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Retraction: MicroRNA-15a inhibits proliferation and induces apoptosis in CNE1 nasopharyngeal carcinoma cells. 撤回:MicroRNA-15a抑制CNE1鼻咽癌细胞增殖并诱导其凋亡
IF 2 4区 医学 Q3 ONCOLOGY Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056899

[This retracts the article DOI: 10.3727/096504016X14611963142290.].

[本文撤回了文章 DOI:10.3727/096504016X14611963142290]。
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引用次数: 0
Retraction: miR-203 suppresses bladder cancer cell growth and targets twist1. 撤稿:miR-203 抑制膀胱癌细胞生长并靶向 twist1。
IF 2 4区 医学 Q3 ONCOLOGY Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056909

[This retracts the article DOI: 10.3727/096504017X15041934685237.].

[本文撤回文章 DOI:10.3727/096504017X15041934685237]。
{"title":"Retraction: miR-203 suppresses bladder cancer cell growth and targets twist1.","authors":"","doi":"10.32604/or.2024.056909","DOIUrl":"https://doi.org/10.32604/or.2024.056909","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.3727/096504017X15041934685237.].</p>","PeriodicalId":19537,"journal":{"name":"Oncology Research","volume":"32 10","pages":"1693-1694"},"PeriodicalIF":2.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: MicroRNA-103 promotes proliferation and inhibits apoptosis in spinal osteosarcoma cells by targeting p57. 撤回:MicroRNA-103 通过靶向 p57 促进脊柱骨肉瘤细胞增殖并抑制其凋亡
IF 2 4区 医学 Q3 ONCOLOGY Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056900

[This retracts the article DOI: 10.3727/096504017X15144741233346.].

[本文撤回文章 DOI:10.3727/096504017X15144741233346]。
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引用次数: 0
Retraction: YEATS domain containing 4 promotes gastric cancer cell proliferation and mediates tumor progression via activating the Wnt/β-Catenin signaling pathway. 撤回:含 YEATS 结构域的 4 通过激活 Wnt/β-Catenin 信号通路促进胃癌细胞增殖并介导肿瘤进展。
IF 2 4区 医学 Q3 ONCOLOGY Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056918

[This retracts the article DOI: 10.3727/096504017X14878528144150.].

[本文收回文章 DOI:10.3727/096504017X14878528144150]。
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引用次数: 0
PD-1+ and TIM-3+ T cells widely express common γ-chain cytokine receptors in multiple myeloma patients, and IL-2, IL-7, IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells. 多发性骨髓瘤患者的 PD-1+ 和 TIM-3+ T 细胞广泛表达共同的 γ 链细胞因子受体,IL-2、IL-7、IL-15 刺激可上调 T 细胞上的 PD-1 和 TIM-3。
IF 2 4区 医学 Q3 ONCOLOGY Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.047893
Egor V Batorov, Alisa D Ineshina, Tatiana A Aristova, Vera V Denisova, Svetlana A Sizikova, Daria S Batorova, Galina Y Ushakova, Ekaterina Y Shevela, Elena R Chernykh

Background: Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma (MM) progression. Simultaneously, previous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with common γ-chain family cytokines in vitro and during homeostatic proliferation. The aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets up-regulating PD-1 and TIM-3 checkpoint molecules.

Methods: The expression of CD25, CD122, CD127 common γ-chain cytokine receptors, phosphorylated signal transducer and activator of transcription-5 (pSTAT5) and eomesodermin (EOMES) was comparatively assessed with flow cytometry in PD-1- and TIM-3-negative and positive T cells before the conditioning and during the first post-transplant month in peripheral blood samples of MM patients.

Results: Substantial proportions of PD-1- and TIM-3-positive T lymphocytes expressed common γ-chain cytokine receptors and pSTAT5. Frequencies of cytokine receptor expressing cells were significantly higher within TIM-3+ T cells compared to PD-1+TIM-3- subsets. Considerable proportions of both PD-1-/TIM-3-negative and positive CD8+ T cells express EOMES, while only moderate frequencies of CD4+ PD-1+/TIM-3+ T cells up-regulate this transcription factor. Besides, the surface presence of CD25 and intranuclear expression of EOMES in CD4+ T cells were mutually exclusive regardless of PD-1 and TIM-3 expression. The stimulation with common γ-chain cytokines up-regulates PD-1 and TIM-3 during the proliferation of initially PD-1/TIM-3-negative T cells but fails to expand initially PD-1+ and TIM-3+ T cell subsets in vitro.

