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Performance Evaluation of a Heat Recovery System Combined with a Helical-Type Heat Exchanger as a Water Heater 结合螺旋式换热器作为热水器的热回收系统性能评价
Pub Date : 2023-01-27 DOI: 10.37275/nasetjournal.v3i2.35
I Putu Aris Eka Saputra, M. Sucipta, Hendra Wijaksana
A heat recovery system is a form of reuse of wasted heat energy as a water heater. The water heater is an effort to utilize heat from the work of the compressor without reducing the function of the air conditioner as a room cooler. This study aimed to evaluate the coefficient of performance between standard air conditioners and modified air conditioners with heat recovery systems using a helical-type heat exchanger with a distance of 0 cm between coils. This was an experimental study on a helical-type heat exchanger. Tests were carried out on standard split air conditioners and modified split air conditioners with heat exchangers. The independent variables in this study are variations of the helical type heat exchanger with a distance of 0 cm between the coil and variations in the air setting at the evaporator output. 16ºC, 20ºC and 24ºC. The dependent variable in this study is the coefficient of performance. The evaporator outlet air temperature setting of 16°C has the greatest heat recovery system value, and this is because the evaporator outlet air temperature setting of 16°C has the largest h2 value compared to other evaporator outlet air temperature settings. The greater the evaporator output air temperature setting, the greater the value of the resulting heat recovery system. In conclusion, the highest coefficient of performance is found at the evaporation exit temperature of 24ºC, and the variation in the distance between the coil is 0 cm. Meanwhile, the hottest water temperature is found in the evaporator air setting of 16ºC with a variation of the distance between the coil of 0 cm.
热回收系统是将废热作为热水器进行再利用的一种形式。热水器是在不降低空调作为房间冷却器的功能的情况下利用压缩机工作产生的热量的一种努力。本研究旨在评估标准空调和带有热回收系统的改进空调之间的性能系数,该空调采用螺旋式热交换器,盘管之间的距离为0 cm。本文对螺旋式换热器进行了实验研究。对标准分体式空调和带热交换器的改进型分体式空调进行了试验。本研究的自变量为盘管之间距离为0 cm的螺旋式换热器的变化和蒸发器输出端空气设置的变化。16ºC, 20ºC和24ºC。本研究的因变量为绩效系数。蒸发器出口空气温度设置为16℃时,热回收系统值最大,这是因为蒸发器出口空气温度设置为16℃时,相比其他蒸发器出口空气温度设置,h2值最大。蒸发器输出的空气温度设定越大,产生的热回收系统的价值就越大。综上所述,蒸发出口温度为24℃时,性能系数最高,线圈间距变化为0 cm。蒸发器空气设定温度为16℃时水温最高,盘管间距变化为0 cm。
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引用次数: 0
Evaluation of Serpentine-Type Heat Exchanger Application on Water Heater with Passages Number Variation 蛇形换热器在变道数热水器上的应用评价
Pub Date : 2023-01-27 DOI: 10.37275/nasetjournal.v4i1.36
I Gede Arya Dimas Wisnu Murti Surawardana, M. Sucipta, Hendra Wijaksana
For some people, using warm water for bathing needs is a tertiary need because getting warm water requires additional costs. Generally, people/industry use water heaters that are sold in the market. These water heaters generally use electricity, solar power, or natural gas. This study aimed to evaluate the use of heat recovery systems as water heaters with variations in the number of passages. This research is an experimental study on a serpentine-type heat exchanger. Tests were carried out on standard split air conditioners and split air conditioners integrated with heat exchangers. The independent variables in this study were variations of the heat exchanger type serpentine with a length of 4 m, with each heat exchanger having a height of 20, 25, and 30 cm, with variations of 10, 12, and 14 passages and variations of evaporator output air settings 16ºC, 20ºC and 24ºC. The use of the evaporator outlet air temperature setting produces a different refrigeration effect value. The lower the evaporator output air temperature setting, the lower the resulting refrigeration effect value. The air temperature leaving the evaporator is 24ºC which results in a higher refrigeration effect value. This study showed the best heater performance at the evaporator air setting of 16ºC with a variation of 10 passages. In conclusion, the addition of a heat recovery system with serpentine-type heat exchanger variations 10 passages, 12 passages, 14 passages, and 24°C temperature loading variations, 20°C and 16°C on the evaporator burst will have an impact on decreasing the coefficient of performance on the split air conditioner system.
