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Molecular biology, biochemistry, and biophysics最新文献

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Coupled oscillator theory of enzyme action. 酶作用的耦合振荡器理论。
Molecular biology, biochemistry, and biophysics
Pub Date : 1980-01-01 DOI: 10.1007/978-3-642-81503-4_7
M D Williams, J L Fox
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引用次数: 2
Three multifunctional protein kinase systems in transmembrane control. 跨膜控制中的三种多功能蛋白激酶系统。
Molecular biology, biochemistry, and biophysics
Pub Date : 1980-01-01 DOI: 10.1007/978-3-642-81503-4_9
Y Nishizuka
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引用次数: 51
Regulation of muscle contraction by Ca ion. 钙离子对肌肉收缩的调节。
Molecular biology, biochemistry, and biophysics
Pub Date : 1980-01-01 DOI: 10.1007/978-3-642-81503-4_14
S Ebashi, Y Nonomura, K Kohama, T Kitazawa, T Mikawa
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引用次数: 19
Structural and dynamic aspects of recognition between tRNAs and aminoacyl-tRNA synthetases. trna和氨基- trna合成酶之间识别的结构和动态方面。
Molecular biology, biochemistry, and biophysics
Pub Date : 1980-01-01 DOI: 10.1007/978-3-642-81503-4_22
D G Knorre, V V Vlassov
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引用次数: 5
On codon- anticodon interactions. 关于密码子-反密码子相互作用。
Molecular biology, biochemistry, and biophysics
Pub Date : 1980-01-01 DOI: 10.1007/978-3-642-81503-4_27
H Grosjean, H Chantrenne
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引用次数: 30
Suicide substrates: mechanism-based inactivators of specific target enzymes. 自杀底物:特定靶酶的基于机制的失活剂。
Molecular biology, biochemistry, and biophysics
Pub Date : 1980-01-01 DOI: 10.1007/978-3-642-81503-4_5
C Walsh
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引用次数: 5
Subunit interaction of adenylylated glutamine synthetase. 腺苷化谷氨酰胺合成酶的亚基相互作用。
Molecular biology, biochemistry, and biophysics
Pub Date : 1980-01-01 DOI: 10.1007/978-3-642-81503-4_11
E R Stadtman, R J Hohman, J N Davis, M Wittenberger, P B Chock, S G Rhee

The glutamine synthetase (GS) activity in Escherichia coli is regulated by a bicyclic interconvertible enzyme cascade which involves the cyclic adenylylation (inactivation) and deadenylylation (activation) of GS on the one hand, and the modulation of these processes by the uridylylation and deuridylylation of Shapiro's regulatory protein on the other. The specific activity of GS in a given metabolic state is determined by the fraction of its subunits that are adenylylated, and this fraction is determined by the concentration of over 40 metabolites. Through allosteric and substrate interactions with one or more of the cascade enzymes, these metabolites alter the rates of the covalent modification and demodification reactions. By means of immunoprecipitation studies with anti-AMP specific antibodies, it has been established that the partially adenylylated glutamine synthetase, which is present in a given steady state, is a mixture of hybrid molecules containing different numbers and possibly distributions of adenylylated subunits. Partial separation of these hybrid mixtures has been achieved by affinity chromatography on Affi-Blue Sepharose columns. From immunochemical studies it is evident that anti-AMP antibodies can react with adenylylated subunits of all molecular species of GS, but that the capacities of these primary antigen-antibody reactions to yield precipitable aggregates is very dependent of the number of adenylylated subunits per molecule, and much less so upon the total concentration of adenylylated subunits present. the studies suggest that precipitability is a function either of the distribution of adenylylated subunits within hybrid species, or of the kinetics of intra- vs intermolecular bivalent interactions.

