Neurosurgery最新文献

Background and objectives: Treatment of symptomatic spinal dural arteriovenous fistulas (SDAVF) reduces spinal cord injury and prevents irreversible neurological deficits. It remains unclear whether endovascular embolization vs open surgical treatment of SDAVF is associated with better neurological outcomes. We aimed to compare neurological outcomes between patients who underwent endovascular embolization vs open surgical treatment as primary treatment of SDAVF.

Methods: Patients who underwent endovascular embolization or open surgical treatment as primary treatment of SDAVFs at our institution between 2012 and 2023 were retrospectively identified. The primary outcome assessed was neurological status measured using the Frankel grade and Nurick classification systems. Outcomes at final follow-up were compared with preintervention neurological status.

Results: A total of 48 patients (63.8 ± 11.1 years, 75.0% men) met study inclusion criteria. Endovascular embolization was performed in 29 patients, and open surgical treatment was performed in 19 patients. Baseline neurological function was similar for both treatment groups. At final follow-up, similar rates of Frankel (20.7% vs 21.1%, P > .999) and Nurick grade (55.2% vs 57.9%, P > .999) improvement were observed in endovascular vs open surgical treatment groups. Patients who underwent endovascular embolization had a shorter hospital stay (3.1 ± 2.3 vs 5.3 ± 1.8 days; mean difference = 2.2 days, 95% CI 0.93-3.42, P = .001). Reintervention for symptomatic SDAVF was required for 3 (10.3%) patients who underwent endovascular embolization and 0 (0.0%) patients who underwent open surgical treatment (P = .267).

Conclusion: Both endovascular embolization and open surgical treatment significantly improved neurological symptoms among patients with SDAVF, and similar neurological outcomes were achieved at final follow-up. Although high recurrence rates have been reported with endovascular treatment, they may be similar to open surgery in the hands of experienced operators. Treatment selection should be guided by multidisciplinary discussion of patient-specific risk factors.

Background and objectives: Identifying predictors of shunt failure in acute care settings is challenging. Previous studies largely rely on traditional statistical analyses to evaluate risk factors associated with shunt failure. However, these methods have not been adapted for emergency department (ED) presentations, where machine learning (ML) techniques may offer enhanced predictive power. Thus, we explored the application of ML and artificial intelligence in predicting necessity for shunt revision in pediatric ED visits.

Methods: A retrospective analysis was conducted on 1167 pediatric neurosurgical consults for suspected shunt malfunction from 2017 to 2022. We collected 24 historical, clinical, and radiographic variables. Various ML techniques were used, including support vector machine, K-nearest neighbors, random forest, an artificial neural network (ANN), and a proprietary large language model named ShuntGPT (SGPT), which classifies the need for shunt revision.

Results: Among 1167 ED consults for shunt malfunction, 285 patients (24.4%) underwent revision. Multivariate analysis identified increased ventricle size, abnormal shunt series, lethargy, altered mental status, and bradycardia as predictors of need for revision. The best-performing ML models included ANN (accuracy 84%, area under the curve [AUC] 0.88, 71% sensitivity, 88% specificity) and SGPT (accuracy 87%, precision 0.80, recall 0.64, AUC 0.927). Traditional classifiers (support vector machine, K-nearest neighbors, random forest) achieved AUCs of 0.81 to 0.86 with varying trade-offs in sensitivity and precision. With imaging results removed from training data, the performance of all models suffered, however, SGPT retained a high level of discrimination (AUC 0.84). SGPT continued to show high accuracy (83%) on a separate validation cohort.

Conclusion: Advanced ML models generally outperformed traditional statistical analyses, albeit with concerns about overfitting due to the extensive variable set. SGPT, in particular, showed superior performance, likely due to its capacity to interpret nuanced text. This model represents a promising tool to enhance decision-making in pediatric acute care settings regarding shunt malfunctions.

Background and objectives: Access to specialty surgical care is growing in many low-income countries, but it remains unclear how hospital workforces can leverage technology to manage large numbers of increasingly complex patients. Large language models (LLMs) may be helpful for this type of clinical decision support, but their real-world performance and safety remain uncertain. The objective of this study was to evaluate feasibility, usability, and potential benefits and risks of an LLM-based assistant for postoperative neurosurgical care in the Gambia.

