Warren B Logge, Kirsten C Morley, Paul S Haber, Andrew J Baillie
Introduction: Individuals with alcohol use disorder (AUD) have difficulties regulating alcohol consumption, despite adverse drinking-related consequences. This may be due to incapacity incorporating previous negative feedback from drinking, resulting in impaired decision-making.
Methods: We assessed whether decision-making is impaired in participants with AUD related to severity of AUD, indexed by severe negative drinking consequences using the Drinkers Inventory of Consequences (DrInC) and reward and punishment sensitivity with the Behavioural Inhibition System Behavioural Activation System (BIS BAS) scales. 36 treatment-seeking alcohol-dependent participants completed the Iowa gambling task (IGT) with skin conductance responses (SCRs) measured continuously as an index of somatic autonomic arousal to evaluate impaired expectancy of negative outcomes.
Results: Two-thirds of the sample showed behavioural impairment during the IGT, with greater AUD severity related to worse performance. BIS moderated IGT performance according to severity of AUD, with increased anticipatory SCRs for those with fewer reported DrInC severe consequences. Participants with more DrInC severe consequences showed IGT deficits and reduced SCRs regardless of BIS scores. BAS-Reward was associated with increased anticipatory SCRs to disadvantageous deck choices among those with lower AUD severity, while SCRs did not differ related to AUD severity for reward outcomes.
Discussion: Effective decision-making in the IGT and adaptive somatic responses were moderated by punishment sensitivity contingent on severity of AUD in these drinkers, with impairments in expectancy to negative outcomes from risky choices, including reduced somatic responses, resulting in poor decision-making processes that may help explain impaired drinking and worse drinking-related consequences.
{"title":"Impaired Decision-Making and Skin Conductance Responses Are Associated with Reward and Punishment Sensitivity in Individuals with Severe Alcohol Use Disorder.","authors":"Warren B Logge, Kirsten C Morley, Paul S Haber, Andrew J Baillie","doi":"10.1159/000529156","DOIUrl":"https://doi.org/10.1159/000529156","url":null,"abstract":"<p><strong>Introduction: </strong>Individuals with alcohol use disorder (AUD) have difficulties regulating alcohol consumption, despite adverse drinking-related consequences. This may be due to incapacity incorporating previous negative feedback from drinking, resulting in impaired decision-making.</p><p><strong>Methods: </strong>We assessed whether decision-making is impaired in participants with AUD related to severity of AUD, indexed by severe negative drinking consequences using the Drinkers Inventory of Consequences (DrInC) and reward and punishment sensitivity with the Behavioural Inhibition System Behavioural Activation System (BIS BAS) scales. 36 treatment-seeking alcohol-dependent participants completed the Iowa gambling task (IGT) with skin conductance responses (SCRs) measured continuously as an index of somatic autonomic arousal to evaluate impaired expectancy of negative outcomes.</p><p><strong>Results: </strong>Two-thirds of the sample showed behavioural impairment during the IGT, with greater AUD severity related to worse performance. BIS moderated IGT performance according to severity of AUD, with increased anticipatory SCRs for those with fewer reported DrInC severe consequences. Participants with more DrInC severe consequences showed IGT deficits and reduced SCRs regardless of BIS scores. BAS-Reward was associated with increased anticipatory SCRs to disadvantageous deck choices among those with lower AUD severity, while SCRs did not differ related to AUD severity for reward outcomes.</p><p><strong>Discussion: </strong>Effective decision-making in the IGT and adaptive somatic responses were moderated by punishment sensitivity contingent on severity of AUD in these drinkers, with impairments in expectancy to negative outcomes from risky choices, including reduced somatic responses, resulting in poor decision-making processes that may help explain impaired drinking and worse drinking-related consequences.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"82 2","pages":"117-129"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9935596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katharina M Kubera, Mike M Schmitgen, Viviane Hildebrandt, Corinne Neukel, Marie-Luise Otte, Maurizio Sicorello, Sylvia Steinmann, Sabine C Herpertz, Robert Christian Wolf
Introduction: Auditory verbal hallucinations (AVH) are transdiagnostic phenomena that can occur in several mental disorders, including borderline personality disorder (BPD). Despite the transdiagnostic relevance of these symptoms, very little is known about neural signatures of AVH in BPD.