Conclusions: Both PD-1 and TIM-3 expressing T cells appear to be able to respond to homeostatic cytokine stimulation. Differences in common γ-chain cytokine receptor expression between PD-1+ and TIM-3+ T cells may reflect functional dissimilarity of these cell subsets. Checkpoint blockade appears to alleviate lymphopenia-induced proliferation of PD-1+ T cells but may raise the possibility of immune-mediated adverse events.

背景:免疫检查点配体与受体之间的相互作用似乎与多发性骨髓瘤(MM)的进展有关。同时,先前的研究表明,在体外和同种异体增殖过程中,T细胞在常见的γ-链家族细胞因子刺激下可能会表达PD-1和TIM-3。本研究的目的是研究同源增殖对某些上调 PD-1 和 TIM-3 检查点分子的 T 细胞亚群扩增的影响:方法:用流式细胞术比较评估了MM患者外周血样本中PD-1和TIM-3阴性和阳性T细胞在调理前和移植后第一个月的CD25、CD122、CD127常见γ-链细胞因子受体、磷酸化信号转导子和转录激活子-5(pSTAT5)以及表皮生长因子(EOMES)的表达情况:结果:PD-1和TIM-3阳性T淋巴细胞中有相当一部分表达共同的γ-链细胞因子受体和pSTAT5。与 PD-1+TIM-3- 亚群相比,TIM-3+ T 细胞表达细胞因子受体的频率明显更高。相当比例的 PD-1-/TIM-3 阴性和阳性 CD8+ T 细胞都表达 EOMES,而只有中等频率的 CD4+ PD-1+/TIM-3+ T 细胞上调该转录因子。此外,无论 PD-1 和 TIM-3 表达如何,CD4+ T 细胞表面 CD25 的存在和核内 EOMES 的表达是相互排斥的。在最初PD-1/TIM-3阴性的T细胞增殖过程中,普通γ-链细胞因子的刺激会上调PD-1和TIM-3,但却无法在体外扩增最初PD-1+和TIM-3+的T细胞亚群:结论:表达 PD-1 和 TIM-3 的 T 细胞似乎都能对平衡细胞因子刺激做出反应。PD-1+和TIM-3+ T细胞之间共同的γ-链细胞因子受体表达的差异可能反映了这些细胞亚群的功能差异。检查点阻断似乎能缓解淋巴细胞减少症诱导的 PD-1+ T 细胞增殖,但可能会引发免疫介导的不良反应。
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引用次数: 0
Retraction: Long noncoding RNA CAMTA1 promotes proliferation and mobility of the human breast cancer cell line MDA-MB-231 via targeting miR-20b. 撤回:长非编码 RNA CAMTA1 通过靶向 miR-20b 促进人类乳腺癌细胞系 MDA-MB-231 的增殖和移动。
IF 2 4区 医学 Q3 ONCOLOGY Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056894

[This retracts the article DOI: 10.3727/096504017X14953948675395.].

[本文撤回了文章 DOI:10.3727/096504017X14953948675395]。
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引用次数: 0
Retraction: miRNA-497 negatively regulates the growth and motility of chondrosarcoma cells by targeting Cdc25A. 撤稿:miRNA-497 通过靶向 Cdc25A 负向调控软骨肉瘤细胞的生长和运动。
IF 2 4区 医学 Q3 ONCOLOGY Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056919

[This retracts the article DOI: 10.3727/096504016X14519157902681.].

[本文撤回了文章 DOI:10.3727/096504016X14519157902681]。
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引用次数: 0
The role of cholesterol metabolism in lung cancer. 胆固醇代谢在肺癌中的作用。
IF 2 4区 医学 Q3 ONCOLOGY Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.047933
Weigang Xiu, Xingyu Liu, Kaixin Hu, Qin Zhang, Huashan Shi

Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis pathways, through the modulation of receptors and enzymes such as liver X receptor and sterol-regulatory element binding protein 2, effectively restrains lung tumor growth. Similarly, promoting cholesterol excretion yields comparable effects. Cholesterol metabolites, including oxysterols and isoprenoids, play a crucial role in regulating cholesterol metabolism within tumor cells, consequently impacting cancer progression. In lung cancer patients, both the cholesterol levels in the tumor microenvironment and within tumor cells significantly influence cell growth, proliferation, and metastasis. The effects of cholesterol metabolism are further mediated by the reprogramming of immune cells such as T cells, B cells, macrophages, myeloid-derived suppressor cells, among others. Ongoing research is investigating drugs targeting cholesterol metabolism for clinical treatments. Statins, targeting the cholesterol biosynthesis pathway, are widely employed in lung cancer treatment, either as standalone agents or in combination with other drugs. Additionally, drugs focusing on cholesterol transportation have shown promise as effective therapies for lung cancer. In this review, we summarized current research regarding the rule of cholesterol metabolism and therapeutic advances in lung cancer.

