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Reconstruction of small and moderate defects of the perineum 会阴小、中度缺损的重建
Pub Date : 2022-11-03 DOI: 10.33574/hjog.0517
Charilaos Ioannidis
Introduction: Resection of benign, premalignant or malignant lesions of the perineum result in tissue defects, which are preferably reconstructed with a flap rather than closed primarily or covered with a skin graft. Numerous skin flaps have been utilized with varying success rates. Patients and Methods: The charts of all female patients with perineal defects operated by the author during the past five years were retrospectively reviewed. Two flaps were used: a modified Limberg (rhomboid rotation) flap for small defects and a bilateral medial thigh V-Y advancement flap for moderate defects. Results: Seven patients were found. Two patients were operated because of benign pathology and five because of a pre- or malignant lesion. Two small and five moderate defects resulted after the resection. All flaps survived and there were no major complications. All patients had sensation on the flap postoperatively and were pleased with the functional and aesthetic result. Conclusion: Small perineal defects are satisfactorily restored with a rotation rhomboid flap, whereas moderate sized defects are best reconstructed with bilateral medial thigh V-Y flaps.
导言:会阴良性、癌前或恶性病变的切除会导致组织缺损,这些组织缺损最好用皮瓣重建,而不是主要闭合或用皮肤移植物覆盖。许多皮瓣已被使用,成功率各不相同。患者与方法:对近五年来笔者所做的女性会阴缺损手术的病历进行回顾性分析。使用两种皮瓣:改良的Limberg(菱形旋转)皮瓣用于小缺陷,双侧大腿内侧V-Y推进皮瓣用于中度缺陷。结果:共发现7例患者。2例患者因良性病理而手术,5例因癌前病变或恶性病变而手术。术后形成2个小缺损,5个中等缺损。所有皮瓣均存活,无重大并发症。所有患者术后对皮瓣感觉良好,功能和美观均满意。结论:小的会阴缺损可采用旋转菱形皮瓣修复,中等大小的会阴缺损可采用双侧大腿内侧V-Y皮瓣修复。
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引用次数: 0
Revisiting the effectiveness of a forgotten technique: the value of blue dye on sentinel lymph node biopsies of gynecological cancer 重新审视一项被遗忘的技术的有效性:蓝色染料在妇科癌症前哨淋巴结活检中的价值
Pub Date : 2022-11-03 DOI: 10.33574/hjog.0513
V. Pergialiotis, I. Koutroumpa, D. Haidopoulos, George Daskalakis, A. Rodolakis, N. Thomakos, D. Loutradis
Sentinel lymph node biopsy with blue dye has been used extensively in the past for the evaluation of patients with gynecological cancer. While the technique has been negatively criticized as inaccurate in detecting an appropriate number of lymph nodes bilaterally, novel studies seem to suggest an acceptable detection rate that is directly attributed to the number of cases performed as well as the type of dye that is used. Taking into consideration the significant impact of comprehensive pelvic lymphadenectomy on the quality of life of these patients, it seems reasonable to suggest its use in the absence of appropriate economic resources, such as in low income countries. In the present study we summarize the available evidence concerning the diagnostic performance of the various techniques that are used in sentinel lymph node resection in gynecologic oncology, focusing on the potential benefits of blue dye in specific settings.
前哨淋巴结活检与蓝色染料在过去被广泛用于妇科癌症患者的评估。虽然这项技术一直被批评为在检测适当数量的双侧淋巴结方面不准确,但新的研究似乎表明,可以接受的检出率直接归因于所执行的病例数量以及所使用的染料类型。考虑到全面盆腔淋巴结切除术对这些患者生活质量的重大影响,在缺乏适当经济资源的情况下,如低收入国家,建议使用盆腔淋巴结切除术似乎是合理的。在本研究中,我们总结了有关妇科肿瘤学前哨淋巴结切除术中使用的各种技术的诊断性能的现有证据,重点关注蓝色染料在特定情况下的潜在益处。
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引用次数: 0
Laparoscopic surgery for clear cell endometrial carcinoma, is it a realistic approach? 腹腔镜手术治疗透明细胞子宫内膜癌是一种现实的方法吗?
