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Commentary: Vestibular Schwannoma Koos Grade 1 International Study of Active Surveillance Versus Stereotactic Radiosurgery: The VISAS-K1 Study. 评论:前庭许旺瘤科斯1级主动监测与立体定向放射外科手术的国际研究:VISAS-K1 研究。
IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-06 DOI: 10.1227/neu.0000000000003217
Michael J Link
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引用次数: 0
Vestibular Schwannoma Koos Grade I International Study of Active Surveillance Versus Stereotactic Radiosurgery: The VISAS-K1 Study. 前庭许旺瘤科斯 I 级主动监测与立体定向放射外科手术的国际研究:VISAS-K1 研究
IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-06 DOI: 10.1227/neu.0000000000003215
Othman Bin-Alamer, Hussam Abou-Al-Shaar, Selcuk Peker, Yavuz Samanci, Isabelle Pelcher, Sabrina Begley, Anuj Goenka, Michael Schulder, Jean-Nicolas Tourigny, David Mathieu, Andréanne Hamel, Robert G Briggs, Cheng Yu, Gabriel Zada, Steven L Giannotta, Herwin Speckter, Sarai Palque, Manjul Tripathi, Saurabh Kumar, Rupinder Kaur, Narendra Kumar, Brandon Rogowski, Matthew J Shepard, Bryan A Johnson, Daniel M Trifiletti, Ronald E Warnick, Samantha Dayawansa, Elad Mashiach, Fernando De Nigris Vasconcellos, Kenneth Bernstein, Zane Schnurman, Juan Alzate, Douglas Kondziolka, Jason P Sheehan

Background and objective: This investigation evaluates the safety and efficacy of stereotactic radiosurgery (SRS) vs observation for Koos grade I vestibular schwannomas (VS).

Methods: In a multicenter study, we retrospectively analyzed data of patients with Koos grade I VS who underwent SRS (SRS group) or were observed (observation group). Propensity score matching was used to equilibrate demographics, tumor size, and audiometric data across groups. The outcome analyzed included tumor control, preservation of serviceable hearing, and neurological function.

Results: The study matched 142 patients, providing a median follow-up period of 36 months. SRS significantly enhanced tumor control compared with observation, with a 100% control rate at both 5- and 8-year marks in the SRS group vs 48.6% and 29.5% in the observation group at the same time intervals, respectively (P < .001). Preservation of serviceable hearing outcomes between groups showed no significant difference at 5 and 8 years, ensuring a comparable quality of auditory function (SRS 70.1% vs observation 53.4% at 5 years; P = .33). Furthermore, SRS was associated with a reduced likelihood of tinnitus (odds ratio [OR] = 0.46, P = .04), vestibular dysfunction (OR = 0.17, P = .002), and overall cranial nerve dysfunction (OR = 0.49, P = .03) at last follow-up.

Conclusion: SRS management of patients with Koos grade I VS was associated with superior tumor control and reduced odds for cranial nerve dysfunction, while not compromising hearing preservation compared with observation. These findings support the safety and efficacy of SRS as a primary care approach for this patient population.

背景和目的:这项研究评估了立体定向放射外科治疗 Koos I 级前庭神经分裂瘤(VS)的安全性和有效性:本研究评估了立体定向放射手术(SRS)与观察治疗 Koos I 级前庭神经分裂瘤(VS)的安全性和有效性:在一项多中心研究中,我们回顾性分析了Koos I级VS患者接受SRS治疗(SRS组)或观察治疗(观察组)的数据。我们采用倾向评分匹配法来平衡各组的人口统计学、肿瘤大小和听力数据。分析的结果包括肿瘤控制、可用听力的保留和神经功能:研究匹配了 142 名患者,中位随访时间为 36 个月。与观察组相比,SRS明显提高了肿瘤控制率,SRS组5年和8年的肿瘤控制率均为100%,而观察组同期的肿瘤控制率分别为48.6%和29.5%(P < .001)。在 5 年和 8 年期间,两组患者的听力保持结果没有明显差异,确保了听觉功能的质量相当(5 年时,SRS 组为 70.1%,观察组为 53.4%;P = .33)。此外,在最后一次随访时,SRS 与耳鸣(几率比 [OR] = 0.46,P = .04)、前庭功能障碍(OR = 0.17,P = .002)和总体颅神经功能障碍(OR = 0.49,P = .03)的可能性降低有关:结论:与观察组相比,对Koos I级VS患者进行SRS治疗能更好地控制肿瘤,降低颅神经功能障碍的几率,同时不影响听力保护。这些研究结果支持将 SRS 作为该类患者的初级治疗方法的安全性和有效性。
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引用次数: 0
Vestibular Schwannoma Koos Grade II International Study of Active Surveillance Versus Stereotactic Radiosurgery: The VISAS-K2 Study. 前庭许旺瘤 Koos II 级主动监测与立体定向放射外科手术的国际研究:VISAS-K2 研究
IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-06 DOI: 10.1227/neu.0000000000003216
Othman Bin-Alamer, Hussam Abou-Al-Shaar, Selcuk Peker, Yavuz Samanci, Isabelle Pelcher, Sabrina Begley, Anuj Goenka, Michael Schulder, Jean-Nicolas Tourigny, David Mathieu, Andréanne Hamel, Robert G Briggs, Cheng Yu, Gabriel Zada, Steven L Giannotta, Herwin Speckter, Sarai Palque, Manjul Tripathi, Saurabh Kumar, Rupinder Kaur, Narendra Kumar, Brandon Rogowski, Matthew J Shepard, Bryan A Johnson, Daniel M Trifiletti, Ronald E Warnick, Samantha Dayawansa, Elad Mashiach, Fernando De Nigris Vasconcellos, Kenneth Bernstein, Zane Schnurman, Juan Alzate, Douglas Kondziolka, Jason P Sheehan

Background and objectives: This study assessed the efficacy and safety of stereotactic radiosurgery (SRS) in comparison with watchful waiting for managing Koos grade II vestibular schwannomas (VS).

