Pub Date : 2023-10-31DOI: 10.1557/s43580-023-00669-0
J. Mangaiyarkkarasi, S. Sasikumar, V. Meenakumari, J. Shanthalakshmi Revathy
{"title":"A multidimensional approach to understanding wide band gap MgO: Structural, morphological, optical, and electron density insights","authors":"J. Mangaiyarkkarasi, S. Sasikumar, V. Meenakumari, J. Shanthalakshmi Revathy","doi":"10.1557/s43580-023-00669-0","DOIUrl":"https://doi.org/10.1557/s43580-023-00669-0","url":null,"abstract":"","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135808682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-31DOI: 10.1557/s43580-023-00668-1
Juan José Reyes Salgado, Pablo Marco Trejo García, Laura Elvira Serrano de la Rosa, Emmanuel Eduardo Huelitl Ocelotl
{"title":"Study of physical properties of cold welding epoxy matrix with polypyrrole inclusions","authors":"Juan José Reyes Salgado, Pablo Marco Trejo García, Laura Elvira Serrano de la Rosa, Emmanuel Eduardo Huelitl Ocelotl","doi":"10.1557/s43580-023-00668-1","DOIUrl":"https://doi.org/10.1557/s43580-023-00668-1","url":null,"abstract":"","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"318 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135872833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-26DOI: 10.1557/s43580-023-00664-5
Facundo Arriaga, Diego Velázquez, Fernando Lanzini
{"title":"Computational study of the $${text{DO}}_3+{text{L}}2_1$$ two-phase field in $$beta$$ Cu–Al–Mn","authors":"Facundo Arriaga, Diego Velázquez, Fernando Lanzini","doi":"10.1557/s43580-023-00664-5","DOIUrl":"https://doi.org/10.1557/s43580-023-00664-5","url":null,"abstract":"","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134910279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-24DOI: 10.1101/2023.07.22.550178
Ruofan Yu, Shelby Roseman, Allison P Siegenfeld, Son C Nguyen, Eric F Joyce, Brian B Liau, Ian D Krantz, Katherine A Alexander, Shelley L Berger
The interchromatin space in the cell nucleus contains various membrane-less nuclear bodies. Recent findings indicate that nuclear speckles, comprising a distinct nuclear body, exhibit interactions with certain chromatin regions in a ground state. Key questions are how this ground state of chromatin-nuclear speckle association is established and what are the gene regulatory roles of this layer of nuclear organization. We report here that chromatin structural factors CTCF and cohesin are required for full ground state association between DNA and nuclear speckles. Disruption of ground state DNA-speckle contacts via either CTCF depletion or cohesin depletion had minor effects on basal level expression of speckle-associated genes, however we show strong negative effects on stimulus-dependent induction of speckle-associated genes. We identified a putative speckle targeting motif (STM) within cohesin subunit RAD21 and demonstrated that the STM is required for chromatin-nuclear speckle association. In contrast to reduction of CTCF or RAD21, depletion of the cohesin releasing factor WAPL stabilized cohesin on chromatin and DNA-speckle contacts, resulting in enhanced inducibility of speckle-associated genes. In addition, we observed disruption of chromatin-nuclear speckle association in patient derived cells with Cornelia de Lange syndrome (CdLS), a congenital neurodevelopmental diagnosis involving defective cohesin pathways, thus revealing nuclear speckles as an avenue for therapeutic inquiry. In summary, our findings reveal a mechanism to establish the ground organizational state of chromatin-speckle association, to promote gene inducibility, and with relevance to human disease.