Pub Date : 2022-11-03 DOI: 10.33574/hjog.0515
E. Zachariou, V. Pergialiotis, E. Iliopoulos, D. Haidopoulos
Clear cell endometrial carcinoma is an aggressive form of endometrial cancer that has a poor prognosis for survival. Over the past ten years, laparoscopic surgery has replaced open surgery as the preferred method of treating early-stage endometrial cancer. However, its effect on the prognosis of patients with clear cell carcinoma is still unclear. In the current systematic review, we examined the information that was published in the following databases: Medline, Scopus, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials, CENTRAL, and Google Scholar. Three studies were found to be significantly diverse; as a result, meta-analysis was not possible. Current research reveals that compared to traditional laparotomy, minimally invasive surgery does not significantly influence progression-free and overall survival rates; nevertheless, given the relative dearth of data, more research is required before the technique’s safety can be determined.
透明细胞子宫内膜癌是一种侵袭性子宫内膜癌,预后差。在过去的十年里,腹腔镜手术已经取代开放手术成为治疗早期子宫内膜癌的首选方法。然而,其对透明细胞癌患者预后的影响尚不清楚。在当前的系统评价中,我们检查了发表在以下数据库中的信息:Medline、Scopus、Clinicaltrials.gov、EMBASE、Cochrane Central Register of Controlled Trials、Central和Google Scholar。三项研究发现差异显著;因此,meta分析是不可能的。目前的研究表明,与传统剖腹手术相比,微创手术对无进展生存率和总生存率没有显著影响;然而,考虑到数据的相对缺乏,在确定这项技术的安全性之前,还需要进行更多的研究。
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引用次数: 0
Ovarian Vein Thrombosis 卵巢静脉血栓
Pub Date : 2022-11-03 DOI: 10.33574/hjog.0516
T. Kanellopoulou
Ovarian vein thrombosis (OVT) is a rare type of venous thromboembolism most common diagnosed in the postpartum period and peaking around 2-6 days after delivery. Clinical symptoms are not specific including fever and abdominal pain and the right ovarian vein is more frequently involved (70-80% of cases). The diagnosis of OVT is a clinical challenge because there are multiple other conditions that can present similarly, including ovarian torsion, tubo-ovarian abscess, pelvic inflammatory disease, puerperal endometritis, appendicitis, inflammatory bowel disease and pyelonephritis. Ultrasound Doppler is the first-line imaging; however, most cases are confirmed with computed tomography or magnetic resonance imaging. Mortality related to ovarian vein thrombosis is low due to the combination treatment of broad-spectrum antibiotics and anticoagulation. Extension of thrombus to inferior vena cava or renal veins and rarely pulmonary embolism could also occur. OVT is actually a type of deep vein thrombosis that could be life-threatening however mortality is low due to the combination treatment of broad-spectrum antibiotics and anticoagulation. Anticoagulant treatment duration of 3 to 6 months has been recommended like typical cases of venous thromboembolism.
卵巢静脉血栓形成(OVT)是一种罕见的静脉血栓栓塞症,最常见于产后,在分娩后2-6天左右达到高峰。临床症状不特殊,包括发烧和腹痛,右侧卵巢静脉更常受累(70-80%的病例)。OVT的诊断是一项临床挑战,因为有多种其他疾病可以出现类似的症状,包括卵巢扭转、输卵管卵巢脓肿、盆腔炎、产褥期子宫内膜炎、阑尾炎、炎症性肠病和肾盂肾炎。超声多普勒是一线成像;然而,大多数病例通过计算机断层扫描或磁共振成像证实。由于广谱抗生素和抗凝药物的联合治疗,卵巢静脉血栓的死亡率较低。血栓延伸至下腔静脉或肾静脉,很少发生肺栓塞。OVT实际上是一种可能危及生命的深静脉血栓形成,但由于广谱抗生素和抗凝剂的联合治疗,死亡率很低。静脉血栓栓塞的典型病例建议抗凝治疗时间为3 ~ 6个月。
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引用次数: 0
Adverse pregnancy outcomes in twins and their association with the conception method 双胞胎不良妊娠结局及其与受孕方法的关系
Pub Date : 2022-11-03 DOI: 10.33574/hjog.0514
Angeliki Rouvali, I. Sapantzoglou, S. Stavros, P. Antsaklis, M. Theodora, Georgios Daskalakis
Assisted reproductive technology (ART) has given the opportunity of conception to a large proportion of subfertile women and, at the same time, has led to a substantial increase of multiple pregnancies. Several studies have shown that in vitro fertilization conceived twin pregnancies carry a significant risk of perinatal morbidity and complications. However, it remains unknown whether IVF per se actually increases the risk of pregnancy complications in twin pregnancies or if these should be attributed to the maternal characteristics. In the present review we summarize the findings of published studies related to the most common pregnancy complications encountered in IVF conceived twin pregnancies.
