03.008
<div><h3>Background and objectives</h3><p>Acute kidney injury (AKI) is common among hospitalized patients with COVID-19 and associated with worse prognosis. The Spanish Society of Nephrology created the AKI-COVID Registry to characterize the population admitted for COVID-19 that developed AKI in Spanish hospitals. The need of renal replacement therapy (RRT) therapeutic modalities, and mortality in these patients were assessed.</p></div><div><h3>Material and method</h3><p>In a retrospective study, we analyzed data from the AKI-COVID Registry, which included patients hospitalized in 30 Spanish hospitals from May 2020 to November 2021. Clinical and demographic variables, factors related to the severity of COVID-19 and AKI, and survival data were recorded. A multivariate regression analysis was performed to study factors related to RRT and mortality.</p></div><div><h3>Results</h3><p>Data from 730 patients were recorded. A total of 71.9% were men, with a mean age of 70 years (60–78), 70.1% were hypertensive, 32.9% diabetic, 33.3% with cardiovascular disease and 23.9% had some degree of chronic kidney disease (CKD). Pneumonia was diagnosed in 94.6%, requiring ventilatory support in 54.2% and admission to the ICU in 44.1% of cases.</p><p>The median time from the onset of COVID-19 symptoms to the appearance of AKI (37.1% KDIGO I, 18.3% KDIGO II, 44.6% KDIGO III) was 6 days (4–10). A total of 235 (33.9%) patients required RRT: 155 patients with continuous renal replacement therapy, 89 alternate-day dialysis, 36 daily dialysis, 24 extended hemodialysis and 17 patients with hemodiafiltration. Smoking habit (OR 3.41), ventilatory support (OR 20.2), maximum creatinine value (OR 2.41) and time to AKI onset (OR 1.13) were predictors of the need for RRT; age was a protective factor (0.95). The group without RRT was characterized by older age, less severe AKI, shorter kidney injury onset and recovery time (<em>p</em> <!--><<!--> <!-->0.05). 38.6% of patients died during hospitalization; serious AKI and RRT were more frequent in the death group. In the multivariate analysis, age (OR 1.03), previous chronic kidney disease (OR 2.21), development of pneumonia (OR 2.89), ventilatory support (OR 3.34) and RRT (OR 2.28) were predictors of mortality while chronic treatment with ARBs was identified as a protective factor (OR 0.55).</p></div><div><h3>Conclusions</h3><p>Patients with AKI during hospitalization for COVID-19 had a high mean age, comorbidities and severe infection. We defined two different clinical patterns: an AKI of early onset, in older patients that resolves in a few days without the need for RRT; and another more severe pattern, with greater need for RRT, and late onset, which was related to greater severity of the infectious disease. The severity of the infection, age and the presence of CKD prior to admission were identified as risk factors for mortality in these patients. In addition chronic treatment with ARBs was identified as a protective factor
背景和目的急性肾损伤(AKI)在 COVID-19 住院患者中很常见,并与预后恶化有关。西班牙肾脏病学会创建了 AKI-COVID 注册表,以描述西班牙医院中因 COVID-19 而入院并发生 AKI 的人群的特征。材料和方法在一项回顾性研究中,我们分析了 AKI-COVID 登记处的数据,其中包括 2020 年 5 月至 2021 年 11 月期间在 30 家西班牙医院住院的患者。我们记录了临床和人口统计学变量、与 COVID-19 和 AKI 严重程度相关的因素以及生存数据。结果 记录了 730 名患者的数据。71.9%的患者为男性,平均年龄为70岁(60-78岁),70.1%患有高血压,32.9%患有糖尿病,33.3%患有心血管疾病,23.9%患有某种程度的慢性肾病(CKD)。从出现 COVID-19 症状到出现 AKI(37.1% KDIGO I,18.3% KDIGO II,44.6% KDIGO III)的中位时间为 6 天(4-10 天)。共有 235 名(33.9%)患者需要接受 RRT 治疗:155 名患者接受持续肾脏替代治疗,89 名患者接受隔日透析,36 名患者接受每日透析,24 名患者接受延长血液透析,17 名患者接受血液滤过。吸烟习惯(OR 3.41)、通气支持(OR 20.2)、肌酐最高值(OR 2.41)和 AKI 发病时间(OR 1.13)是需要 RRT 的预测因素;年龄是一个保护因素(0.95)。无 RRT 组的特点是年龄较大、AKI 病情较轻、肾损伤发生时间和恢复时间较短(P < 0.05)。38.6%的患者在住院期间死亡;在死亡组中,严重的 AKI 和 RRT 更为常见。在多变量分析中,年龄(OR 1.03)、既往慢性肾脏病(OR 2.21)、肺炎(OR 2.89)、呼吸支持(OR 3.34)和 RRT(OR 2.28)是预测死亡率的因素,而长期使用 ARBs 治疗被认为是一个保护因素(OR 0.55)。我们定义了两种不同的临床模式:一种是早发性 AKI,年龄较大的患者可在几天内缓解,无需进行 RRT;另一种是更严重的模式,更需要进行 RRT,且发病较晚,这与感染性疾病的严重程度有关。感染的严重程度、年龄和入院前是否患有慢性肾功能衰竭被认为是这些患者死亡的风险因素。此外,长期接受抗逆转录酶抑制剂治疗被认为是死亡率的保护因素。
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引用次数: 0
Nomenclatura en cuidados paliativos y de soporte renal: no solo al final de la vida 姑息和肾脏支持护理术语:不仅在生命结束时
IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.05.006