Methods: A retrospective, multicentric analysis was conducted, focusing on patients with Koos grade II VS who either received SRS (SRS group) or were observed (observation group). To ensure comparability between groups, propensity score matching was used, including factors such as demographic characteristics, tumor dimensions, and hearing assessments. The primary end points examined were tumor control, maintenance of serviceable hearing, and neurological outcomes.

Results: A total of 92 patients were equally matched across both cohorts, with a median follow-up of 37 months for the SRS group and 27.5 months for those observed. The SRS cohort exhibited superior tumor control over observation across 3, 5, and 8 years, achieving a 100% control rate vs 47.9%, 40.1%, and 34.3% for the observation group at these time intervals, respectively (P < .001). Serviceable hearing preservation rates were comparable between the 2 groups throughout 3, 5, and 7 years (72.9% for SRS vs 65.4% for observation at 3 years; P = .86). Moreover, SRS management correlated with a lower incidence of vestibular symptoms (odds ratio = 0.11, P = .002), with no significant disparity in the deterioration of cranial nerve (CN) V or CN VII functions. Notably, the likelihood of experiencing any CN impairment was significantly diminished in the SRS cohort (odds ratio = 0.47, P = .04).

Conclusion: For patients with Koos grade II VS, SRS offers superior tumor control rate and a lower risk of CN dysfunction without sacrificing hearing preservation.

背景和目的:本研究评估了立体定向放射外科手术(SRS)与观察等待治疗 Koos II 级前庭神经分裂瘤(VS)的疗效和安全性:进行了一项多中心回顾性分析,主要针对接受 SRS(SRS 组)或观察(观察组)的 Koos II 级 VS 患者。为确保组间的可比性,采用了倾向评分匹配法,包括人口统计学特征、肿瘤尺寸和听力评估等因素。研究的主要终点是肿瘤控制、听力维持和神经系统结果:两个队列中共有 92 名患者匹配度相同,SRS 组的中位随访时间为 37 个月,观察组的中位随访时间为 27.5 个月。在3年、5年和8年的随访中,SRS组的肿瘤控制率优于观察组,达到100%,而观察组在这些时间间隔内的肿瘤控制率分别为47.9%、40.1%和34.3%(P < .001)。在 3 年、5 年和 7 年期间,两组的听力保存率相当(3 年时,SRS 为 72.9% ,观察组为 65.4%;P = .86)。此外,SRS 治疗与较低的前庭症状发生率相关(几率比 = 0.11,P = .002),在颅神经 (CN) V 或 CN VII 功能恶化方面没有明显差异。值得注意的是,SRS 组群中出现任何 CN 功能障碍的可能性显著降低(几率比 = 0.47,P = .04):结论:对于 Koos II 级 VS 患者,SRS 可提供更高的肿瘤控制率和更低的 CN 功能障碍风险,同时不会牺牲听力的保护。
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引用次数: 0
Neurosurgery in Pakistan: Past, Present, and Future. 巴基斯坦的神经外科:过去、现在和未来。
IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-04 DOI: 10.1227/neu.0000000000003257
Erum Ajmal, Hamza Khilji, Ernest J Barthélemy, Tariq Khan

Background and objectives: Since its independence from India in 1947, Pakistan has struggled with economic crises such as global debt, corruption, constant regime change, and a decades-long war against terrorism. The resulting socioeconomic barriers have stymied efforts to develop a comprehensive and equitably accessible healthcare system, especially regarding safe, timely, and affordable surgical care. This article evaluates neurosurgery's development, current state, and prospects in Pakistan, a lower-middle-income country.

Methods: We performed a literature search using PubMed and analyzed relevant articles to better understand the state and landscape of neurosurgery in Pakistan. Moreover, we conducted ecological research by querying the databases of the World Bank and the Institute of Health Metrics and Evaluation to evaluate the neurological and neurosurgical disease burden in the Pakistani population.

Results: The neurosurgical workforce in Pakistan has demonstrated rapid growth over the past two decades, with approximately 450 neurosurgeons and a neurosurgeon-per-100 000 population density of 0.114. Nonetheless, access to essential neurosurgical procedures for the treatment of diseases such as stroke has been difficult to ensure, which likely contributes to Pakistan's stroke burden, ie, stroke was still the third most common cause of death in 2019, causing 21.7% of all deaths.

Conclusion: While Pakistan's political and economic instability has adversely affected the development of neurosurgery, the field has still made great strides and demonstrates a promising future in providing equitable neurosurgical care to all Pakistan's people.

背景和目标:自 1947 年从印度独立以来,巴基斯坦一直在全球债务、腐败、政权不断更迭以及长达数十年的反恐战争等经济危机中挣扎。由此产生的社会经济障碍阻碍了发展全面、公平的医疗保健系统的努力,尤其是在安全、及时和可负担得起的外科护理方面。本文对中低收入国家巴基斯坦的神经外科发展、现状和前景进行了评估:我们使用 PubMed 进行了文献检索,并对相关文章进行了分析,以更好地了解巴基斯坦神经外科的现状和前景。此外,我们还通过查询世界银行和卫生计量与评估研究所的数据库进行了生态研究,以评估巴基斯坦人口的神经和神经外科疾病负担:过去二十年来,巴基斯坦的神经外科医生队伍迅速壮大,约有 450 名神经外科医生,每 10 万人口中神经外科医生的密度为 0.114。然而,用于治疗中风等疾病的基本神经外科手术一直难以获得,这可能是造成巴基斯坦中风负担的原因之一,即中风仍是 2019 年第三大常见死因,占死亡总数的 21.7%:虽然巴基斯坦的政治和经济不稳定对神经外科的发展造成了不利影响,但该领域仍然取得了长足的进步,并在为巴基斯坦全体人民提供公平的神经外科医疗服务方面展现出了美好的前景。
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引用次数: 0
Dynamic Craniotomy With Khanna NuCrani Plates as an Alternative to Craniotomy With Fixed Plates in Traumatic Brain Injury. 在创伤性脑损伤中使用 Khanna NuCrani 钢板进行动态开颅手术,作为使用固定钢板进行开颅手术的替代方案。
IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-04 DOI: 10.1227/neu.0000000000003244
Paul R Krafft, Ian Tafel, Anjali Khanna, Patrick Han, Rohit Khanna

Background and objectives: Dynamic craniotomy as opposed to a fixed plate craniotomy provides cranial decompression with a controlled outward bone flap movement to accommodate postoperative cerebral swelling and/or hemorrhage. The objective of this study was to evaluate if fixation of the bone flap following a trauma craniotomy with dynamic plates provides any advantage over fixed plates.