辅助生殖技术(ART)使很大一部分生育能力低下的妇女有机会怀孕,同时也导致多胎妊娠的大量增加。几项研究表明,体外受精孕育的双胎妊娠具有围产期发病率和并发症的显著风险。然而,目前尚不清楚IVF本身是否会增加双胎妊娠并发症的风险,或者是否应归因于母体特征。在本综述中,我们总结了已发表的有关IVF妊娠双胎妊娠中最常见妊娠并发症的研究结果。
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引用次数: 0
Indications for admission in a high-risk pregnancy unit in Greece: Comparison between native and migrant women. A single-center experience 希腊高危妊娠病房的入院指征:本地和移民妇女的比较。单中心体验
Pub Date : 2022-07-03 DOI: 10.33574/hjog.0510
I. Tsakiridis, A. Mamopoulos, I. Kalogiannidis, Nikolaos Dagklis, A. Athanasiadis, T. Dagklis
Introduction: Migrant pregnant women may require antenatal hospitalization due to complications of pregnancy. The aim of this study was to investigate the indications for admission, the baseline and the obstetric characteristics of migrant women hospitalized in a high-risk pregnancy unit (HRPU) and compare them with the native-Greek individuals. Materials and Methods: A retrospective cohort study was conducted during the period 2005-2019. All pregnant women at ≥ 24 gestational weeks admitted in a University hospital HRPU were eligible for the study. Epidemiological characteristics, along with the indications for admission were studied and comparisons of several parameters between native-Greek and migrant pregnant women were conducted. Results: Overall, 3,823 women were included in the study, of which 838 (21.9%) were migrant women. The main indication for hospital admission was threatened preterm labor (38.0%). When we compared the two groups in terms of indications for admission, we found that maternal indications were more common in migrants than Greek pregnant women (32.8% vs 26.8%; p=0.001; OR:1.332; 95% CI:1.129-1.571). Compared to native women, migrants were younger (28.7±6.1 vs 30.9±6.4 years, p<0.001), more often multiparous (p<0.001; OR:3.883 95% CI:3.307-4.561), reported more often spontaneous conception (p<0.001; OR:0.425 95% CI:0.271-0.667) and were more likely to smoke during pregnancy (p=0.043; OR:1.209 95% CI:1.006-1.452). Conclusions: During the study period, threatened preterm labor followed by maternal complications were the most common indications for hospitalization. Migrant women were admitted to the HRPU more often than Greek ones for maternal complications. Finally, migrant status was associated with the method of conception, parity and smoking.
导读:由于妊娠并发症,流动孕妇可能需要产前住院治疗。本研究的目的是调查高危妊娠病房(HRPU)住院的移民妇女的入院指征、基线和产科特征,并将其与希腊本地人进行比较。材料与方法:2005-2019年进行回顾性队列研究。所有在大学医院HRPU住院的≥24孕周的孕妇都有资格参加这项研究。研究了流行病学特征以及入院适应症,并对希腊本土孕妇和移民孕妇的几个参数进行了比较。结果:研究共纳入3823名妇女,其中838名(21.9%)为流动妇女。入院的主要指征为先兆早产(38.0%)。当我们比较两组入院指征时,我们发现孕产妇指征在移民中比希腊孕妇更常见(32.8% vs 26.8%;p = 0.001;OR: 1.332;95%置信区间:1.129—-1.571)。与当地妇女相比,移民妇女更年轻(28.7±6.1岁vs 30.9±6.4岁,p<0.001),多胎率更高(p<0.001;OR:3.883 95% CI:3.307-4.561),自然受孕的发生率更高(p<0.001;OR:0.425 95% CI:0.271-0.667),怀孕期间吸烟的可能性更大(p=0.043;Or:1.209 (95% ci:1.006-1.452)。结论:在研究期间,先兆早产后的产妇并发症是最常见的住院指征。由于产妇并发症,移民妇女比希腊妇女更常被送往HRPU。最后,移民身份与怀孕方式、胎次和吸烟有关。
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引用次数: 0
The lockdown effect on gynaecological cancer surgeries during the COVID-19 pandemic COVID-19大流行期间对妇科癌症手术的封锁效应
Pub Date : 2022-07-03 DOI: 10.33574/hjog.0511
Vasilis Theodoulidis, A. Prodromidou, K. Aggelou, Anastasia Mortaki, K. Trimmi, N. Thomakos
The COVID-19 outbreak increased significantly the burden of hospital based services in an international setting. Facilities dealing with cancer cases had to cope with the burden of the disease and with the waiting lists that continuously grow as cancer patients tend to refer with increasing rates in referral centers. Surgical departments with oncological patients had to prioritize patients in order to help provide optimal care, without posing them at risk of a potential infection during their hospitalization. In the present article we report the experience of the Gynecologic oncology section of the First Department of Obstetrics and Gynecology of the National and Kapodistrian University of Athens during the first 12 months of the pandemic.
