Obesity research & clinical practice最新文献

Are new obesity medications fueling eating and body image disorders? 新的减肥药物会加剧饮食和身体形象失调吗？

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice

Pub Date : 2026-01-29 DOI: 10.1016/j.orcp.2026.01.004

Jônatas Oliveira

引用次数: 0

Vitamin D, adiposity, and cardiometabolic risk: Insights from a multivariable cross-sectional study 维生素D、肥胖和心脏代谢风险：来自多变量横断面研究的见解。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice

Pub Date : 2026-01-01 DOI: 10.1016/j.orcp.2025.12.005

Carla Colombo , Valentina Fabiano , Lucia Labati , Martina Loiodice , Daniele Ceruti , Irene Campi , Valentina Cuneo , Gianvincenzo Zuccotti , Valeria Calcaterra

Introduction

Vitamin D deficiency has been implicated in various metabolic disorders, but its relationship with adiposity and atherogenic risk remains not fully elucidated. We assessed associations between serum vitamin D levels and a wide range of metabolic, atherogenic, and adiposity-related markers in adults stratified by weight status.

Methods

A cross-sectional analysis was conducted on 130 adults categorized according to their body weight status into: normal weight, overweight, and obesity. Additionally, participants were grouped based on serum vitamin D levels (threshold 20 ng/mL) Clinical, metabolic, and anthropometric variables were compared across groups. A principal component analysis (PCA) was applied to explore underlying patterns of association.

Results

As expected, significant differences in cardiometabolic parameters emerged across weight categories (p < 0.05). However, vitamin D levels showed no significant correlation with most metabolic variables in either univariate or multivariate analysis. PCA revealed that vitamin D and body mass index (BMI) were consistently represented as opposing vectors, suggesting distinct but potentially interacting influences on metabolic risk. While BMI was associated with indices such as TG/HDL, atherogenic index of plasma, and cardiometabolic risk index, vitamin D correlated more closely with HDL, total cholesterol, and Triglyceride-Cholesterol Body Index.

Conclusions

Findings indicate that vitamin D may influence cardiometabolic profiles through mechanisms that are at least partially independent of adiposity. Despite the lack of direct correlations, the divergent associations observed in PCA suggest possible interaction effects between BMI and vitamin D. Further longitudinal studies are needed to evaluate vitamin D’s role as a context-dependent modulator of metabolic risk.

维生素D缺乏与多种代谢紊乱有关，但其与肥胖和动脉粥样硬化风险的关系仍未完全阐明。我们评估了血清维生素D水平与成人按体重分层的代谢、动脉粥样硬化和肥胖相关标志物之间的关系。方法：对130名成人进行横断面分析，按体重状况分为正常体重、超重和肥胖。此外，根据血清维生素D水平（阈值20 ng/mL）对参与者进行分组，比较各组的临床、代谢和人体测量变量。应用主成分分析（PCA）来探索关联的潜在模式。结果：正如预期的那样，不同体重类别的心脏代谢参数出现了显著差异（p ）。结论：研究结果表明，维生素D可能通过至少部分独立于肥胖的机制影响心脏代谢谱。尽管缺乏直接相关性，但PCA中观察到的不同关联表明BMI和维生素D之间可能存在相互作用。需要进一步的纵向研究来评估维生素D作为代谢风险的上下文依赖调节剂的作用。

{"title":"Vitamin D, adiposity, and cardiometabolic risk: Insights from a multivariable cross-sectional study","authors":"Carla Colombo , Valentina Fabiano , Lucia Labati , Martina Loiodice , Daniele Ceruti , Irene Campi , Valentina Cuneo , Gianvincenzo Zuccotti , Valeria Calcaterra","doi":"10.1016/j.orcp.2025.12.005","DOIUrl":"10.1016/j.orcp.2025.12.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Vitamin D deficiency has been implicated in various metabolic disorders, but its relationship with adiposity and atherogenic risk remains not fully elucidated. We assessed associations between serum vitamin D levels and a wide range of metabolic, atherogenic, and adiposity-related markers in adults stratified by weight status.</div></div><div><h3>Methods</h3><div>A cross-sectional analysis was conducted on 130 adults categorized according to their body weight status into: normal weight, overweight, and obesity. Additionally, participants were grouped based on serum vitamin D levels (threshold 20 ng/mL) Clinical, metabolic, and anthropometric variables were compared across groups. A principal component analysis (PCA) was applied to explore underlying patterns of association.</div></div><div><h3>Results</h3><div>As expected, significant differences in cardiometabolic parameters emerged across weight categories (p < 0.05). However, vitamin D levels showed no significant correlation with most metabolic variables in either univariate or multivariate analysis. PCA revealed that vitamin D and body mass index (BMI) were consistently represented as opposing vectors, suggesting distinct but potentially interacting influences on metabolic risk. While BMI was associated with indices such as TG/HDL, atherogenic index of plasma, and cardiometabolic risk index, vitamin D correlated more closely with HDL, total cholesterol, and Triglyceride-Cholesterol Body Index.</div></div><div><h3>Conclusions</h3><div>Findings indicate that vitamin D may influence cardiometabolic profiles through mechanisms that are at least partially independent of adiposity. Despite the lack of direct correlations, the divergent associations observed in PCA suggest possible interaction effects between BMI and vitamin D. Further longitudinal studies are needed to evaluate vitamin D’s role as a context-dependent modulator of metabolic risk.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 43-51"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Children’s experience of screening and evaluation for MASLD in overweight and obesity 超重和肥胖儿童MASLD筛查和评估的经验。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice

Pub Date : 2026-01-01 DOI: 10.1016/j.orcp.2025.12.010

Anne-Sophie R. Stroes, Laura Draijer, Hedy A. van Oers, Malika Chegary, Felix Kreier, Erim van Os, Joery Goede, Venje Boonstra, Ilse Westerbeek, Saskia Bouma, D. Meeike Kusters, Roosje Roelants, Ulrich Beuers, Adriaan G. Holleboom, Marc A. Benninga, Bart G.P. Koot

Objective

This study evaluates self-reported discomfort in children undergoing screening and evaluation for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) that includes blood sampling and vibration-controlled transient elastography (VCTE) or shear-wave elastography (SWE).

Methods

In this cross-sectional multicenter cohort study, children with overweight or obesity, referred for MASLD evaluation after elevated ALT, were included. Children subsequently underwent anthropometric measurements, blood sampling, VCTE, and SWE during an outpatient visit. Discomfort was assessed using the validated “Discomfort in Research with Children” (DISCO-RC) questionnaire on a 5-point Likert scale.

Results

118 children (mean age 13 years) were included. Discomfort related to MASLD screening was low, with median domain scores of 1–2 before the MASLD evaluation visit and 1 after. Prior to the visit, 76–82 % reported “no” to “slight” discomfort (score 1–2) across domains; during the visit, this was 91–95 %. Median procedural discomfort per domain was 1 for both VCTE and SWE, though cumulative discomfort (6 domains) was greater for VCTE than SWE (8 [IQR 6,9] versus 7 [IQR 6,8] p < 0.001).

Conclusions

Screening and subsequent evaluation for MASLD, including VCTE or SWE for liver fibrosis assessment, is associated with minimal discomfort and is highly acceptable to children, supporting this screening strategy in pediatric clinical practice.

目的：本研究评估接受代谢功能障碍相关脂肪变性肝病（MASLD）筛查和评估的儿童自我报告的不适，包括血液采样和振动控制瞬时弹性成像（VCTE）或剪切波弹性成像（SWE）。方法：在这项横断面多中心队列研究中，纳入了ALT升高后进行MASLD评估的超重或肥胖儿童。随后，儿童在门诊期间接受了人体测量、血液采样、VCTE和SWE。不适评估使用有效的“不适的研究与儿童”（DISCO-RC）问卷5分李克特量表。结果：纳入118例儿童，平均年龄13岁。与MASLD筛查相关的不适感较低，MASLD评估访问前和访问后的中位域得分分别为1-2分和1分。在访问之前，76-82 %的人在各个领域报告“没有”到“轻微”不适（得分1-2）；在访问期间，这是91-95 %。VCTE和SWE的每个域的程序性不适中位数均为1，尽管VCTE的累积不适（6个域）大于SWE (8 [IQR 6,9]对7 [IQR 6,8] p 结论：对MASLD进行筛查和后续评估，包括VCTE或SWE进行肝纤维化评估，与最小的不适相关，并且对儿童来说是高度可接受的，支持儿科临床实践中的这种筛查策略。

{"title":"Children’s experience of screening and evaluation for MASLD in overweight and obesity","authors":"Anne-Sophie R. Stroes, Laura Draijer, Hedy A. van Oers, Malika Chegary, Felix Kreier, Erim van Os, Joery Goede, Venje Boonstra, Ilse Westerbeek, Saskia Bouma, D. Meeike Kusters, Roosje Roelants, Ulrich Beuers, Adriaan G. Holleboom, Marc A. Benninga, Bart G.P. Koot","doi":"10.1016/j.orcp.2025.12.010","DOIUrl":"10.1016/j.orcp.2025.12.010","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluates self-reported discomfort in children undergoing screening and evaluation for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) that includes blood sampling and vibration-controlled transient elastography (VCTE) or shear-wave elastography (SWE).</div></div><div><h3>Methods</h3><div>In this cross-sectional multicenter cohort study, children with overweight or obesity, referred for MASLD evaluation after elevated ALT, were included. Children subsequently underwent anthropometric measurements, blood sampling, VCTE, and SWE during an outpatient visit. Discomfort was assessed using the validated “Discomfort in Research with Children” (DISCO-RC) questionnaire on a 5-point Likert scale.</div></div><div><h3>Results</h3><div>118 children (mean age 13 years) were included. Discomfort related to MASLD screening was low, with median domain scores of 1–2 before the MASLD evaluation visit and 1 after. Prior to the visit, 76–82 % reported “no” to “slight” discomfort (score 1–2) across domains; during the visit, this was 91–95 %. Median procedural discomfort per domain was 1 for both VCTE and SWE, though cumulative discomfort (6 domains) was greater for VCTE than SWE (8 [IQR 6,9] versus 7 [IQR 6,8] <em>p</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>Screening and subsequent evaluation for MASLD, including VCTE or SWE for liver fibrosis assessment, is associated with minimal discomfort and is highly acceptable to children, supporting this screening strategy in pediatric clinical practice.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 76-79"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Class 3 obesity in a multidisciplinary weight management program: the effect of psychological trauma on 12-month outcomes 多学科体重管理项目中的3级肥胖：心理创伤对12个月预后的影响。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice

Pub Date : 2026-01-01 DOI: 10.1016/j.orcp.2025.12.009

Ritesh Chimoriya , Colin Wu , Kate McBride , Kathy Grudzinskas , Nic Kormas , Phillipa Hay , Milan K. Piya

Objective

To examine the prevalence of psychological trauma and its effect on 12-month weight change, eating disorder risk, and health-related quality of life (HRQOL), among individuals with class 3 obesity (BMI ≥40 kg/m²) attending an intensive multidisciplinary weight management program (WMP).

Methods

This retrospective cohort study included patients in a Sydney hospital-based WMP (2018–2021) who consulted a clinical psychologist. The Eating Disorder Examination Questionnaire-Short (EDE-QS), Kessler Psychological Distress Scale (K10), and 36-Item Short Form Survey (SF-36) were completed at baseline and 12 months. Mental and physical component summary (MCS and PCS) scores were derived from SF-36. History of trauma was extracted from clinical notes in electronic medical records.

Results

Of 269 participants, 46.1 % (n = 124) reported previous psychological trauma. At baseline, participants with trauma had higher K10 and lower MCS scores than individuals without trauma. After 12 months, there were similar improvements in weight change, EDE-QS, K10, PCS and MCS scores, with no significant differences between participants with or without trauma. Presence of trauma was associated with baseline EDE-QS, K10 and MCS scores, but not with changes over 12 months.

Conclusions

There is a high prevalence of psychological trauma among individuals with class 3 obesity presenting to a multidisciplinary WMP. Similar 12-month weight loss and HRQOL improvements were observed among those with or without trauma when access to a mental healthcare professional was embedded within the team.

目的：探讨参加多学科体重管理计划（WMP）的3级肥胖（BMI≥40 kg/m2）患者的心理创伤患病率及其对12个月体重变化、饮食失调风险和健康相关生活质量（HRQOL）的影响。方法：本回顾性队列研究纳入了悉尼医院WMP（2018-2021）中咨询临床心理学家的患者。在基线和12个月完成进食障碍检查问卷（ed - qs）、凯斯勒心理困扰量表（K10）和36项简短问卷调查（SF-36）。心理和身体成分总结（MCS和PCS）得分来源于SF-36。从电子病历的临床记录中提取创伤史。结果：269名参与者中，46.1% % （n = 124）报告了先前的心理创伤。在基线时，有创伤的参与者比没有创伤的人有更高的K10和更低的MCS得分。12个月后，在体重变化、ed - qs、K10、PCS和MCS评分方面也有类似的改善，在有或没有创伤的参与者之间没有显著差异。创伤的存在与基线ed - qs、K10和MCS评分相关，但与12个月的变化无关。结论：在出现多学科WMP的3级肥胖患者中，心理创伤的患病率很高。当在团队中嵌入精神保健专业人员时，在有或没有创伤的人中观察到类似的12个月体重减轻和HRQOL改善。