Methods: A review of our clinical series of 25 consecutive adult patients undergoing dynamic craniotomy with the Khanna NuCrani reversibly expandable bone flap fixation plates for the treatment of traumatic brain injury associated with mass lesions including subdural, epidural, and cerebral hematomas was conducted.

Results: Postoperative cerebral swelling was encountered in 21 of 25 patients (84%), which was compensated for with outward bone flap movement in all these patients and associated decreased midline shift. Severe brain swelling with outward bone flap movement of 8 mm or more was noted in 40% of the patients. All patients had a normal intracranial pressure after surgery. None of the patients required any reoperations for hematoma evacuation, rescue decompressive craniectomies, cranioplasty, or complications related to wound healing. The bone flap retracted after the resolution of the brain swelling, and none of the patients reported cosmetic symptoms related to bone flap or wound healing. Overall, 84% (21 of 25) of the patients achieved a good outcome.

Conclusion: Craniotomy bone flap fixation with dynamic plates is an alternative to craniotomy with fixed plates. The main advantage of dynamic craniotomy over a craniotomy with fixed plates is that it allows for immediate intracranial volume expansion with reversible outward bone flap migration in patients who may develop postoperative worsening brain swelling and/or hemorrhage, with decreased need for repeat surgeries and associated complications.

背景和目的:与固定钢板开颅术相比,动态开颅术可在控制骨瓣向外移动的情况下进行颅骨减压,以适应术后脑肿胀和/或出血。本研究的目的是评估使用动态钢板固定创伤开颅术后的骨瓣是否比固定钢板更有优势:方法:我们对连续 25 例接受动态开颅手术并使用 Khanna NuCrani 可逆扩张骨瓣固定板治疗创伤性脑损伤伴肿块病变(包括硬膜下、硬膜外和脑血肿)的成年患者的临床系列进行了回顾性研究:结果:25 例患者中有 21 例(84%)术后出现脑肿胀,所有这些患者都通过骨瓣外移得到了补偿,中线移位也随之减少。40%的患者出现了严重的脑肿胀,骨瓣外移达 8 毫米或更多。所有患者术后颅内压均正常。没有一名患者因血肿清除、减压开颅手术、颅骨成形术或伤口愈合相关并发症而需要再次手术。骨瓣在脑肿胀消退后回缩,没有患者报告与骨瓣或伤口愈合有关的外观症状。总体而言,84%的患者(25例中的21例)取得了良好的疗效:结论:用动态钢板固定开颅骨瓣是固定钢板开颅术的一种替代方法。与使用固定钢板的开颅手术相比,动态开颅手术的主要优势在于,对于术后可能出现脑肿胀加重和/或出血的患者,动态开颅手术可使颅内体积立即扩大,骨瓣可逆性外移,减少了重复手术的需要和相关并发症。
{"title":"Dynamic Craniotomy With Khanna NuCrani Plates as an Alternative to Craniotomy With Fixed Plates in Traumatic Brain Injury.","authors":"Paul R Krafft, Ian Tafel, Anjali Khanna, Patrick Han, Rohit Khanna","doi":"10.1227/neu.0000000000003244","DOIUrl":"https://doi.org/10.1227/neu.0000000000003244","url":null,"abstract":"<p><strong>Background and objectives: </strong>Dynamic craniotomy as opposed to a fixed plate craniotomy provides cranial decompression with a controlled outward bone flap movement to accommodate postoperative cerebral swelling and/or hemorrhage. The objective of this study was to evaluate if fixation of the bone flap following a trauma craniotomy with dynamic plates provides any advantage over fixed plates.</p><p><strong>Methods: </strong>A review of our clinical series of 25 consecutive adult patients undergoing dynamic craniotomy with the Khanna NuCrani reversibly expandable bone flap fixation plates for the treatment of traumatic brain injury associated with mass lesions including subdural, epidural, and cerebral hematomas was conducted.</p><p><strong>Results: </strong>Postoperative cerebral swelling was encountered in 21 of 25 patients (84%), which was compensated for with outward bone flap movement in all these patients and associated decreased midline shift. Severe brain swelling with outward bone flap movement of 8 mm or more was noted in 40% of the patients. All patients had a normal intracranial pressure after surgery. None of the patients required any reoperations for hematoma evacuation, rescue decompressive craniectomies, cranioplasty, or complications related to wound healing. The bone flap retracted after the resolution of the brain swelling, and none of the patients reported cosmetic symptoms related to bone flap or wound healing. Overall, 84% (21 of 25) of the patients achieved a good outcome.</p><p><strong>Conclusion: </strong>Craniotomy bone flap fixation with dynamic plates is an alternative to craniotomy with fixed plates. The main advantage of dynamic craniotomy over a craniotomy with fixed plates is that it allows for immediate intracranial volume expansion with reversible outward bone flap migration in patients who may develop postoperative worsening brain swelling and/or hemorrhage, with decreased need for repeat surgeries and associated complications.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Benefits of Photodynamic Therapy Using Talaporfin Sodium in Patients With Isocitrate Dehydrogenase-Wildtype Diagnosed Glioblastoma: A Retrospective Study of 100 Cases. 使用他拉泊芬钠对异柠檬酸脱氢酶野生型胶质母细胞瘤患者进行光动力疗法的临床疗效:100 例病例的回顾性研究。
IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-04 DOI: 10.1227/neu.0000000000003247
Yosuke Fujimoto, Yuichi Fujita, Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Yusuke Ikeuchi, Hirofumi Iwahashi, Shoji Sanada, Yoshihiro Muragaki, Takashi Sasayama

Background and objectives: Photodynamic therapy (PDT) with talaporfin sodium is an intraoperative local therapy administered after the surgical removal of malignant gliomas. However, its clinical efficacy in a large patient population has not been determined. To analyze the clinical outcomes and prognosis in isocitrate dehydrogenase (IDH)-wildtype glioblastoma patients treated with PDT.