COVID-19疫情大大增加了国际环境下医院服务的负担。处理癌症病例的设施必须应对疾病的负担,以及随着癌症患者倾向于转诊到转诊中心的比率不断增加而不断增加的等候名单。有肿瘤患者的外科部门必须优先考虑患者,以帮助提供最佳护理,而不会使他们在住院期间面临潜在感染的风险。在本文中,我们报告了雅典国立大学和卡波迪特里亚大学第一妇产科妇科肿瘤科在大流行的头12个月的经验。
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引用次数: 0
Effect of estradiol levels after hCG trigger on embryo quality, implantation, and IVF outcome, using donor ovarian stimulation protocols 使用供体卵巢刺激方案,hCG触发后雌二醇水平对胚胎质量、着床和体外受精结果的影响
Pub Date : 2022-07-03 DOI: 10.33574/hjog.0509
S. Stavros, G. Kalabalikis, D. Mavrogianni, D. Loutradis, P. Drakakis, Isabella Spyropoulou
In this study, we aimed at delineating the possible effect of estradiol (E2) levels on the day of β-hCG administration on the ovary by analysingthe Embryo Score (ES) of early day 2, 44hrs post insemination. Oocyte donor ovarian stimulation protocols were thus used in order to avoid any possible counteractions of E2 with the endometrium. All oocytes were microinjected and all embryo transfers were fresh.E2 and E2/oocyte correlated positively with the ES on day 2 of embryo development. In contrast, the E2 and E2/oocyte do not appear to significantly affect the implantation and clinical pregnancy rates. Furthermore, E2 levels on the day of β-hCG administration were positively associated with fast and slowly dividing embryos compared to “ideally” dividing embryos on day 2. E2 levels corresponding to the “ideal” ES (E216) on day 2 sonographically translated into 12 mature oocytes. Embryos with “ideal” ES on day 2 were positively associated with implantation and gestational sac rates, as well as lower spontaneous miscarriage rates, in comparison to the fast and slowly dividing embryos. We propose that a) ES on day 2 of embryo development, 44hrs post insemination, is a valuable prognostic marker of embryo quality in ovarian stimulation protocols and b) an ovarian stimulation protocol may most likely be successful if not more than 12 oocytes are collected, i.e. E2 levels do not exceed 3.309pg/ml or on the day of hCG administration.
在本研究中,我们旨在通过分析受精后早期244h的胚胎评分(ES)来描述雌二醇(E2)水平在卵巢注射β-hCG当天的可能影响。因此,使用卵母细胞供体卵巢刺激方案是为了避免E2与子宫内膜的任何可能的反作用。所有卵母细胞均微注射,胚胎移植均新鲜。E2和E2/卵母细胞与胚胎发育第2天的ES呈正相关。相反,E2和E2/卵母细胞似乎对着床率和临床妊娠率没有显著影响。此外,与第2天“理想”分裂的胚胎相比,β-hCG给药当天E2水平与快速和缓慢分裂的胚胎呈正相关。E2水平对应的“理想”ES (E216)在第2天超声翻译成12个成熟卵母细胞。与快速和缓慢分裂的胚胎相比,第2天具有“理想”ES的胚胎与着床率和妊娠囊率呈正相关,并且自然流产率较低。我们认为,a)胚胎发育第2天,即授精后44小时的ES是卵巢刺激方案中胚胎质量的一个有价值的预后指标;b)如果收集到的卵母细胞不超过12个,即E2水平不超过3.309pg/ml或在hCG给药当天,卵巢刺激方案最有可能成功。
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引用次数: 0
Risk Factors for Intrauterine Deaths in The Third Trimester of Pregnancy. A holistic approach of case series and literature review 妊娠晚期宫内死亡的危险因素个案系列及文献回顾的整体方法
Pub Date : 2022-07-03 DOI: 10.33574/hjog.0507
S. Stavros, Eleni Papamattheou, Styliani Preka, D. Mavrogianni, E. Domali, P. Drakakis
Objectives: There is a plethora of references in the international bibliography regarding correlation of various risk factors and intrauterine death in the third trimester, such as gestational diabetes mellitus, preeclampsia, endometrial infections as well as endometrial growth restriction. The purpose of the present study is to analyze demographic and socio-economic factors to draw conclusions on improving health services for pregnant women. Methods: 41 cases of intrauterine deaths, after 28 weeks of pregnancy, were studied