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Combined effect of carrying both CFH (rs1061170) and TGFβ1 (rs1800469) gene variants on the risks of various forms of age-related macular degeneration 携带CFH(rs1061170)和TGFβ1(rs1800469)基因变体对各种形式的年龄相关性黄斑变性风险的联合影响
Q4 Medicine Pub Date : 2023-09-04 DOI: 10.31288/oftalmolzh202342633
Дар'я Перетягіна, Надія Ульянова, Л.Є. Фіщук, З.І. Россоха
Background: Age-related macular degeneration (AMD) is one of the most common disorders that can lead to total central vision loss after choroidal neovascularization or geographic atrophy (GA). Because the genetic component of the disease plays an important role in the pathogenesis, has an impact on the clinical presentation, and determines the response to treatment, studies on the genetic component of AMD are relevant for better understanding the molecular mechanisms underlying the pathogenesis.Purpose: To investigate associations among TGFβ1 C509T (rs1800469) and CFH T1277С (rs1061170) polymorphisms, their gene-to-gene interactions and the risks of various forms of AMD.Material and Methods: This was a case-control study. The case group included 61 patients with AMD. Of these, 31 were diagnosed with late dry AMD (GA), and 30, with wet AMD (neovascular AMD or nAMD). Patients with nAMD were divided into two subgroups of 14 patients with type 1 or occult subretinal neovascular membrane (SNM), the SNM1 subgroup and 16 patients with type 2 or classical SNM, the SNM2 subgroup. The control group was composed of 50 individuals with no eye disease and of an age distribution similar to that of the case group. Polymerase chain reaction (PCR) and restriction analysis of gene amplification products were performed to determine TGFβ1 rs1800469 and CFH rs1061170.Results: We found a significant effect of TGFβ1 C509T (rs1800469) and CFH T1277C (rs1061170) gene variants on the risks of various forms of AMD. CFH 1277TT genotype was associated with decreased AMD risk, whereas 1277CC genotype, with increased AMD risk (first and foremost, increased GA risk) (р less 0.05). TGFβ1 509CC genotype was associated with increased risk, whereas TGFβ1 509TT genotype, with decreased risk of both GA and SNM2.Conclusion: For the first time, a combined effect of gene variants of interest on the susceptibility to the development of AMD has been investigated, and synergism between these variants in increasing the risk of certain forms of the disease (e.g., GA) established. The results obtained create prerequisites for developing individualized prediction of risk and novel treatment strategies for the disease.
背景:年龄相关性黄斑变性(AMD)是最常见的疾病之一,可导致脉络膜新生血管或地理性萎缩(GA)后的中心视力完全丧失。由于AMD的遗传成分在发病机制中起着重要作用,对临床表现有影响,并决定了对治疗的反应,因此对AMD遗传成分的研究有助于更好地了解发病机制的分子机制。目的:研究转化生长因子β1 C509T(rs1800469)和CFH T1277С(rs1061170)多态性、基因间相互作用和各种形式AMD风险之间的关系。材料和方法:这是一项病例对照研究。病例组包括61名AMD患者。其中,31例被诊断为晚期干型AMD(GA),30例诊断为湿型AMD(新生血管性AMD或nAMD)。nAMD患者被分为两个亚组,14名患有1型或隐匿性视网膜下新生血管膜(SNM)的患者,即SNM1亚组和16名患有2型或经典SNM的患者,SNM2亚组。对照组由50名无眼病的患者组成,年龄分布与病例组相似。通过聚合酶链式反应(PCR)和基因扩增产物的限制性分析来测定TGFβ1 rs1800469和CFH rs1061170。CFH 1277TT基因型与AMD风险降低相关,而1277CC基因型则与AMD风险增加相关(首先是GA风险增加)(р小于0.05)。TGFβ1 509CC基因型与风险增加相关,而TGFβ2 509TT基因型则降低GA和SNM2的风险。结论:首次,已经研究了感兴趣的基因变体对AMD发展的易感性的联合作用,并确定了这些变体之间在增加某些形式的疾病(例如GA)的风险方面的协同作用。所获得的结果为开发个性化的风险预测和新的疾病治疗策略创造了先决条件。
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引用次数: 0
Prospects for predicting long-term treatment outcomes in patients with combat ocular trauma 预测战斗性眼外伤患者长期治疗结果的前景
Q4 Medicine Pub Date : 2023-06-30 DOI: 10.31288/oftalmolzh202333437
Б.Б. Жупан, І. А. Лурін, Н.В. Медведовська, І.І. Храмов
Introduction. The analysis of experience in changing approaches to organizing medical care for combat eye injuries, changing treatment tactics for such patients during armed conflicts in the 20th and 21st centuries, domestic experience in providing medical care for eye and its adnexal injuries, highlights the search for informative methods of predicting long-term outcomes of the applied treatment methods.The aim of the study was to determine the informativeness of constructing a forecast of functional changes of the visual analyzer based on the results of treatment of patients with eye injuries during dynamic retrospective observation. Materials and Methods: The primary material for the study was medical documentation of combat eye injury patients (data from medical histories, outpatient cards, and discharge summaries) for the period of 2014-2015, who were treated at the National Military Medical Clinical Center "Main Military Clinical Hospital" (NMMCC "MMCH"). Indicators of the functional state of the visual analyzer were evaluated upon admission to the NMMCC "MMCH" and after 180 days following the injury. The study used the proposed F. Kuhn and colleagues' scale for evaluating long-term treatment outcomes (OTS-Ocular Trauma Score).Results. It was found that overall, the