{"title":"Class 3 obesity in a multidisciplinary weight management program: the effect of psychological trauma on 12-month outcomes","authors":"Ritesh Chimoriya , Colin Wu , Kate McBride , Kathy Grudzinskas , Nic Kormas , Phillipa Hay , Milan K. Piya","doi":"10.1016/j.orcp.2025.12.009","DOIUrl":"10.1016/j.orcp.2025.12.009","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the prevalence of psychological trauma and its effect on 12-month weight change, eating disorder risk, and health-related quality of life (HRQOL), among individuals with class 3 obesity (BMI ≥40 kg/m<sup>2</sup>) attending an intensive multidisciplinary weight management program (WMP).</div></div><div><h3>Methods</h3><div>This retrospective cohort study included patients in a Sydney hospital-based WMP (2018–2021) who consulted a clinical psychologist. The Eating Disorder Examination Questionnaire-Short (EDE-QS), Kessler Psychological Distress Scale (K10), and 36-Item Short Form Survey (SF-36) were completed at baseline and 12 months. Mental and physical component summary (MCS and PCS) scores were derived from SF-36. History of trauma was extracted from clinical notes in electronic medical records.</div></div><div><h3>Results</h3><div>Of 269 participants, 46.1 % (n = 124) reported previous psychological trauma. At baseline, participants with trauma had higher K10 and lower MCS scores than individuals without trauma. After 12 months, there were similar improvements in weight change, EDE-QS, K10, PCS and MCS scores, with no significant differences between participants with or without trauma. Presence of trauma was associated with baseline EDE-QS, K10 and MCS scores, but not with changes over 12 months.</div></div><div><h3>Conclusions</h3><div>There is a high prevalence of psychological trauma among individuals with class 3 obesity presenting to a multidisciplinary WMP. Similar 12-month weight loss and HRQOL improvements were observed among those with or without trauma when access to a mental healthcare professional was embedded within the team.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 68-75"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of a kindergarten-based obesity prevention intervention to reduce risk of overweight at school entry 以幼儿园为基础的肥胖预防干预对降低入学时超重风险的有效性。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice

Pub Date : 2026-01-01 DOI: 10.1016/j.orcp.2025.12.011

Mette Fogh , Rasmus Møller Jørgensen , Henrik Støvring , Gunnar Toft , Helle Terkildsen Maindal , Jens Meldgaard Bruun , Jane Nautrup Østergaard

Background

Accelerated weight gain from two to six years of age is associated with overweight and obesity in adolescence. Kindergartens may play an important role in shaping early healthy behaviors, making this setting ideal for interventions aiming at preventing childhood obesity.

Objectives

To examine the effectiveness of a kindergarten-based obesity prevention intervention on Body-Mass-Index (BMI) z-score and risk of overweight at school entry.

Methods

A kindergarten-based obesity prevention intervention group (n = 1755) was compared to a usual care group (n = 750). The intervention consisted of two workshops focusing on developing activities to promote healthy behaviors, delivered to kindergarten staff and parents. The children's weight and height were measured once during mandatory school health examination between ages five to seven years. Socioeconomic data were obtained from national registers. Group differences in BMI z-score and risk of overweight were analyzed, adjusted for socioeconomic data.

Results

No significant differences were found in BMI z-score (mean difference: 0.03, 95 % Confidence Interval (CI): −0.06, 0.12) or risk of overweight (risk ratio: 0.96, 95 % CI: 0.78, 1.19) between the groups. However, children with lower parental education showed a trend toward lower BMI z-score in the intervention group compared to the usual care group (P = 0.09).

Conclusion

While the kindergarten-based obesity prevention intervention showed no overall effect on BMI z-score or overweight risk at the population level, children from families with lower parental education levels may have more benefit of the intervention.

背景：2 - 6岁体重加速增加与青春期超重和肥胖有关。幼儿园可能在塑造早期健康行为方面发挥重要作用，使其成为预防儿童肥胖干预的理想场所。目的：探讨以幼儿园为基础的肥胖预防干预对入学时体重指数（BMI） z-score和超重风险的影响。方法：以幼儿园为基础的肥胖预防干预组（n = 1755）与常规护理组（n = 750）进行比较。干预措施包括两个讲习班，重点是发展促进健康行为的活动，向幼儿园工作人员和家长提供。儿童的体重和身高在5至7岁的强制性学校健康检查期间测量一次。社会经济数据来自国家登记册。分析BMI z-score和超重风险的组间差异，并根据社会经济数据进行调整。结果：两组间BMI z-score（平均差值：0.03,95 %置信区间（CI）： -0.06, 0.12）或超重风险（风险比：0.96,95 % CI: 0.78, 1.19）无显著差异。而父母受教育程度较低的儿童，干预组BMI z-score较常规护理组低（P = 0.09）。结论：以幼儿园为基础的预防肥胖干预在人群水平上对BMI z-score和超重风险没有整体影响，但来自父母教育水平较低家庭的儿童可能从干预中获益更多。