对一些人来说,使用温水洗澡是第三需要,因为获得温水需要额外的费用。一般来说,人们/工业使用市场上出售的热水器。这些热水器通常使用电力、太阳能或天然气。本研究的目的是评估使用的热回收系统作为热水器在通道数量的变化。本研究是对蛇纹石式换热器的实验研究。对标准分体式空调和带热交换器的分体式空调进行了试验。本研究的自变量为长度为4 m的蛇形换热器类型的变化,每个换热器的高度为20、25和30 cm, 10、12和14通道的变化以及蒸发器输出空气设置16ºC、20ºC和24ºC的变化。利用蒸发器出口空气温度的设定产生不同的制冷效果值。蒸发器输出空气温度设定越低,产生的制冷效果值越低。离开蒸发器的空气温度为24℃,制冷效果值更高。本研究表明,在蒸发器空气设置为16ºC时,加热器性能最佳,变化10次。综上所述,在分体式空调系统中增加蛇形换热器10通道、12通道、14通道以及温度负荷为24°C、20°C和16°C时,蒸发器爆裂对分体式空调系统性能系数的降低有影响。
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引用次数: 0
The Effect of Variation in Expansion Valve Capacity on Cooling Performance in Cold Storage Machines 膨胀阀容量变化对冷库制冷性能的影响
Pub Date : 2022-08-31 DOI: 10.37275/nasetjournal.v3i2.31
I Putu Gede Krisna Mahendra Putra, Hendra Wijaksana, Made Sucipta
The rapid development of the food storage industry in Indonesia, especially for basic ingredients, is very influential in the business world, such as the business of supplying food, fresh meat, and vegetables, all of which require a storage device that can maintain the freshness and quality of the food. These various products. One example of such a tool is cold storage. The increasing demand for food products makes suppliers have to meet the great demand for food by increasing the supply of products. With such conditions, many suppliers or owners of cold storage complain that the cooling performance of cold storage is not being achieved as needed. The effect of variations of the three expansion valves shows that the 2.8 TR expansion valve has cooled, whereas the 2.8 TR expansion valve has a higher refrigeration effect, and the compressor work on the 3.7 TR expansion valve and 4.4 TR expansion valve has a significant increase. This can be caused by the increased refrigerant flow so that the compressor makes a greater effort to compress the refrigerant, and from that, the system workability (COP) has decreased. The effect of the variation of the three expansion valves shows that the expansion valve 4.4 TR has a faster decrease in room temperature, where the initial room temperature is considered uniform. The 4.4 TR expansion valve opens the valve gap earlier, and the refrigerant flow that flows is greater when the engine is started so that heat is absorbed by the evaporator faster.