Methods: We used structural magnetic resonance imaging to investigate multiple markers of brain morphology in BPD patients presenting with a lifetime history of AVH (AVH, n = 6) versus BPD patients without AVH (nAVH, n = 10) and healthy controls (HC, n = 12). The Computational Anatomy Toolbox (CAT12) was used for surface-based morphometric analyses that considered cortical thickness (CTh), gyrification (CG), and complexity of cortical folding (CCF). Factorial models were used to explore differences between AVH patients and HC, as well as between the patient groups.
Results: Compared to HC, AVH patients showed distinct abnormalities in key regions of the language network, i.e., aberrant CTh and CG in right superior temporal gyrus and abnormal CCF in left inferior frontal gyrus. Further abnormalities were found in right prefrontal cortex (CTh) and left orbitofrontal cortex (CCF). Compared to nAVH patients, individuals with AVH showed abnormal CTh in right prefrontal cortex, along with CCF differences in right transverse temporal, superior parietal, and parahippocampal gyri. CG differences between the patient groups were found in left orbitofrontal cortex.
Conclusion: The data suggest a transdiagnostic neural signature of voice-hearing that converges on key regions involved in speech generation and perception, memory and executive control. It is possible that cortical features of distinct evolutionary and genetic origin, i.e., CTh and CG/CCF, differently contribute to AVH vulnerability in BPD.
听觉言语幻觉(AVH)是一种跨诊断现象,可发生在几种精神障碍中,包括边缘型人格障碍(BPD)。尽管这些症状与跨诊断相关,但对BPD中AVH的神经特征知之甚少。方法:采用结构磁共振成像技术对有AVH病史的BPD患者(AVH, n = 6)、无AVH病史的BPD患者(nAVH, n = 10)和健康对照组(HC, n = 12)进行脑形态学的多项指标研究。计算解剖工具箱(CAT12)用于基于表面的形态计量学分析,考虑皮质厚度(CTh),回转(CG)和皮质折叠的复杂性(CCF)。阶乘模型用于探讨AVH患者和HC患者之间以及患者组之间的差异。结果:与HC相比,AVH患者在语言网络关键区域表现出明显异常,即右侧颞上回CTh和CG异常,左侧额下回CCF异常。右侧前额皮质(CTh)和左侧眶额皮质(CCF)进一步发现异常。与nAVH患者相比,AVH患者右侧前额叶皮层CTh异常,右侧颞横回、顶叶上回和海马旁回CCF差异。两组患者的左眼窝额叶皮层存在CG差异。结论:数据提示语音听力的跨诊断神经特征集中在涉及语音产生和感知、记忆和执行控制的关键区域。可能是不同进化和遗传起源的皮质特征,即CTh和CG/CCF,不同地促进了BPD中AVH的易损性。
{"title":"Structural Correlates of Lifetime Voice-Hearing in Patients with Borderline Personality Disorder: A Pilot Study.","authors":"Katharina M Kubera, Mike M Schmitgen, Viviane Hildebrandt, Corinne Neukel, Marie-Luise Otte, Maurizio Sicorello, Sylvia Steinmann, Sabine C Herpertz, Robert Christian Wolf","doi":"10.1159/000528039","DOIUrl":"https://doi.org/10.1159/000528039","url":null,"abstract":"<p><strong>Introduction: </strong>Auditory verbal hallucinations (AVH) are transdiagnostic phenomena that can occur in several mental disorders, including borderline personality disorder (BPD). Despite the transdiagnostic relevance of these symptoms, very little is known about neural signatures of AVH in BPD.</p><p><strong>Methods: </strong>We used structural magnetic resonance imaging to investigate multiple markers of brain morphology in BPD patients presenting with a lifetime history of AVH (AVH, n = 6) versus BPD patients without AVH (nAVH, n = 10) and healthy controls (HC, n = 12). The Computational Anatomy Toolbox (CAT12) was used for surface-based morphometric analyses that considered cortical thickness (CTh), gyrification (CG), and complexity of cortical folding (CCF). Factorial models were used to explore differences between AVH patients and HC, as well as between the patient groups.</p><p><strong>Results: </strong>Compared to HC, AVH patients showed distinct abnormalities in key regions of the language network, i.e., aberrant CTh and CG in right superior temporal gyrus and abnormal CCF in left inferior frontal gyrus. Further abnormalities were found in right prefrontal cortex (CTh) and left orbitofrontal cortex (CCF). Compared to nAVH patients, individuals with AVH showed abnormal CTh in right prefrontal cortex, along with CCF differences in right transverse temporal, superior parietal, and parahippocampal gyri. CG differences between the patient groups were found in left orbitofrontal cortex.</p><p><strong>Conclusion: </strong>The data suggest a transdiagnostic neural signature of voice-hearing that converges on key regions involved in speech generation and perception, memory and executive control. It is possible that cortical features of distinct evolutionary and genetic origin, i.e., CTh and CG/CCF, differently contribute to AVH vulnerability in BPD.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"82 2","pages":"72-80"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9245883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Although abundant research delving into the acute exercise-induced modulation of cognitive performance and the P300-ERP component has been conducted, there is a lack of consensus regarding whether or not this type of intervention has a beneficial effect on cognition and how it relates to the P300-ERP.
