Ophthalmology. Retina最新文献

英文中文

Intraocular Solitary Fibrous Tumor. 眼内孤立性纤维性肿瘤。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-08 DOI: 10.1016/j.oret.2025.12.011

Yang Meng, Sainan Xiao, Tao Li

引用次数: 0

Malabsorption Syndromes and Risk of Age-Related Macular Degeneration. 吸收不良综合征和年龄相关性黄斑变性的风险：来自真实世界数据的证据。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-08 DOI: 10.1016/j.oret.2026.01.002

Hejin Jeong, Priya S Eppel, David C Kaelber, Rishi P Singh, Katherine E Talcott

Purpose: Despite mechanistic links connecting malnutrition and gut microbiome with retinal health, clinical research exploring the relationship between malabsorption syndromes and age-related macular degeneration (AMD) remains limited. This study compared the risks of AMD diagnosis in patients with and without various malabsorption syndrome diagnoses.

Design: Retrospective cohort study of aggregated, deidentified patient data from multiple health care organizations across the United States using the TriNetX US Collaborative Research Network in November 2025.

Participants: Adults with a cataract-related International Classification of Diseases (ICD) encounter diagnosis codes and no baseline AMD ICD encounter diagnosis codes were divided into groups based on the presence of ICD encounter diagnosis codes for celiac disease, ulcerative colitis (UC), Crohn's disease (CrD), chronic pancreatitis (CP), and short bowel syndrome (SBS). Within the CP cohort, patients with pancreatic enzyme replacement therapy (PERT) prescription orders were subanalyzed. For each cohort, a corresponding control cohort of patients without the respective ICD encounter diagnosis codes was created.

Methods: The study and control cohorts were propensity-matched 1:1 on demographic factors, comorbidities, and disease-related conditions and prescription orders. The matched cohorts were compared on the risk of having AMD ICD encounter diagnoses.

Main outcome measures: Risk ratios (RRs) and 95% confidence intervals (CIs) of having an AMD ICD encounter diagnosis code with an accompanying retinal OCT Common Procedural Terminology code. Significance was defined as CI ≤0.9 or ≥1.1.

Results: Compared with controls without inflammatory bowel diseases, the CrD cohort (n = 9537, RR = 1.42, CI = 1.15-1.74), but not the UC cohort (n = 15,039, RR = 1.28, CI = 1.09-1.51), had a higher risk of having early/intermediate AMD. Chronic pancreatitis was associated with an increased risk of AMD (n = 12,856, RR = 1.82, CI = 1.53-2.16), even in the PERT subset (n = 3812, RR = 1.83, CI = 1.35-2.48). Short bowel syndrome (n = 3747) was associated with an increased risk of advanced/exudative AMD (RR = 1.98, CI = 1.31-2.98), but not early/intermediate AMD (RR = 1.28, CI = 0.96-1.71). Celiac disease was not associated with increased AMD risk (n = 9315, RR = 1.09, CI = 0.88-1.35).

Conclusions: Chronic noninfectious causes of malabsorption syndromes-CrD, CP, and SBS-may represent underrecognized risk factors of AMD. This explorative study adds clinical evidence for a potential role of the gut-retina axis in the pathogenesis of AMD.