印尼食品仓储行业的快速发展,尤其是基础食材的快速发展,在商业领域具有非常大的影响力,例如供应食品、鲜肉和蔬菜的业务,都需要一种能够保持食品新鲜度和质量的存储设备。这些不同的产品。这种工具的一个例子是冷库。对食品需求的增加使得供应商不得不通过增加产品供应来满足对食品的巨大需求。在这种情况下,许多冷库的供应商或业主抱怨冷库的冷却性能没有达到所需。三种膨胀阀的变化效果表明,2.8 TR膨胀阀有冷却作用,2.8 TR膨胀阀制冷效果更高,3.7 TR膨胀阀和4.4 TR膨胀阀的压缩机功明显增加。这可能是由于制冷剂流量增加,压缩机需要更大的努力来压缩制冷剂,从而导致系统可工作性(COP)下降。三种膨胀阀的变化效应表明,在初始室温均匀的情况下,4.4 TR膨胀阀在室温下的下降速度更快。4.4 TR膨胀阀开启阀隙较早,发动机启动时流动的制冷剂流量较大,热量被蒸发器更快吸收。
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引用次数: 0
The Effect of Volume Fraction Variations Epoxy-Rice Straw Composite Fibers with NaOH Treatment on Tensile and Bending Strength NaOH处理环氧-稻草复合纤维体积分数变化对拉伸和弯曲强度的影响
Pub Date : 2022-08-15 DOI: 10.37275/nasetjournal.v3i2.30
Muhammad Raihan Dwi Wibowo, Cok Istri Putri Kusuma Kencanawati, I Putu Lokantara
Rice straw waste is often a problem for farmers because of the lack of utilization until finally, only burning is done. The use of rice straw for composites aims to increase the economy and maximize the potential of rice straw waste to be more useful in the industry. This research uses epoxy sikadur 52-id mixed hardener in the ratio (2:1) as a matrix, and rice straw fiber as reinforcement, with a fiber length of 3 cm. The composition of fiber and resin uses a volume fraction of 10% fiber: 90% resin, 20% fiber: 80% resin, and 30% fiber: 70% resin. Printing using acrylic prints with a hand lay-up technique. The size of the test specimen refers to ASTM D-3039 for the tensile test and ASTM D790-03 for the bending test. The greatest tensile voltage is found in the volume fraction of 30% fiber of 25,431 MPa. The highest strain occurred in the volume fraction of 30% fiber 1.779. The largest modulus of elasticity comes from the volume fraction of 30% fiber of 1,988 GPa. In the bending test, the largest tensile voltage is found in the volume fraction of 30% fiber, which is 93.260 MPa. The highest strain occurred at a 10% fiber volume fraction of 4.721. The largest modulus of elasticity comes from the volume fraction of 30% fiber which is 3.739 GPa. In both types of testing, it was found that the volume fraction of 30% fiber had the highest tensile and bending strength.
水稻秸秆的浪费往往是农民的一个问题,因为缺乏利用,直到最后,只做焚烧。将稻草用于复合材料的目的是提高经济效益,并最大限度地发挥稻草废料在工业上更有用的潜力。本研究采用环氧sikadur 52-id混合硬化剂按比例(2:1)为基体,稻草纤维为增强剂,纤维长度为3cm。纤维与树脂的组成采用10%纤维:90%树脂、20%纤维:80%树脂、30%纤维:70%树脂的体积分数。印刷使用丙烯酸版画与手铺技术。试件尺寸拉伸试验参照ASTM D-3039,弯曲试验参照ASTM D790-03。拉伸电压在30%纤维体积分数为25,431 MPa时最大。当纤维体积分数为30%时,应变最大,为1.779。30%纤维体积分数为1988 GPa时弹性模量最大。在弯曲试验中,纤维体积分数为30%时拉伸电压最大,为93.260 MPa。当纤维体积分数为4.721时,应变最高。纤维体积分数为30%时弹性模量最大,为3.739 GPa。在两种类型的测试中,发现30%纤维体积分数具有最高的拉伸和弯曲强度。
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引用次数: 0
In vitro Naringenin SNEDDS Release Test by Dissolution 体外溶出法测定柚皮素SNEDDS的释放度
Pub Date : 2022-06-22 DOI: 10.37275/nasetjournal.v3i2.29
Gendis Purno Yudanti, Ilham Kuncahyo, Endang Diyah Ikasari
Naringenin is the main flavanone in grapefruit which has anti-inflammatory, anti-cancer, hepatoprotective and antilipid peroxidation effects. Its low solubility in water causes dissolution and low bioavailability when taken orally. This study aims to increase the solubility and bioavailability of naringenin by using the SNEDDS technique. Initial characterization to determine the optimum formula was carried out using the D-optimal mixture design method, namely by optimizing the composition of SNEDDS which consisted of triacetin as the oil phase, tween 80 as surfactant and transcutol P as cosurfactant as an independent factor and SNEDDS characterization included emulsification time, drug loading, size globules and percent transmittance in response. The optimization results showed that the optimum formula was obtained at the composition of 10% triacetin, 70% tween 80 and 20% transcutol P. The dissolution test showed that the SNEDDS of naringenin was capable of dissolution (Q30) of 87,50% ±1,73 at the 30th minute and the f2 value of 28,93 so it can be concluded that the dissolution profile between the SNEDDS of naringenin and the naringenin capsules is not identical.  