{"title":"CTCF/cohesin organize the ground state of chromatin-nuclear speckle association.","authors":"Ruofan Yu, Shelby Roseman, Allison P Siegenfeld, Son C Nguyen, Eric F Joyce, Brian B Liau, Ian D Krantz, Katherine A Alexander, Shelley L Berger","doi":"10.1101/2023.07.22.550178","DOIUrl":"10.1101/2023.07.22.550178","url":null,"abstract":"<p><p>The interchromatin space in the cell nucleus contains various membrane-less nuclear bodies. Recent findings indicate that nuclear speckles, comprising a distinct nuclear body, exhibit interactions with certain chromatin regions in a ground state. Key questions are how this ground state of chromatin-nuclear speckle association is established and what are the gene regulatory roles of this layer of nuclear organization. We report here that chromatin structural factors CTCF and cohesin are required for full ground state association between DNA and nuclear speckles. Disruption of ground state DNA-speckle contacts via either CTCF depletion or cohesin depletion had minor effects on basal level expression of speckle-associated genes, however we show strong negative effects on stimulus-dependent induction of speckle-associated genes. We identified a putative speckle targeting motif (STM) within cohesin subunit RAD21 and demonstrated that the STM is required for chromatin-nuclear speckle association. In contrast to reduction of CTCF or RAD21, depletion of the cohesin releasing factor WAPL stabilized cohesin on chromatin and DNA-speckle contacts, resulting in enhanced inducibility of speckle-associated genes. In addition, we observed disruption of chromatin-nuclear speckle association in patient derived cells with Cornelia de Lange syndrome (CdLS), a congenital neurodevelopmental diagnosis involving defective cohesin pathways, thus revealing nuclear speckles as an avenue for therapeutic inquiry. In summary, our findings reveal a mechanism to establish the ground organizational state of chromatin-speckle association, to promote gene inducibility, and with relevance to human disease.</p>","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89325195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.1557/s43580-023-00671-6
İmran Kanmaz, Murat Tomakin
{"title":"Effect of precursor solution molarity on electrical and optical properties of spin-coated titanium dioxide (TiO2) thin films","authors":"İmran Kanmaz, Murat Tomakin","doi":"10.1557/s43580-023-00671-6","DOIUrl":"https://doi.org/10.1557/s43580-023-00671-6","url":null,"abstract":"","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"9 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135366340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.1557/s43580-023-00667-2
Sahra Genc, Sally Thompson, Owen Hill, Leif Gislason, Dakota Rodriguez, Farjana Showme, Alex Motler, Sarah M. Schreiner, Adrian Gestos, Virginia L. Ferguson, Jeff Jessing
Abstract In the last decade, organ-on-a-chip technology has been researched as an alternative to animal and cell culture models (Buhidma et al. in NPJ Parkinson’s Dis, 2020; Pearce et al. in Eur Cells Mater 13:1–10, 2007; Huh et al. in Nat Protoc 8:2135–2157, 2013). While extensive research has focused on the biological functions of these chips, there has been limited exploration of functional materials that can accurately replicate the biological environment. Our group concentrated on a lung-on-a-chip featuring a newly fabricated porous silicon bio-membrane. This bio-membrane mimics the interstitial space found between epithelial and endothelial cells in vivo, with a thickness of approximately 1 μm (Ingber in Cell 164:1105–1109, 2016). This study aims to establish a fabrication method for producing a thin, uniform porous silicon membrane with a predictable reduced modulus . We conducted mechanical and morphological characterization using scanning electron microscopy and nanoindentation. A small, parametric study was conducted to determine the reduced modulus of the porous silicon and how it may relate to the morphological features of the membrane. We compare our results to other works. Graphical Abstract
在过去的十年中，器官芯片技术被研究作为动物和细胞培养模型的替代方法(Buhidma et al. In NPJ Parkinson 's Dis, 2020;Pearce et al. journal of chengdu electro - mechaical, 2007;Huh et al. in Nat Protoc 8:2135-2157, 2013)。虽然广泛的研究集中在这些芯片的生物功能上，但对能够准确复制生物环境的功能材料的探索有限。我们的团队专注于一种肺芯片，其特点是一种新制造的多孔硅生物膜。这种生物膜模拟了体内上皮细胞和内皮细胞之间的间隙，厚度约为1 μm (Ingber in Cell 164:1105-1109, 2016)。本研究旨在建立一种制造方法，用于生产具有可预测的降低模量的薄而均匀的多孔硅膜。我们使用扫描电子显微镜和纳米压痕进行了机械和形态表征。一个小的，参数化的研究进行了确定减少的多孔硅的模量，以及它如何可能涉及到膜的形态特征。我们将我们的结果与其他作品进行比较。图形抽象
{"title":"Morphological and mechanical characterization of a novel porous silicon membrane used in a lung-on-a-chip system","authors":"Sahra Genc, Sally Thompson, Owen Hill, Leif Gislason, Dakota Rodriguez, Farjana Showme, Alex Motler, Sarah M. Schreiner, Adrian Gestos, Virginia L. Ferguson, Jeff Jessing","doi":"10.1557/s43580-023-00667-2","DOIUrl":"https://doi.org/10.1557/s43580-023-00667-2","url":null,"abstract":"Abstract In the last decade, organ-on-a-chip technology has been researched as an alternative to animal and cell culture models (Buhidma et al. in NPJ Parkinson’s Dis, 2020; Pearce et al. in Eur Cells Mater 13:1–10, 2007; Huh et al. in Nat Protoc 8:2135–2157, 2013). While extensive research has focused on the biological functions of these chips, there has been limited exploration of functional materials that can accurately replicate the biological environment. Our group concentrated on a lung-on-a-chip