Methods: This retrospective study included patients with newly diagnosed IDH-wildtype glioblastoma treated at Kobe University Hospital between January 2013 and December 2022. PDT involves irradiation of the resection cavity with a 664-nm semiconductor laser after an intravenous infusion of talaporfin sodium. The main outcome measures were the recurrence patterns and survival times, which were compared between the PDT and non-PDT groups. Univariate and multivariate analyses were used to determine the prognostic factors. In addition, adverse events and prognostic factors in the PDT group were analyzed.

Results: A total of 44 and 56 patients were included in the PDT and non-PDT groups, respectively. The local recurrence rate was significantly lower in the PDT group than in the non-PDT group (51.3% vs 83.9%), whereas the distant recurrence and dissemination rates were significantly higher in the PDT group than in the non-PDT group (48.7% vs 16.1%). Two grade 3 adverse events were observed in the PDT group. The median progression-free survival and overall survival times were significantly longer in the PDT group than in the non-PDT group (progression-free survival: 10.8 vs 9.3 months, respectively, and overall survival: 24.6 vs 17.6 months, respectively). Multivariate analysis of the PDT groups revealed that younger age was an independent prognostic factor.

Conclusion: PDT with talaporfin sodium provided effective local control with minimal adverse effects. The survival time of the patients treated with PDT was significantly longer than that of the patients who did not receive PDT. Therefore, a randomized controlled clinical trial on PDT is warranted.

背景和目的:使用他拉泊芬钠的光动力疗法(PDT)是在手术切除恶性胶质瘤后进行的术中局部治疗。然而,其在大量患者中的临床疗效尚未确定。目的:分析接受过PDT治疗的异柠檬酸脱氢酶(IDH)-野生型胶质母细胞瘤患者的临床疗效和预后:这项回顾性研究纳入了2013年1月至2022年12月期间在神户大学医院接受治疗的新诊断IDH-野生型胶质母细胞瘤患者。PDT包括在静脉输注他拉泊芬钠后用664纳米半导体激光照射切除腔。主要结果指标是复发模式和生存时间,并在PDT组和非PDT组之间进行比较。单变量和多变量分析用于确定预后因素。此外,还分析了PDT组的不良事件和预后因素:结果:PDT 组和非 PDT 组分别有 44 名和 56 名患者。PDT组的局部复发率明显低于非PDT组(51.3% vs 83.9%),而PDT组的远处复发率和扩散率明显高于非PDT组(48.7% vs 16.1%)。PDT组出现了两例3级不良反应。PDT组的中位无进展生存期和总生存期明显长于非PDT组(无进展生存期:10.8个月对9.3个月,总生存期:24.6个月对17.6个月)。对PDT组进行的多变量分析表明,年龄较小是一个独立的预后因素:结论:使用他拉泊芬钠进行光动力疗法可有效控制局部病灶,且不良反应极小。结论:使用他拉泊芬钠进行光动力疗法可有效控制局部病灶,且不良反应极少,接受光动力疗法治疗的患者的生存时间明显长于未接受光动力疗法治疗的患者。因此,有必要对光导疗法进行随机对照临床试验。
{"title":"Clinical Benefits of Photodynamic Therapy Using Talaporfin Sodium in Patients With Isocitrate Dehydrogenase-Wildtype Diagnosed Glioblastoma: A Retrospective Study of 100 Cases.","authors":"Yosuke Fujimoto, Yuichi Fujita, Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Yusuke Ikeuchi, Hirofumi Iwahashi, Shoji Sanada, Yoshihiro Muragaki, Takashi Sasayama","doi":"10.1227/neu.0000000000003247","DOIUrl":"https://doi.org/10.1227/neu.0000000000003247","url":null,"abstract":"<p><strong>Background and objectives: </strong>Photodynamic therapy (PDT) with talaporfin sodium is an intraoperative local therapy administered after the surgical removal of malignant gliomas. However, its clinical efficacy in a large patient population has not been determined. To analyze the clinical outcomes and prognosis in isocitrate dehydrogenase (IDH)-wildtype glioblastoma patients treated with PDT.</p><p><strong>Methods: </strong>This retrospective study included patients with newly diagnosed IDH-wildtype glioblastoma treated at Kobe University Hospital between January 2013 and December 2022. PDT involves irradiation of the resection cavity with a 664-nm semiconductor laser after an intravenous infusion of talaporfin sodium. The main outcome measures were the recurrence patterns and survival times, which were compared between the PDT and non-PDT groups. Univariate and multivariate analyses were used to determine the prognostic factors. In addition, adverse events and prognostic factors in the PDT group were analyzed.</p><p><strong>Results: </strong>A total of 44 and 56 patients were included in the PDT and non-PDT groups, respectively. The local recurrence rate was significantly lower in the PDT group than in the non-PDT group (51.3% vs 83.9%), whereas the distant recurrence and dissemination rates were significantly higher in the PDT group than in the non-PDT group (48.7% vs 16.1%). Two grade 3 adverse events were observed in the PDT group. The median progression-free survival and overall survival times were significantly longer in the PDT group than in the non-PDT group (progression-free survival: 10.8 vs 9.3 months, respectively, and overall survival: 24.6 vs 17.6 months, respectively). Multivariate analysis of the PDT groups revealed that younger age was an independent prognostic factor.</p><p><strong>Conclusion: </strong>PDT with talaporfin sodium provided effective local control with minimal adverse effects. The survival time of the patients treated with PDT was significantly longer than that of the patients who did not receive PDT. Therefore, a randomized controlled clinical trial on PDT is warranted.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updated 5-Year Institutional Bibliometric Profiles for United States Neurosurgery Residency Programs and the Relationship Between Social Media Presence and Objective Departmental Metrics. 美国神经外科住院医师项目的最新五年机构文献计量概况以及社交媒体存在与客观部门指标之间的关系。
IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-04 DOI: 10.1227/neu.0000000000003256
Andrew N Chang, Deborah Boyett, Dean Chou, Andrew K Chan

Background and objectives: The authors report current 3-year and 5-year institutional bibliometric profiles and investigate the correlations between objective metrics of neurosurgical residency programs and social media presence, including residency program size, faculty count, Doximity rankings, and measures of research output.