Methods: To examine the possible sources of this discrepancy, we conducted a meta-analysis of ERP results together with cognitive performance that were systemically stratified by relevant demographic and methodological moderators.
Results: Our results indicate that while acute exercise exerted an overall stable effect on cognitive improvement, associated with enlarged P300 amplitudes, the effect size varied across factors of age, biological sex, exercise intensity, exercise type, control type, and experimental design. Future research taking into consideration modulating factors as to avoid misestimating the beneficial effects of acute exercise are encouraged.
Conclusion: All in all, and to our knowledge, this is the first meta-analysis quantitatively summarizing the relevant literature on the associations between P300-ERP correlates, acute exercise, and its positive influence on attention and cognitive performance in healthy individuals.
{"title":"Meta-Analysis of Electroencephalographic Correlates and Cognitive Performance for Acute Exercise-Induced Modulation.","authors":"Róger Marcelo Martínez, Chenyi Chen, Yang-Teng Fan, Hui-Hua Wu, Pin-Shiuan Du, Guan-Ya Chen, Yu-Chun Chen","doi":"10.1159/000529307","DOIUrl":"https://doi.org/10.1159/000529307","url":null,"abstract":"<p><strong>Introduction: </strong>Although abundant research delving into the acute exercise-induced modulation of cognitive performance and the P300-ERP component has been conducted, there is a lack of consensus regarding whether or not this type of intervention has a beneficial effect on cognition and how it relates to the P300-ERP.</p><p><strong>Methods: </strong>To examine the possible sources of this discrepancy, we conducted a meta-analysis of ERP results together with cognitive performance that were systemically stratified by relevant demographic and methodological moderators.</p><p><strong>Results: </strong>Our results indicate that while acute exercise exerted an overall stable effect on cognitive improvement, associated with enlarged P300 amplitudes, the effect size varied across factors of age, biological sex, exercise intensity, exercise type, control type, and experimental design. Future research taking into consideration modulating factors as to avoid misestimating the beneficial effects of acute exercise are encouraged.</p><p><strong>Conclusion: </strong>All in all, and to our knowledge, this is the first meta-analysis quantitatively summarizing the relevant literature on the associations between P300-ERP correlates, acute exercise, and its positive influence on attention and cognitive performance in healthy individuals.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"82 3","pages":"131-149"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9943731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anastasios Ziogas, Andreas Mokros, Wolfram Kawohl, Mateo de Bardeci, Ilyas Olbrich, Benedikt Habermeyer, Elmar Habermeyer, Sebastian Olbrich
Introduction: It is unclear if sexual orientation is a biological trait that has neurofunctional footprints. With deep learning, the power to classify biological datasets without an a priori selection of features has increased by magnitudes. The aim of this study was to correctly classify resting-state electroencephalogram (EEG) data from males with different sexual orientation using deep learning and to explore techniques to identify the learned distinguishing features.