featuring a newly fabricated porous silicon bio-membrane. This bio-membrane mimics the interstitial space found between epithelial and endothelial cells in vivo, with a thickness of approximately 1 μm (Ingber in Cell 164:1105–1109, 2016). This study aims to establish a fabrication method for producing a thin, uniform porous silicon membrane with a predictable reduced modulus . We conducted mechanical and morphological characterization using scanning electron microscopy and nanoindentation. A small, parametric study was conducted to determine the reduced modulus of the porous silicon and how it may relate to the morphological features of the membrane. We compare our results to other works. Graphical Abstract","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"35 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135413524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-19DOI: 10.1557/s43580-023-00666-3
Juan Carlos Santiago-Jiménez, Fray De Landa Castillo-Alvarado, Alberto García-Quiroz, Gabriel Ramírez-Damaso
{"title":"Interaction sites in the receptor-binding domain (RBD) of the spike wild-type SARS-CoV-2 protein of the posaconazole (POS) drug and its quantum–mechanical characterization","authors":"Juan Carlos Santiago-Jiménez, Fray De Landa Castillo-Alvarado, Alberto García-Quiroz, Gabriel Ramírez-Damaso","doi":"10.1557/s43580-023-00666-3","DOIUrl":"https://doi.org/10.1557/s43580-023-00666-3","url":null,"abstract":"","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135728949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-19DOI: 10.1557/s43580-023-00663-6
J. August Ridenour, Brian L. Chaloux, Michelle D. Johannes, Matthew T. Finn, Heonjune Ryou, Albert Epshteyn
The ionic conductivity, thermal stability, and general viability for use as electrolytes in fuel cells are examined for two borophosphate polyelectrolyte compounds (e.g., sodium borophosphate (NaBOB, Na5[BOB(PO4)3)]) and ammonium borophosphate (NH4BOB, (NH4)3H2[BOB(PO4)3])). Bulk synthesis methods are presented for laboratory scale reactions (> 5 g) using low-temperature ionic liquid fluxes. Electrochemical impedance spectroscopy (EIS) was used to determine temperature-dependent ionic conductivities of the NH4BOB and NaBOB to be on the order of 2 µS cm−1 and 0.1 µS cm−1 at 200 °C, respectively. Although NH4BOB displays higher ionic conductivity compared to NaBOB at equivalent temperatures, thermal gravimetric analysis (TGA) shows much higher thermal stability for NaBOB, exhibiting no mass loss below 600 °C. The thermal stability of NaBOB was also assessed under reducing (~ 1 atm H2) conditions, finding no reductive thermal degradation below 400 °C. Ab initio molecular dynamics (AIMD) simulations show free proton (H+) movement is related to gyrational mobility of the polyanionic borophosphate chains.
{"title":"High thermal stability 1D borophosphate proton conducting polyelectrolytes","authors":"J. August Ridenour, Brian L. Chaloux, Michelle D. Johannes, Matthew T. Finn, Heonjune Ryou, Albert Epshteyn","doi":"10.1557/s43580-023-00663-6","DOIUrl":"https://doi.org/10.1557/s43580-023-00663-6","url":null,"abstract":"The ionic conductivity, thermal stability, and general viability for use as electrolytes in fuel cells are examined for two borophosphate polyelectrolyte compounds (e.g., sodium borophosphate (NaBOB, Na5[BOB(PO4)3)]) and ammonium borophosphate (NH4BOB, (NH4)3H2[BOB(PO4)3])). Bulk synthesis methods are presented for laboratory scale reactions (> 5 g) using low-temperature ionic liquid fluxes. Electrochemical impedance spectroscopy (EIS) was used to determine temperature-dependent ionic conductivities of the NH4BOB and NaBOB to be on the order of 2 µS cm−1 and 0.1 µS cm−1 at 200 °C, respectively. Although NH4BOB displays higher ionic conductivity compared to NaBOB at equivalent temperatures, thermal gravimetric analysis (TGA) shows much higher thermal stability for NaBOB, exhibiting no mass loss below 600 °C. The thermal stability of NaBOB was also assessed under reducing (~ 1 atm H2) conditions, finding no reductive thermal degradation below 400 °C. Ab initio molecular dynamics (AIMD) simulations show free proton (H+) movement is related to gyrational mobility of the polyanionic borophosphate chains.","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135728561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study and formulation of microemulsions for the synthesis of Fe2O3–Ag nanoparticles: Characterization and evaluation of antimicrobial activity","authors":"Rossannie Guasamucare, Iris Miraballes, Ricardo Faccio, Silvana Albores, Juan Pereira, Livia Arizaga","doi":"10.1557/s43580-023-00656-5","DOIUrl":"https://doi.org/10.1557/s43580-023-00656-5","url":null,"abstract":"","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135728897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-16DOI: 10.1557/s43580-023-00662-7
Heriberto Granados-Becerra, Martin Ricardo Barajas-Álvarez, Víctor H. López-Morelos, Alberto Ruiz
{"title":"Creep behavior and microstructural characterization of Inconel-625/Inconel-600 welded joint","authors":"Heriberto Granados-Becerra, Martin Ricardo Barajas-Álvarez, Víctor H. López-Morelos, Alberto Ruiz","doi":"10.1557/s43580-023-00662-7","DOIUrl":"https://doi.org/10.1557/s43580-023-00662-7","url":null,"abstract":"","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136115931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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