Financial disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：尽管营养不良和肠道微生物组与视网膜健康之间存在机制联系，但探索吸收不良综合征与年龄相关性黄斑变性（AMD）之间关系的临床研究仍然有限。本研究比较了有和没有各种吸收不良综合征诊断的患者AMD诊断的风险。设计：回顾性队列研究，使用TriNetX美国合作研究网络，于2025年11月对来自美国多个医疗保健组织的汇总、去识别的患者数据进行研究。参与者：具有白内障相关国际疾病分类（ICD）遇到诊断代码和无基线AMD ICD遇到诊断代码的成年人根据是否存在乳糜泻（CeD）、溃疡性结肠炎（UC）、克罗恩病（CrD）、慢性胰腺炎（CP）和短肠综合征（SBS）的ICD遇到诊断代码分为两组。在CP队列中，对接受胰酶替代疗法（PERT）处方的患者进行亚分析。对于每个队列，创建一个相应的对照队列，其中没有相应的ICD遭遇诊断代码。方法：研究组和对照组在人口学因素、合并症、疾病相关条件和处方上按1:1的倾向性匹配。比较匹配的队列患AMD ICD遭遇诊断的风险。主要结果测量：AMD ICD遇到诊断代码并伴随视网膜光学相干断层扫描通用程序术语代码的风险比（RR）和95%置信区间（CI）。显著性定义为CI≤0.9或≥1.1。结果：与没有IBD的对照组相比，CrD组（n= 9537， RR=1.42， CI=1.16-1.74）有更高的早期/中期AMD风险，而UC组（n= 15039， RR=1.28， CI=1.09-1.51）没有。CP与AMD风险增加相关（n=12,856， RR=1.82， CI=1.53-2.16），即使在PERT子集中也是如此（n=3,812， RR=1.83， CI=1.35-2.48）。SBS （n=3,747）与晚期/渗出性AMD的风险增加相关（RR=1.98， CI=1.31-2.98），但与早期/中期AMD无关（RR=1.28， CI=0.96-1.71）。CeD与AMD风险增加无关（n=9,315， RR=1.09， CI=0.88-1.35）。结论：慢性非感染性吸收不良综合征（crd、CP和sbs）可能是AMD未被充分认识的危险因素。这项探索性研究为肠-视网膜轴在AMD发病机制中的潜在作用提供了临床证据。

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引用次数: 0

Corrigendum.

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-07 DOI: 10.1016/j.oret.2025.12.017

引用次数: 0

Vitreoretinal Abnormalities in Poretti-Boltshauser Syndrome: An Imaging Overview. porretti - boltshauser综合征的玻璃体视网膜异常：影像学综述。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-07 DOI: 10.1016/j.oret.2025.12.010

Samet Gulkas, Ines Fenniri, Anne Fulton

引用次数: 0

Aggressive-Retinopathy of Prematurity or Oxygen-Induced Retinopathy? 侵袭性：早产儿视网膜病变还是氧致视网膜病变？

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-07 DOI: 10.1016/j.oret.2025.12.009

Abhishek Singh, Deepshikha Agrawal, Anil Babanrao Gangwe

引用次数: 0

Resolution of Retained Perfluoro-n-Octane After Retinal Detachment Repair. 视网膜脱离修复后残留全氟辛烷的溶解

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-06 DOI: 10.1016/j.oret.2025.12.007

Walton Spivey, Victor T Copeland, Mohan N Iyer

引用次数: 0

Arteriovenous Malformation with Central Retinal Vein Occlusion and Intraretinal Hyporeflective Spaces 动静脉畸形伴视网膜中央静脉闭塞和视网膜内低反射间隙。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-01 Epub Date: 2025-05-28 DOI: 10.1016/j.oret.2025.04.018

Andrea Coletto MD , Valerie Krivosic MD , Elodie Bousquet MD, PhD

引用次数: 0

Internal Limiting Membrane Peeling for Grade C Proliferative Vitreoretinopathy 内限制膜剥离治疗C级增殖性玻璃体视网膜病变的疗效：一项国际多中心研究。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-01 Epub Date: 2025-06-17 DOI: 10.1016/j.oret.2025.06.006

Taku Wakabayashi MD, PhD , Annika G. Samuelson MD , Yusuke Oshima MD, PhD , Vishal Swaminathan MD , Akihiko Shiraki MD , Bita Momenaei MD , Anahita Sehgal MD , Satoshi Imamura MD , Yuichiro Ishida MD , Keita Baba MD , David Xu MD , Nobuhiko Shiraki MD, PhD , Hisashi Fukuyama MD , Kotaro Tsuboi MD , Ava Torjani MD , Robert M. Abishek MD , Michael N. Cohen MD , Ajay E. Kuriyan MD , Carl H. Park MD , Marc J. Spirn MD , Yoshihiro Yonekawa MD

Purpose

To evaluate the efficacy of internal limiting membrane (ILM) peeling on the anatomic and visual outcomes of pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) with grade C proliferative vitreoretinopathy (PVR).

Design

Multicenter, interventional, clinical cohort study.

