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Culture-negative endocarditis due to Mycoplasma pneumoniae 肺炎支原体所致培养阴性心内膜炎
Pub Date : 2013-02-01 DOI: 10.13172/2052-0077-2-2-408
C. Augustatou, C. Glynos, P. Cokkinos, J. Papaparaskevas
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引用次数: 2
Frontotemporal dementia patient with bipolar disorder: a case report 额颞叶痴呆合并双相情感障碍1例
Pub Date : 2013-02-01 DOI: 10.13172/2052-0077-2-2-423
Eylem Özten, S. Hızlı, C. Şalçini, Gaye Kağan, O. Tanrıdağ
Introduction A diagnosis of frontotemporal dementia may be delayed or missed because early symptoms may develop gradually and can mimic symptoms of a variety of disorders or conditions. We aimed to write a report on a patient with frontotemporal dementia with bipolar disorder. Case report This is the case of a 63-year-old man with frontotemporal dementia whose presentation was consistent with bipolar affective disorder. With brain imaging and neurocognitive testing, frontotemporal dementia was diagnosed. Conclusion A differential diagnosis between bipolar disorder and frontotemporal dementia is difficult to establish. Frontotemporal dementia is a heterogeneous disease with a large variety of cognitive dysfunctions. Introduction Frontotemporal dementias (FTDs) are defined as the second most common cause for dementias under the age of 65 after Alzheimer’s disease and the third most common cause for neurodegenerative dementias after Alzheimer’s and Lewy body dementia1. FTD starts between the ages of 45–65 years and is seen equally in both genders2,3. The average life expectancy from onset of the disease ranges from 6–9 years2,3. FTD belongs to a group of heterogeneous diseases with different clinical and pathological findings4. FTD has three different subtypes including a behavioural variant, a semantic variant and a progressive, nonfluent aphasia5. In the behavioural variant, changes in eating habits6, loss of empathy, behavioural disinhibition, loss of social awareness, inappropriate affect, apathy and stereotypical behaviours, can be seen7. Brain imaging studies revealed—when the temporal region is affected—a significant decrease in emotional processing, disaffection in interpersonal relations, inappropriate social behaviours, jokes with sexual content, hypomanic-like behaviours and—when the frontal area is affected—apathy, reduction in social activity and tendency for criminal behaviours8,9. In FTD, mood, behaviour and speech disorders are seen before the memory impairment; thus, clinically heterogeneous symptoms may lead to misdiagnosis with psychiatric disorders. In this article, we have presented a case of a man who was misdiagnosed with late-onset bipolar disorder, but then diagnosed with FTD after neuropsychiatric examination, neuroimaging and neurocognitive testing.
额颞叶痴呆的诊断可能会延迟或遗漏,因为早期症状可能逐渐发展,并可能模仿各种疾病或病症的症状。我们的目的是写一篇关于额颞叶痴呆合并双相情感障碍患者的报告。病例报告:这是一个63岁男性额颞叶痴呆的病例,其表现与双相情感障碍一致。通过脑成像和神经认知测试,诊断为额颞叶痴呆。结论双相情感障碍与额颞叶痴呆的鉴别诊断比较困难。额颞叶痴呆是一种具有多种认知功能障碍的异质性疾病。额颞叶痴呆(FTDs)被定义为65岁以下痴呆症的第二大常见原因,仅次于阿尔茨海默病,是继阿尔茨海默病和路易体痴呆之后神经退行性痴呆的第三大常见原因。手足口病的发病年龄在45-65岁之间,男女发病率相同。从发病起的平均预期寿命为6-9岁。FTD属于一组异质性疾病,具有不同的临床和病理表现。FTD有三种不同的亚型,包括行为变异、语义变异和进行性非流利性失语症。在行为变异中,可以看到饮食习惯的改变、同理心的丧失、行为抑制的解除、社会意识的丧失、不恰当的情感、冷漠和刻板的行为。脑成像研究显示,当颞区受到影响时,情绪处理、人际关系中的不满情绪、不适当的社会行为、含有性内容的笑话、轻度躁狂行为显著减少,而当额区受到影响时,则表现为冷漠、社会活动减少和犯罪行为倾向8,9。在FTD中,情绪、行为和语言障碍出现在记忆障碍之前;因此,临床异质性症状可能导致误诊为精神障碍。在这篇文章中,我们报告了一个被误诊为晚发性双相情感障碍的男性病例,但在神经精神检查、神经影像学和神经认知测试后被诊断为FTD。
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引用次数: 0
A rare case of Spigelian hernia penetrating the external oblique muscle 刺穿外斜肌的Spigelian疝一例
Pub Date : 2013-02-01 DOI: 10.13172/2052-0077-2-2-407
T. Mariolis-Sapsakos, V. Kalles, I. Papapanagiotou, A. Mekras, K. Birbas, I. Kaklamanos, G. Bonatsos
strangulation that lead to serious complications, while their clinical presentation is often vague, leading to delayed diagnosis. Primary repair has so far been the treatment of choice, while other techniques can also be considered depending on the patient’s characteristics and the hernia type. A thorough physical examination along with high clinical suspicion remains crucial in the diagnosis of the Spigelian hernia; additionally, modern imaging modalities assist in timely and accurate preoperative diagnosis. Prompt surgical treatment is the key to avoid complications.
