R. Sakakibara, A. Shimizu, O. Takahashi, Tsuyoshi Ogata, S. Sawai, T. Uchiyama, Tatsuya Yamamoto
The question of whether Parkinson's disease (PD) patients have nocturnal polyuria (NP) has not yet been fully answered.
帕金森病（PD）患者是否有夜间多尿（NP）的问题尚未得到充分回答。
{"title":"Parkinson's disease and nocturnal polyuria","authors":"R. Sakakibara, A. Shimizu, O. Takahashi, Tsuyoshi Ogata, S. Sawai, T. Uchiyama, Tatsuya Yamamoto","doi":"10.1111/ncn3.12686","DOIUrl":"https://doi.org/10.1111/ncn3.12686","url":null,"abstract":"The question of whether Parkinson's disease (PD) patients have nocturnal polyuria (NP) has not yet been fully answered.","PeriodicalId":19154,"journal":{"name":"Neurology and Clinical Neuroscience","volume":"11 1","pages":"27 - 31"},"PeriodicalIF":0.4,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42496017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shunji Edagawa, N. Ito, Y. Nakamura, T. Toyoshima, Y. Ohkubo, S. Chiba
Cytology of cerebrospinal fluid is the gold standard for diagnosing leptomeningeal carcinomatosis, despite its low sensitivity. Herein, we report a case of leptomeningeal carcinomatosis in a patient with relapsed lung adenocarcinoma who presented with tinnitus and hearing loss for 3 months. Magnetic resonance imaging revealed characteristic fluid‐attenuated inversion recovery and diffusion‐weighted imaging hyperintensities along the leptomeningeal surfaces of the brainstem. The ratio of the concentration of carcinoembryonic antigen in the serum and cerebrospinal fluid was 1.2:1. The cerebrospinal fluid cytology obtained at the fourth lumbar puncture revealed suspected malignancy, and a definitive diagnosis of metastatic adenocarcinoma was confirmed via brain biopsy. This case supports the utility of characteristic magnetic resonance imaging appearance and repeated lumber punctures as an evaluation for leptomeningeal carcinomatosis.
{"title":"Characteristic magnetic resonance imaging of leptomeningeal metastases of lung adenocarcinoma: Fluid‐attenuated inversion recovery and diffusion‐weighted imaging hyperintensity on brainstem surfaces","authors":"Shunji Edagawa, N. Ito, Y. Nakamura, T. Toyoshima, Y. Ohkubo, S. Chiba","doi":"10.1111/ncn3.12684","DOIUrl":"https://doi.org/10.1111/ncn3.12684","url":null,"abstract":"Cytology of cerebrospinal fluid is the gold standard for diagnosing leptomeningeal carcinomatosis, despite its low sensitivity. Herein, we report a case of leptomeningeal carcinomatosis in a patient with relapsed lung adenocarcinoma who presented with tinnitus and hearing loss for 3 months. Magnetic resonance imaging revealed characteristic fluid‐attenuated inversion recovery and diffusion‐weighted imaging hyperintensities along the leptomeningeal surfaces of the brainstem. The ratio of the concentration of carcinoembryonic antigen in the serum and cerebrospinal fluid was 1.2:1. The cerebrospinal fluid cytology obtained at the fourth lumbar puncture revealed suspected malignancy, and a definitive diagnosis of metastatic adenocarcinoma was confirmed via brain biopsy. This case supports the utility of characteristic magnetic resonance imaging appearance and repeated lumber punctures as an evaluation for leptomeningeal carcinomatosis.","PeriodicalId":19154,"journal":{"name":"Neurology and Clinical Neuroscience","volume":"11 1","pages":"55 - 57"},"PeriodicalIF":0.4,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46508403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kazunori Iwao, Mitsuru Watanabe, T. Mukaino, T. Fujii, R. Yamasaki, N. Isobe
Chromosomally integrated human herpesvirus 6 (ciHHV6) is a condition where HHV6‐DNA is integrated into the host germline genome. ciHHV6 can be misdiagnosed as active HHV6 infection. We report a 30‐year‐old woman presenting with psychological symptoms without a history of immunodeficiency. She had an ovarian teratoma and anti‐N‐methyl‐D‐aspartate receptor (NMDAR) antibodies in the cerebrospinal fluid (CSF) with HHV6‐DNA in the serum and CSF. The final diagnosis was anti‐NMDAR encephalitis and ciHHV6 because laparoscopic oophorectomy and immunotherapy ameliorated her symptoms and HHV6‐DNA was detected in her oral mucosa cells. This case suggests the need to assess whether HHV6‐DNA is related to infection or ciHHV6 when HHV6‐DNA is detected in the CSF of patients with encephalitis.