The multidimensional view of the disease is fundamental in the care of complex diseases such as chronic kidney disease (CKD). It is appropriate to define and unify concepts that allow the different professionals involved in care to provide multidisciplinary care tailored to the needs of each individual.

Given the increasing incidence of CKD worldwide and the fact that the disease may progress at different rates, there is a need to establish personalized, comprehensive approaches for each patient and their families at an earlier stage. This approach goes beyond the simple control of uremic symptoms or congestion and consists of addressing not only symptomatic but also functional, social and coping problems at an early stage, facilitating decision making both in the CKD and in acute settings, potentially irreversible situations or interventions that do not improve life expectancy.

To ensure excellence in care, it is important to assess indicators of palliative care and renal support, such as the presence of advance and shared care planning, the inclusion of psychosocial, ethical, spiritual and bereavement care. This enables the provision of comprehensive, humanized, and high-quality care for patients and their families.

Palliative and renal care is not just about patients in the last days of life. Defining, unifying, and evaluating the concepts will allow them to be applied in a timely manner at each specific moment of the CKD trajectory.

多维疾病观是治疗慢性肾脏病(CKD)等复杂疾病的基础。鉴于慢性肾脏病在全球的发病率越来越高,而且病情发展速度各不相同,因此有必要在早期阶段就为每位患者及其家属制定个性化的综合治疗方案。这种方法不仅仅是简单地控制尿毒症症状或充血,还包括在早期阶段不仅要解决症状性问题,还要解决功能性、社会性和应对性问题,促进在慢性肾脏病和急性期环境下做出决策,处理可能无法挽回的情况或无法改善预期寿命的干预措施。为了确保提供卓越的护理,必须对姑息治疗和肾脏支持的指标进行评估,例如是否有预先和共同的护理计划,是否包含社会心理、伦理、精神和丧亲护理。姑息关怀和肾脏支持不仅仅是针对生命最后阶段的病人。定义、统一和评估这些概念将使它们能够在慢性肾脏病发展轨迹的每个特定时刻得到及时应用。
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引用次数: 0
Hiperaldosteronismo e hiperparatiroidismo. Una amistad inquietante 肾上腺皮质激素过多症和甲状旁腺功能亢进症。令人不安的友谊
IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.12.005

Classically, aldosterone actions are associated with the stability of the effective circulating volume and with blood pressure control, while parathormone actions are linked to bone mineral metabolism, calcium, and phosphate homeostasis. Nevertheless, the relationship between these two hormonal axes surpasses these areas. A bidirectional interrelation between calcium-phosphorus metabolism and blood pressure control can lead to alterations in both. This can have significant implications for the evolution and treatment of patients. To illustrate this relationship, we present two clinical cases that demonstrate the pathophysiology involved.

通常,醛固酮的作用与有效循环容量的稳定和血压控制有关,而副睾酮的作用则与骨矿物质代谢、钙和磷酸盐的平衡有关。然而,这两种激素轴之间的关系远不止这些领域。钙磷代谢与血压控制之间的双向相互关系可导致两者的改变。这对患者的演变和治疗有重大影响。为了说明这种关系,我们介绍了两个临床病例,以展示其中涉及的病理生理学。
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引用次数: 0
期刊
Nefrologia
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