柚皮素是葡萄柚中主要的黄酮,具有抗炎、抗癌、保肝、抗脂质过氧化等作用。它在水中的溶解度低,口服时导致溶解和低生物利用度。本研究旨在利用SNEDDS技术提高柚皮素的溶解度和生物利用度。采用d -最优混合设计方法对SNEDDS进行初步表征,确定最佳配方,即以三乙酸乙酯为油相,吐温80为表面活性剂,transcutol P为助表面活性剂为独立因素,以乳化时间、载药量、粒径球和透光率为响应因素对SNEDDS的组成进行优化。优化结果表明,在三乙酸乙酯含量为10%、吐温含量为70%、吐温含量为80%、吐温含量为20%的条件下,柚皮素的最佳溶出度为87,50%±1,73,溶出度为28,93,表明柚皮素与柚皮素胶囊的溶出度不完全相同。
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引用次数: 0
The Structural Planning of Bunda Halimah Hospital Universitas Batam Using Steel Frame Construction 巴淡岛大学Bunda Halimah医院钢框架结构规划
Pub Date : 2022-05-31 DOI: 10.37275/nasetjournal.v3i1.28
Edi Indera
The structural planning of the Bunda Halimah Hospital Universitas Batam uses steel frame construction, planning includes calculating the load acting on the structure, namely in the form of dead loads, living loads, not taking into account earthquake loads. The height of the column in the planning of the Structure of the Bunda Halimah Hospital, is as high as 23.5 m. The process of analyzing the planning of building structures using the ETABS program. Guided by the Indonesian Steel Building Loading Regulations 1984 and SNI steel, to analyze the calculation of the dimensions of columns, beams and plates. The results of the loading calculation based on the Indonesian Steel Building Planning Regulations of 1984 were obtained for this building using WF 250x250x9x14kg/m child beams, WF Main Beams 300x300x10x15kg/m, WF building columns 350x350x12x19 kg/m, and using concrete plates for roofs with a thickness of 100 mm of D8 – 200 mm reinforcement and concrete plates for floors with a thickness of 120 mm of D8 - 200 mm reinforcement.  
巴淡大学Bunda Halimah医院的结构规划采用钢框架结构,规划包括计算作用在结构上的荷载,即恒载、活载的形式,不考虑地震荷载。在本达哈利玛医院的结构规划中,柱子的高度高达23.5米。利用ETABS程序分析建筑结构规划的过程。以1984年印尼钢结构建筑荷载规定和SNI钢为指导,对柱、梁、板的尺寸进行了分析计算。根据1984年印度尼西亚钢结构建筑规划条例的荷载计算结果,该建筑采用WF 250x250x9x14kg/m的子梁,WF主梁300x300x10x15kg/m, WF建筑柱350x350x12x19kg /m,屋顶采用厚度为100mm的D8 - 200mm钢筋混凝土板,地板采用厚度为120mm的D8 - 200mm钢筋混凝土板。
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引用次数: 0
Experimental Study of Permeability Characteristics of Bamboo Betung Activated Carbon as Alternative Pad Material for Direct Evaporative Cooling System 竹间活性炭作为直接蒸发冷却系统替代垫料的渗透特性实验研究
Pub Date : 2022-05-27 DOI: 10.37275/nasetjournal.v3i1.27
I. M. F. Arya Putra, Hendra Wijaksana, I Gede Teddy Prananda Surya
The increased growth in the building sector, especially in big cities, has triggered an increase in the need for electrical energy for cooling systems, most of which use compressor-based cooling systems. Direct Evaporative Cooling (DEC) is evaporative that produces cooling by utilizing the latent heat of evaporation of water on the wet surface of the pad material. The pad material must be sufficiently porous to allow the free flow of air through it and must have a large enough wet surface area. This study used carbonized and activated bamboo Betung as a material for the DEC system. The research was conducted to obtain the permeability characteristics