retrospectively from the archives of the 1st Department of Obstetrics and Gynecology Alexandra Hospital, during a 3-year period (2015-2018). The risk factors assessed, were the age, the race (White/Caucasian, Ethnic, Asian, and Black), the socio-economic status, smoking, body mass index (BMI), educational level, gestational age, monitoring (or lack) of the pregnancy, and pathology observed during the pregnancy though. Results: The average age of women was 31 years old, the average body mass index (BMI) was 27.4, while most of them were White-Caucasian (75,6 %) The majority of women had a low educational and socio-economic level, 68,3 % (28/41) and 61% (25/41) respectively. On top of that, 14/41 (34.1 %) were smokers, the mean age of gestation was the 32 weeks of pregnancy, and the fetal gender was female (63.41%). The gestational preeclampsia was found to be the most important factor for intrauterine death and most of the women had not monitoring during the pregnancy (61%). Conclusions: Interpretation of the results showed that low educational level and low socio-economic level were independent risk factors for endometrial third trimester deaths. On the contrary preeclampsia was the leading cause of death.
目的:国际文献对妊娠晚期各种危险因素与宫内死亡的相关性研究较多,如妊娠期糖尿病、先兆子痫、子宫内膜感染、子宫内膜生长受限等。本研究的目的是分析人口和社会经济因素,以得出关于改善孕妇保健服务的结论。方法:回顾性分析亚历山德拉医院妇产科一科2015-2018年3年间41例妊娠28周后宫内死亡病例。评估的危险因素包括年龄、种族(白人/高加索人、少数民族、亚洲人和黑人)、社会经济地位、吸烟、体重指数(BMI)、教育水平、胎龄、妊娠监测(或缺乏)以及妊娠期间观察到的病理。结果:女性的平均年龄为31岁,平均体重指数(BMI)为27.4,以白种人(75.6%)居多,文化程度和社会经济水平较低的女性居多,分别为68.3%(28/41)和61%(25/41)。吸烟占14/41(34.1%),平均孕龄32周,胎性别为女(63.41%)。妊娠前期子痫是宫内死亡的最重要因素,大多数妇女在妊娠期间没有进行监测(61%)。结论:对结果的解释显示,低教育水平和低社会经济水平是子宫内膜晚期死亡的独立危险因素。相反,先兆子痫是导致死亡的主要原因。
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引用次数: 0
Laparoscopic treatment of a complex adnexal mass of the retroperitoneal space: A case report 腹腔镜治疗腹膜后间隙复杂附件肿块1例
Pub Date : 2022-07-03 DOI: 10.33574/hjog.0512
T. Liakakos, K. Papakonstantinou, Michail Panagiotopoulos, D. Papageorgiou
Complex adnexal cystic masses in women of reproductive age should be carefully evaluated before the final diagnosis is set. Adnexal cystic masses are not necessary malignant. On the contrary, they usually refer to a benign and not cancerous pathology. A certain benign pathology behind adnexal masses is endometriosis. Endometriosis occurs in 10-15% of women of reproductive age and presents great diversity both in the way it manifests and in its location. We report a case of a multiparous woman of reproductive age that was referred to our clinic due to abdominal and back pain. The imaging examinations revealed a cystic mass of the left parametrium that was laparoscopically removed. The histopathology set the diagnosis of endometrioma. The aim of our work is to highlight the endometrioma of the retroperitoneal space as part of the differential diagnosis of the cystic masses of the parametrium.
育龄妇女的复杂附件囊性肿块在最终诊断前应仔细评估。附件囊性肿块不一定是恶性的。相反,它们通常指的是良性而非癌性病理。附件肿块背后的某种良性病理是子宫内膜异位症。子宫内膜异位症发生在10-15%的育龄妇女中,在其表现方式和位置上都有很大的多样性。我们报告一例多胞胎育龄妇女,被转介到我们的诊所由于腹部和背部疼痛。影像学检查显示左侧参数囊性肿块,经腹腔镜切除。组织病理学诊断为子宫内膜异位瘤。我们工作的目的是强调腹膜后间隙子宫内膜瘤作为参数囊性肿块鉴别诊断的一部分。
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引用次数: 0
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Hellenic Journal of Obstetrics and Gynecology
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