Methods: A list of neurosurgery residency programs was obtained through the Doximity Residency Navigator. Publication history of faculty members was compiled using Scopus and analyzed to create institutional bibliometric profiles from 2018-2022 to 2020-2022. Mann-Whitney U tests were used to compare departmental metrics for institutions with and without social media accounts. Spearman rank correlations were used to examine the relationship between social media following and metrics, and between Twitter following and methods of Twitter use.

Results: 74% (n = 86) of neurosurgery programs have a Twitter account, 47% (n = 55) have a Facebook account, 63% (n = 73) have Instagram accounts, and 16% (n = 19) have LinkedIn accounts. The most notable differences were found when comparing departments with and without Twitter accounts, where a difference was found in all metrics except the average H-index. Residency program size, faculty count, average H-index, 3-year and 5-year publication and citation counts per faculty, and institutional H-indices were significantly correlated with Twitter following. Higher Doximity rankings were correlated with Twitter following and Facebook likes. There is a greater increase in 5-year citations per publication from 2009-2013 to 2018-2022 for institutions that created departmental Twitter accounts after 2013. Articles that were tweeted about had higher 3-year citations per publication than the institution's overall 3-year citations per publication.

Conclusion: Our findings provide updated insight into the relationship between social media presence and objective academic metrics of neurosurgery departments. We identify and quantify correlations between social media platforms and program characteristics, with a focus on research output. These metrics can be used to guide programs in their development of social media.

背景和目的:作者报告了当前3年和5年的机构文献计量概况,并调查了神经外科住院医师项目的客观指标与社交媒体存在之间的相关性,包括住院医师项目的规模、教师人数、Doximity排名以及研究产出的衡量标准:方法:通过 Doximity Residency Navigator 获取神经外科住院医师培训项目列表。使用Scopus汇编了教职员工的发表历史,并对其进行分析,以创建2018-2022年至2020-2022年的机构文献计量概况。Mann-Whitney U 检验用于比较有社交媒体账户和没有社交媒体账户的机构的部门指标。斯皮尔曼等级相关性用于检验社交媒体关注度与指标之间的关系,以及推特关注度与推特使用方法之间的关系:74%(n = 86)的神经外科项目拥有 Twitter 帐户,47%(n = 55)拥有 Facebook 帐户,63%(n = 73)拥有 Instagram 帐户,16%(n = 19)拥有 LinkedIn 帐户。有 Twitter 账户和没有 Twitter 账户的科室之间的差异最为明显,除平均 H 指数外,其他指标均存在差异。住院医师项目规模、教师人数、平均H指数、每位教师3年和5年的发表文章和引用次数以及机构H指数都与Twitter关注度有显著相关。较高的 Doximity 排名与 Twitter 关注度和 Facebook 点赞数相关。从2009-2013年到2018-2022年,在2013年后创建部门推特账户的机构,每篇论文的5年被引次数增幅更大。被推特关注的文章每篇出版物的3年被引次数高于该机构每篇出版物的总体3年被引次数:我们的研究结果为神经外科部门社交媒体存在与客观学术指标之间的关系提供了最新见解。我们确定并量化了社交媒体平台与项目特征之间的相关性,重点关注研究成果。这些指标可用于指导项目发展社交媒体。
{"title":"Updated 5-Year Institutional Bibliometric Profiles for United States Neurosurgery Residency Programs and the Relationship Between Social Media Presence and Objective Departmental Metrics.","authors":"Andrew N Chang, Deborah Boyett, Dean Chou, Andrew K Chan","doi":"10.1227/neu.0000000000003256","DOIUrl":"https://doi.org/10.1227/neu.0000000000003256","url":null,"abstract":"<p><strong>Background and objectives: </strong>The authors report current 3-year and 5-year institutional bibliometric profiles and investigate the correlations between objective metrics of neurosurgical residency programs and social media presence, including residency program size, faculty count, Doximity rankings, and measures of research output.</p><p><strong>Methods: </strong>A list of neurosurgery residency programs was obtained through the Doximity Residency Navigator. Publication history of faculty members was compiled using Scopus and analyzed to create institutional bibliometric profiles from 2018-2022 to 2020-2022. Mann-Whitney U tests were used to compare departmental metrics for institutions with and without social media accounts. Spearman rank correlations were used to examine the relationship between social media following and metrics, and between Twitter following and methods of Twitter use.</p><p><strong>Results: </strong>74% (n = 86) of neurosurgery programs have a Twitter account, 47% (n = 55) have a Facebook account, 63% (n = 73) have Instagram accounts, and 16% (n = 19) have LinkedIn accounts. The most notable differences were found when comparing departments with and without Twitter accounts, where a difference was found in all metrics except the average H-index. Residency program size, faculty count, average H-index, 3-year and 5-year publication and citation counts per faculty, and institutional H-indices were significantly correlated with Twitter following. Higher Doximity rankings were correlated with Twitter following and Facebook likes. There is a greater increase in 5-year citations per publication from 2009-2013 to 2018-2022 for institutions that created departmental Twitter accounts after 2013. Articles that were tweeted about had higher 3-year citations per publication than the institution's overall 3-year citations per publication.</p><p><strong>Conclusion: </strong>Our findings provide updated insight into the relationship between social media presence and objective academic metrics of neurosurgery departments. We identify and quantify correlations between social media platforms and program characteristics, with a focus on research output. These metrics can be used to guide programs in their development of social media.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Injury Characteristics and Risk Factors of Sport-Related Concussion Among High School Athletes in School-Sponsored Sports. 参加学校赞助体育运动的高中运动员的损伤特征和运动相关脑震荡的风险因素。
IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-01 DOI: 10.1227/neu.0000000000003250
Annabelle Shaffer, Helen Kemprecos, Zelda Moran, Aaron T Anderson, Adam Tarr, John Flannell, Graham Huesmann, Tracey M Wszalek, Jerrad Zimmerman, Paul M Arnold

Background and objectives: Over a million sport-related concussions (SRC) affect children annually in the United States, posing a significant public health concern. Limited data exist on the premorbid risk factors and injury characteristics of SRCs in high school athletes. This study aims to understand acute SRC injury characteristics and describe premorbid risk factors in high school athletes.

