Pub Date : 2024-11-01Epub Date: 2024-01-31DOI: 10.4103/NRR.NRR-D-23-01663
Valerie M K Verge, Nataliya Tokarska, Justin M Naniong
{"title":"Unraveling the potential of acute intermittent hypoxia as a strategy for inducing robust repair in multiple sclerosis.","authors":"Valerie M K Verge, Nataliya Tokarska, Justin M Naniong","doi":"10.4103/NRR.NRR-D-23-01663","DOIUrl":"10.4103/NRR.NRR-D-23-01663","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01Epub Date: 2024-03-08DOI: 10.4103/NRR.NRR-D-23-01790
Ibrahim Olabayode Saliu, Guoyan Zhao
{"title":"New insights into astrocyte diversity from the lens of transcriptional regulation and their implications for neurodegenerative disease treatments.","authors":"Ibrahim Olabayode Saliu, Guoyan Zhao","doi":"10.4103/NRR.NRR-D-23-01790","DOIUrl":"10.4103/NRR.NRR-D-23-01790","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01Epub Date: 2024-01-31DOI: 10.4103/NRR.NRR-D-23-01754
Juan Antonio López-Villodres, Beatriz García-Díaz
{"title":"Oligodendroctyes: the forgotten players of diabetes pathophysiology.","authors":"Juan Antonio López-Villodres, Beatriz García-Díaz","doi":"10.4103/NRR.NRR-D-23-01754","DOIUrl":"10.4103/NRR.NRR-D-23-01754","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01Epub Date: 2024-03-08DOI: 10.4103/NRR.NRR-D-23-01927
Gefei Chen, Jan Johansson
{"title":"Potential of molecular chaperones for treating Alzheimer's disease.","authors":"Gefei Chen, Jan Johansson","doi":"10.4103/NRR.NRR-D-23-01927","DOIUrl":"10.4103/NRR.NRR-D-23-01927","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01Epub Date: 2024-01-31DOI: 10.4103/NRR.NRR-D-23-01470
Karina Lindner, Anne-Claude Gavin
Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer's disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. its synthesis, secretion, degradation, and lipidation, is affected in Alzheimer's disease.
载脂蛋白 E 是大脑中的主要脂质转运体，也是神经元-胃囊代谢耦合中的重要角色。它通过滋养和解毒神经元，确保神经元在应激条件和过度活跃的情况下存活。载脂蛋白 E 的多态性，加上环境压力和/或与年龄有关的改变，会影响晚发性阿尔茨海默病的发病风险。在这篇综述中，我们将讨论脂蛋白 E 的合成、分泌、降解和脂化等脂蛋白 E 平衡状态如何影响阿尔茨海默病的现有知识。
{"title":"Isoform- and cell-state-specific APOE homeostasis and function.","authors":"Karina Lindner, Anne-Claude Gavin","doi":"10.4103/NRR.NRR-D-23-01470","DOIUrl":"10.4103/NRR.NRR-D-23-01470","url":null,"abstract":"<p><p>Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer's disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. its synthesis, secretion, degradation, and lipidation, is affected in Alzheimer's disease.</p>","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01Epub Date: 2024-01-31DOI: 10.4103/NRR.NRR-D-23-01614
Charles H Nelson, Udai B Pandey
The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction (NEDCAM) has resulted in an increased interest in GEMIN5, a multifunction RNA-binding protein. As the largest member of the survival motor neuron complex, GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent protein. Although many questions remain regarding both the pathogenesis and pathophysiology of this new disorder, considerable progress has been made in the brief time since its discovery. In this review, we examine GEMIN5 within the context of NEDCAM, focusing on the structure, function, and expression of the protein specifically in regard to the disorder itself. Additionally, we explore the current animal models of NEDCAM, as well as potential molecular pathways for treatment and future directions of study. This review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.
{"title":"Function and dysfunction of GEMIN5: understanding a novel neurodevelopmental disorder.","authors":"Charles H Nelson, Udai B Pandey","doi":"10.4103/NRR.NRR-D-23-01614","DOIUrl":"10.4103/NRR.NRR-D-23-01614","url":null,"abstract":"<p><p>The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction (NEDCAM) has resulted in an increased interest in GEMIN5, a multifunction RNA-binding protein. As the largest member of the survival motor neuron complex, GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent protein. Although many questions remain regarding both the pathogenesis and pathophysiology of this new disorder, considerable progress has been made in the brief time since its discovery. In this review, we examine GEMIN5 within the context of NEDCAM, focusing on the structure, function, and expression of the protein specifically in regard to the disorder itself. Additionally, we explore the current animal models of NEDCAM, as well as potential molecular pathways for treatment and future directions of study. This review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.</p>","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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