results of treatment for combat eye injuries and their adnexa at the NMMCC "MMCH" during the study period of 2014-2015 showed a high correlation with the calculated values of the probability of preserving visual functions according to the OTS scale. Almost all patients with a case of blindness remained blind in the injured eye six months later. In the group with light projection and movement of the hand near the face, an improvement in visual function in most cases (65%) was noted, while, according to the OTS scale, these patients in most cases remain in this group or move to the group with blindness. Cases with visual acuity of 0.005-0.1 after 6 months improve visual acuity with the transition in most cases to 0.1 and above. The same trend, but, as expected, with a higher probability in groups with visual acuity of 0.1-0.4 and above 0.5. The identified discrepancies justify the need for adaptation of the OTS scale for predicting functional changes in combat eye injuries, as it has been developed for use in eye injuries during peacetime.Conclusion: Considering the large number of wounded soldiers with severe eye injuries during the war with rf, scientific research on the implementation of a system for predicting long-term functional outcomes of the treatment of combat eye trauma based on clinical data at the time of initial examination remains relevant. The results obtained with the OTS (Ocular Trauma Score) assessment scale in most cases correspond to the results of the treatment of injured patients in the ophthalmology clinic of the NMMCC "MMCH" in 2014-2015. Further development of the existing OTS system and its adaptation to domestic conditions and the realities of p
介绍分析了20世纪和21世纪武装冲突期间组织战斗性眼损伤医疗护理方法的变化、此类患者治疗策略的变化、国内提供眼损伤及其附件损伤医疗护理的经验,强调了对预测应用治疗方法长期结果的信息方法的探索。本研究的目的是根据动态回顾性观察中眼损伤患者的治疗结果,确定构建视觉分析仪功能变化预测的信息性。材料和方法:该研究的主要材料是2014-2015年期间在国家军事医学临床中心“主要军事临床医院”(NMMCC“MMCH”)接受治疗的战斗性眼损伤患者的医疗文件(来自病史、门诊卡和出院总结的数据)。视觉分析仪的功能状态指标在进入NMMCC“MMCH”时和受伤后180天后进行评估。本研究采用F.Kuhn及其同事提出的长期治疗效果评估量表(OTS眼部创伤评分),2014-2015年研究期间,NMMCC“MMCH”对战斗眼损伤及其附件的治疗结果显示,与根据OTS量表计算的保留视觉功能的概率值高度相关。几乎所有失明的患者在六个月后受伤的眼睛仍然失明。在面部附近有光投射和手移动的组中,大多数情况下(65%)的视觉功能有所改善,而根据OTS量表,这些患者在大多数情况下仍留在该组或转移到失明组。6个月后视力为0.005-0.1的病例视力改善,大多数病例的视力过渡到0.1及以上。同样的趋势,但正如预期的那样,在视力为0.1-0.4和0.5以上的人群中,概率更高。所发现的差异证明了调整OTS量表以预测作战眼损伤功能变化的必要性,因为它是为和平时期的眼损伤而开发的。结论:考虑到在rf战争中有大量严重眼部损伤的受伤士兵,基于初步检查时的临床数据预测作战眼部创伤治疗的长期功能结果的系统的实施仍然具有相关性。大多数情况下,OTS(眼部创伤评分)评估量表获得的结果与2014-2015年NMMCC“MMCH”眼科诊所对受伤患者的治疗结果一致。进一步发展现有的OTS系统,使其适应国内条件和为战斗性眼外伤提供眼科护理的现实,有望进行进一步研究。
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引用次数: 0
Predicting optic atrophy in patients with anterior uveitis by computed tomography-based assessment of optic nerve diameter 基于计算机断层扫描的视神经直径评估预测前葡萄膜炎患者视神经萎缩
Q4 Medicine Pub Date : 2023-06-30 DOI: 10.31288/oftalmolzh202333841
Л.В. Венгер, Олексій Ковтун, В.В. Савко
Background: An objective assessment of factors for ocular inflammation and its sequelae and diagnostic assessment of possible development of the sequelae in early phases of uveitis are essential for early and effective treatment of endogenous uveitis.Purpose: To determine whether it is possible to predict optic atrophy in patients with anterior uveitis using computed tomography (CT)-based assessment of optic nerve diameter.Material and Methods: Patients with anterior uveitis underwent a routine eye examination (ophthalmoscopy, biomicroscopy, intraocular pressure (IOP) measurement, and Humphrey perimetry). In addition, they underwent CT-based assessment of optic disc diameter at 3-5 mm from the entrance into the orbit in the affected eye and the contralateral healthy eye. Patients received treatment as per the protocol.Results: The percentage difference in optic nerve diameter between patients with uveitis complicated by optic neuritis and those with uveitis only for affected eyes was large (33.1%) and statistically significant. At 3 months and 6 months after initiation of treatment, mean optic disc diameter in patients with optic neuritis decreased by 37.2% and 49.1%, respectively, compared to baseline values. At 6 months, a decrease in optic nerve diameter among optic neuritis patients was observed both in those who received treatment and in those who failed to receive treatment, but was less marked in the former patients. Particularly, from 3 months to 6 months, optic nerve diameter decreased by 17.3% in treated optic neuritis patients versus 23.5% in those who remained untreated.Conclusion: CT-based data on the change in the optic nerve diameter at the entrance into the orbit in patients with optic neuritis is an objective characteristic of the presence and grade of atrophic process. Early identification of the potential for development of optic atrophy in individuals with optic neuritis will make it possible to treat them early and, consequently, to prevent or stabilize the process.