Methods: Athletes (aged 14-19 years) from 19 central Illinois high schools participating in school-sponsored sports from 2009 to 2023 were included. Sports Concussion Assessment Tool evaluations were performed as part of preseason and postinjury evaluations. Injury characteristics, such as mechanism, setting, and symptoms, were described using all SRCs in the study period. Odds ratios (OR) were computed to determine risk factors using athletes with a baseline Sports Concussion Assessment Tool before SRC and nonconcussed athletes.

Results: In total, 4360 athletes were included (3953 without SRC; 407 with ≥1 SRC of whom 168 had a previous baseline). Overall, 24.2% of SRCs occurred in female athletes, and most SRCs occurred in competitions while playing American football (52.3%), soccer (20.4%), and basketball (7.6%). Blow/hit to the head was the most common mechanism. Headache was the most severe symptom (2.55 ± 1.51 [SD]), and symptoms of emotionality and nervousness/anxiety were significantly more severe in female athletes (P < .05). Students with previous concussions (OR 2.64 95% CI [1.81, 3.78]), previous hospitalization for head injury (OR 3.19 95% CI [1.9, 5.14]), headache/migraine disorders (OR 2.23 95% CI [1.29, 3.66]), and learning disabilities (OR 2.69 95% CI [1.47, 4.61]) had greater odds of SRC (P < .05). Lower odds of SRC were seen in athletes identifying as Black or African American (vs White) (OR 0.54 95% CI [0.32, 0.86]) and those attending larger (vs smaller) schools (OR 0.64 95% CI [0.46, 0.88]).

Conclusion: Understanding SRC risk factors and characteristics in high school athletes is critical for developing prevention and management programs, guiding neurosurgeons in mitigating SRC risk, and informing return-to-play decisions.

背景和目标:在美国,每年有超过一百万名儿童受到与运动相关的脑震荡(SRC)的影响,这是一个重大的公共卫生问题。有关高中运动员发生 SRC 前的风险因素和损伤特征的数据十分有限。本研究旨在了解高中运动员的急性SRC损伤特征,并描述其发病前的风险因素:研究对象包括伊利诺伊州中部 19 所高中的运动员(14-19 岁),他们在 2009 年至 2023 年期间参加了学校主办的运动会。作为季前赛和受伤后评估的一部分,对运动脑震荡评估工具进行了评估。研究期间的所有 SRC 都对损伤特征(如机制、环境和症状)进行了描述。通过计算比值比 (OR),以确定在 SRC 前使用运动脑震荡评估工具进行基线评估的运动员和非脑震荡运动员的风险因素:共纳入了 4360 名运动员(3953 人未接受过 SRC;407 人接受过≥1 次 SRC,其中 168 人曾接受过基线评估)。总体而言,24.2%的SRC发生在女运动员身上,大多数SRC发生在美式足球(52.3%)、足球(20.4%)和篮球(7.6%)比赛中。头部受到打击/撞击是最常见的发病机制。头痛是最严重的症状(2.55 ± 1.51 [标码]),女性运动员的情绪化和紧张/焦虑症状明显更严重(P < .05)。曾有脑震荡(OR 2.64 95% CI [1.81,3.78])、曾因头部受伤住院(OR 3.19 95% CI [1.9,5.14])、头痛/偏头痛(OR 2.23 95% CI [1.29,3.66])和学习障碍(OR 2.69 95% CI [1.47,4.61])的学生出现 SRC 的几率更高(P < .05)。黑人或非裔美国人(vs 白人)(OR 0.54 95% CI [0.32,0.86])以及就读于较大(vs 较小)学校(OR 0.64 95% CI [0.46,0.88])的运动员发生 SRC 的几率较低:了解高中运动员的 SRC 风险因素和特征对于制定预防和管理计划、指导神经外科医生降低 SRC 风险以及为重返赛场决策提供信息至关重要。
{"title":"Injury Characteristics and Risk Factors of Sport-Related Concussion Among High School Athletes in School-Sponsored Sports.","authors":"Annabelle Shaffer, Helen Kemprecos, Zelda Moran, Aaron T Anderson, Adam Tarr, John Flannell, Graham Huesmann, Tracey M Wszalek, Jerrad Zimmerman, Paul M Arnold","doi":"10.1227/neu.0000000000003250","DOIUrl":"https://doi.org/10.1227/neu.0000000000003250","url":null,"abstract":"<p><strong>Background and objectives: </strong>Over a million sport-related concussions (SRC) affect children annually in the United States, posing a significant public health concern. Limited data exist on the premorbid risk factors and injury characteristics of SRCs in high school athletes. This study aims to understand acute SRC injury characteristics and describe premorbid risk factors in high school athletes.</p><p><strong>Methods: </strong>Athletes (aged 14-19 years) from 19 central Illinois high schools participating in school-sponsored sports from 2009 to 2023 were included. Sports Concussion Assessment Tool evaluations were performed as part of preseason and postinjury evaluations. Injury characteristics, such as mechanism, setting, and symptoms, were described using all SRCs in the study period. Odds ratios (OR) were computed to determine risk factors using athletes with a baseline Sports Concussion Assessment Tool before SRC and nonconcussed athletes.</p><p><strong>Results: </strong>In total, 4360 athletes were included (3953 without SRC; 407 with ≥1 SRC of whom 168 had a previous baseline). Overall, 24.2% of SRCs occurred in female athletes, and most SRCs occurred in competitions while playing American football (52.3%), soccer (20.4%), and basketball (7.6%). Blow/hit to the head was the most common mechanism. Headache was the most severe symptom (2.55 ± 1.51 [SD]), and symptoms of emotionality and nervousness/anxiety were significantly more severe in female athletes (P < .05). Students with previous concussions (OR 2.64 95% CI [1.81, 3.78]), previous hospitalization for head injury (OR 3.19 95% CI [1.9, 5.14]), headache/migraine disorders (OR 2.23 95% CI [1.29, 3.66]), and learning disabilities (OR 2.69 95% CI [1.47, 4.61]) had greater odds of SRC (P < .05). Lower odds of SRC were seen in athletes identifying as Black or African American (vs White) (OR 0.54 95% CI [0.32, 0.86]) and those attending larger (vs smaller) schools (OR 0.64 95% CI [0.46, 0.88]).</p><p><strong>Conclusion: </strong>Understanding SRC risk factors and characteristics in high school athletes is critical for developing prevention and management programs, guiding neurosurgeons in mitigating SRC risk, and informing return-to-play decisions.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Antibacterial Envelopes in Neuromodulation Surgeries With Implantable Device Insertion: A Systematic Review and Meta-Analysis. 在植入可植入设备的神经调控手术中使用抗菌包膜:系统回顾与元分析》。
IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-01 DOI: 10.1227/neu.0000000000003242
Helen Michaela de Oliveira, Lucas Mendes Barbosa, Fernanda Valeriano Zamora, Bruna Oliveira de Paula, Guilherme Oliveira de Paula, Julie G Pilitsis, Pablo Ramon Fruett da Costa

