The amyloidoses are a heterogeneous group of diseases caused by the extracellular deposition of abnormally folded fibrillar proteins in organs and tissues, causing their dysfunction. The quality and life expectancy depend on the affected organ, with cardiac involvement being the main determinant of survival and quality of life. Diagnosis requires tissue biopsy and protein typing. Its late detection is associated with a lower prognosis and survival. The most common form of amyloidosis is caused by monoclonal light chain (AL) deposition, for which new immunologi-cal agents and chemotherapy aimed at suppressing plasma cell cloning have been shown to improve survival. For transthyretin amyloidosis (ATTR), the second in frequency, there are protein-stabilizing therapies and therapies aimed at stopping its synthesis through genetic silencing. This review focuses on the hematological bases for the clinical cardiologist.
{"title":"Diagnóstico de amiloidosis sistémica. Bases hematológicas útiles para el cardiólogo clínico","authors":"E. Riva","doi":"10.29277/cardio.37.1.11","DOIUrl":"https://doi.org/10.29277/cardio.37.1.11","url":null,"abstract":"The amyloidoses are a heterogeneous group of diseases caused by the extracellular deposition of abnormally folded fibrillar proteins in organs and tissues, causing their dysfunction. The quality and life expectancy depend on the affected organ, with cardiac involvement being the main determinant of survival and quality of life. Diagnosis requires tissue biopsy and protein typing. Its late detection is associated with a lower prognosis and survival. The most common form of amyloidosis is caused by monoclonal light chain (AL) deposition, for which new immunologi-cal agents and chemotherapy aimed at suppressing plasma cell cloning have been shown to improve survival. For transthyretin amyloidosis (ATTR), the second in frequency, there are protein-stabilizing therapies and therapies aimed at stopping its synthesis through genetic silencing. This review focuses on the hematological bases for the clinical cardiologist.","PeriodicalId":191575,"journal":{"name":"Revista Uruguaya de Cardiología","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116595020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Barranco, Alejandra Spinelli, Virginia Beneditto
Cardiac amyloidosis is an entity on increasing recognition, transthyretin variety is the most diagnosed in the third age. There is a recent availability of drugs that can improve the prognosis and quality of life of these patients. We present a case of transthyretin amyloidosis and the first use of tafamidis in our country.
{"title":"Primer uso de tafamidis en amiloidosis cardíaca TTR en Uruguay","authors":"D. Barranco, Alejandra Spinelli, Virginia Beneditto","doi":"10.29277/cardio.37.1.12","DOIUrl":"https://doi.org/10.29277/cardio.37.1.12","url":null,"abstract":"Cardiac amyloidosis is an entity on increasing recognition, transthyretin variety is the most diagnosed in the third age. There is a recent availability of drugs that can improve the prognosis and quality of life of these patients. We present a case of transthyretin amyloidosis and the first use of tafamidis in our country.","PeriodicalId":191575,"journal":{"name":"Revista Uruguaya de Cardiología","volume":"387 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115481436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plastia mitral en endocartitis infecciosa: reporte de un caso","authors":"","doi":"10.29277/cardio.37.1.4","DOIUrl":"https://doi.org/10.29277/cardio.37.1.4","url":null,"abstract":"","PeriodicalId":191575,"journal":{"name":"Revista Uruguaya de Cardiología","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127696125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preeclampsia can be associated with acute fatty liver of pregnancy, a rare disease. This report describes the case of a 35-year-old patient, gravida 3, pregnant with twins, who presented with severe pre-eclampsia associated with acute fatty liver of pregnancy. Early diagnosis and treatment of both pathologies was performed, resulting in good maternal-fetal evolution.