Methods: A prospective, single-arm implementation study was conducted at the Edward Francis Small Teaching Hospital. A convenience sample of 4 medical officers (MOs) and 5 nurses assigned to the neurosurgical service participated. A prompted GPT-4o Turbo was deployed on OpenAI Pro accounts to support performance. Usability, helpfulness, and safety were the primary outcomes. Cost-effectiveness was a secondary outcome.

Results: Participants completed 75 LLM-assisted interactions on 9 postoperative neurosurgery patients. Usability metrics indicated a moderately high cognitive workload, marginally acceptable usability of the LLM system, and high perceived ease of use. Management plan quality improved in 45 of 75 mock rounds interactions (60%), with a mean improvement of 8.5% (P < .001) on mock rounds scoring rubrics. The improvement was greater for MOs (21.0% change) than nurses (6.5% change). In hypothetical case dilemmas, MO plan accuracy improved by 22.7% (P = .001), and critical errors declined from 33.3% to 0%. Fourteen care changes for 9 patients were attributed to LLM suggestions, including 6 that potentially prevented major morbidity. No unsafe outputs were detected. Exploratory cost analysis suggested potential savings from clinical care changes exceeded the labor costs involved in LLM use.

Conclusion: LLM use was associated with improved plan quality without observed safety concerns, while also prompting clinically meaningful care changes. Larger, controlled studies are needed to determine generalizability, durability of benefit, and patient-centered outcomes.

Background and objectives: Supratentorial herniation is traditionally described as a mechanical shift of brain structures due to elevated intracranial pressure. However, this model inadequately explains the stepwise physiological decline observed in patients with progressive brainstem dysfunction. We aimed to propose and support a novel conceptual model of herniation based on a vertically oriented compaction gradient and the emergence of a "demarcation line of tissue compaction" as a physiological boundary between viable and irreversibly failing neural tissue.

Methods: A prospective observational study was conducted between 2022 and 2025, involving 287 patients with traumatic supratentorial brain herniation admitted to the neurosurgical departments of 3 urban hospitals. Clinical staging was based on consciousness, pupillary reactivity, brainstem reflexes, motor responses, respiratory pattern, and the Kerdo Vegetative Index. Postmortem morphological analysis was conducted in 129 cases to determine the rostrocaudal extent of brainstem injury.

Results: Five distinct stages of herniation were identified, each correlated with specific clinical features and anatomic damage. A progressive downward pattern of neurological deterioration and structural destruction was observed from the diencephalon to the medulla. The progression was often preceded by a physiological cluster-Hyper-H triad-manifesting as hyperthermia, hypertonia, and hormonal dysregulation. Clinical signs and autonomic shifts consistently mirrored this descent. The findings support the presence of a transitional frontier-termed the demarcation line of compaction-separating salvageable function from collapse.

Conclusion: Supratentorial herniation represents not only spatial displacement but also a structured physiological degradation. The compaction model provides a dynamic framework for understanding herniation progression and may assist in bedside assessment, staging, and early intervention. The Hyper-H triad may serve as an early physiological indicator of impending herniation. Further prospective and imaging-based studies are warranted to validate this approach.

Background and objectives: Lung cancer is the most common primary neoplasm that metastasizes to the brain. Although stereotactic radiosurgery (SRS) using American Society for Radiation Oncology guideline-suggested doses improves local control, it may increase adverse radiation events (AREs). This study evaluates whether reduced SRS doses can achieve comparable local control while minimizing toxicity in patients with brain metastases from non-small cell lung cancer (NSCLC) primary receiving concurrent systemic therapy.

Methods: We conducted a retrospective study of 264 patients with 1390 metastases from lung primary treated with SRS between December 2015 and January 2025. Of these, 82 patients with 433 metastases had NSCLC and received concurrent systemic therapy, defined as immunotherapy or targeted therapy within 30 days of SRS. Propensity score matching identified 38 patients with 93 metastases in the higher-dose (HD) group (20-24 Gy for <2 cm, 18 Gy for ≥2 to <3 cm) and 42 patients with 93 metastases in the reduced-dose (RD) group (<20 Gy for <2 cm, <18 Gy for ≥2 to <3 cm).