背景:客观评估眼部炎症及其后遗症的影响因素,并对葡萄膜炎早期可能发生的后遗症进行诊断评估,对于内源性葡萄膜炎的早期有效治疗至关重要。目的:探讨利用基于计算机断层扫描(CT)的视神经直径评估来预测前葡萄膜炎患者视神经萎缩的可能性。材料和方法:对前葡萄膜炎患者进行常规眼科检查(检眼镜、生物显微镜、眼内压(IOP)测量和汉弗莱视周术)。此外,他们还接受了基于ct的视盘直径评估,从患眼和对侧健康眼的眼眶入口3-5 mm处。患者按照方案接受治疗。结果:葡萄膜炎合并视神经炎与仅患眼的葡萄膜炎患者视神经直径百分比差异较大(33.1%),差异有统计学意义。在开始治疗后3个月和6个月,视神经炎患者的平均视盘直径分别比基线值下降了37.2%和49.1%。在6个月时,视神经炎患者中接受治疗和未接受治疗的患者均观察到视神经直径减少,但前者患者的视神经直径减少较少。特别是,从3个月到6个月,视神经炎治疗组视神经直径下降了17.3%,而未治疗组视神经直径下降了23.5%。结论:视神经炎患者眶入口处视神经直径变化的ct数据是判断萎缩过程存在及程度的客观特征。早期识别视神经炎患者视神经萎缩的发展潜力将使早期治疗成为可能,从而预防或稳定这一过程。
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引用次数: 0
Analysis of subjective signs in patients after secondary glaucoma surgeries 继发性青光眼术后患者主观体征分析
Q4 Medicine Pub Date : 2023-06-30 DOI: 10.31288/oftalmolzh20233914
Juraj Sekáč, Silvia Ferkova, I. Popov, J. Valášková, R. Furda, D. Lysková, P. Plesníková, J. Rybar, Angelika Puzserova, A. Furdová
PurposeImplementation of quality-of-life standards for patients with secondary glaucoma after surgery.Material and methodsData analysis included secondary surgical glaucoma patients with a time interval of 4 years. Patients were followed up to 3 years after surgery to answer questions related to subjective perceptions after the surgical intervention (pain, discomfort, near vision, distance vision, intermediate vision, and normal activity). We were also interested in the overall quality of life and the effect on the patient's psyche when performing certain surgical techniques.ResultsAs part of the questionnaire, patients were asked 36 questions. Responses were received from 98 patients. Thirty-five respondents (97.2%) of patients who underwent cyclocryopexy reported tolerable, minimal, or no pain during and immediately after surgery, with the majority of patients reporting minimal pain. Twenty-one patients (58.3%) did not complain of pain until one year after surgery.According to the survey, 16 respondents (25%) had undergone trabeculectomy. Most respondents reported tolerable pain during surgery, minimal pain for 2 weeks after surgery, and no or minimal pain 2 years after surgery. Eleven respondents (68.8%) answered that their eyesight improved in daily life, but the majority of nine (56.3%) did not notice any change in their vision during short-distance movement, short-distance work, or reading. Most serious problems had patients after cyclocryocoagulation or enucleation of the eye globe.ConclusionSecondary glaucoma surgery for every patient should be personalized and tailored to the patient's every need, taking into account the patient's current health status, knowledge and skills as well as socioeconomic circumstances.
目的探讨继发性青光眼术后患者生活质量标准的实施。资料与方法资料分析纳入时间间隔为4年的继发性手术青光眼患者。患者术后随访3年,回答手术干预后主观感受(疼痛、不适、近视力、远视、中间视力和正常活动)相关问题。我们也对患者的整体生活质量和在实施某些手术技术时对患者心理的影响感兴趣。结果在调查问卷中,共向患者提问36个问题。收到了98名患者的回复。35名接受环冷冻固定术的患者(97.2%)报告手术期间和术后可耐受、轻微或无疼痛,大多数患者报告轻微疼痛。21例患者(58.3%)术后1年才出现疼痛。根据调查,16名受访者(25%)接受了小梁切除术。大多数受访者报告手术时疼痛可忍受,术后2周疼痛最小,术后2年无疼痛或疼痛最小。11名受访者(68.8%)表示在日常生活中视力有所改善,但9名受访者中的大多数(56.3%)表示在短距离运动、短距离工作或阅读时视力没有任何变化。最严重的问题发生在眼球冷冻或眼球摘除术后。结论继发性青光眼手术治疗应考虑患者的健康状况、知识技能和社会经济条件,根据患者的需求进行个性化治疗。
{"title":"Analysis of subjective signs in patients after secondary glaucoma surgeries","authors":"Juraj Sekáč, Silvia Ferkova, I. Popov, J. Valášková, R. Furda, D. Lysková, P. Plesníková, J. Rybar, Angelika Puzserova, A. Furdová","doi":"10.31288/oftalmolzh20233914","DOIUrl":"https://doi.org/10.31288/oftalmolzh20233914","url":null,"abstract":"Purpose\u0000Implementation of quality-of-life standards for patients with secondary glaucoma after surgery.\u0000Material and methods\u0000Data analysis included secondary surgical glaucoma patients with a time interval of 4 years. Patients were followed up to 3 years after surgery to answer questions related to subjective perceptions after the surgical intervention (pain, discomfort, near vision, distance vision, intermediate vision, and normal activity). We were also interested in the overall quality of life and the effect on the patient's psyche when performing certain surgical techniques.\u0000Results\u0000As part of the questionnaire, patients were asked 36 questions. Responses were received from 98 patients. Thirty-five respondents (97.2%) of patients who underwent cyclocryopexy reported tolerable, minimal, or no pain during and immediately after surgery, with the majority of patients reporting minimal pain. Twenty-one patients (58.3%) did not complain of pain until one year after surgery.\u0000According to the survey, 16 respondents (25%) had undergone trabeculectomy. Most respondents reported tolerable pain during surgery, minimal pain for 2 weeks after surgery, and no or minimal pain 2 years after surgery. Eleven respondents (68.8%) answered that their eyesight improved in daily life, but the majority of nine (56.3%) did not notice any change in their vision during short-distance movement, short-distance work, or reading. Most serious problems had patients after cyclocryocoagulation or enucleation of the eye globe.\u0000Conclusion\u0000Secondary glaucoma surgery for every patient should be personalized and tailored to the patient's every need, taking into account the patient's current health status, knowledge and skills as well as socioeconomic circumstances.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47563701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Craniofacial malignant tumors, their extensions, and surgical strategy for their treatment 颅面恶性肿瘤,其扩展,及其治疗的外科策略
Q4 Medicine Pub Date : 2023-06-30 DOI: 10.31288/oftalmolzh202334955
Орест Ігорович Паламар, А. П. Гук, Д. І. Оконський, О. С. Усатов, Б.О. Давиденко
Purpose: To identify extension routes of craniofacial malignancies and formulate a surgical treatment plan based thereupon.Material and Methods: We retrospectively reviewed the medical records of 253 patients with craniofacial malignancies who underwent surgical treatment at the Romodanov Neurosurgery Institute from 2002 through 2022. Of the 253 patients, 112 had a primary tumor, and 141, a secondary tumor. Preoperative Karnofsky performance scores ranged from 50 to 70 points. Patients underwent neurological and ophthalmological status assessment, as per routine protocols.Results: Epithelial malignancies were the most common (53.7%), whereas anaplastic meningioma and embryonal malignancies were rather uncommon (1.2% and 0.4%, respectively) craniofacial malignancies. The presence of certain clinical symptoms was associated primarily with tumor origin and extension. A high rate of general brain and rhinological symptoms in our study sample was caused by a high percentage of intracranial and paranasal sinus tumors. Craniofacial malignancies most commonly originate from the midline (particularly, anterior midline skull base). Ethmoidal labyrinth was the most common site of origin (45.0%), followed by a sphenoid sinus (12.2%), pterygopalatine and infratemporal fossae (9.9%), whereas the cavernous sinus and olfactory fossa were the least common sites of origin (0.4% and 1.2%, respectively). Craniofacial tumors extended most commonly intracranially (transdurally, epidurally, via adhesion to the dura mater, and/or cavernous sinus growth) or intraorbitally. Anterior craniofacial resection (bifrontal craniotomy with combined with either lateral rhinotomy or supraorbital advancement; or a subcranial approach) was the most common surgical treatment. Postoperative cerebrospinal fluid rhinorrhea and infectious complications (meningitis and meningoencephalitis) were the most frequent complications. The overall postoperative mortality rate was 2.0%.Conclusion: First, compared to the transcranial and facial approaches, the craniofacial resection is advantageous in terms of the radicality of tumor excision. Second, the subcranial approach is preferable to the bifrontal approach in the presence of marked extracranial tumor component, whereas the transbasal Derome approach is effective in the presence of marked extracranial and/or intracranial tumor components. Finally, both the orbitozygomatic and infratemporal approaches allow for the radicality of excision of lateral skull base malignancies, but the latter approach is associated with a lower rate of complications.