{"title":"A case report of anti‐N‐methyl‐d‐aspartate receptor encephalitis with chromosomally integrated human herpesvirus 6","authors":"Kazunori Iwao, Mitsuru Watanabe, T. Mukaino, T. Fujii, R. Yamasaki, N. Isobe","doi":"10.1111/ncn3.12681","DOIUrl":"https://doi.org/10.1111/ncn3.12681","url":null,"abstract":"Chromosomally integrated human herpesvirus 6 (ciHHV6) is a condition where HHV6‐DNA is integrated into the host germline genome. ciHHV6 can be misdiagnosed as active HHV6 infection. We report a 30‐year‐old woman presenting with psychological symptoms without a history of immunodeficiency. She had an ovarian teratoma and anti‐N‐methyl‐D‐aspartate receptor (NMDAR) antibodies in the cerebrospinal fluid (CSF) with HHV6‐DNA in the serum and CSF. The final diagnosis was anti‐NMDAR encephalitis and ciHHV6 because laparoscopic oophorectomy and immunotherapy ameliorated her symptoms and HHV6‐DNA was detected in her oral mucosa cells. This case suggests the need to assess whether HHV6‐DNA is related to infection or ciHHV6 when HHV6‐DNA is detected in the CSF of patients with encephalitis.","PeriodicalId":19154,"journal":{"name":"Neurology and Clinical Neuroscience","volume":"11 1","pages":"52 - 54"},"PeriodicalIF":0.4,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42122819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oculopharyngodistal myopathy","authors":"N. Eura, M. Ogasawara, I. Nishino","doi":"10.1111/ncn3.12680","DOIUrl":"https://doi.org/10.1111/ncn3.12680","url":null,"abstract":"","PeriodicalId":19154,"journal":{"name":"Neurology and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46127198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Matsui, Mika Takahara, H. Yamazaki, N. Takamatsu, Y. Osaki, Ryuji Kaji, I. Nishino, S. Yamashita, Y. Izumi
We report a case of an 82‐year‐old woman with inclusion body myositis (IBM), who presented with severe dysphagia, finger flexor weakness, and respiratory dysfunction. In addition, the patient showed prominent forearm weakness with quadriceps sparing and was seropositive for the anti‐cytosolic 5′‐nucleotidase 1A (NT5c1A) antibody. The presence of the anti‐NT5c1A antibody is presumably associated with dysphagia. We speculate that the anti‐NT5c1A antibody is associated with the large discrepancy between distal upper limb weakness and proximal lower limb weakness in IBM.
{"title":"Case of anti‐NT5c1A antibody‐seropositive inclusion body myositis associated with severe dysphagia and prominent forearm weakness","authors":"N. Matsui, Mika Takahara, H. Yamazaki, N. Takamatsu, Y. Osaki, Ryuji Kaji, I. Nishino, S. Yamashita, Y. Izumi","doi":"10.1111/ncn3.12678","DOIUrl":"https://doi.org/10.1111/ncn3.12678","url":null,"abstract":"We report a case of an 82‐year‐old woman with inclusion body myositis (IBM), who presented with severe dysphagia, finger flexor weakness, and respiratory dysfunction. In addition, the patient showed prominent forearm weakness with quadriceps sparing and was seropositive for the anti‐cytosolic 5′‐nucleotidase 1A (NT5c1A) antibody. The presence of the anti‐NT5c1A antibody is presumably associated with dysphagia. We speculate that the anti‐NT5c1A antibody is associated with the large discrepancy between distal upper limb weakness and proximal lower limb weakness in IBM.","PeriodicalId":19154,"journal":{"name":"Neurology and Clinical Neuroscience","volume":"11 1","pages":"46 - 48"},"PeriodicalIF":0.4,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45406427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Zivelonghi, C. D. De Pasqual, M. Plebani, M. Capellari
A 46‐year‐old man presented to the Emergency Department because of food bolus impaction after an emergent esophagogastroduodenoscopy (EGD). Three hours after the procedure, awakening from general anesthesia, he complained drowsiness and left‐sided weakness. Brain CT scan was unremarkable, while CT angiography performed later revealed signs of pneumomediastinum likely from an esophageal laceration. Thorough cardiological, hematological, and rheumatological investigations during hospital stay proved unremarkable. Cerebral air embolism (CAE) has been reported as a potential complication of endoscopic procedures, but the precise mechanism is still unknown.
{"title":"Cerebral air embolism: A hidden cause of acute ischemic stroke","authors":"C. Zivelonghi, C. D. De Pasqual, M. Plebani, M. Capellari","doi":"10.1111/ncn3.12676","DOIUrl":"https://doi.org/10.1111/ncn3.12676","url":null,"abstract":"A 46‐year‐old man presented to the Emergency Department because of food bolus impaction after an emergent esophagogastroduodenoscopy (EGD). Three hours after the procedure, awakening from general anesthesia, he complained drowsiness and left‐sided weakness. Brain CT scan was unremarkable, while CT angiography performed later revealed signs of pneumomediastinum likely from an esophageal laceration. Thorough cardiological, hematological, and rheumatological investigations during hospital stay proved unremarkable. Cerebral air embolism (CAE) has been reported as a potential complication of endoscopic procedures, but the precise mechanism is still unknown.","PeriodicalId":19154,"journal":{"name":"Neurology and Clinical Neuroscience","volume":"11 1","pages":"43 - 45"},"PeriodicalIF":0.4,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44978186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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