{"title":"Effectiveness of a kindergarten-based obesity prevention intervention to reduce risk of overweight at school entry","authors":"Mette Fogh , Rasmus Møller Jørgensen , Henrik Støvring , Gunnar Toft , Helle Terkildsen Maindal , Jens Meldgaard Bruun , Jane Nautrup Østergaard","doi":"10.1016/j.orcp.2025.12.011","DOIUrl":"10.1016/j.orcp.2025.12.011","url":null,"abstract":"<div><h3>Background</h3><div>Accelerated weight gain from two to six years of age is associated with overweight and obesity in adolescence. Kindergartens may play an important role in shaping early healthy behaviors, making this setting ideal for interventions aiming at preventing childhood obesity.</div></div><div><h3>Objectives</h3><div>To examine the effectiveness of a kindergarten-based obesity prevention intervention on Body-Mass-Index (BMI) z-score and risk of overweight at school entry.</div></div><div><h3>Methods</h3><div>A kindergarten-based obesity prevention intervention group (n = 1755) was compared to a usual care group (n = 750). The intervention consisted of two workshops focusing on developing activities to promote healthy behaviors, delivered to kindergarten staff and parents. The children's weight and height were measured once during mandatory school health examination between ages five to seven years. Socioeconomic data were obtained from national registers. Group differences in BMI z-score and risk of overweight were analyzed, adjusted for socioeconomic data.</div></div><div><h3>Results</h3><div>No significant differences were found in BMI z-score (mean difference: 0.03, 95 % Confidence Interval (CI): −0.06, 0.12) or risk of overweight (risk ratio: 0.96, 95 % CI: 0.78, 1.19) between the groups. However, children with lower parental education showed a trend toward lower BMI z-score in the intervention group compared to the usual care group (P = 0.09).</div></div><div><h3>Conclusion</h3><div>While the kindergarten-based obesity prevention intervention showed no overall effect on BMI z-score or overweight risk at the population level, children from families with lower parental education levels may have more benefit of the intervention.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 52-58"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Development and early evaluation of OPTIMAP: A digitally enabled nurse-led multidisciplinary pathway for care of people with severe obesity in a Public Australian Health Network” [Obesity Research & Clinical Practice, 19(6), 2025, 544–548] “OPTIMAP的开发和早期评估：在澳大利亚公共健康网络中护理严重肥胖患者的数字化护士主导的多学科途径”的更正[肥胖研究与临床实践，19(6),2025,544-548]。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice

Pub Date : 2026-01-01 DOI: 10.1016/j.orcp.2025.12.007

Matthew Y. Lim , Katie Belobrajdic , Melani Mallee , Marni A. Nenke , Melissa Carapetis , David Jesudason , Shalvin Prasad , Adam J. Nelson , Leonie Heilbronn , Elena Dicus , Gary Wittert , Emily J. Meyer

引用次数: 0

The impact of internalised weight stigma and engagement with weight-inclusive approaches to health on experienced weight stigma and psychosocial health: A cross-sectional analysis of Australian community adults 内化体重耻辱感和参与体重包容性健康方法对体重耻辱感和心理社会健康的影响：对澳大利亚社区成年人的横断面分析。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice

Pub Date : 2026-01-01 DOI: 10.1016/j.orcp.2025.12.006

Hugh Bidstrup , Leah Brennan , Leah Kaufmann , Alexandra Phillips , Xochitl de la Piedad Garcia

Objective

To explore the relationship between weight stigma and psychosocial health, and to characterise the extent to which individuals are engaged with weight inclusive (i.e., weight neutral, “non-diet”) approaches to health. First, we aimed to (1) estimate whether internalised weight stigma mediated the relationship between experienced weight stigma and psychosocial health and (2) understand the role that awareness, engagement, and endorsement (AEE) of non-diet approaches to health might have in affecting this mediation. All methods were pre-registered (see osf.io/uwf7n).

Methods

Participants (n = 418; M_Age = 36.8, SD = 12.5; M_BMI = 29.5, SD = 6.8) completed an online survey on measures including non-diet AEE, weight stigma, and psychosocial health.

Results

Consistent with hypotheses, weight stigma was positively correlated with adverse psychosocial health. Internalised weight stigma mediated the relationship between experienced weight stigma and all 16 psychosocial health correlates measured, including psychological distress, disordered eating, and intuitive eating (controlling for BMI). AEE of non-diet approaches was associated with external forms of weight stigma, but not internal, self-directed weight stigma (partially supporting hypothesis). Contrary to hypotheses, there were few consistent relationships between non-diet AEE and psychosocial health correlates, and AEE of non-diet approaches to health did not moderate the hypothesised mediation effect.

Conclusion

We found that internalised weight stigma mediated experienced weight stigmas’ effects, and that weight stigma was consistently related to adverse psychosocial health. However, the results were mixed for non-diet AEE. At the bivariate level, there was some indication of non-diet AEE’s importance, but not at the level of our hypothesised moderating effect.