of the carbonized bamboo pad material at various temperatures of 400oC, 500oC 600oC, 700oC, and 800oC and then activated at a temperature of 600oC with a holding time of 60 minutes. Based on the results of the research on the permeability characteristics of bamboo Betung activated carbon material, which was carbonized at a temperature of 400oC and activated at a temperature of 600oC with a holding time of 60 minutes (ABR 400) had the highest permeability of 13.6 x 10-15 m2. Meanwhile, the lowest permeability was produced by bamboo Betung material which was carbonized at a temperature of 800oC and activated at an activation temperature of 600oC with a holding time of 60 minutes (ABR 800) which is only 0.56x10-15 m2.
建筑行业的增长,特别是在大城市,引发了冷却系统电能需求的增加,其中大多数使用基于压缩机的冷却系统。直接蒸发冷却(DEC)是通过利用垫料湿表面上的水蒸发潜热来产生冷却的蒸发。衬垫材料必须具有足够的多孔性,以允许空气自由流动,并且必须具有足够大的湿表面积。本研究以经炭化活化的贝当竹为材料,制作DEC系统。研究炭化竹垫材料在400℃、500℃、600℃、700℃、800℃等不同温度下的渗透特性,然后在600℃下活化,保温时间为60分钟。根据竹间活性炭材料的渗透性特性研究结果,经400℃炭化,600℃活化,保温时间60分钟(abr400),其渗透性最高,为13.6 × 10-15 m2。同时,在800℃炭化,600℃活化,保温60分钟的竹Betung材料的渗透率最低(abr800),仅为0.56x10-15 m2。
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引用次数: 0
Simulation of Airflow Patterns and Aerodynamic Forces on a Chambered Airfoil and Symmetric Airfoil with Maximum Thickness Variation 模拟气流模式和空气动力对一个室翼型和对称翼型与最大厚度变化
Pub Date : 2022-05-27 DOI: 10.37275/nasetjournal.v3i1.26
I. G. Kartana, Anak Agung Adhi Suryanwan, I Gusti Ketut Sukadana
Flow across the airfoil can cause drag and lift forces. The difference in pressure between the top and bottom surfaces of the airfoil creates a force that is perpendicular to the flow of fluid, and this force is called the lift force, and parallel to the flow is called the drag force. The author conducted research on simulating airflow patterns across the airfoil with maximum thickness variations. In this research, the simulation method is CFD (Computational Fluid Dynamic) using ANSYS Fluent software. The solution or solver method used in this simulation is the SIMPLE (Semi Implicit Method for Pressure Linked Equation) scheme. The flow pattern is shown by the streamline formed on the symmetric airfoil for α=0°, which will be symmetric, as well as the separation on the two sides, both the upper and lower sides. In contrast to the chambered airfoil, flow separation occurs only on the upper side. This indicates that there will be a pressure difference on the upper side and lower side so that the lift force can occur even though α=0°, because the lower side shows the pressure side. The greater the maximum thickness, the faster flow separation occurs. Then the higher the velocity value, the flow separation will be delayed due to an increase in the momentum of the working fluid flow, which overcomes the shear stress that occurs. At the angle of attack α=0°, the greater the maximum thickness of the chambered airfoil produces a greater lift force, while the symmetric airfoil does not produce lift.