导致严重的并发症,而他们的临床表现往往是模糊的,导致延误诊断。到目前为止,初级修复是首选的治疗方法,而根据患者的特点和疝气类型,也可以考虑其他技术。彻底的身体检查以及高度的临床怀疑仍然是诊断Spigelian疝的关键;此外,现代成像方式有助于及时准确的术前诊断。及时手术治疗是避免并发症的关键。
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引用次数: 5
Management of retinal diseases 视网膜疾病的处理
Pub Date : 2013-01-01 DOI: 10.13172/2052-0077-2-1-371
N. Kumar
Introduction Many recent researches have contributed immensely in the management of retinal diseases. In this critical review, we discuss the management of retinal diseases. Conclusion Currently, age-related macular degeneration is managed primarily by anti-vascular growth factor agents. Newer reports on combination therapy may help in managing this visually debilitating condition in a better way. There are many new reports regarding the use of aflibercept and Ozurdex® (Allergan Inc., Irvine, California, USA) in the management of diabetic macular oedema and macular oedema associated with retinal vein occlusions. In the light of recent reports, retinopathy of prematurity may be often managed with bevacizumab. Introduction of ocriplasmin and Argus-II Retinal Prosthesis System (Second Sight Medical Products, Inc., Sylmar, California, USA) may offer ophthalmologists newer ways to treat some important vitreoretinal conditions.
近年来的许多研究对视网膜疾病的治疗做出了巨大贡献。在这篇重要的综述中,我们讨论视网膜疾病的管理。结论目前,老年性黄斑变性的治疗主要采用抗血管生长因子药物。最新的联合治疗报告可能有助于以更好的方式控制这种视力衰弱的状况。关于使用阿非利赛普和Ozurdex®(Allergan Inc., Irvine, California, USA)治疗糖尿病性黄斑水肿和视网膜静脉闭塞性黄斑水肿有许多新的报道。根据最近的报道,早产儿视网膜病变通常可以用贝伐单抗治疗。ocriplasmin和Argus-II视网膜假体系统(Second Sight Medical Products, Inc., Sylmar, California, USA)的引入可能为眼科医生提供治疗一些重要玻璃体视网膜疾病的新方法。
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引用次数: 1
Co-expression of Oct-4 and Survivin genes in human ovarian luteinized granulosa cells during in vitro fertilisation or intracytoplasmic sperm injection and embryo transfer programs 体外受精、胞浆内精子注射和胚胎移植过程中人类卵巢黄体化颗粒细胞Oct-4和Survivin基因的共表达
Pub Date : 2013-01-01 DOI: 10.13172/2052-0077-2-1-361
M. Varras
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引用次数: 0
Intestinal obstruction due to an obturator hernia: a case report with a review of the literature 由于闭孔疝引起的肠梗阻:一例报告并复习文献
Pub Date : 2013-01-01 DOI: 10.13172/2052-0077-2-1-365
Z. Antoniou, E. Volakaki, E. Giannakos, D. Kostopoulos, A. Chalazonitis
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引用次数: 6
Prenatal diagnosis of a huge foetal immature sacrococcygeal teratoma: our experience of a rare case and review of the literature 产前诊断一个巨大的胎儿未成熟的骶尾骨畸胎瘤:我们的经验一个罕见的病例和文献复习
Pub Date : 2013-01-01 DOI: 10.13172/2052-0077-2-1-406
M. Varras, G. Diakakis, I. Monselas, C. Akrivis
increased blood flow into the tumour. Pulsed Doppler showed the resistance index of flow velocity waveforms on the tumoural arteries to be 0.51. Amnioreduction of 740 cc amniotic fluid was performed under ultrasonographic examination. Caesar ean section was performed at 33 weeks’ gestation due to profuse polyhydramnios via an upper vertical incision in the uterus. After the stabilization of the newborn, tumour resection was successfully performed on the first day after delivery. Grossly, in the surgical specimen the tumour measured 18 cm in its maximum diameter and weighted 1 500 g. Conclusion Prenatal diagnosis and ultrasonographic follow-up are needed for the good prognosis of sacrococcygeal teratomas. Prenatal intervention should be considered when the foetus develops hydrops for foetal salvage or in cases with placentomegaly to avoid the maternal risk of mirror syndrome.