Methods: Three cohorts (homosexual men, heterosexual men, and a mixed sex cohort), one pretrained network on sex classification, and one newly trained network for sexual orientation classification were used to classify sex. Further, Grad-CAM methodology and source localization were used to identify the spatiotemporal patterns that were used for differentiation by the networks.
Results: Using a pretrained network for classification of males and females, no differences existed between classification of homosexual and heterosexual males. The newly trained network was able, however, to correctly classify the cohorts with a total accuracy of 83%. The retrograde activation using Grad-CAM technology yielded distinctive functional EEG patterns in the Brodmann area 40 and 1 when combined with Fourier analysis and a source localization.
Discussion: This study shows that electrophysiological trait markers of male sexual orientation can be identified using deep learning. These patterns are different from the differentiating signatures of males and females in a resting-state EEG.
{"title":"Deep Learning in the Identification of Electroencephalogram Sources Associated with Sexual Orientation.","authors":"Anastasios Ziogas, Andreas Mokros, Wolfram Kawohl, Mateo de Bardeci, Ilyas Olbrich, Benedikt Habermeyer, Elmar Habermeyer, Sebastian Olbrich","doi":"10.1159/000530931","DOIUrl":"https://doi.org/10.1159/000530931","url":null,"abstract":"<p><strong>Introduction: </strong>It is unclear if sexual orientation is a biological trait that has neurofunctional footprints. With deep learning, the power to classify biological datasets without an a priori selection of features has increased by magnitudes. The aim of this study was to correctly classify resting-state electroencephalogram (EEG) data from males with different sexual orientation using deep learning and to explore techniques to identify the learned distinguishing features.</p><p><strong>Methods: </strong>Three cohorts (homosexual men, heterosexual men, and a mixed sex cohort), one pretrained network on sex classification, and one newly trained network for sexual orientation classification were used to classify sex. Further, Grad-CAM methodology and source localization were used to identify the spatiotemporal patterns that were used for differentiation by the networks.</p><p><strong>Results: </strong>Using a pretrained network for classification of males and females, no differences existed between classification of homosexual and heterosexual males. The newly trained network was able, however, to correctly classify the cohorts with a total accuracy of 83%. The retrograde activation using Grad-CAM technology yielded distinctive functional EEG patterns in the Brodmann area 40 and 1 when combined with Fourier analysis and a source localization.</p><p><strong>Discussion: </strong>This study shows that electrophysiological trait markers of male sexual orientation can be identified using deep learning. These patterns are different from the differentiating signatures of males and females in a resting-state EEG.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"82 4","pages":"234-245"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10645442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bolun Cheng, Shiqiang Cheng, Chun'e Li, Wenming Wei, Li Liu, Peilin Meng, Xuena Yang, Yumeng Jia, Yan Wen, Feng Zhang
Introduction: Observational studies highlight associations of common diseases with individual schizophrenia symptoms. However, it is unclear whether these diseases are associated with individual treatment-resistant schizophrenia (TRS). We aimed to explore the genetic associations between common immune diseases, metabolic diseases, psychiatric disorders, gut microbiota and TRS.
Methods: Genome-wide association study (GWAS) summary data of European participants (n = ∼456,327) included TRS, 11 psychiatric disorders, 23 immune and metabolic diseases, body mass index, height, and 211 gut microbiota. In this genetic correlation and two-sample Mendelian randomization (MR) study, linkage disequilibrium score (LDSC) regression was applied to infer genetic correlation estimates. Two-sample MR tested potential causal associations of genetic variants associated with common immune diseases, metabolic diseases, psychiatric disorders, and gut microbiota with TRS.
Results: LDSC revealed candidate associations between attention deficit/hyperactivity disorder (ADHD), schizophrenia, intestinal infectious diseases, obesity and TRS (genetic correlation range, 0.230-0.702; p < 0.05). Two-sample MR analyses suggested that ADHD was positively associated with TRS (estimate [SE] = 0.204 [0.073], p = 0.005), a finding that remained stable across statistical models. Besides, schizophrenia and genus Barnesiella levels were causally associated with TRS but not consistent across MR approaches.
Conclusion: This study reports genetic correlations between ADHD, schizophrenia, intestinal infectious diseases, obesity and TRS. The study also found that genus Barnesiella was associated with TRS. These findings may have clinical implications, highlighting the possible strategy for TRS prevention.
