R. Miao, Xue-tao Zhang, P. Guo, En-Qi He, Fangmei Zhou, D. Zhao, Ying-yi Zhang
[Objective]To investigate the change of indicators of oxidative stress in serum of patients with silicosis,and explore the mechanism of the development of silicosis.[Methods]Indicators of oxidative stress in serum including superoxide dismutase(SOD),nitric oxide(NO),serum glutathione peroxidase(GSH-Px),total antioxidant capacity(T-AOC),nitric oxide synthase(NOS),and lipid malondialdehyde(MDA) were determined in 100 cases of control group,200 cases of dust-exposed group,32 cases of observed group(the original diagnosed 0 + patients) and 130 cases of silicosis group.[Results] Compared with the control group,NO,GSH-Px were significantly increased,and SOD were decreased significantly in dust-exposed group and silicosis group(P0.05,P0.01).Compared with the control group and dust-exposed group,T-AOC,NOS,MDA levels in silicosis group were significantly increased.(P0.05,P0.01).GSH-Px in the silicosis group was increased significantly(P0.01) than that in dust-exposed group.GSH-Px were increased in phase Ⅲ silicosis group than that in observation group and phaseⅠ silicosis group(P0.05).Pearson correlation analysis showed serum GSH-Px had a significant positive correlation with silicosis staging,grouping,seniority exposed to dust,type of work(P0.01).[Conclusion]The imbalance of oxidative and anti-oxidation system is related with the occurrence and development of silicosis.The monitoring on oxidative stress indicators is benefit for the prediction and prognosis assessment of silicosis.
{"title":"Effect of oxidative stress on development of silicosis","authors":"R. Miao, Xue-tao Zhang, P. Guo, En-Qi He, Fangmei Zhou, D. Zhao, Ying-yi Zhang","doi":"10.5320/WJR.V2.I1.1","DOIUrl":"https://doi.org/10.5320/WJR.V2.I1.1","url":null,"abstract":"[Objective]To investigate the change of indicators of oxidative stress in serum of patients with silicosis,and explore the mechanism of the development of silicosis.[Methods]Indicators of oxidative stress in serum including superoxide dismutase(SOD),nitric oxide(NO),serum glutathione peroxidase(GSH-Px),total antioxidant capacity(T-AOC),nitric oxide synthase(NOS),and lipid malondialdehyde(MDA) were determined in 100 cases of control group,200 cases of dust-exposed group,32 cases of observed group(the original diagnosed 0 + patients) and 130 cases of silicosis group.[Results] Compared with the control group,NO,GSH-Px were significantly increased,and SOD were decreased significantly in dust-exposed group and silicosis group(P0.05,P0.01).Compared with the control group and dust-exposed group,T-AOC,NOS,MDA levels in silicosis group were significantly increased.(P0.05,P0.01).GSH-Px in the silicosis group was increased significantly(P0.01) than that in dust-exposed group.GSH-Px were increased in phase Ⅲ silicosis group than that in observation group and phaseⅠ silicosis group(P0.05).Pearson correlation analysis showed serum GSH-Px had a significant positive correlation with silicosis staging,grouping,seniority exposed to dust,type of work(P0.01).[Conclusion]The imbalance of oxidative and anti-oxidation system is related with the occurrence and development of silicosis.The monitoring on oxidative stress indicators is benefit for the prediction and prognosis assessment of silicosis.","PeriodicalId":19398,"journal":{"name":"职业与健康","volume":"2 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2012-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70776745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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