Background and objectives: Neuromodulation is an advanced therapeutic intervention for managing various neurological, psychiatric, and functional disorders. However, a significant challenge is the risk of infections at the device implantation site. Previous studies have shown that antibacterial envelopes used in cardiovascular surgeries significantly reduce infection risk. It is postulated that similar benefits could occur in neurosurgeries involving implant insertion, but the literature lacks studies analyzing this efficacy. This study aimed to evaluate the effectiveness of antibacterial envelopes in reducing infection rates associated with neuromodulation implants.

Methods: We systematically searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases up to August 2024 for clinical trials comparing the use of antibacterial impregnated envelopes in patients undergoing neuromodulation-related implant insertion. This study followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Statistical analyses were performed using R version 4.3.2. Risk of bias was assessed using the Risk Of Bias In Nonrandomized Studies-of Interventions tool, and the quality of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation assessment. The study was registered in Prospective Register of Systematic Reviews.

Results: Four studies, comprising 1242 patients, were included, of whom 704 (56.7%) received antibacterial envelopes. The pooled analysis showed that the odds of infection were 77% lower in patients using the antibacterial envelope compared with the control group (odds ratios = 0.23; 95% CI = 0.10-0.51; P < .001; I2 = 2%).

Conclusion: The use of an antibacterial envelope significantly reduces the odds of infection in patients undergoing neuromodulation-related implant insertion by 77%. These findings underscore the potential of antibacterial envelopes to improve postoperative outcomes.

背景和目的:神经调控是一种先进的治疗干预手段,可用于治疗各种神经、精神和功能性疾病。然而,一个重大挑战是装置植入部位的感染风险。先前的研究表明,心血管手术中使用的抗菌包膜可显著降低感染风险。据推测,神经外科手术中的植入物植入也会产生类似的益处,但文献中缺乏对这种功效的分析研究。本研究旨在评估抗菌包膜在降低神经调控植入物相关感染率方面的效果:我们系统地检索了 PubMed、Embase 和 Cochrane Central Register of Controlled Trials 数据库(截止到 2024 年 8 月)中关于比较在接受神经调控相关植入物的患者中使用抗菌浸渍包膜的临床试验。本研究遵循《系统综述和元分析首选报告项目》指南。统计分析使用 R 4.3.2 版本进行。使用 "非随机干预研究中的偏倚风险 "工具对偏倚风险进行了评估,并使用 "建议评估、开发和评价分级 "对证据质量进行了评估。该研究已在前瞻性系统综述注册中心注册:结果:共纳入了四项研究,包括 1242 名患者,其中 704 人(56.7%)接受了抗菌包膜治疗。汇总分析显示,与对照组相比,使用抗菌包膜的患者感染几率降低了 77%(几率比 = 0.23;95% CI = 0.10-0.51;P < .001;I2 = 2%):结论:使用抗菌包膜可将接受神经调控相关植入物插入手术的患者的感染几率大幅降低 77%。这些发现强调了抗菌包膜改善术后效果的潜力。
{"title":"Use of Antibacterial Envelopes in Neuromodulation Surgeries With Implantable Device Insertion: A Systematic Review and Meta-Analysis.","authors":"Helen Michaela de Oliveira, Lucas Mendes Barbosa, Fernanda Valeriano Zamora, Bruna Oliveira de Paula, Guilherme Oliveira de Paula, Julie G Pilitsis, Pablo Ramon Fruett da Costa","doi":"10.1227/neu.0000000000003242","DOIUrl":"https://doi.org/10.1227/neu.0000000000003242","url":null,"abstract":"<p><strong>Background and objectives: </strong>Neuromodulation is an advanced therapeutic intervention for managing various neurological, psychiatric, and functional disorders. However, a significant challenge is the risk of infections at the device implantation site. Previous studies have shown that antibacterial envelopes used in cardiovascular surgeries significantly reduce infection risk. It is postulated that similar benefits could occur in neurosurgeries involving implant insertion, but the literature lacks studies analyzing this efficacy. This study aimed to evaluate the effectiveness of antibacterial envelopes in reducing infection rates associated with neuromodulation implants.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases up to August 2024 for clinical trials comparing the use of antibacterial impregnated envelopes in patients undergoing neuromodulation-related implant insertion. This study followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Statistical analyses were performed using R version 4.3.2. Risk of bias was assessed using the Risk Of Bias In Nonrandomized Studies-of Interventions tool, and the quality of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation assessment. The study was registered in Prospective Register of Systematic Reviews.</p><p><strong>Results: </strong>Four studies, comprising 1242 patients, were included, of whom 704 (56.7%) received antibacterial envelopes. The pooled analysis showed that the odds of infection were 77% lower in patients using the antibacterial envelope compared with the control group (odds ratios = 0.23; 95% CI = 0.10-0.51; P < .001; I2 = 2%).</p><p><strong>Conclusion: </strong>The use of an antibacterial envelope significantly reduces the odds of infection in patients undergoing neuromodulation-related implant insertion by 77%. These findings underscore the potential of antibacterial envelopes to improve postoperative outcomes.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MicroRNA Analysis in Meningiomas with Different Degrees of Tissue Stiffness: A Potential Tool for Effective Preoperative Planning. 不同组织僵硬度脑膜瘤的微RNA分析:有效术前规划的潜在工具
IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-01 DOI: 10.1227/neu.0000000000003222
Milos Duba, Dagmar Al Tukmachi, Tetiana Samoilenko, Marek Vecera, Michaela Ruckova, Tereza Vankova, Lenka Radova, Milos Kerkovsky, Marek Dostal, Tereza Koprivova, Ivana Roskova, Andrej Mrlian, Ondrej Hrdy, Jaroslav Duba, Leos Kren, Martin Smrcka, Ondrej Slaby, Pavel Fadrus, Jiri Sana