流入肿瘤的血流量增加。脉冲多普勒显示肿瘤动脉血流速度波形阻力指数为0.51。超声检查下取羊水740毫升。因羊水过多,孕33周经子宫上垂直切口行凯撒剖宫产术。新生儿稳定后,于分娩后第一天成功切除肿瘤。大体而言,在手术标本中,肿瘤的最大直径为18厘米,重1 500 g。结论骶尾翼畸胎瘤需要产前诊断和超声随访,才能获得良好的预后。当胎儿发生积水抢救胎儿或胎盘肿大时,应考虑进行产前干预,以避免母体发生镜像综合征的风险。
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引用次数: 3
Giant, solitary, ancient schwannoma of the cervico-thoracic spine: a case report and review of the literature 巨大、孤立、古老的颈胸椎神经鞘瘤:1例报告及文献复习
Pub Date : 2013-01-01 DOI: 10.13172/2052-0077-2-1-362
E. Mwaka, P. Senyonjo, M. Kakyama, M. Nyati, N. Orwotho, R. Lukande
iatrogenic post-operative instability. Histopathological examination showed ancient schwannoma. The patient’s neurological status is steadily improving. Conclusion Giant ancient schwannomas at the cervico-thoracic spine are uncommon. These tumours can be successfully removed even in resource-limited settings as long as the technical expertise is available.
医源性术后不稳定。组织病理学检查为古发神经鞘瘤。病人的神经系统状况正在稳步改善。结论颈胸椎巨大的古老神经鞘瘤并不常见。即使在资源有限的情况下,只要有技术专长,这些肿瘤也可以成功切除。
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引用次数: 2
Extragenital adenomatoid tumour of the omentum: an unusual location 子宫外网膜腺瘤样肿瘤:一个不寻常的位置
Pub Date : 2013-01-01 DOI: 10.13172/2052-0077-2-1-364
E. Skafida, A. Tsavari, K. Koulia, D. Myoteri, X. Grammatoglou, A. Zisi, M. Varras, T. Vasilakaki
Introduction Adenomatoid tumours are benig - n neoplasms that are mesothelial in origin and are usually confined to the genital tract and have rarely been reported at other sites such as the omentum, pleura, heart, liver, adrenal gland, retroperitoneum and intestinal mesentery. This paper discusses the unusual location of an extragenital adenomatoid tumour of the omentum. Case report We report the case of a 32-year-old woman who presented to our hospital with a four-day history of fever and pain in the right iliac fossa. Ultrasonography revealed a right ovarian cyst which was 2.5 cm in diameter and fluid in douglaseio. A right partial oopho - rectomy was performed, and duri - ng the operation, a well circu - mscribed mass measuring 2 cm was observed in the omentum. Histological evaluation of the cyst showed features of a cracked lute - al cyst and the mass showed feat - ures of an adenomatoid tumour. In the immunohistochemical study, the lesional cells were positive for calretinin, D240, CK5/6, HMBE1, CKAE1, CKAE3 and calponin. The treatment in such cases is tumour excision. W e report the case of an unusual extragenital adenomatoid tumour.