目的:明确颅面恶性肿瘤的扩散途径,并据此制定外科治疗方案。材料和方法:我们回顾性地回顾了2002年至2022年在Romodanov神经外科研究所接受手术治疗的253例颅面恶性肿瘤患者的医疗记录。在253例患者中,112例为原发肿瘤,141例为继发肿瘤。术前Karnofsky评分为50 - 70分。按照常规方案,对患者进行神经和眼科状态评估。结果:上皮性恶性肿瘤最为常见(53.7%),而间变性脑膜瘤和胚胎性恶性肿瘤较为少见(分别为1.2%和0.4%)。某些临床症状的出现主要与肿瘤的起源和扩展有关。在我们的研究样本中,一般脑和鼻症状的高比例是由颅内和鼻窦肿瘤的高比例引起的。颅面恶性肿瘤最常起源于中线(特别是前中线颅底)。以筛迷路最常见(45.0%),其次为蝶窦(12.2%)、翼腭窝和颞下窝(9.9%),海绵窦和嗅窝最不常见(分别为0.4%和1.2%)。颅面肿瘤最常扩展到颅内(经硬膜、硬膜外、通过硬脑膜粘连和/或海绵窦生长)或眶内。前颅面切除术(双额开颅联合鼻外侧切开术或眶上进路;或颅下入路)是最常见的手术治疗方法。术后脑脊液鼻漏和感染性并发症(脑膜炎和脑膜脑炎)是最常见的并发症。术后总死亡率为2.0%。结论:首先,与经颅入路和面入路相比,颅面切除术在肿瘤切除的根治性方面具有优势。其次,在存在明显的颅外肿瘤成分时,颅下入路优于双额入路,而在存在明显的颅外和/或颅内肿瘤成分时,经基底颅底入路是有效的。最后,眶颧和颞下入路都可以根治性切除外侧颅底恶性肿瘤,但后一种入路并发症发生率较低。
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引用次数: 0
EPIDEMIOLOGICAL AND CLINICAL-FUNCTIONAL ASPECTS OF THE COMBINED COURSE OF AGE-RELATED MACULAR DEGENERATION AND PRIMARY GLAUCOMA 年龄相关性黄斑变性和原发性青光眼合并病程的流行病学和临床功能方面
Q4 Medicine Pub Date : 2023-06-30 DOI: 10.31288/oftalmolzh2023338
D. Tuychibaeva
Relevance. Age-related macular degeneration (AMD) and glaucoma are currently the main causes of irreversible vision loss in developed countries.Purpose. To study the epidemiological and clinical-functional aspects of the combined course of age-related macular degeneration and primary glaucoma and to assess the quality of life of these patients.Material and Methods. The analysis of 5,000 outpatient records of patients over 35 years of age who were observed in the consultative polyclinic of the multidisciplinary clinic of the Tashkent Medical Academy in the period 2011-2022 was carried out. All patients were divided into three groups: group 1 - glaucoma, group 2 - AMD, group 3 - glaucoma + AMD.Results. A retrospective analysis of 5,000 outpatient records of patients older than 35 years revealed the presence of glaucoma in 30.3% of cases, AMD - in 37.94%, their combination - in 20.3%. At the same time, in the structure of AMD, signs of the dry form of the disease were diagnosed in 74% of cases, geographical atrophy - in 12% and wet form - in 14%. However, it requires careful monitoring of the dynamics of visual-functional and structural changes in the retina and optic nerve, as well as timely correction of therapy.Conclusion. The combined course of diseases having a neurodegenerative nature of the lesion leads to a decrease in not only visual, but also cognitive functions, significantly affects the quality of life of patients of the older age group and their adaptation in society.