目的：探讨体重耻辱感与心理社会健康之间的关系，并描述个体采用体重包容性（即体重中性，“非饮食”）健康方法的程度。首先，我们的目的是(1)估计内在化的体重耻辱感是否介导了体重耻辱感与心理社会健康之间的关系；(2)了解非饮食健康途径的意识、参与和认可（AEE）在影响这种中介中的作用。所有方法都进行了预注册（见osf.io/uwf7n）。方法：参与者（n = 418;MAge = 36.8, SD = 12.5; MBMI = 29.5, SD = 6.8）完成了一项包括非饮食性AEE、体重耻辱感和心理健康在内的在线调查。结果：与假设一致，体重耻辱感与不良心理健康呈正相关。内化的体重耻辱感介导了体重耻辱感与所有16种心理健康相关指标之间的关系，包括心理困扰、饮食失调和直觉性饮食（控制BMI）。非饮食方法的AEE与外部形式的体重耻辱感有关，但与内部的、自我导向的体重耻辱感无关（部分支持假设）。与假设相反，非饮食性心理表达与心理健康相关因素之间几乎没有一致的关系，非饮食性心理表达对健康的影响并没有调节假设的中介效应。结论：我们发现内在化的体重耻辱感介导了经验体重耻辱感的影响，并且体重耻辱感始终与不良的心理社会健康相关。然而，非饮食AEE的结果则喜忧参半。在双变量水平上，有一些迹象表明非饮食的AEE的重要性，但不是在我们假设的调节效应的水平上。

{"title":"The impact of internalised weight stigma and engagement with weight-inclusive approaches to health on experienced weight stigma and psychosocial health: A cross-sectional analysis of Australian community adults","authors":"Hugh Bidstrup , Leah Brennan , Leah Kaufmann , Alexandra Phillips , Xochitl de la Piedad Garcia","doi":"10.1016/j.orcp.2025.12.006","DOIUrl":"10.1016/j.orcp.2025.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the relationship between weight stigma and psychosocial health, and to characterise the extent to which individuals are engaged with weight inclusive (i.e., weight neutral, “non-diet”) approaches to health. First, we aimed to (1) estimate whether internalised weight stigma mediated the relationship between experienced weight stigma and psychosocial health and (2) understand the role that awareness, engagement, and endorsement (AEE) of non-diet approaches to health might have in affecting this mediation. All methods were pre-registered (see osf.io/uwf7n).</div></div><div><h3>Methods</h3><div>Participants (<em>n</em> = 418; <em>M</em><sub>Age</sub> = 36.8, <em>SD</em> = 12.5; <em>M</em><sub>BMI</sub> = 29.5, <em>SD</em> = 6.8) completed an online survey on measures including non-diet AEE, weight stigma, and psychosocial health.</div></div><div><h3>Results</h3><div>Consistent with hypotheses, weight stigma was positively correlated with adverse psychosocial health. Internalised weight stigma mediated the relationship between experienced weight stigma and all 16 psychosocial health correlates measured, including psychological distress, disordered eating, and intuitive eating (controlling for BMI). AEE of non-diet approaches was associated with external forms of weight stigma, but not internal, self-directed weight stigma (partially supporting hypothesis). Contrary to hypotheses, there were few consistent relationships between non-diet AEE and psychosocial health correlates, and AEE of non-diet approaches to health did not moderate the hypothesised mediation effect.</div></div><div><h3>Conclusion</h3><div>We found that internalised weight stigma mediated experienced weight stigmas’ effects, and that weight stigma was consistently related to adverse psychosocial health. However, the results were mixed for non-diet AEE. At the bivariate level, there was some indication of non-diet AEE’s importance, but not at the level of our hypothesised moderating effect.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 59-67"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between small vessel disease and persons with overweight and obesity: A study using peak width of skeletonized mean diffusivity 小血管疾病与超重和肥胖人群之间的关系：一项使用骨化平均扩散系数峰宽的研究

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice

Pub Date : 2026-01-01 DOI: 10.1016/j.orcp.2026.01.001

Kang Min Park , Jin-Hong Wi , Bong Soo Park , Jinseung Kim

Background

Obesity and overweight are established contributors to cerebrovascular disease, including small vessel disease (SVD). Peak width of skeletonized mean diffusivity (PSMD), a diffusion tensor imaging-based marker, sensitively detects white matter microstructural changes linked to SVD. However, the relationship between body mass index (BMI) and PSMD remains unclear.

Methods

We analyzed data from 62 neurologically and medically healthy adults who underwent brain magnetic resonance imaging with diffusion tensor imaging. Participants were recruited as normal controls and categorized by World Health Organization Asia-Pacific BMI criteria. PSMD values were compared across BMI groups. Spearman correlation and age-adjusted residual analyses assessed associations between BMI and PSMD.

Results

PSMD showed a significant positive correlation with BMI (ρ = 0.42, p = 0.0007), which remained after adjusting for age (ρ = 0.38, p = 0.0021). Overweight individuals (BMI 23.0–24.9 kg/m²) exhibited significantly higher PSMD values than normal-weight participants (BMI 18.5–22.9 kg/m²), both before and after adjustment. When overweight and obese participants (BMI ≥ 23.0 kg/m²) were combined, this group also demonstrated elevated PSMD. The association with obesity (BMI ≥ 25.0 kg/m²) was present but attenuated after age adjustment.

Conclusions

This study is the first to demonstrate a significant association between higher BMI and PSMD, even at overweight levels in Asian populations. These findings suggest that excess body weight is linked to early microstructural white matter changes consistent with SVD, and PSMD may serve as a useful imaging biomarker for obesity-related cerebral microvascular damage.