血清胆固醇代谢升高与肺癌风险降低有关。胆固醇代谢紊乱在肺癌患者和肿瘤细胞中都很明显。通过调节肝 X 受体和固醇调节因子结合蛋白 2 等受体和酶,抑制肿瘤细胞胆固醇摄取或生物合成途径,可有效抑制肺癌的生长。同样,促进胆固醇排泄也能产生类似的效果。胆固醇代谢产物,包括氧基甾醇和异肾上腺素,在调节肿瘤细胞内的胆固醇代谢方面起着至关重要的作用,从而影响癌症的进展。在肺癌患者中,肿瘤微环境中和肿瘤细胞内的胆固醇水平都会对细胞的生长、增殖和转移产生重大影响。胆固醇代谢的影响通过免疫细胞(如 T 细胞、B 细胞、巨噬细胞、髓源抑制细胞等)的重编程进一步介导。目前正在研究针对胆固醇代谢的临床治疗药物。针对胆固醇生物合成途径的他汀类药物被广泛用于肺癌治疗,既可单独使用,也可与其他药物联合使用。此外,针对胆固醇运输的药物也有望成为肺癌的有效疗法。在这篇综述中,我们总结了目前有关胆固醇代谢规律和肺癌治疗进展的研究。
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引用次数: 0
Research progress on the role of adipocyte exosomes in cancer progression. 关于脂肪细胞外泌体在癌症进展中的作用的研究进展。
IF 2 4区 医学 Q3 ONCOLOGY Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.043482
Yun Wang, Xiaojiang Li, Dalong Liu, Zhifeng Wang, Jichen Xia, Lijun Wang, Xudong Zhang

Exosomes, minute vesicles ubiquitously released by diverse cell types, serve as critical mediators in intercellular communication. Their pathophysiological relevance, especially in malignancies, has garnered significant attention. A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and clinically valuable techniques. The cargo conveyed by exosomes exerts transformative effects on both local and distant microenvironments, thereby influencing a broad spectrum of biological responses in recipient cells. These membrane-bound extracellular vesicles (EVs) play a pivotal role in delivering bioactive molecules among cells and organs. Cellular and biological processes in recipient cells, ranging from stromal cell reprogramming to immunological responses, extracellular matrix formation, and modulation of cancer cell activation, expansion, and metastasis, are subject to exosome-mediated cell-to-cell communication. Moreover, exosomes have been implicated in endowing cancer cells with resistance to treatment. Extensive research has explored the potential of exosomes as therapeutic targets and diagnostic indicators. This comprehensive review seeks to provide an in-depth understanding of the pivotal components and roles of exosomes in tumorigenesis, growth, progression, and therapeutic responses. The insights into the multifaceted involvement of exosomes in malignant cancers are essential for the scientific community, fostering the development of novel therapeutic and diagnostic strategies in the relentless pursuit of cancer.

外泌体是由不同类型细胞释放的微小囊泡,是细胞间通信的关键媒介。外泌体与病理生理学的相关性,尤其是与恶性肿瘤的相关性,已引起人们的极大关注。对外泌体对癌症发展影响的细致探索,为创新和有临床价值的技术开辟了道路。外泌体所携带的货物会对局部和远处的微环境产生改变作用,从而影响受体细胞的各种生物反应。这些膜结合的细胞外囊泡(EVs)在细胞和器官间传递生物活性分子方面发挥着关键作用。受体细胞的细胞和生物过程,从基质细胞重编程到免疫反应、细胞外基质形成,以及癌细胞活化、扩增和转移的调控,都受到外泌体介导的细胞间通讯的影响。此外,外泌体还与赋予癌细胞抗药性有关。大量研究探索了外泌体作为治疗靶点和诊断指标的潜力。这篇综合综述力图让人们深入了解外泌体在肿瘤发生、生长、进展和治疗反应中的关键成分和作用。深入了解外泌体在恶性癌症中的多方面参与对科学界至关重要,有助于开发新的治疗和诊断策略,对癌症穷追不舍。
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引用次数: 0
Retraction: MicroRNA-1284 inhibits cell viability and induces apoptosis of ovarian cancer cell line OVCAR3. 撤回:MicroRNA-1284 抑制卵巢癌细胞株 OVCAR3 的细胞活力并诱导其凋亡
IF 2 4区 医学 Q3 ONCOLOGY Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056905

[This retracts the article DOI: 10.3727/096504016X14685034103518.].

[本文撤回了文章 DOI:10.3727/096504016X14685034103518]。
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引用次数: 0
期刊
Oncology Research
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