Subjects

Consecutive patients who underwent PPV for grade C PVR with a minimum of 6-month follow-up.

Methods

We compared the anatomic and visual outcomes of grade C PVR surgery after vitrectomy with PVR membrane peeling plus, or without, ILM peeling, in patients treated at 6 institutions between January 2015 and January 2022. Internal limiting membrane peeling was performed within the macula, arcade to arcade, or beyond the arcades (extended ILM peeling).

Main Outcome Measures

Single surgery anatomic success at 3 months and 6 months with versus without ILM peeling.

Results

We included a total of 370 eyes (370 patients); 157 eyes (42.4%) treated with ILM peeling were compared with 213 eyes (57.6%) treated without ILM peeling. Mean follow-up was 23.2 ± 13.9 months. No differences were noted in baseline characteristics or surgical techniques. Single surgery anatomic success was significantly higher in the ILM peeling group (86.6% vs. 73.2% at 3 months [P = 0.002] and 75.2% vs. 65.3% at 6 months [P = 0.041], respectively). The retinal reattachment rate under fluid without tamponade was significantly higher in the ILM peeling group at 6 months (68.8% vs. 51.6%, P < 0.001). Both groups showed visual improvement after surgery (both P < 0.001). However, the ILM peeling group showed significantly better visual acuity and visual improvement (1.11 ± 0.70 vs. 1.29 ± 0.80 [P = 0.020] and 0.48 ± 0.77 vs. 0.24 ± 0.90 [P = 0.018], respectively). The ILM peeling group had significantly fewer subsequent vitreoretinal surgeries (P = 0.002), including subsequent epiretinal membrane surgeries (8.9% vs. 17.8%, P = 0.015). No ILM peeling was associated with more posterior breaks when the retina redetached (P = 0.045). Multivariable regression analysis showed that extended ILM peeling was significantly associated with higher likelihood of retinal reattachment without tamponade (under fluid) at 6 months and better final visual acuity (P = 0.040 and 0.031, respectively).

Conclusions

Internal limiting membrane peeling, particularly extended ILM peeling, for RRD with grade C PVR resulted in superior anatomic and visual outcomes compared with vitrectomy without ILM peeling in this study.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：探讨内限制膜（ILM）剥离对玻璃体平面部切除术（PPV）治疗孔源性视网膜脱离（RRD）合并C级增殖性玻璃体视网膜病变（PVR）的解剖和视觉效果的影响。设计：多中心、介入、临床队列研究。受试者：连续接受PPV治疗的c级PVR患者，随访至少6个月。方法：我们比较了2015年1月至2022年1月期间在6家机构接受玻璃体切除术后，PVR膜剥离加ILM剥离的c级PVR手术的解剖和视觉结果。在黄斑内、街机间或街机外进行ILM剥离（扩展ILM剥离）。主要结局指标：单次手术解剖成功（SSAS）在3个月和6个月有与没有ILM剥离。结果：我们共纳入370只眼（370例患者）；有ILM剥落者157只眼（42.4%），未剥落者213只眼（57.6%）。平均随访23.2±13.9个月。在基线特征或手术技术方面没有差异。ILM剥皮组的SSAS显著升高（3个月时为86.6% vs. 73.2%， 6个月时为75.2% vs. 65.3%）（P分别=0.002和0.041）。6个月时，在无压塞的液体下，ILM剥离组的视网膜再附着率显著高于前者（68.8% vs. 51.6%）。结论：对于伴有C级PVR的RRD， ILM剥离，特别是延长的ILM剥离，与没有ILM剥离的玻璃体切除术相比，在本研究中具有更好的解剖和视觉效果。

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引用次数: 0

Analysis of Aqueous Interleukin-6 in Diabetic Retinopathy 糖尿病视网膜病变中白介素-6的分析：328只眼的前瞻性对照试验。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-01 Epub Date: 2025-06-27 DOI: 10.1016/j.oret.2025.06.014

Abhiram R. Manda , Lok Hin Lee PhD , Megan S. Steinkerchner MD , Jinsong Sheng MD , Lindsay Veach , Sapna Gangaputra MD, MPH , Stephen J. Kim MD

Objective

To analyze the relationship of aqueous interleukin-6 (IL-6) with diabetic retinopathy (DR) severity.