Background and objectives: Meningioma, the most common primary intracranial tumor, presents challenges in surgical treatment because of varying tissue stiffness. This study explores the molecular background of meningioma stiffness, a critical factor in surgical planning and prognosis, focusing on the utility of microRNAs (miRNAs) as diagnostic biomarkers of tissue stiffness.

Methods: Patients with meningiomas treated surgically at the University Hospital Brno were included in this study. Total RNA, isolated from tumor tissue samples, underwent quality control and small RNA sequencing to analyze miRNA expression. Differentially expressed miRNAs were identified, and their association with tumor stiffness was assessed.

Results: This study identified specific miRNAs differentially expressed in meningiomas with different stiffness levels. Key miRNAs, such as miR-31-5p and miR-34b-5p, showed significant upregulation in stiffer meningiomas. These findings were validated using reverse transcription-quantitative polymerase chain reaction, revealing a potential link between miRNA expression and tumor consistency. The expression of miR-31-5p was most notably associated with the stiffness of the tumor tissue (sensitivity = 71% and specificity = 83%).

Conclusion: This research highlights the potential of miRNAs as biomarkers for determining meningioma tissue stiffness. Identifying specific miRNAs associated with tumor consistency could improve preoperative planning and patient prognosis. These findings pave the way for further exploration of miRNAs in the clinical assessment of meningiomas.

背景和目的:脑膜瘤是最常见的原发性颅内肿瘤,由于组织僵硬度不同,给手术治疗带来了挑战。脑膜瘤僵硬度是影响手术计划和预后的关键因素,本研究探讨了脑膜瘤僵硬度的分子背景,重点研究了微小核糖核酸(miRNA)作为组织僵硬度诊断生物标志物的效用:研究对象包括在布尔诺大学医院接受手术治疗的脑膜瘤患者。从肿瘤组织样本中分离出的总 RNA 经过质量控制和小 RNA 测序,以分析 miRNA 的表达。结果发现了表达不同的 miRNA,并评估了它们与肿瘤硬度的关系:结果:这项研究发现了在不同硬度水平的脑膜瘤中表达不同的特定 miRNA。miR-31-5p和miR-34b-5p等关键miRNA在硬度较高的脑膜瘤中表现出显著的上调。反转录定量聚合酶链反应验证了这些发现,揭示了 miRNA 表达与肿瘤一致性之间的潜在联系。miR-31-5p的表达与肿瘤组织的僵硬程度最明显相关(敏感性=71%,特异性=83%):这项研究凸显了 miRNA 作为生物标记物确定脑膜瘤组织硬度的潜力。确定与肿瘤一致性相关的特定 miRNA 可改善术前计划和患者预后。这些发现为进一步探索 miRNA 在脑膜瘤临床评估中的应用铺平了道路。
{"title":"MicroRNA Analysis in Meningiomas with Different Degrees of Tissue Stiffness: A Potential Tool for Effective Preoperative Planning.","authors":"Milos Duba, Dagmar Al Tukmachi, Tetiana Samoilenko, Marek Vecera, Michaela Ruckova, Tereza Vankova, Lenka Radova, Milos Kerkovsky, Marek Dostal, Tereza Koprivova, Ivana Roskova, Andrej Mrlian, Ondrej Hrdy, Jaroslav Duba, Leos Kren, Martin Smrcka, Ondrej Slaby, Pavel Fadrus, Jiri Sana","doi":"10.1227/neu.0000000000003222","DOIUrl":"https://doi.org/10.1227/neu.0000000000003222","url":null,"abstract":"<p><strong>Background and objectives: </strong>Meningioma, the most common primary intracranial tumor, presents challenges in surgical treatment because of varying tissue stiffness. This study explores the molecular background of meningioma stiffness, a critical factor in surgical planning and prognosis, focusing on the utility of microRNAs (miRNAs) as diagnostic biomarkers of tissue stiffness.</p><p><strong>Methods: </strong>Patients with meningiomas treated surgically at the University Hospital Brno were included in this study. Total RNA, isolated from tumor tissue samples, underwent quality control and small RNA sequencing to analyze miRNA expression. Differentially expressed miRNAs were identified, and their association with tumor stiffness was assessed.</p><p><strong>Results: </strong>This study identified specific miRNAs differentially expressed in meningiomas with different stiffness levels. Key miRNAs, such as miR-31-5p and miR-34b-5p, showed significant upregulation in stiffer meningiomas. These findings were validated using reverse transcription-quantitative polymerase chain reaction, revealing a potential link between miRNA expression and tumor consistency. The expression of miR-31-5p was most notably associated with the stiffness of the tumor tissue (sensitivity = 71% and specificity = 83%).</p><p><strong>Conclusion: </strong>This research highlights the potential of miRNAs as biomarkers for determining meningioma tissue stiffness. Identifying specific miRNAs associated with tumor consistency could improve preoperative planning and patient prognosis. These findings pave the way for further exploration of miRNAs in the clinical assessment of meningiomas.</p>","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Neurosurgery
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