Results: Radiographic AREs, including perilesional edema and radiation necrosis, were significantly more common in the HD group than in the RD group (23.7% vs 10.8%, P = .020). Local control was noninferior in the RD group (94.6%) compared with the HD group (90.3%, P = .400). Cumulative progression at 1, 3, and 5 years remained comparable between the RD (13%, 15%, and 15%, respectively) and HD (7.2%, 10%, and 10%, respectively) groups (P = .500).

Conclusion: In the contemporary era, RD SRS delivered concurrently with immunotherapy or targeted therapy may lower AREs without compromising local control to treat NSCLC brain metastases.

Background and objectives: Venous sinus stenting (VSS) has emerged as an alternative treatment for selected idiopathic intracranial hypertension (IIH) cases, but its comparative effectiveness and safety vs ventricular shunting (VS) remain uncertain. Given the heterogeneity of IIH, we hypothesized that outcomes differ by patient phenotype defined by obesity and visual disturbance at diagnosis.

Methods: Adults with IIH who underwent VSS or VS shunting were identified using TriNetX. Patients were stratified into 4 prespecified phenotypes: nonobese-visual-disturbance (NO-V), nonobese-no-visual-disturbance (NO-NV), obese-visual-disturbance (OV), and obese-no-visual-disturbance (ONV). Within each phenotype, 1:1 propensity score matching balanced baseline demographics, comorbidities, and laboratory parameters. Primary outcomes were persistent headache, papilledema, and visual disturbance within 24 months. Secondary outcomes included retreatment, head computed tomography use, and emergency department visits.

Results: After matching (NO-V = 69, NO-NV = 186, OV = 305, ONV = 440 per arm), cohorts were well balanced. In NO-NV, VS was associated with higher rates of headache (risk difference [RD]: 0.11, P = .049), visual disturbances (RD: 0.11, P = .010), and emergency department visits (RD: 0.15, P = .006). NO-V showed no primary outcome differences, although vestibular disorders were more common with shunts (RD: 0.15, P = .008). In OV, VS shunting was linked to higher rates of visual deficits (RD: 0.11, P = .045). Conversely, in ONV, shunting was associated with lower rates of papilledema (RD: -0.6, P = .024) and pulsatile tinnitus (RD: -0.5, P = .004) but increased headaches (RD: 0.12, P < .001). Across phenotypes, shunted patients had greater head computed tomography use and retreatment rates, while VSS patients more often required ongoing medical therapy.

Conclusion: The comparative effectiveness of VSS and VS in IIH varies by phenotype. VSS appears preferable in nonobese patients without visual symptoms, whereas VS may better control papilledema in obese patients without visual disturbance. Both treatments show similar efficacy in patients with baseline visual impairment. These findings underscore the need for phenotype-guided, prospective trials.

Background and objectives: Meningioma consistency is linked to important clinical and surgical outcomes, and preoperative knowledge of consistency may have significant implications for operative planning and decision making. This study aimed to determine whether intraoperative meningioma consistency is associated with preoperative T2-weighted imaging (T2WI) and diffusion-weighted imaging.

Methods: Tumor consistency was prospectively assigned in 188 meningioma patients at the time of surgery over a twelve-year period (2012-2024) using a 5-point scale with validated interuser reliability. Signal intensity was quantified as the intensity ratio between region of interest in the meningioma and the middle cerebellar peduncle using a previously validated methodology (tumor/cerebellar peduncle T2WI intensity [TCTI] ratios). Mean and maximum signal intensity were measured using T2 and diffusion-weighted MRI sequences.

Results: When using mean T2WI measurements, TCTI ratios were lower for grade 4 + 5 tumors (1.41 ± 0.31, 95% CI: -0.418 to -0.182, P < .001) compared with consistency grade 3 tumors (1.71 ± 0.32, reference group) and grade 1 + 2 tumors (1.98 ± 0.36, 95% CI: -0.453 to -0.074, P < .004). A similar trend was observed using max region of interest measurements. No association was found between consistency and diffusion-weighted imaging. TCTI ratios using mean (odds ratio: 0.031, 95% CI: 0.009 to 0.101, P < .001) and max (odds ratio: 0.027, 95% CI: 0.007 to 0.097, P < .001) measurements were independent predictors of consistency when adjusting for covariates. In an receiver operating characteristic analysis comparing T2 mean ratios for grade 1 + 2 to 4 + 5 tumors, the area under the curve was 0.868 and precision-recall area under the curve was 0.960. A TCTI ratio cutoff of 1.536 was 75.0% sensitive and 100% specific in differentiating grade 1 + 2 and grade 4 + 5 tumors using T2WI alone.