关联年龄相关性黄斑变性(AMD)和青光眼是目前发达国家不可逆视力丧失的主要原因。意图研究年龄相关性黄斑变性和原发性青光眼合并病程的流行病学和临床功能方面,并评估这些患者的生活质量。材料和方法。分析了2011-2022年期间在塔什干医学院多学科诊所咨询综合诊所观察到的5 000名35岁以上患者的门诊记录。所有患者被分为三组:第1组-青光眼,第2组-AMD,第3组-青光眼+AMD。结果。对5000名35岁以上患者的门诊记录进行回顾性分析,发现30.3%的病例存在青光眼,37.94%的病例存在AMD,20.3%的病例存在合并AMD,74%的病例诊断为干燥型,12%诊断为地域性萎缩,14%诊断为湿润型。然而,它需要仔细监测视网膜和视神经视觉功能和结构变化的动态,并及时纠正治疗。结论病变具有神经退行性的综合病程不仅会导致视觉功能下降,还会导致认知功能下降,严重影响老年患者的生活质量及其社会适应能力。
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引用次数: 0
Особливості зміни фонової енцефалограми у відповідь на функціональні навантаження у хворих на дисбінокулярну амбліопію залежно від фіксації амбліопічного ока
Q4 Medicine Pub Date : 2023-06-30 DOI: 10.31288/oftalmolzh202335660
Ірина Михайлівна Бойчук, Бадрі Ваєл
Background: Analysis of electroencephalogram (EEG) visual-evoked potentials (VEPs) is important for assessing the general integrity of the visual pathway. Pathology in any portion of the visual pathway causes changes in VEP. Percentages of alpha, beta, delta and theta rhythms in the EEG record, frequencies and amplitudes of these waves, and the level of alpha-rhythm suppression are essential for characterizing the state of the visual system. Purpose: To indentify the features of the state of the visual system and changes in the background EEG in response to activation procedures in strabismic amblyopes depending on type of fixation in the amblyopic eye. Material and Methods: Fifty-two strabismic amblyopic patients aged 5-8 years and 15 healthy children of the same age underwent an examination. Of the amblyopic children, 32 had unilateral amblyopia with esotropia (6-15 degrees). Of these 32 children, 20 had eccentric fixation and 12 children, central fixation. The 10–20 system of electrode placement was employed to perform EEG in all children. Rhythms of the background EEG, interhemispheric asymmetry and alpha, theta and delta wave percentages were assessed. Brain potentials were recorded using standard activation procedures to activate deep brain structures. Results: Alpha rhythm was not discernable in the background EEG in the occipital areas in 3.0 ± 2.6 % of cases, and the alpha index was below the normal range in 48.6 ± 8.2 % of patients with a visual acuity worse than 0.3. Delta index was above the normal range (25%-45%) in 48.6 ± 8.2 %, and theta index was above the normal range (with a mean value of 48.4 ± 8.2 %) in 48.6 ± 8.2 % of children. Reduced percentage of alpha activity was found in almost half of strabismic amblyopic children, indicating immaturity of the synchronizing system and impaired oculomotor tuning in the eyes of these children. Abnormal bilateral EEG response to eye-opening stimulation and abnormal bilateral EEG rhythmic driving response (RDR) were seen in most children with eccentric fixation, but not in most children with central fixation. Photic stimulation in strabismic amblyopic children resulted in bilaterally asymmetrical and synchronous theta and delta waves in symmetric frontal (theta and delta percent time of 46.0 ± 8.4%) and occipital (theta and delta percent time of 50.0 ± 8.4%) responses. Conclusion: Increased theta and delta wave percentages in frontal and occipital derivations were found in strabysmic amblyopes (irrespective of type of fixation in the amblyopic eye) compared to healthy controls. Abnormal EEG response to eye opening and abnormal EEG RDR were found in strabysmic amblyopes. This indicates the presence of functional changes in the midline brain structures including the corpus callosum, which impedes the development of binocular vision in strabismic amblyopes.
背景:脑电图(EEG)视觉诱发电位(VEPs)分析对于评估视觉通路的总体完整性非常重要。视觉通路任何部分的病理变化都会引起VEP的变化。脑电图记录中alpha, beta, delta和theta节律的百分比,这些波的频率和振幅,以及alpha节律抑制的水平对于表征视觉系统的状态至关重要。目的:探讨斜视性弱视视视系统的状态特征和背景脑电图的变化对激活过程的响应,这取决于弱视眼的固定类型。材料与方法:对52例5 ~ 8岁的斜视弱视患者和15例同龄健康儿童进行检查。其中32例为单侧弱视伴内斜视(6-15度)。32例患儿中偏心固定20例,中心固定12例。所有患儿均采用10-20电极放置系统进行脑电图。评估背景脑电图的节律、半球间不对称性以及α、θ和δ波的百分比。使用标准激活程序记录脑电位以激活脑深部结构。结果:3.0±2.6%的患者枕区背景脑电图未见α节律,48.6±8.2%的视力低于0.3的患者α指数低于正常范围。48.6±8.2%的儿童Delta指数高于正常范围(25% ~ 45%),48.6±8.2%的儿童theta指数高于正常范围(平均值48.4±8.2%)。在几乎一半的斜视性弱视儿童中发现α活动百分比降低,表明这些儿童眼睛的同步系统不成熟和眼动调节受损。大多数偏心固定患儿双侧脑电图对睁眼刺激的异常反应和双侧脑电图节律驱动反应(RDR)异常,而大多数中心固定患儿未见异常。光刺激对斜视性弱视儿童产生双侧对称额叶(θ和δ的百分之时间为46.0±8.4%)和枕叶(θ和δ的百分之时间为50.0±8.4%)不对称和同步的θ和δ波。结论:与健康对照相比,斜视性弱视患者(不论固定方式)额部和枕部衍生波的θ波和δ波百分比增加。斜视性弱视患者睁眼时EEG反应异常,RDR异常。这表明包括胼胝体在内的大脑中线结构存在功能变化,这阻碍了斜视性弱视的双眼视觉发展。
{"title":"Особливості зміни фонової енцефалограми у відповідь на функціональні навантаження у хворих на дисбінокулярну амбліопію залежно від фіксації амбліопічного ока","authors":"Ірина Михайлівна Бойчук, Бадрі Ваєл","doi":"10.31288/oftalmolzh202335660","DOIUrl":"https://doi.org/10.31288/oftalmolzh202335660","url":null,"abstract":"Background: Analysis of electroencephalogram (EEG) visual-evoked potentials (VEPs) is important for assessing the general integrity of the visual pathway. Pathology in any portion of the visual pathway causes changes in VEP. Percentages of alpha, beta, delta and theta rhythms in the EEG record, frequencies and amplitudes of these waves, and the level of alpha-rhythm suppression are essential for characterizing the state of the visual system. Purpose: To indentify the features of the state of the visual system and changes in the background EEG in response to activation procedures in strabismic amblyopes depending on type of fixation in the amblyopic eye. Material and Methods: Fifty-two strabismic