气流穿过翼型会造成阻力和升力。翼型的顶部和底部表面之间的压力差产生了一种垂直于流体流动的力,这种力称为升力,平行于流体流动的力称为阻力。作者进行了模拟气流模式的研究横跨最大厚度变化的翼型。本研究采用CFD (Computational Fluid Dynamic,计算流体动力学)仿真方法,采用ANSYS Fluent软件。在此模拟中使用的解或求解器方法是SIMPLE(压力链接方程的半隐式方法)格式。流动模式是由流线上形成的对称翼型为α=0°,这将是对称的,以及两侧的分离,无论是上侧和下侧。在对比室翼型,流动分离只发生在上部。这表明,即使α=0°,上下侧也会存在压力差,因此升力可以发生,因为下侧显示压力侧。最大厚度越大,流动分离越快。那么速度值越高,由于工作流体流动动量的增加,流动分离将被推迟,这克服了所发生的剪切应力。在迎角α=0°,更大的最大厚度的室翼型产生更大的升力,而对称翼型不产生升力。
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引用次数: 0
Development of a Simultaneous Sulfadiazine, Sulfamethoxazole, and Tetracycline Antibiotic Level Determination Method with High-Performance Liquid Chromatography 高效液相色谱法同时测定磺胺嘧啶、磺胺甲恶唑和四环素抗生素水平的建立
Pub Date : 2022-05-24 DOI: 10.37275/nasetjournal.v3i1.25
Yanulia Handayani, Iswandi, Supriyadi
Sulfonamides and tetracyclines are a group of synthetic antibacterials that are widely used in veterinary practice for the treatment and prevention of infections in animals that can be consumed by humans. The purpose of this study was to determine the optimum conditions for High-Performance Liquid Chromatography for simultaneous analysis of sulfadiazine, sulfamethoxazole, and tetracycline and meet the validation requirements. The research method used is the HPLC method. The instruments used are Agilent 1220 Infinity II low-pressure dual-channel gradient valve, variable wavelength detector (VWD) BI detector, the column used is Agilent 5 TC-C18 (250 x 4.6 mm), motion phase A = acetic acid 0.08%: acetonitrile (9:1) and motion phase B = methanol with a flow rate gradient of 0.5 mL/minute and UV-VIS detector at wavelength 295 hm. The results showed that the method of determining the levels of sulfadiazine, sulfamethoxazole, and tetracycline met the requirements of selectivity, accuracy, precision, linearity, LOD, and LOQ and could be applied to fish samples. The accuracy parameter test obtained recovery results between 96.99%-103.16% at all sample concentration levels of 80%, 100%, and 120%. Testing the precision parameters showed that all sample concentrations were 100% repeated for 6 times replications, fulfilling the precision requirements, namely, the concentration of ≥10 ppm was < 7.3%. The linearity test showed that the correlation coefficient of sulfadiazine was 0.999, sulfamethoxazole was 0.999, and tetracycline was 0.998. LOD and LOQ values of sulfadiazine 1.15 ppm and 3.84 ppm, sulfamethoxazole LOD 2.51 ppm and LOQ 8.37 ppm, and tetracycline LOD 3.37 ppm and LOQ 11.22 ppm. Applications to fish samples were carried out by addition and obtained levels of 14.79 ppm sulfadiazine, 14.01 ppm sulfamethoxazole, and 45.05 ppm tetracycline.   