Conclusion: In meningiomas, the TCTI ratio is associated with intraoperative tumor consistency, with higher signal intensity ratios predicting softer meningioma consistency. Application in this manner may augment surgical planning and improve preoperative patient counseling.

Background and objectives: Clinical risk factors for seizure presentation in meningioma patients have been reported, but molecular correlates of seizures in meningioma remain unexplored.

Methods: We assessed a total of 144 primary meningiomas for clinical data and performed bulk RNA sequencing (n = 141), whole-exome sequencing (n = 35), targeted DNA sequencing (n = 67), and DNA methylation analysis (n = 62).

Results: Clinically, seizure presentation was associated with higher rates of emergency room presentation (P = .005), altered consciousness (P = .014), and fewer headaches (P = .015). Radiographically, seizure presentation correlated with higher rates of cerebral edema (P = .005), nonhomogenous enhancement (P = .001), and intratumoral calcification (P = .034). Pathologically, seizure presenting tumors had higher molecular immunology borstel 1 index (P = .001) and cellular atypia in World Health Organization grade 1 tumors (P = .023) but were not associated with World Health Organization grade 2 status (P = .059). There was no difference in rates of canonical mutations between groups. Chromosome 14q loss was enriched in the seizure group (P = .004). Seizure presentation was associated with the Molecular Group C (MenG C) (P = .023). Transcriptomic analysis revealed downregulation of GABAergic signaling, synaptic pathways, and neurotransmitter receptors in meningiomas causing seizure. Dysregulated genes included both MenG C-specific (GABRG1, GRIA1, DKK2) and seizure-specific/MenG-independent (GABRA3, GABRQ, GRIK3, NPY1R) genes.

Conclusion: Here, we show that seizure causing meningiomas demonstrate distinct clinical, radiographic, chromosomal, and transcriptional features. Novel associations with seizure presentation in meningioma include MenG C status, chromosome 14q loss, and seizure-specific dysregulation of neurotransmitter receptor genes.

Background and objectives: Meningiomas are the most common primary intracranial tumors, with over 450 000 new cases each year. Although surgical resection remains the standard of care, recurrence occurs in up to 40% of cases. Reoperation poses additional risks due to anatomic changes and scar tissue. Elderly and frail patients experience increased rates of surgical morbidity, limiting treatment options. This study evaluates the potential of embolization, a technique traditionally used preoperatively to reduce intraoperative blood loss, as a definitive or palliative standalone treatment in select cases.

Methods: A systematic review was conducted following Preferred Reporting Items for System reviews and Meta-Analyses guidelines. PubMed/MEDLINE and EMBASE were searched for studies reporting standalone meningioma embolization, defined as embolization without resection or radiotherapy for at least 2 months postprocedure. Two blinded reviewers screened articles using Covidence and conducted standardized data extraction. Variables collected included patient demographics, tumor characteristics, embolic agents, outcomes, and complications.

Results: This review identified 121 patients across 34 studies treated with standalone embolization. Of these, 67 patients had long-term follow-up. Symptomatic improvement was reported in 77 ± 6% of symptomatic patients, with radiographic tumor shrinkage observed in 84 ± 6%, and complete resolution seen in 5%. The major complication rate (5%) was comparable with that of preoperative embolization (3%-6%) and lower than that of surgical resection (7%-31%).

Conclusion: Standalone embolization potentially represents a lower-risk alternative for meningioma patients unsuitable for surgery or refractory to standard treatments. Although current evidence is limited and largely retrospective, reported outcomes support further prospective investigation. Mechanistically, ischemia-induced necrosis may be the underlying cause of tumor and symptom regression. Larger studies are needed to establish standalone embolization as a safe and effective meningioma treatment.