amblyopic patients aged 5-8 years and 15 healthy children of the same age underwent an examination. Of the amblyopic children, 32 had unilateral amblyopia with esotropia (6-15 degrees). Of these 32 children, 20 had eccentric fixation and 12 children, central fixation. The 10–20 system of electrode placement was employed to perform EEG in all children. Rhythms of the background EEG, interhemispheric asymmetry and alpha, theta and delta wave percentages were assessed. Brain potentials were recorded using standard activation procedures to activate deep brain structures. Results: Alpha rhythm was not discernable in the background EEG in the occipital areas in 3.0 ± 2.6 % of cases, and the alpha index was below the normal range in 48.6 ± 8.2 % of patients with a visual acuity worse than 0.3. Delta index was above the normal range (25%-45%) in 48.6 ± 8.2 %, and theta index was above the normal range (with a mean value of 48.4 ± 8.2 %) in 48.6 ± 8.2 % of children. Reduced percentage of alpha activity was found in almost half of strabismic amblyopic children, indicating immaturity of the synchronizing system and impaired oculomotor tuning in the eyes of these children. Abnormal bilateral EEG response to eye-opening stimulation and abnormal bilateral EEG rhythmic driving response (RDR) were seen in most children with eccentric fixation, but not in most children with central fixation. Photic stimulation in strabismic amblyopic children resulted in bilaterally asymmetrical and synchronous theta and delta waves in symmetric frontal (theta and delta percent time of 46.0 ± 8.4%) and occipital (theta and delta percent time of 50.0 ± 8.4%) responses. Conclusion: Increased theta and delta wave percentages in frontal and occipital derivations were found in strabysmic amblyopes (irrespective of type of fixation in the amblyopic eye) compared to healthy controls. Abnormal EEG response to eye opening and abnormal EEG RDR were found in strabysmic amblyopes. This indicates the presence of functional changes in the midline brain structures including the corpus callosum, which impedes the development of binocular vision in strabismic amblyopes.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43103997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermatologic and ophthalmologic collaboration in the management of skin manifestations of ocular rosacea 皮肤科和眼科合作治疗眼红斑痤疮的皮肤表现
Q4 Medicine Pub Date : 2023-06-30 DOI: 10.31288/oftalmolzh202337478
Н.В. Малачкова, Т.М. Жмудь, Н.В. Кривецька, І.Ю. Пшенічна
This case is presented to (1) improve the efficacy of the identification and differential diagnosis and to avoid mistreatment of the skin manifestations of ocular rosacea exhibiting a clinical appearance of those of other disorders and (2) explore opportunities for building dermatologic and ophthalmologic collaboration in the management of patients with ocular symptoms of rosacea. A 33-year-old female patient was diagnosed with acne vulgaris and seborrhea oleosa by a dermatologist. She received a secondary diagnosis of adrenal hyperandrogenism, iron deficiency anemia and selenium and iodine deficiency. The patient underwent facial skin peeling and was prescribed dermatological treatment. Thereafter, she presented to an ophthalmologist and complained of gritty eyes and blurred vision which she had never before experienced. Ocular manifestations included macerated skin of the eyelid angles, palpebral edema, crusts at the eyelid margin and eyelid telangiectasia. The patient was diagnosed with ocular rosacea, dry eye and keratoconjunctivitis sicca, and obtained the prescribed ophthalmological treatment which resulted in an improvement in her ocular symptoms. Therefore, ocular rosacea should be treated through the cooperative efforts of dermatologists and ophthalmologists based on the constellation of clinical findings and symptoms in a particular case.
本病例旨在(1)提高识别和鉴别诊断的有效性,避免对表现出其他疾病临床表现的眼红斑痤疮皮肤表现的不当处理,以及(2)探索在治疗红斑痤疮眼部症状患者方面建立皮肤科和眼科合作的机会。一名33岁的女性患者被皮肤科医生诊断为寻常痤疮和油性脂溢。她接受了肾上腺高雄激素血症、缺铁性贫血和硒碘缺乏的二级诊断。该患者接受了面部皮肤剥离,并接受了皮肤科治疗。之后,她去看眼科医生,抱怨眼睛粗糙,视力模糊,这是她以前从未经历过的。眼部表现包括眼睑角皮肤浸渍、眼睑水肿、眼睑边缘结痂和眼睑毛细血管扩张。患者被诊断为眼酒渣鼻、干眼症和干燥性角结膜炎,并接受了处方眼科治疗,眼部症状有所改善。因此,应根据特定病例的临床表现和症状,通过皮肤科医生和眼科医生的合作来治疗眼酒渣鼻。
{"title":"Dermatologic and ophthalmologic collaboration in the management of skin manifestations of ocular rosacea","authors":"Н.В. Малачкова, Т.М. Жмудь, Н.В. Кривецька, І.Ю. Пшенічна","doi":"10.31288/oftalmolzh202337478","DOIUrl":"https://doi.org/10.31288/oftalmolzh202337478","url":null,"abstract":"This case is presented to (1) improve the efficacy of the identification and differential diagnosis and to avoid mistreatment of the skin manifestations of ocular rosacea exhibiting a clinical appearance of those of other disorders and (2) explore opportunities for building dermatologic and ophthalmologic collaboration in the management of patients with ocular symptoms of rosacea. A 33-year-old female patient was diagnosed with acne vulgaris and seborrhea oleosa by a dermatologist. She received a secondary diagnosis of adrenal hyperandrogenism, iron deficiency anemia and selenium and iodine deficiency. The patient underwent facial skin peeling and was prescribed dermatological treatment. Thereafter, she presented to an ophthalmologist and complained of gritty eyes and blurred vision which she had never before experienced. Ocular manifestations included macerated skin of the eyelid angles, palpebral edema, crusts at the eyelid margin and eyelid telangiectasia. The patient was diagnosed with ocular rosacea, dry eye and keratoconjunctivitis sicca, and obtained the prescribed ophthalmological treatment which resulted in an improvement in her ocular symptoms. Therefore, ocular rosacea should be treated through the cooperative efforts of dermatologists and ophthalmologists based on the constellation of clinical findings and symptoms in a particular case.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49532040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doppler ocular ultrasound in patients with type 2 diabetes mellitus 多普勒超声在2型糖尿病患者中的应用