Design

Prospective, controlled trial at a tertiary academic medical center.

Subjects

Three hundred twenty-eight eyes of 164 adult type II diabetic patients with varying levels of DR.

Methods

A total of 328 eyes of 164 diabetic patients were enrolled based on DR severity: 46 eyes of 23 patients in the no DR group, 236 eyes of 118 patients in the moderate nonproliferative DR (NPDR) group, and 46 eyes of 23 patients in the proliferative DR (PDR) group. ETDRS visual acuity, spectral-domain OCT, and color fundus photographs were taken at baseline. Blood draw and aqueous sampling of each eye was performed. Blood glucose and hemoglobin A1c (HbA1c) were measured. Aqueous IL-6 was measured using a microparticle bead-based multiplex assay.

Main Outcomes Measures

Aqueous IL-6 levels, HbA1c, DR severity, Diabetic macular edema (DME).

Results

Median HbA1c differed between the 3 DR groups (P = 0.03), but there was no correlation between IL-6 and HbA1c (ρ = 0.08, P = 0.179). Baseline aqueous IL-6 levels were significantly different between DR groups. Median IL-6 and interquartile range was 5.40 pg/mL (2.99–8.77) for eyes in the no DR group, 9.25 pg/mL (5.35–22.35) for eyes in the moderate NPDR group, and 15.71 pg/mL (9.24–48.58) for eyes in the PDR group (P < 0.001). Median central subfield thickness (CST) did not differ significantly between the 3 groups (P = 0.351), but there was a significant positive correlation between IL-6 and CST (ρ = 0.18, P = 0.001). There was also a significant positive correlation between IL-6 and macular volume (ρ = 0.12, P = 0.031). Increased IL-6 was significantly associated with increased odds of having DME (odds ratio = 1.00, P = 0.015).

Conclusions

We report the largest analysis of aqueous IL-6 in diabetic eyes. We observed that IL-6 is significantly associated with DR severity and DME. Our results considerably strengthen the prevailing evidence that IL-6 is a key contributor to the pathogenesis of DR and may represent both a biomarker of disease activity and a novel therapeutic target.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：探讨白介素-6 （IL-6）与糖尿病视网膜病变（DR）严重程度的关系。设计：在三级学术医疗中心进行前瞻性对照试验。研究对象：不同程度DR的成人II型糖尿病患者164例328眼。方法：根据DR的严重程度，164例糖尿病患者共328眼入组：无DR组23例46眼，中度非增生性糖尿病视网膜病变（NPDR）组118例236眼，增生性糖尿病视网膜病变（PDR）组23例46眼。基线时拍摄ETDRS视力、光谱域光学相干断层扫描（SDOCT）和彩色眼底照片。对每只眼睛进行抽血和水采样。测量血糖和糖化血红蛋白。水相IL-6的测定采用基于微珠的多重测定法。主要结局和指标：水相IL-6水平、HbA1c、DR严重程度、糖尿病性黄斑水肿（DME）。结果：三组患者HbA1c中位数差异有统计学意义（P = 0.03），但IL-6与HbA1c无相关性（ρ = 0.08, P = 0.179）。DR组间基线水相IL-6水平有显著性差异。无DR组的中位IL-6和四分位数范围（IQR）为5.40 pg/ml(2.99 ~ 8.77)，中度NPDR组为9.25 pg/ml (5.35 ~ 22.35)， PDR组为15.71 pg/ml (9.24 ~ 48.58) （P < 0.001）。中位中心子场厚度（CST）在三组间差异无统计学意义（P = 0.351），但IL-6与CST呈正相关（ρ = 0.18, P = 0.001）。IL-6与黄斑体积也有显著正相关（ρ = 0.12, P = 0.031）。IL-6升高与DME发生率升高显著相关（OR = 1.00, P = 0.015）。结论和相关性：我们报道了糖尿病眼中最大的水相IL-6分析。我们观察到IL-6与DR严重程度和DME显著相关。我们的研究结果大大加强了当前的证据，即IL-6是DR发病机制的关键因素，可能代表疾病活性的生物标志物和新的治疗靶点。