大肠杆菌谷氨酰胺合成酶(GS)的活性受一个双环互转换酶级联反应的调控，该酶级联反应一方面涉及GS的环腺苷化(失活)和去乙酰化(活化)，另一方面涉及夏皮罗调节蛋白的尿苷化和去尿苷化对这些过程的调节。GS在特定代谢状态下的比活性是由其腺苷化亚基的比例决定的，而这个比例是由40多种代谢物的浓度决定的。通过变构和底物与一种或多种级联酶的相互作用，这些代谢物改变了共价修饰和去甲基反应的速率。通过抗amp特异性抗体的免疫沉淀研究，已经确定部分腺苷化谷氨酰胺合成酶存在于给定的稳态，是含有不同数量和可能分布的腺苷化亚基的杂化分子的混合物。在Affi-Blue Sepharose的亲和色谱柱上实现了这些混合物的部分分离。免疫化学研究表明，抗amp抗体可以与所有GS分子种类的腺苷化亚基反应，但这些初级抗原-抗体反应产生可沉淀聚集体的能力非常依赖于每个分子中腺苷化亚基的数量，而不太依赖于存在的腺苷化亚基的总浓度。这些研究表明，可沉淀性是杂交种内腺苷化亚基分布的函数，或者是分子内与分子间二价相互作用动力学的函数。
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引用次数: 6
Molecular biology biochemistry and biophysics. 分子生物学，生物化学和生物物理学。
Molecular biology, biochemistry, and biophysics
Pub Date : 1980-01-01
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引用次数: 0
Molecular biology, culture, and society. 分子生物学，文化和社会。
Molecular biology, biochemistry, and biophysics
Pub Date : 1980-01-01 DOI: 10.1007/978-3-642-81503-4_30
R Monro
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引用次数: 0
Effect of catabolite repression on chemotaxis in Salmonella typhimurium. 抑制分解代谢物对鼠伤寒沙门菌趋化性的影响。
Molecular biology, biochemistry, and biophysics
Pub Date : 1980-01-01 DOI: 10.1007/978-3-642-81503-4_10
D E Koshland, M J Anderson

The chemotaxis of Salmonella typhimurium LT2-ST1, grown with different sole carbon sources toward ribose, allose, serine, aspartate, and glucose, was examined. Maximum chemotaxis toward serine, aspartate, and glucose were unchanged with either glucose or citrate as the carbon source. The height of the peak in the ribose response curve was 25% of a standard serine response when the bacteria were grown on citrate. However, when the bacteria were grown on glucose, the ribose response was 1% of the serine standard, and when on glycerol, 5%. Chemotaxis toward allose, a competitive inhibitor of ribose chemotaxis, was similarly affected. The amount of ribose binding protein, the receptor for ribose chemotaxis, was determined in bacteria grown on citrate, glucose, or glycerol. The amount of ribose-binding protein released from cells grown on glucose or glycerol was appreciably less than the amount released from cells grown on citrate. These data suggest that the observed effect on ribose chemotaxis is due to catabolite repression of ribose-binding protein and another component of the chemotactic system.

研究了不同单一碳源培养的鼠伤寒沙门氏菌LT2-ST1对核糖、近醛、丝氨酸、天冬氨酸和葡萄糖的趋化性。无论是葡萄糖还是柠檬酸作为碳源，对丝氨酸、天冬氨酸和葡萄糖的趋化性都没有变化。当细菌在柠檬酸盐上生长时，核糖反应曲线的峰值高度为标准丝氨酸反应的25%。然而，当细菌在葡萄糖上生长时，核糖反应是丝氨酸标准的1%，在甘油上生长时是5%。趋化性对allose，一种核糖趋化性的竞争性抑制剂，同样受到影响。核糖结合蛋白(核糖趋化性的受体)的数量被测定在柠檬酸盐、葡萄糖或甘油上生长的细菌中。在葡萄糖或甘油上生长的细胞释放的核糖结合蛋白的量明显少于在柠檬酸盐上生长的细胞释放的量。这些数据表明，观察到的对核糖趋化性的影响是由于分解代谢物抑制了核糖结合蛋白和趋化系统的另一个组成部分。
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引用次数: 2
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