Q4 Medicine Pub Date : 2023-06-30 DOI: 10.31288/oftalmolzh202331723
Ігор Аліфанов
Purpose: To determine ocular blood flow parameters by Doppler ultrasound scanning in type 2 diabetic patients with different stages of diabetic retinopathy.Material and Methods: In this prospective study, forty-five patients (90 eyes) with type 2 diabetes mellitus were divided into three groups of 15 patients each: no diabetic retinopathy group (DR0), non-proliferative retinopathy (NPDR), and proliferative retinopathy (PDR) groups. Doppler indices such as systolic blood flow velocity (Vs), diastolic blood flow velocity (Vd), time-averaged maximum velocity (TAMXV), pulsatility index (PI) and resistivity index (RI) in the ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (SPCA) were determined. ANOVA was used for quantitative comparisons between the three groups.Results: There was a significant (р less 0.05) decrease in (a) the Vs from 71.1 +- 20.6 cm/s in the DR0 group to 59.9 +- 16.7 cm/s in the NPDR group and 47.4 +- 16.4 cm/s in the PDR group, (b) Vd from 22.1 +- 6.9 cm/s to 17.0 +- 6.6 cm/s and 12.3 +- 5.9 cm/s, respectively; and (c) TAMXV from 37.2 +- 11.3 cm/s to 31.9 +- 9.1 cm/s and 25.3 +- 9.7 cm/s, respectively, and an increase in the RI from 0.69 +- 0.06 cm/s to 0.71 +- 0.09 cm/s and 0.75 +- 0.08 cm/s, respectively, in the OA. In addition, there was a significant decrease in the Vd from 9.9 +- 5.4 cm/s in the DR0 group to 8.1 +- 3.8 cm/s in the NPDR group and 5.5 +- 3.1 cm/s in the PDR group, and an increase in the PI from 1.34 +- 0.16 cm/s to 1.46 +- 0.28 cm/s and 1.54 +- 0.24 cm/s, respectively, and in the RI from 0.71 +- 0.06 cm/s to 0.75 +- 0.07 cm/s and 0.80 +- 0.05 cm/s, respectively, in the CRA. Moreover, there was a significant decrease in the Vd from 4.3 +- 1.6 cm/s in the DR0 group to 3.2 +- 2.0 cm/s in the NPDR group and 3.1 +- 2.2 cm/s in the PDR group, and an increase in the PI from 1.32 +- 0.21 cm/s to 1.37 +- 0.24 cm/s and 1.54 +- 0.26 cm/s, respectively, and in the RI from 0.76 +- 0.04 cm/s to 0.82 +- 0.06 cm/s and 0.82 +- 0.06 cm/s, respectively, in the SPCA.Conclusion: We found that the arteries examined in patients with diabetic retinopathy tended to have decreased blood flow velocities and increased resistivity and pulsatility indices, with the greatest changes observed in patients with PDR. In addition, the difference in mean values of most Doppler indices between the PDR and NPDR groups was larger than that between the NPDR and DR0 groups.
目的:通过多普勒超声扫描测定2型糖尿病患者不同阶段糖尿病视网膜病变的眼血流参数。材料和方法:在这项前瞻性研究中,45例2型糖尿病患者(90眼)被分为三组,每组15例:无糖尿病视网膜病变组(DR0)、非增殖性视网膜病变(NPDR)和增殖性视网膜病(PDR)组。测定眼动脉(OA)、视网膜中央动脉(CRA)和睫状后短动脉(SPCA)的收缩血流速度(Vs)、舒张血流速度(Vd)、时间平均最大速度(TAMXV)、搏动指数(PI)和电阻率指数(RI)等多普勒指标。方差分析用于三组之间的定量比较。结果:(a)Vs从DR0组的71.1+-20.6cm/s显著降低到NPDR组的59.9+-16.7cm/s和PDR组的47.4+-16.4cm/s,(b)Vd分别从22.1+-6.9cm/s显著下降到17.0+-6.6cm/s和12.3+-5.9cm/s;和(c)TAMXV分别从37.2+-11.3cm/s增加到31.9+-9.1cm/s和25.3+-9.7cm/s,OA的RI分别从0.69+-0.06cm/s增加到0.71+-0.09cm/s和0.75+-0.08cm/s。此外,在CRA中,Vd从DR0组的9.9+-5.4 cm/s显著降低到NPDR组的8.1+-3.8 cm/s和PDR组的5.5+-3.1 cm/s,PI分别从1.34+-0.16 cm/s增加到1.46+-0.28 cm/s和1.54+-0.24 cm/s,RI分别从0.71+-0.06 cm/s增加到0.75+-0.07 cm/s和0.80+-0.05 cm/s。此外,Vd从DR0组的4.3+-1.6cm/s显著降低到NPDR组的3.2+-2.0cm/s和PDR组的3.1+-2.2cm/s,PI分别从1.32+-0.21cm/s增加到1.37+-0.24cm/s和1.54+-0.26cm/s,RI分别从0.76+-0.04cm/s增加到0.82+-0.06cm/s和0.82+-0.06cm/s,结论:我们发现糖尿病视网膜病变患者检查的动脉往往血流速度降低,电阻率和搏动指数增加,PDR患者的变化最大。此外,PDR和NPDR组之间大多数多普勒指标的平均值差异大于NPDR和DR0组之间的差异。
{"title":"Doppler ocular ultrasound in patients with type 2 diabetes mellitus","authors":"Ігор Аліфанов","doi":"10.31288/oftalmolzh202331723","DOIUrl":"https://doi.org/10.31288/oftalmolzh202331723","url":null,"abstract":"Purpose: To determine ocular blood flow parameters by Doppler ultrasound scanning in type 2 diabetic patients with different stages of diabetic retinopathy.\u0000\u0000Material and Methods: In this prospective study, forty-five patients (90 eyes) with type 2 diabetes mellitus were divided into three groups of 15 patients each: no diabetic retinopathy group (DR0), non-proliferative retinopathy (NPDR), and proliferative retinopathy (PDR) groups. Doppler indices such as systolic blood flow velocity (Vs), diastolic blood flow velocity (Vd), time-averaged maximum velocity (TAMXV), pulsatility index (PI) and resistivity index (RI) in the ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (SPCA) were determined. ANOVA was used for quantitative comparisons between the three groups.