{"title":"Treatment Resistance in Schizophrenia Is Associated with Attention Deficit/Hyperactivity Disorder and Gut Microbiota: A Genetic Correlation and Mendelian Randomization Study.","authors":"Bolun Cheng, Shiqiang Cheng, Chun'e Li, Wenming Wei, Li Liu, Peilin Meng, Xuena Yang, Yumeng Jia, Yan Wen, Feng Zhang","doi":"10.1159/000528316","DOIUrl":"https://doi.org/10.1159/000528316","url":null,"abstract":"<p><strong>Introduction: </strong>Observational studies highlight associations of common diseases with individual schizophrenia symptoms. However, it is unclear whether these diseases are associated with individual treatment-resistant schizophrenia (TRS). We aimed to explore the genetic associations between common immune diseases, metabolic diseases, psychiatric disorders, gut microbiota and TRS.</p><p><strong>Methods: </strong>Genome-wide association study (GWAS) summary data of European participants (n = ∼456,327) included TRS, 11 psychiatric disorders, 23 immune and metabolic diseases, body mass index, height, and 211 gut microbiota. In this genetic correlation and two-sample Mendelian randomization (MR) study, linkage disequilibrium score (LDSC) regression was applied to infer genetic correlation estimates. Two-sample MR tested potential causal associations of genetic variants associated with common immune diseases, metabolic diseases, psychiatric disorders, and gut microbiota with TRS.</p><p><strong>Results: </strong>LDSC revealed candidate associations between attention deficit/hyperactivity disorder (ADHD), schizophrenia, intestinal infectious diseases, obesity and TRS (genetic correlation range, 0.230-0.702; p < 0.05). Two-sample MR analyses suggested that ADHD was positively associated with TRS (estimate [SE] = 0.204 [0.073], p = 0.005), a finding that remained stable across statistical models. Besides, schizophrenia and genus Barnesiella levels were causally associated with TRS but not consistent across MR approaches.</p><p><strong>Conclusion: </strong>This study reports genetic correlations between ADHD, schizophrenia, intestinal infectious diseases, obesity and TRS. The study also found that genus Barnesiella was associated with TRS. These findings may have clinical implications, highlighting the possible strategy for TRS prevention.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"82 1","pages":"24-32"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9227166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matti Gärtner, Anne Weigand, Christian Keicher, Marvin Sören Meiering, David Weigner, Luisa Carstens, Rita Hertrampf, Christian Beckmann, Maarten Mennes, Andreas Wunder, Simone Grimm
Introduction: Cognition and emotion are fundamentally integrated in the brain and mutually contribute to behavior. The relation between working memory (WM) and emotion is particularly suited to investigate cognition-emotion interaction since WM is an essential component of many higher cognitive functions. Ketamine affects not only WM but also has a profound impact on emotional processing. Effects of acute ketamine challenge are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release. Accordingly, a combination of these approaches should be particularly suited to investigate cognition-emotion interaction.
Methods: Seventy five healthy subjects were investigated in a double-blind, placebo-controlled, randomized, single-dose, parallel-group study with three treatment conditions. All subjects underwent two scanning sessions (acute/post 24 h).
Results: Compared to placebo, acute ketamine administration induced significant dissociative, psychotomimetic, and cognitive effects, as well as an increase in neural activity during WM for positive stimuli. Inhibition of glutamate release by pretreatment with lamotrigine did not influence ketamine's subjective effects, but significantly attenuated its impact on emotional WM and associated neural activity. There was no effect on these measures 24 h after ketamine administration.
Conclusion: Our results demonstrate differential acute effects of modulated glutamate release and a swift restoration of disturbed neurobehavioral homeostasis in healthy subjects.