{"title":"Analysis of Aqueous Interleukin-6 in Diabetic Retinopathy","authors":"Abhiram R. Manda , Lok Hin Lee PhD , Megan S. Steinkerchner MD , Jinsong Sheng MD , Lindsay Veach , Sapna Gangaputra MD, MPH , Stephen J. Kim MD","doi":"10.1016/j.oret.2025.06.014","DOIUrl":"10.1016/j.oret.2025.06.014","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the relationship of aqueous interleukin-6 (IL-6) with diabetic retinopathy (DR) severity.</div></div><div><h3>Design</h3><div>Prospective, controlled trial at a tertiary academic medical center.</div></div><div><h3>Subjects</h3><div>Three hundred twenty-eight eyes of 164 adult type II diabetic patients with varying levels of DR.</div></div><div><h3>Methods</h3><div>A total of 328 eyes of 164 diabetic patients were enrolled based on DR severity: 46 eyes of 23 patients in the no DR group, 236 eyes of 118 patients in the moderate nonproliferative DR (NPDR) group, and 46 eyes of 23 patients in the proliferative DR (PDR) group. ETDRS visual acuity, spectral-domain OCT, and color fundus photographs were taken at baseline. Blood draw and aqueous sampling of each eye was performed. Blood glucose and hemoglobin A1c (HbA1c) were measured. Aqueous IL-6 was measured using a microparticle bead-based multiplex assay.</div></div><div><h3>Main Outcomes Measures</h3><div>Aqueous IL-6 levels, HbA1c, DR severity, Diabetic macular edema (DME).</div></div><div><h3>Results</h3><div>Median HbA1c differed between the 3 DR groups (<em>P</em> = 0.03), but there was no correlation between IL-6 and HbA1c (ρ = 0.08, <em>P</em> = 0.179). Baseline aqueous IL-6 levels were significantly different between DR groups. Median IL-6 and interquartile range was 5.40 pg/mL (2.99–8.77) for eyes in the no DR group, 9.25 pg/mL (5.35–22.35) for eyes in the moderate NPDR group, and 15.71 pg/mL (9.24–48.58) for eyes in the PDR group (<em>P</em> < 0.001). Median central subfield thickness (CST) did not differ significantly between the 3 groups (<em>P</em> = 0.351), but there was a significant positive correlation between IL-6 and CST (ρ = 0.18, <em>P</em> = 0.001). There was also a significant positive correlation between IL-6 and macular volume (ρ = 0.12, <em>P</em> = 0.031). Increased IL-6 was significantly associated with increased odds of having DME (odds ratio = 1.00, <em>P</em> = 0.015).</div></div><div><h3>Conclusions</h3><div>We report the largest analysis of aqueous IL-6 in diabetic eyes. We observed that IL-6 is significantly associated with DR severity and DME. Our results considerably strengthen the prevailing evidence that IL-6 is a key contributor to the pathogenesis of DR and may represent both a biomarker of disease activity and a novel therapeutic target.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19501,"journal":{"name":"Ophthalmology. Retina","volume":"10 1","pages":"Pages 81-87"},"PeriodicalIF":5.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and Outcomes of Patients with Neovascular Age-Related Macular Degeneration by Anti-VEGF Exposure in United States Clinical Practice 美国临床实践中抗vegf暴露对新生血管性AMD患者的特点和预后影响

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-01 Epub Date: 2025-07-02 DOI: 10.1016/j.oret.2025.06.016

Anita Barikian MD , Jaya B. Kumar MD , April J. McCullough MD , Fabiana Q. Silva MD , Steven Sherman MPH , Kathryn Tanenbaum BA , Hadi Moini PhD , Rishi P. Singh MD

Objective

To assess 1-year visual outcomes of patients in routine clinical practice treated with ≥7 anti-VEGF injections for neovascular age-related macular degeneration (nAMD), baseline characteristics associated with receiving ≥7 anti-VEGF injections, and impact of treatment exposure on visual outcomes.

Design

Retrospective analysis.

Participants

Treatment-naive eyes with baseline best-corrected visual acuity (BCVA) ≥20/400, from patients aged ≥55 years with nAMD diagnosed from January 1, 2013 to December 31, 2019.