磺胺类药物和四环素类药物是一组合成抗菌素,在兽医实践中广泛用于治疗和预防可被人类食用的动物感染。本研究的目的是确定高效液相色谱法同时分析磺胺嘧啶、磺胺甲恶唑和四环素的最佳条件,并满足验证要求。研究方法采用HPLC法。所用仪器为Agilent 1220 Infinity II低压双通道梯度阀,可变波长检测器(VWD) BI检测器,色谱柱为Agilent 5 TC-C18 (250 × 4.6 mm),运动相A =乙酸0.08%:乙腈(9:1),运动相B =甲醇,流速梯度0.5 mL/min,波长295 hm UV-VIS检测器。结果表明,磺胺嘧啶、磺胺甲恶唑和四环素的含量测定方法符合选择性、准确度、精密度、线性、定量限和定量限要求,可应用于鱼类样品。在样品浓度为80%、100%和120%时,准确度参数测试的回收率在96.99% ~ 103.16%之间。精密度参数测试表明,所有样品浓度重复6次均为100%,满足精密度要求,即≥10 ppm的浓度< 7.3%。线性检验结果表明,磺胺嘧啶、磺胺甲恶唑、四环素的相关系数分别为0.999、0.999和0.998。磺胺嘧啶的LOD和LOQ分别为1.15 ppm和3.84 ppm,磺胺甲恶唑的LOD为2.51 ppm, LOQ为8.37 ppm,四环素的LOD为3.37 ppm, LOQ为11.22 ppm。通过添加对鱼样品进行应用,获得了14.79 ppm磺胺嘧啶、14.01 ppm磺胺甲恶唑和45.05 ppm四环素的水平。
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引用次数: 1
Fenofibrate Characterization of Solid Lipid Nanoparticles Using the High Shear Homogenization Method 非诺贝特固体脂质纳米颗粒的高剪切均质化表征
Pub Date : 2022-03-29 DOI: 10.37275/nasetjournal.v2i2.21
Muhimmatul Khoiriyah, Jason Merari Perangirangin, Ilham Kuncahyo
Fenofibrate is a drug that can be used to treat hyperlipidemia where the drug is included in the category of Biopharmaceutical classification system II with poor solubility and high permeability. This causes the need to improve the drug delivery system (DDS) made using the solid lipid nanoparticle (SLN) method. SLN fenofibrate can be made using the high shear homogenization method by determining the formula using Factorial 22 Design Expert 12. The formula is made with a concentration of 0.31-1.25% GMS and 1.25-2% Tween-40, then SLN fenofibrate is made by mixing all ingredients until an emulsion is formed and continued with the SLN critical parameter test. From the test results, the critical parameters of SLN fenofibrate for the particle size of 8 formulas 490; 561; 601; 697; 916; 1040; 1818, and 2410 nm. The results obtained for the polydispersity index, respectively, were 0.02; 0.04; 0.08; 0.30; 0.35; 0.48; 0.51, and 0.65. The zeta potential value of the 8 formulas obtained successive values of 2.8; 3.5; 4.2; 4.8; 5.5; 5.8; 8.1, and 8.8 mV. Calculation of the efficiency of the SLN fenofibrate drug obtained successive values of 77.23; 78.53; 79.51; 80.47; 81.17; 87.38; 87.39, and 87.82%. The SLN method can improve drugs that are included in the Biopharmaceutical classification system class II category with the distribution of test results in the particle size range, and the adsorbed drug is more than 70%.
非诺贝特是一种可用于治疗高脂血症的药物,其溶解度差,渗透性高,属于生物制药分类系统II类。这导致需要改进使用固体脂质纳米颗粒(SLN)方法制成的药物输送系统(DDS)。利用析因22 Design Expert 12确定配方,采用高剪切均质法制备SLN非诺贝特。以0.31-1.25%的GMS和1.25-2%的Tween-40配制成配方,将所有原料混合至乳液形成,继续进行SLN关键参数测试。从试验结果来看,非诺贝特SLN的关键参数为8个配方的粒径490;561;601;697;916;1040;1818和2410纳米。多分散性指数分别为0.02;0.04;0.08;0.30;0.35;0.48;0.51和0.65。8个公式的zeta电位值依次为2.8;3.5;4.2;4.8;5.5;5.8;8.1和8.8 mV。计算非诺贝特类药物的SLN效率连续值为77.23;78.53;79.51;80.47;81.17;87.38;87.39和87.82%。SLN方法可以改善纳入生物制药分类系统II类的药物,试验结果分布在粒径范围内,吸附药物在70%以上。
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引用次数: 0
期刊
Natural Sciences Engineering and Technology Journal
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