{"title":"Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain.","authors":"Matti Gärtner, Anne Weigand, Christian Keicher, Marvin Sören Meiering, David Weigner, Luisa Carstens, Rita Hertrampf, Christian Beckmann, Maarten Mennes, Andreas Wunder, Simone Grimm","doi":"10.1159/000528315","DOIUrl":"https://doi.org/10.1159/000528315","url":null,"abstract":"<p><strong>Introduction: </strong>Cognition and emotion are fundamentally integrated in the brain and mutually contribute to behavior. The relation between working memory (WM) and emotion is particularly suited to investigate cognition-emotion interaction since WM is an essential component of many higher cognitive functions. Ketamine affects not only WM but also has a profound impact on emotional processing. Effects of acute ketamine challenge are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release. Accordingly, a combination of these approaches should be particularly suited to investigate cognition-emotion interaction.</p><p><strong>Methods: </strong>Seventy five healthy subjects were investigated in a double-blind, placebo-controlled, randomized, single-dose, parallel-group study with three treatment conditions. All subjects underwent two scanning sessions (acute/post 24 h).</p><p><strong>Results: </strong>Compared to placebo, acute ketamine administration induced significant dissociative, psychotomimetic, and cognitive effects, as well as an increase in neural activity during WM for positive stimuli. Inhibition of glutamate release by pretreatment with lamotrigine did not influence ketamine's subjective effects, but significantly attenuated its impact on emotional WM and associated neural activity. There was no effect on these measures 24 h after ketamine administration.</p><p><strong>Conclusion: </strong>Our results demonstrate differential acute effects of modulated glutamate release and a swift restoration of disturbed neurobehavioral homeostasis in healthy subjects.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"82 2","pages":"91-103"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9238969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front & Back Matter","authors":"G. Bologna, P. Monteleone, G. Okugawa","doi":"10.1159/000528497","DOIUrl":"https://doi.org/10.1159/000528497","url":null,"abstract":"","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44079516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Founded 1975 by J. Mendlewicz (Brussels) Since 1983 integrating ‘International Pharmacopsychiatry’, founded 1968 by F.A. Freyhan (New York), N. Petrilowitsch (Mainz), P. Pichot (Paris) Section Editor ‘Biological Psychiatry’ and Associate Editor 1975–2007 J. Mendlewicz (Brussels) Section Editor ‘Pharmacopsychiatry’ and Associate Editor 1990–2006 B. Saletu (Vienna) Section Editor ‘Biological Psychology/Pharmacopsychology’ and Associate Editor 1990– P. Netter (Giessen) Section Editor ‘Pharmacoelectroencephalography’ and Associate Editor 1990–2002 W.M. Herrmann (Berlin), 2003– T. Kinoshita (Osaka) Official Journal of the International Pharmaco-EEG Society (IPEG)
1975年由J. Mendlewicz(布鲁塞尔)创立,1983年开始整合“国际药物精神病学”,1968年由F.A. Freyhan(纽约),N. Petrilowitsch(美因茨),P. Pichot(巴黎)“生物精神病学”分科编辑和副编辑1975-2007 J. Mendlewicz(布鲁塞尔)“药物精神病学”分科编辑和副编辑1990 - 2006 B. Saletu(维也纳)“生物心理学/药物心理”分科编辑和副编辑1990 - P. Netter(吉森)“药物脑电图”分科编辑和副编辑1990 - 2002 W.M. Herrmann(柏林),2003 - T.木下(大阪)国际药物脑电图学会官方杂志(IPEG)
{"title":"Contents Vol. 81, 2022","authors":"P. Monteleone, G. Okugawa","doi":"10.1159/000528492","DOIUrl":"https://doi.org/10.1159/000528492","url":null,"abstract":"Founded 1975 by J. Mendlewicz (Brussels) Since 1983 integrating ‘International Pharmacopsychiatry’, founded 1968 by F.A. Freyhan (New York), N. Petrilowitsch (Mainz), P. Pichot (Paris) Section Editor ‘Biological Psychiatry’ and Associate Editor 1975–2007 J. Mendlewicz (Brussels) Section Editor ‘Pharmacopsychiatry’ and Associate Editor 1990–2006 B. Saletu (Vienna) Section Editor ‘Biological Psychology/Pharmacopsychology’ and Associate Editor 1990– P. Netter (Giessen) Section Editor ‘Pharmacoelectroencephalography’ and Associate Editor 1990–2002 W.M. Herrmann (Berlin), 2003– T. Kinoshita (Osaka) Official Journal of the International Pharmaco-EEG Society (IPEG)","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"81 1","pages":"I - VI"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45718201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}