Methods

This analysis included eyes from the American Academy of Ophthalmology IRIS Registry® (Intelligent Research in Sight). Visual outcomes were evaluated by treatment exposure (≥7 or <7 intravitreal anti-VEGF injections) through year 1. Baseline factors associated with ≥7 anti-VEGF injections and impact of treatment exposure on visual outcomes were evaluated by logistic regression.

Main Outcome Measures

Best-corrected visual acuity change from baseline by treatment exposure, association between baseline factors and treatment exposure, and magnitude of BCVA change by baseline factors and treatment exposure at year 1.

Results

Of 295 561 eligible eyes, 184 258 actively treated were analyzed (≥7 anti-VEGF injections: 109 696 eyes [59.5%]; <7 injections: 74 562 eyes [40.5%]). At year 1, eyes receiving ≥7 injections achieved greater BCVA gains versus those receiving <7 injections (least squares mean change [95% confidence interval]: +3.4 [3.3–3.5] vs. −0.2 [−0.3 to 0.0] letters). Asian or Black race (vs. White); Hispanic ethnicity (vs. non-Hispanic or Latino); Medicaid insurance (vs. Medicare); and treatment by a nonretina specialist were associated with lower odds of receiving ≥7 injections. For both treatment exposure groups, BCVA <20/200 to 20/400 (vs. 20/100–20/200) was associated with greater visual gains, whereas BCVA >20/80, age ≥85 years (vs. 75–84 years), treatment by a nonretina specialist, and Medicaid insurance were associated with lower BCVA gains.

Conclusions

Over one-third of newly diagnosed eyes with nAMD received <7 anti-VEGF injections and experienced worse visual outcomes at year 1 versus eyes receiving ≥7 injections. Race, insurance type, and physician specialty impacted treatment exposure in nAMD management, whereas age, baseline BCVA, and insurance type impacted visual outcomes regardless of treatment exposure.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：评估常规临床实践中接受≥7次抗vegf注射治疗的新生血管性年龄相关性黄斑变性（nAMD）患者的1年视力结果，接受≥7次抗vegf注射的基线特征，以及治疗暴露对视力结果的影响。设计：回顾性分析。参与者：基线最佳矫正视力(BCVA)≥20/400的未接受治疗的眼睛，来自2013年1月1日至2019年12月31日诊断为nAMD的年龄≥55岁的患者。方法：本分析纳入了美国眼科智能研究学会（AAO） IRIS®注册中心的眼睛。通过第一年的治疗暴露（≥7或< 7次玻璃体内抗vegf注射）来评估视力结果。通过logistic回归评估与≥7次抗vegf注射相关的基线因素以及治疗暴露对视力结果的影响。主要结局指标：治疗暴露后BCVA从基线变化，基线因素与治疗暴露之间的相关性，以及第1年基线因素与治疗暴露后BCVA变化幅度。结果：在295,561只符合条件的眼睛中，分析了184,258只积极治疗的眼睛(≥7次抗vegf注射：109,696只眼睛[59.5%]；< 7针：74,562眼[40.5%])。在第一年，接受≥7次注射的眼睛比接受< 7次注射的眼睛获得了更大的BCVA增益(最小二乘平均变化[95%置信区间；CI: 3.4 +(3.3 - 3.5)和-0.2(-0.3 - 0.0)字母)。亚洲或黑人种族（相对于白人）；西班牙裔（相对于非西班牙裔或拉丁裔）；医疗补助保险（vs.医疗保险）；由非视网膜专科医生治疗与接受≥7次注射的几率较低相关。对于两个治疗暴露组，BCVA < 20/200 -20/400 （vs. 20/100-20/200）与更大的视力增益相关，而BCVA bbb20 /80、年龄≥85岁（vs. 75-84岁）、非视网膜专科医生治疗和医疗补助保险与较低的BCVA增益相关。结论：超过三分之一的新诊断患有nAMD的眼睛接受了< 7次抗vegf注射，与接受≥7次注射的眼睛相比，第一年的视力结果更差。种族、保险类型和医生专业影响nAMD管理的治疗暴露，而年龄、基线BCVA和保险类型影响视力结果，无论治疗暴露如何。

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