腺瘤样肿瘤是一种起源于间皮细胞的良性肿瘤,通常局限于生殖道,很少报道在其他部位如网膜、胸膜、心脏、肝脏、肾上腺、腹膜后和肠系膜。本文讨论了子宫外网膜腺瘤样肿瘤的异常位置。病例报告我们报告一名32岁的女性,她以四天的发烧和右髂窝疼痛史来到我们医院。超声示右侧卵巢囊肿,直径2.5 cm,腹腔积液。行右侧部分卵巢切除术,术中发现大网膜内有2厘米围合良好的肿块。囊肿的组织学检查表现为裂口黄体囊肿,肿块表现为腺瘤样肿瘤。免疫组化结果显示,病变细胞calretinin、D240、CK5/6、HMBE1、CKAE1、CKAE3、calponin阳性。在这种情况下的治疗是肿瘤切除。我们报告一个不寻常的病例外生殖器腺瘤样肿瘤。结论腺瘤样肿瘤常在外科手术中偶然发现。因此,肿瘤切除是首选的治疗方法。腺瘤样肿瘤是起源于间皮细胞的良性肿瘤,通常局限于生殖道。在男性中,这些肿瘤发生在附睾、睾丸被膜、前列腺、精索和睾丸实质。据报道,在女性中,这些肿瘤发生在子宫、输卵管,很少发生在卵巢1,2,3,4。然而,在其他部位,如网膜、胸膜、心脏、肝脏、肾上腺、腹膜后、肠系膜和淋巴结,也有罕见的生殖器外腺瘤样肿瘤的报道5,6,7,8。最初,它起源于1942年,但“腺瘤样肿瘤”一词是由Golden和Ash在1959年创造的。今天,从腺瘤样肿瘤的组织学、免疫表型和超微结构来看,腺瘤样肿瘤的间皮分化得到了很好的认识1,2,10。在本报告中,我们描述了腺瘤样肿瘤的另一个不寻常的位置。病例报告我们报告一名32岁的女性,她以4天的发烧和右髂窝疼痛病史来到我们医院。无恶性肿瘤家族史。实验室检查包括全血计数、生化检查和肿瘤标志物(CEA、Ca19-9、Ca125)均正常。超声及腹部及盆腔计算机断层扫描示右侧卵巢囊肿,直径2.5 cm,腹腔积液。行右侧部分卵巢切除术,术中发现大网膜内有2厘米围合良好的肿块。该囊肿的组织学检查显示为裂孔性黄体囊肿。在显微镜下,肿块具有可变的结构模式,包括囊肿、管状通道和由扁平或立方细胞排列的腺样空间。许多细胞具有空泡质和印戒状或成脂细胞样细胞形态。基质由疏松或致密的胶原组织组成,呈透明化。未见明显的细胞学异型性、肿瘤细胞坏死或有丝分裂象(图1[A]和1[B])。在免疫组化研究中,病变细胞calretinin、D240、CK5/6、HMBE1、CKAE1、CKAE3和calponin呈阳性(图2)。肿瘤的组织化学分析显示缺乏粘蛋白,这一特征有助于与转移性腺癌区分。基于以上特征性形态学及免疫组化表现,诊断为腺瘤样肿瘤。患者术后三年无复发。腺瘤样肿瘤的间皮起源被广泛接受,并得到电子显微镜和免疫组织化学研究的支持。然而,不同的作者提出了这些肿瘤的多种组织发生起源,包括间皮细胞、中肾细胞、勒勒细胞和内皮细胞的起源1,2,10。这些肿瘤在生殖器中明显占优势的原因*通讯作者Email: evelinaskafida@yahoo.gr 1希腊比雷埃夫斯“Tzaneion”综合医院病理学部2希腊雅典大学“kapodistriako”化学系3希腊雅典“Elena Venizelou”综合妇产医院妇产科第三科
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引用次数: 1
Autoimmune oophoritis: Clinical presentation of an unusual clinical entity 自身免疫性卵巢炎:一种不寻常临床实体的临床表现
Pub Date : 2013-01-01 DOI: 10.13172/2052-0077-2-1-369
M. Varras, A. Anastasiadis, J. Panelos, E. Balassi, A. Demou, C. Akrivis
Introduction Autoimmune oophoritis is a rare condition , which provokes ovarian failure with either primary amenorrhea or secondary amenorrhea and a subsequent loss of fertility and ovarian hormonal function. The purpose of this report is to document the clinical findings from two patients with aut-oimmune oophoritis. Cases report Two cases of autoimmune oophorit-is are presented whose histopathol-ogical findings were consistent with international literature. Both cases were histopathologically characteri-sed by lymphocytic and plasmacytic inflammatory infiltrations around the cystic follicles. The inflammation was located both in the theca and gr-anular layers. Conclusion Patients with autoimmune oophorit-is should be recognised by the histo-pathology of the ovarian biopsies as they are at an increased risk of developing other autoimmune disorders.
自身免疫性卵巢炎是一种罕见的疾病,它引起卵巢功能衰竭,伴有原发性闭经或继发性闭经,随后丧失生育能力和卵巢激素功能。本报告的目的是记录两例自身免疫性卵巢炎的临床表现。报告两例自身免疫性卵巢囊肿,其组织病理学结果与国际文献一致。两例患者的组织病理学特征均为囊泡周围淋巴细胞和浆细胞性炎症浸润。炎症位于鞘膜层和环膜层。结论自身免疫性卵巢囊肿患者发生其他自身免疫性疾病的风险增加,应通过卵巢活检的组织病理学来识别。
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引用次数: 1
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OA Case Reports
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