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Obesity research & clinical practice最新文献

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Obesity phenotyping not BMI associated with the likelihood of cardiac surgery 肥胖表型而非体重指数与心脏手术的可能性有关
IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 DOI: 10.1016/j.orcp.2024.09.101
Efris EK Kartikasari ⁎, , Brian BR Robinson , Sean SG Galvin , Jason JE Elliott , Caz CH Hales
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引用次数: 0
Can adiposity measures enhance the predictive power of the triglyceride-glucose index for metabolic syndrome in adults in the United States? 脂肪测量能否增强甘油三酯-葡萄糖指数对美国成年人代谢综合征的预测能力?
IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 DOI: 10.1016/j.orcp.2024.11.001
Alaina C. Glasgow , Andrew R. Heckel , Wonhee Cho, Joon Young Kim

Background

Insulin resistance is a hallmark feature of metabolic syndrome (MetSyn). The triglyceride-glucose (TyG) index is considered a reliable surrogate measure of insulin resistance. However, the efficacy of the TyG-index combined with adiposity measures for identifying MetSyn in U.S. adults is unknown.

Methods

In the present cross-sectional study, 2746 men and women from the 2017–2020 National Health and Nutrition Examination Survey (NHANES) with physical and laboratory characteristics were included. Predictive powers (estimated by the area under the curve of receiver operating characteristic [ROC-AUC]) of TyG-index combined with adiposity for MetSyn were compared with other traditional surrogate markers of insulin resistance including the TyG index, homeostatic assessment of insulin resistance (HOMA-IR), 1/fasting insulin, and quantitative insulin sensitivity check index (QUICKI).

Results

Predictive power of TyG-WHtR (ROC-AUC: 0.875) for MetSyn was highest, followed by TyG-WC (0.866), TyG-BMI (0.845), TyG index (0.832), HOMA-IR (0.820), QUICKI (0.820) and 1/fasting insulin (0.786). TyG-WHtR and TyG-WC showed significantly higher ROC-AUCs compared with TyG-index, HOMA-IR, 1/fasting insulin, and QUICKI (p ≤ 0.001).

Conclusions

TyG index combined with adiposity metrics is more effective in predicting MetSyn when compared to insulin resistance surrogates (TyG index, HOMA-IR, 1/fasting insulin, and QUICKI) which has been widely used in large cohort observational studies.
背景:胰岛素抵抗是代谢综合征(MetSyn)的标志性特征:胰岛素抵抗是代谢综合征(MetSyn)的标志性特征。甘油三酯-葡萄糖(TyG)指数被认为是胰岛素抵抗的可靠替代指标。然而,TyG 指数与脂肪测量相结合对识别美国成年人 MetSyn 的有效性尚不清楚:在本横断面研究中,纳入了 2017-2020 年美国国家健康与营养调查(NHANES)中具有体格和实验室特征的 2746 名男性和女性。研究人员将TyG指数结合脂肪率对MetSyn的预测能力(通过接收器操作特征曲线下面积[ROC-AUC]估算)与其他传统的胰岛素抵抗替代标记物进行了比较,包括TyG指数、胰岛素抵抗的稳态评估(HOMA-IR)、1/空腹胰岛素和定量胰岛素敏感性检查指数(QUICKI):结果:TyG-WHtR对MetSyn的预测能力最高(ROC-AUC:0.875),其次是TyG-WC(0.866)、TyG-BMI(0.845)、TyG指数(0.832)、HOMA-IR(0.820)、QUICKI(0.820)和1/空腹胰岛素(0.786)。与TyG指数、HOMA-IR、1/空腹胰岛素和QUICKI相比,TyG-WHtR和TyG-WC的ROC-AUCs明显更高(P≤0.001):与胰岛素抵抗代用指标(TyG指数、HOMA-IR、1/空腹胰岛素和QUICKI)相比,TyG指数结合脂肪指标能更有效地预测MetSyn。
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引用次数: 0
The Role of Sphingolipids in NASH Progression Revealed by Lipidomics 脂质组学揭示鞘磷脂在 NASH 进展中的作用
IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 DOI: 10.1016/j.orcp.2024.09.026
Xin Liu ⁎, , Long Chung , Yingxin Jiang , Da Liu , Mark Gorrell , Jacob Qi
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引用次数: 0
Evaluating Education on Overweight and Obesity in Children in Australian Medical Curricula: Advancing Effective Training and Practice 评估澳大利亚医学课程中有关儿童超重和肥胖症的教育:推进有效的培训和实践
IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 DOI: 10.1016/j.orcp.2024.09.012
Emma Schwartzkoff , Linda Ferrington ⁎, , Terri Pikora , Nicola Kerr , Michelle Gooey , Jennifer Lindley , Conor Gilligan , Gordana Popovic , Jessica Macer-Wright , Gina La Hera Fuentes , Helen Skouteris , Gina Arena , Lillian Smythe
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引用次数: 0
Pick me for kids: children's perspectives on healthy food and drink marketing in sport and recreation facilities 为孩子们挑选我:儿童对体育和娱乐设施中健康食品和饮料营销的看法
IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 DOI: 10.1016/j.orcp.2024.09.053
Amy Wakem , Li Kheng Chai ⁎, , Mathew Dick , Aidan Dennis , Clare Murray , Kora Uhlmann , Simone Nalatu
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引用次数: 0
Interrogating the anti-obesogenic effect of a novel ceramide synthase inhibitor in high-fat fed mice 探究新型神经酰胺合成酶抑制剂对高脂喂养小鼠的抗致肥效应
IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 DOI: 10.1016/j.orcp.2024.09.040
Laura L.Y. Choong ⁎, , Sarah E. Hancock , Amy Nguyen , Iliya Dragutinovic , Elysha N. Taylor , Jonathan C. Morris , Nigel Turner
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引用次数: 0
The Effects of High Salt Intake on Antidiabetic Medication 高盐摄入对抗抑郁药物的影响
IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 DOI: 10.1016/j.orcp.2024.09.042
Qi Wu ⁎, , Chenxu Loki Yan , Xin Zhou , Divyesh Naidu , Matthew Wong , Shu Lin , YanChuan Shi
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引用次数: 0
Antecedents of weight stigma in Australian undergraduate students 澳大利亚大学生体重耻辱感的前因
IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 DOI: 10.1016/j.orcp.2024.09.098
Megan Mitchell ⁎, , Aline Kunnel , Andrea R Deussen , Jennie Louise , Jodie M Dodd , Alyson Crozier
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引用次数: 0
Examining the influence of excess dietary salt on the development of obesity 研究食盐过量对肥胖症发病的影响
IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 DOI: 10.1016/j.orcp.2024.09.059
Divyesh Naidu ⁎, , Qi Wu , Chenxu Loki Yan , Yanchuan Shi
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引用次数: 0
Investigation of hepatocyte cell models to recapitulate metabolic associated steatohepatitis 研究肝细胞模型以再现代谢相关性脂肪性肝炎
IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 DOI: 10.1016/j.orcp.2024.09.066
Mitchell T Hallam ⁎, , Aaron W Jurrjens , Calkin C Calkin , Michael K Keating , Brian G Drew
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引用次数: 0
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Obesity research & clinical practice
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