{"title":"Preeclampsia de presentación grave asociada a hígado graso agudo del embarazo","authors":"J. Castelli, Anabela Fernández, Caso Clínico","doi":"10.29277/cardio.37.1.5","DOIUrl":"https://doi.org/10.29277/cardio.37.1.5","url":null,"abstract":"Preeclampsia can be associated with acute fatty liver of pregnancy, a rare disease. This report describes the case of a 35-year-old patient, gravida 3, pregnant with twins, who presented with severe pre-eclampsia associated with acute fatty liver of pregnancy. Early diagnosis and treatment of both pathologies was performed, resulting in good maternal-fetal evolution.","PeriodicalId":191575,"journal":{"name":"Revista Uruguaya de Cardiología","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125017232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
VOL 25 NÚM 2 FEBRERO 2006 características de tipo genético y ambiental, que actúan individualmente o entre sí, con lo que desencadenan la presencia de un proceso cardiovascular. Surge entonces el termino «riesgo», que implica la presencia de una característica o factor que aumentan la probabilidad de presentar alguna enfermedad cardiovascular. Los expertos definen el «factor de riesgo cardiovascular» como cualquier característica o circunstancias detectables de una persona o grupo de personas que se relacionan con un aumento de la probabilidad de presentar o desarrollar una enfermedad cardiovascular. L as enfermedades del sistema circulatorio más comunes son la enfermedad isquémica del corazón y la enfermedad cerebrovascular o ictus (AVC). En conjunto producen algo más del 60% de la mortalidad cardiovascular, aunque la enfermedad isquémica del corazón es la que ocasiona, en España, un mayor número de muertes. En cada sociedad hay grupos de individuos que tienen más probabilidades que otros de presentar determinadas enfermedades cardiovasculares. Esta vulnerabilidad de algunos colectivos se debe a la presencia de determinadas Enfermedades cardiovasculares
{"title":"Enfermedades cardiovasculares: ¿qué perciben las mujeres del Uruguay?","authors":"","doi":"10.29277/cardio.37.1.1","DOIUrl":"https://doi.org/10.29277/cardio.37.1.1","url":null,"abstract":"VOL 25 NÚM 2 FEBRERO 2006 características de tipo genético y ambiental, que actúan individualmente o entre sí, con lo que desencadenan la presencia de un proceso cardiovascular. Surge entonces el termino «riesgo», que implica la presencia de una característica o factor que aumentan la probabilidad de presentar alguna enfermedad cardiovascular. Los expertos definen el «factor de riesgo cardiovascular» como cualquier característica o circunstancias detectables de una persona o grupo de personas que se relacionan con un aumento de la probabilidad de presentar o desarrollar una enfermedad cardiovascular. L as enfermedades del sistema circulatorio más comunes son la enfermedad isquémica del corazón y la enfermedad cerebrovascular o ictus (AVC). En conjunto producen algo más del 60% de la mortalidad cardiovascular, aunque la enfermedad isquémica del corazón es la que ocasiona, en España, un mayor número de muertes. En cada sociedad hay grupos de individuos que tienen más probabilidades que otros de presentar determinadas enfermedades cardiovasculares. Esta vulnerabilidad de algunos colectivos se debe a la presencia de determinadas Enfermedades cardiovasculares","PeriodicalId":191575,"journal":{"name":"Revista Uruguaya de Cardiología","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122193990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Síncope por mixoma auricular: a propósito de un caso clínico","authors":"Gabriel Fripp","doi":"10.29277/cardio.37.1.10","DOIUrl":"https://doi.org/10.29277/cardio.37.1.10","url":null,"abstract":"","PeriodicalId":191575,"journal":{"name":"Revista Uruguaya de Cardiología","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126074573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gimena Loza, Victoria Briano, A. Perdomo, Á. Niggemeyer, Juan Albistur
{"title":"Síncope y paro cardiorespiratorio, formas graves de presentación de la embolia pulmonar central. Reporte de tres casos clínicos","authors":"Gimena Loza, Victoria Briano, A. Perdomo, Á. Niggemeyer, Juan Albistur","doi":"10.29277/cardio.36.2.9","DOIUrl":"https://doi.org/10.29277/cardio.36.2.9","url":null,"abstract":"","PeriodicalId":191575,"journal":{"name":"Revista Uruguaya de Cardiología","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131253139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novedades de las guías de la Sociedad Europea de Cardiología 2020 sobre manejo del síndrome coronario agudo sin elevación persistente del segmento ST","authors":"Carlos Guamán, Gimena Loza, Juan Albistur","doi":"10.29277/cardio.36.1.11","DOIUrl":"https://doi.org/10.29277/cardio.36.1.11","url":null,"abstract":"","PeriodicalId":191575,"journal":{"name":"Revista Uruguaya de Cardiología","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115153751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Resumen La diabetes mellitus, la insuficiencia cardíaca y la enfermedad renal crónica tienen alta prevalencia en la población. Asimismo, estas patologías están comprendidas en un “círculo vicioso” porque comparten mecanismos fisiopatológicos que predisponen a su coexistencia en un mismo paciente, incrementando significativamente el riesgo de eventos cardiovasculares. Recientemente se han agregado al arsenal terapéutico las gliflozinas, un grupo de fármacos con beneficios en las tres enfermedades mencionadas. Saber cómo se desarrolló la investigación con estos fármacos y sus mecanismos de acción es fundamental para optimizar el tratamiento de los pacientes.
{"title":"Gliflozinas: más que antidiabéticos orales. Una breve revisión de la literatura","authors":"V. González","doi":"10.29277/cardio.36.1.14","DOIUrl":"https://doi.org/10.29277/cardio.36.1.14","url":null,"abstract":"Resumen La diabetes mellitus, la insuficiencia cardíaca y la enfermedad renal crónica tienen alta prevalencia en la población. Asimismo, estas patologías están comprendidas en un “círculo vicioso” porque comparten mecanismos fisiopatológicos que predisponen a su coexistencia en un mismo paciente, incrementando significativamente el riesgo de eventos cardiovasculares. Recientemente se han agregado al arsenal terapéutico las gliflozinas, un grupo de fármacos con beneficios en las tres enfermedades mencionadas. Saber cómo se desarrolló la investigación con estos fármacos y sus mecanismos de acción es fundamental para optimizar el tratamiento de los pacientes.","PeriodicalId":191575,"journal":{"name":"Revista Uruguaya de Cardiología","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121884677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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