背景：肥胖和超重是脑血管疾病，包括小血管疾病（SVD）的确定因素。骨架化平均扩散率（PSMD）的峰宽是一种基于扩散张量成像的标记，可灵敏地检测与SVD相关的白质微结构变化。然而，身体质量指数（BMI）与PSMD之间的关系尚不清楚。方法：我们分析了62例神经系统和医学上健康的成年人的数据，他们接受了脑磁共振弥散张量成像。参与者被招募为正常对照，并按照世界卫生组织亚太BMI标准进行分类。比较BMI组间的PSMD值。Spearman相关和年龄校正残差分析评估了BMI和PSMD之间的关系。结果：PSMD与BMI呈正相关（ρ = 0.42, p = 0.0007），调整年龄后仍呈正相关（ρ = 0.38, p = 0.0021）。调整前后，超重个体（BMI为23.0-24.9 kg/m²）的PSMD值均显著高于正常体重参与者（BMI为18.5-22.9 kg/m²）。当超重和肥胖参与者（BMI≥23.0 kg/m²）合并时，该组也表现出PSMD升高。与肥胖（BMI≥25.0 kg/m²）的相关性存在，但在年龄调整后减弱。结论：这项研究首次证明了高BMI和PSMD之间的显著联系，即使在亚洲人群中超重水平也是如此。这些研究结果表明，超重与SVD相关的早期微结构白质变化有关，PSMD可能作为肥胖相关脑微血管损伤的有用成像生物标志物。

{"title":"Association between small vessel disease and persons with overweight and obesity: A study using peak width of skeletonized mean diffusivity","authors":"Kang Min Park , Jin-Hong Wi , Bong Soo Park , Jinseung Kim","doi":"10.1016/j.orcp.2026.01.001","DOIUrl":"10.1016/j.orcp.2026.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Obesity and overweight are established contributors to cerebrovascular disease, including small vessel disease (SVD). Peak width of skeletonized mean diffusivity (PSMD), a diffusion tensor imaging-based marker, sensitively detects white matter microstructural changes linked to SVD. However, the relationship between body mass index (BMI) and PSMD remains unclear.</div></div><div><h3>Methods</h3><div>We analyzed data from 62 neurologically and medically healthy adults who underwent brain magnetic resonance imaging with diffusion tensor imaging. Participants were recruited as normal controls and categorized by World Health Organization Asia-Pacific BMI criteria. PSMD values were compared across BMI groups. Spearman correlation and age-adjusted residual analyses assessed associations between BMI and PSMD.</div></div><div><h3>Results</h3><div>PSMD showed a significant positive correlation with BMI (ρ = 0.42, p = 0.0007), which remained after adjusting for age (ρ = 0.38, p = 0.0021). Overweight individuals (BMI 23.0–24.9 kg/m²) exhibited significantly higher PSMD values than normal-weight participants (BMI 18.5–22.9 kg/m²), both before and after adjustment. When overweight and obese participants (BMI ≥ 23.0 kg/m²) were combined, this group also demonstrated elevated PSMD. The association with obesity (BMI ≥ 25.0 kg/m²) was present but attenuated after age adjustment.</div></div><div><h3>Conclusions</h3><div>This study is the first to demonstrate a significant association between higher BMI and PSMD, even at overweight levels in Asian populations. These findings suggest that excess body weight is linked to early microstructural white matter changes consistent with SVD, and PSMD may serve as a useful imaging biomarker for obesity-related cerebral microvascular damage.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 35-42"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incoming co-editor-in-chief statement 即将上任的联合主编声明

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice

Pub Date : 2026-01-01 DOI: 10.1016/j.orcp.2026.01.006

Leonie Heilbronn

引用次数: 0

Temporal and tissue-specific changes in iron homeostasis and mitochondrial metabolism of leptin-deficient obese mice: an integrated view 瘦素缺乏肥胖小鼠铁稳态和线粒体代谢的时间和组织特异性变化：综合观点。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice

Pub Date : 2026-01-01 DOI: 10.1016/j.orcp.2025.12.012

Ana Paula Oliveira Ferreira , Kaique Alves de Araujo , Jessica Monteiro Volejnik Pino , Tamirez Villas Boas Petrucci , Marcio Henrique Mello da Luz , Gabriel Orefice de Souza , Isaias Glezer , Jose Donato Jr , Kil Sun Lee