\u0000\u0000Results: There was a significant (р less 0.05) decrease in (a) the Vs from 71.1 +- 20.6 cm/s in the DR0 group to 59.9 +- 16.7 cm/s in the NPDR group and 47.4 +- 16.4 cm/s in the PDR group, (b) Vd from 22.1 +- 6.9 cm/s to 17.0 +- 6.6 cm/s and 12.3 +- 5.9 cm/s, respectively; and (c) TAMXV from 37.2 +- 11.3 cm/s to 31.9 +- 9.1 cm/s and 25.3 +- 9.7 cm/s, respectively, and an increase in the RI from 0.69 +- 0.06 cm/s to 0.71 +- 0.09 cm/s and 0.75 +- 0.08 cm/s, respectively, in the OA. In addition, there was a significant decrease in the Vd from 9.9 +- 5.4 cm/s in the DR0 group to 8.1 +- 3.8 cm/s in the NPDR group and 5.5 +- 3.1 cm/s in the PDR group, and an increase in the PI from 1.34 +- 0.16 cm/s to 1.46 +- 0.28 cm/s and 1.54 +- 0.24 cm/s, respectively, and in the RI from 0.71 +- 0.06 cm/s to 0.75 +- 0.07 cm/s and 0.80 +- 0.05 cm/s, respectively, in the CRA. Moreover, there was a significant decrease in the Vd from 4.3 +- 1.6 cm/s in the DR0 group to 3.2 +- 2.0 cm/s in the NPDR group and 3.1 +- 2.2 cm/s in the PDR group, and an increase in the PI from 1.32 +- 0.21 cm/s to 1.37 +- 0.24 cm/s and 1.54 +- 0.26 cm/s, respectively, and in the RI from 0.76 +- 0.04 cm/s to 0.82 +- 0.06 cm/s and 0.82 +- 0.06 cm/s, respectively, in the SPCA.\u0000\u0000Conclusion: We found that the arteries examined in patients with diabetic retinopathy tended to have decreased blood flow velocities and increased resistivity and pulsatility indices, with the greatest changes observed in patients with PDR. In addition, the difference in mean values of most Doppler indices between the PDR and NPDR groups was larger than that between the NPDR and DR0 groups.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42737930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Agreement of HVID/WTW measurements made by 5 devices and their correspondence to the distance from angle to angle (ATA) 5个设备进行的HVID/WTW测量的一致性及其与角度间距离(ATA)的对应关系
Q4 Medicine Pub Date : 2023-06-30 DOI: 10.31288/oftalmolzh202331518
I. Saliev
Purpose: to determine the consistency of HVID/WTW measurements on 5 devices, and their correspondence to the distance from angle to angle (ATA).MethodsThe relevant information on 30 right eyes was obtained from 30 volunteers. A prospective study was conducted using Wavelight Topolayzer Vario (Alcon), IOL Master 700 (Zeiss), OA2000 (Tomey), AS-OCT Casia 2 (Tomey), Zeiss Atlas 9000 (Carl Zeiss) instruments. Agreement between the measurement s made by these devices in the HVID/WTW was analyzed, and the HVID/WTW scores of each device were compared with ATA scores.ResultsThe average values ​ ​ of HVID/WTW in Wavelight Topolayzer Vario, IOL Master 700, OA2000, Zeiss Atlas 9000 devices were 11.73 ± 0.33 mm, 12.01 ± 0.34 mm, 12.01 ± 0.27 mm, and 12.2 ± 0.37 mm, respectively. The mean ATA was 11.68 mm on the AS-OCT Casia2 device. The smallest difference in ATA and HVID/WTW was observed on the Wavelight Topolyzer Vario instrument which averaged 0.05±0.102mm 95% LoA (-0.41 to 0.32) (p < 0.05). The largest difference was observed between AS-OCT Casia 2 and Atlas 9000 which averaged 0.52±0.234mm 95% LoA (from-1.21 to 0.17) (p < 0.05).ConclusionOur study found that the results of measurements of HVID/WTW on the Wavelight Topolayzer Vario device are optimal when compared with ATA.
目的:确定5台设备HVID/WTW测量值的一致性,以及它们与角度间距离(ATA)的对应关系。方法从30名志愿者中获得30只右眼的相关信息。使用Wavellight Topolayzer Vario(Alcon)、IOL Master 700(蔡司)、OA2000(Tomey)、AS-OCT Casia 2(Tomey。分析了这些设备在HVID/WTW中进行的测量之间的一致性,并将每个设备的HVID/WTW得分与ATA得分进行了比较。结果平均值​ ​ Wavellight Topolayzer Vario、IOL Master 700、OA2000和Zeiss Atlas 9000装置的HVID/WTW分别为11.73±0.33 mm、12.01±0.34 mm、12.02±0.27 mm和12.2±0.37 mm。AS-OCT Casia2装置的平均ATA为11.68mm。在Wavelight Topolyzer Vario仪器上观察到ATA和HVID/WTW的最小差异,平均值为0.05±0.102mm 95%LoA(-0.41至0.32)(p<0.05)。AS-OCT Casia 2和Atlas 9000之间观察到最大差异,平均为0.52±0.234mm 95%LoA,从-1.21至0.17(p<0.05)Topolayzer Vario设备与ATA相比是最佳的。
{"title":"Agreement of HVID/WTW measurements made by 5 devices and their correspondence to the distance from angle to angle (ATA)","authors":"I. Saliev","doi":"10.31288/oftalmolzh202331518","DOIUrl":"https://doi.org/10.31288/oftalmolzh202331518","url":null,"abstract":"Purpose: to determine the consistency of HVID/WTW measurements on 5 devices, and their correspondence to the distance from angle to angle (ATA).\u0000Methods\u0000The relevant information on 30 right eyes was obtained from 30 volunteers. A prospective study was conducted using Wavelight Topolayzer Vario (Alcon), IOL Master 700 (Zeiss), OA2000 (Tomey), AS-OCT Casia 2 (Tomey), Zeiss Atlas 9000 (Carl Zeiss) instruments. Agreement between the measurement s made by these devices in the HVID/WTW was analyzed, and the HVID/WTW scores of each device were compared with ATA scores.\u0000Results\u0000The average values ​ ​ of HVID/WTW in Wavelight Topolayzer Vario, IOL Master 700, OA2000, Zeiss Atlas 9000 devices were 11.73 ± 0.33 mm, 12.01 ± 0.34 mm, 12.01 ± 0.27 mm, and 12.2 ± 0.37 mm, respectively. The mean ATA was 11.68 mm on the AS-OCT Casia2 device. The smallest difference in ATA and HVID/WTW was observed on the Wavelight Topolyzer Vario instrument which averaged 0.05±0.102mm 95% LoA (-0.41 to 0.32) (p < 0.05). The largest difference was observed between AS-OCT Casia 2 and Atlas 9000 which averaged 0.52±0.234mm 95% LoA (from-1.21 to 0.17) (p < 0.05).\u0000Conclusion\u0000Our study found that the results of measurements of HVID/WTW on the Wavelight Topolayzer Vario device are optimal when compared with ATA.","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43065371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Oftalmologicheskii zhurnal
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