Obesity is frequently accompanied by metabolic dysfunction and micronutrient imbalances, including iron. Despite the critical role of iron in metabolic regulation, the tissue-specific effects of iron dysregulation remain unclear. In this study, we used leptin-deficient ob/ob mice to investigate whether iron homeostasis is altered during obesity progression and contributes to organ-specific metabolic adaptations. We measured serum metabolites, tissue iron and relative expression levels of proteins involved in iron homeostasis and key metabolic pathways across multiple organs of ob/ob mice at 3 and 5 months of age (3OB and 5OB), and their respective lean controls (3LC and 5LC). Multivariate analysis revealed that changes in hepatic proteins related to glycemic control and ferritin levels were key factors distinguishing obese mice from lean controls, regardless of age. In contrast, mitochondrial proteins and ferritin in adipose and hippocampal tissues better explained the variance between 3OB and 5OB groups, suggesting that the adipose tissue and hippocampus undergo continuous remodeling during obesity progression. Tissue iron and ferritin levels showed moderate to strong correlations with several key metabolic enzymes, especially with mitochondrial proteins. In linear regressions between tissue ferritin and either cytochrome c oxidase or ATP synthase, these two mitochondrial proteins exhibited opposite angular coefficients across all evaluated tissues. Additionally, 3OB and 5OB mice displayed opposite patterns in adipose tissue and hippocampus, indicating that these proteins play key roles in time- and tissue-specific metabolic adaptation during obesity progression. These findings suggest that local iron dynamics can contribute to metabolic dysfunction in obesity and consequent comorbidities.

肥胖通常伴随着代谢功能障碍和微量营养素失衡，包括铁。尽管铁在代谢调节中起着关键作用，但铁失调的组织特异性影响尚不清楚。在这项研究中，我们使用瘦素缺乏的ob/ob小鼠来研究铁稳态是否在肥胖进展过程中被改变，并有助于器官特异性代谢适应。我们测量了3月龄和5月龄ob/ob小鼠（3OB和5OB）以及它们各自的瘦对照（3LC和5LC）的血清代谢物、组织铁和涉及铁稳态和多器官关键代谢途径的蛋白质的相对表达水平。多变量分析显示，与血糖控制和铁蛋白水平相关的肝脏蛋白的变化是区分肥胖小鼠和瘦小鼠的关键因素，与年龄无关。相比之下，脂肪和海马组织中的线粒体蛋白和铁蛋白更好地解释了3OB组和5OB组之间的差异，表明脂肪组织和海马在肥胖进展过程中经历了持续的重塑。组织铁和铁蛋白水平显示出与几种关键代谢酶，特别是与线粒体蛋白的中度至强相关性。在组织铁蛋白与细胞色素c氧化酶或ATP合酶之间的线性回归中，这两种线粒体蛋白在所有评估组织中表现出相反的角系数。此外，3OB和5OB小鼠在脂肪组织和海马中表现出相反的模式，表明这些蛋白质在肥胖进展过程中在时间和组织特异性代谢适应中发挥关键作用。这些发现表明，局部铁动力学可能导致肥胖的代谢功能障碍和随之而来的合并症。

{"title":"Temporal and tissue-specific changes in iron homeostasis and mitochondrial metabolism of leptin-deficient obese mice: an integrated view","authors":"Ana Paula Oliveira Ferreira , Kaique Alves de Araujo , Jessica Monteiro Volejnik Pino , Tamirez Villas Boas Petrucci , Marcio Henrique Mello da Luz , Gabriel Orefice de Souza , Isaias Glezer , Jose Donato Jr , Kil Sun Lee","doi":"10.1016/j.orcp.2025.12.012","DOIUrl":"10.1016/j.orcp.2025.12.012","url":null,"abstract":"<div><div>Obesity is frequently accompanied by metabolic dysfunction and micronutrient imbalances, including iron. Despite the critical role of iron in metabolic regulation, the tissue-specific effects of iron dysregulation remain unclear. In this study, we used leptin-deficient ob/ob mice to investigate whether iron homeostasis is altered during obesity progression and contributes to organ-specific metabolic adaptations. We measured serum metabolites, tissue iron and relative expression levels of proteins involved in iron homeostasis and key metabolic pathways across multiple organs of ob/ob mice at 3 and 5 months of age (3OB and 5OB), and their respective lean controls (3LC and 5LC). Multivariate analysis revealed that changes in hepatic proteins related to glycemic control and ferritin levels were key factors distinguishing obese mice from lean controls, regardless of age. In contrast, mitochondrial proteins and ferritin in adipose and hippocampal tissues better explained the variance between 3OB and 5OB groups, suggesting that the adipose tissue and hippocampus undergo continuous remodeling during obesity progression. Tissue iron and ferritin levels showed moderate to strong correlations with several key metabolic enzymes, especially with mitochondrial proteins. In linear regressions between tissue ferritin and either cytochrome c oxidase or ATP synthase, these two mitochondrial proteins exhibited opposite angular coefficients across all evaluated tissues. Additionally, 3OB and 5OB mice displayed opposite patterns in adipose tissue and hippocampus, indicating that these proteins play key roles in time- and tissue-specific metabolic adaptation during obesity progression. These findings suggest that local iron dynamics can contribute to metabolic dysfunction in obesity and consequent comorbidities.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 21-28"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0