Pub Date : 2022-02-02DOI: 10.5772/intechopen.101067
Pinar Kiymet Karataban
Individuals with special needs are the most underserved regarding healthcare needs in almost all populations. Special needs patients with intellectual disability have muscle coordination disorder, impaired oral motor function, drooling, weak muscles that cause chewing and swallowing problems. Also, soft diet consumption makes this population more prone to dental disease. They have more caries, missing teeth, orthodontic and periodontal problems. Besides more difficulties obtaining professional dental care than other segments of the population. Though many countries developed community-based systems to improve oral health for people with special needs, providing good oral health mainly depends on the effort of the families. Therefore the education of the caregiver about oral hygiene provision is also critical for the special needs patient to enjoy a lifetime of oral health the same as other members of the society.
{"title":"Oral Aspects and Dental Management of Special Needs Patient","authors":"Pinar Kiymet Karataban","doi":"10.5772/intechopen.101067","DOIUrl":"https://doi.org/10.5772/intechopen.101067","url":null,"abstract":"Individuals with special needs are the most underserved regarding healthcare needs in almost all populations. Special needs patients with intellectual disability have muscle coordination disorder, impaired oral motor function, drooling, weak muscles that cause chewing and swallowing problems. Also, soft diet consumption makes this population more prone to dental disease. They have more caries, missing teeth, orthodontic and periodontal problems. Besides more difficulties obtaining professional dental care than other segments of the population. Though many countries developed community-based systems to improve oral health for people with special needs, providing good oral health mainly depends on the effort of the families. Therefore the education of the caregiver about oral hygiene provision is also critical for the special needs patient to enjoy a lifetime of oral health the same as other members of the society.","PeriodicalId":19603,"journal":{"name":"Oral Health Care [Working Title]","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77914484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-01DOI: 10.5772/intechopen.101414
Benita C. Percival, A. Wann, S. Taylor, Mark Edgar, Miles Gibson, M. Grootveld
Implementations of high-field nuclear magnetic resonance (NMR) facilities into metabolomics studies are unfortunately restricted by their large dimensions, high costings, and specialist technical staff requirements. Therefore, here the application and practical advantages offered by low-field (60 MHz), compact NMR spectrometers for probing the metabolic profiles of human saliva was explored, as was their value in salivary metabolomics studies. Saliva samples were collected from cigarette smoking (n = 11) and non-smoking (n = 31) human participants. 1H NMR spectra were acquired on both low-field (60 MHz) and medium-field (400 MHz) spectrometers. Metabolomics analyses were employed to evaluate the consistencies of salivary metabolite levels determined, and their abilities to distinguish between smokers and non-smokers. Low-field 1H NMR analysis detected up to 15, albeit permitted the reliable quantification of 5, potentially key diagnostic biomolecules simultaneously (LLOQ values 250–400 μmol/L), although these were limited to those with the most prominent resonances. Such low-field profiles were also found to be suitable for salivary metabolomics investigations, which confirmed the successful discrimination between smoking and non-smoking participant sample donors. Differences observed between these groups were largely ascribable to upregulated salivary levels of methanol, and its metabolite formate, in the smoking group, but higher smoking-mediated concentrations of acetate, propionate and glycine may arise from a diminished salivary flow-rate in these participants. In conclusion, determination of salivary biomolecules using low-field, benchtop 1H NMR analysis techniques were found to be valuable for bioanalytical and metabolomics investigations. Future perspectives for the applications of this non-stationary NMR technique, for example for the on-site ‘point-of-care’ testing of saliva samples for diagnostic oral disease screening purposes at dental surgeries and community pharmacies, are considered.
{"title":"Metabolomics Distinction of Cigarette Smokers from Non-Smokers Using Non-Stationary Benchtop Nuclear Magnetic Resonance (NMR) Analysis of Human Saliva","authors":"Benita C. Percival, A. Wann, S. Taylor, Mark Edgar, Miles Gibson, M. Grootveld","doi":"10.5772/intechopen.101414","DOIUrl":"https://doi.org/10.5772/intechopen.101414","url":null,"abstract":"Implementations of high-field nuclear magnetic resonance (NMR) facilities into metabolomics studies are unfortunately restricted by their large dimensions, high costings, and specialist technical staff requirements. Therefore, here the application and practical advantages offered by low-field (60 MHz), compact NMR spectrometers for probing the metabolic profiles of human saliva was explored, as was their value in salivary metabolomics studies. Saliva samples were collected from cigarette smoking (n = 11) and non-smoking (n = 31) human participants. 1H NMR spectra were acquired on both low-field (60 MHz) and medium-field (400 MHz) spectrometers. Metabolomics analyses were employed to evaluate the consistencies of salivary metabolite levels determined, and their abilities to distinguish between smokers and non-smokers. Low-field 1H NMR analysis detected up to 15, albeit permitted the reliable quantification of 5, potentially key diagnostic biomolecules simultaneously (LLOQ values 250–400 μmol/L), although these were limited to those with the most prominent resonances. Such low-field profiles were also found to be suitable for salivary metabolomics investigations, which confirmed the successful discrimination between smoking and non-smoking participant sample donors. Differences observed between these groups were largely ascribable to upregulated salivary levels of methanol, and its metabolite formate, in the smoking group, but higher smoking-mediated concentrations of acetate, propionate and glycine may arise from a diminished salivary flow-rate in these participants. In conclusion, determination of salivary biomolecules using low-field, benchtop 1H NMR analysis techniques were found to be valuable for bioanalytical and metabolomics investigations. Future perspectives for the applications of this non-stationary NMR technique, for example for the on-site ‘point-of-care’ testing of saliva samples for diagnostic oral disease screening purposes at dental surgeries and community pharmacies, are considered.","PeriodicalId":19603,"journal":{"name":"Oral Health Care [Working Title]","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86927793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-01DOI: 10.5772/intechopen.102064
Elif Nadide Akay
The aim of orthodontic treatment is to improve the esthetics of the teeth and face, to provide a beautiful smile, and an adequate and permanent chewing function. In individuals with insufficient oral hygiene, demineralization begins in the mouth with a very low pH value, and as a result, white spot lesions formed by decalcification of the enamel layer can be seen during orthodontic treatment. Since lesions are the first stage of caries formation, it is possible to stop caries development at this stage. Many methods, such as improving oral hygiene, regulating diets, fluoridated agents, laser, casein phosphopeptide, and microabrasion, are used in the treatment of white spot lesions. Preventive methods are of great importance in terms of preventing future tooth loss and reducing the treatment process. The purpose of this article is to manage white spot lesions in orthodontic treatment and to examine risk factors and preventive methods based on the latest evidence.
{"title":"Preventive Methods and Treatments of White Spot Lesions in Orthodontics","authors":"Elif Nadide Akay","doi":"10.5772/intechopen.102064","DOIUrl":"https://doi.org/10.5772/intechopen.102064","url":null,"abstract":"The aim of orthodontic treatment is to improve the esthetics of the teeth and face, to provide a beautiful smile, and an adequate and permanent chewing function. In individuals with insufficient oral hygiene, demineralization begins in the mouth with a very low pH value, and as a result, white spot lesions formed by decalcification of the enamel layer can be seen during orthodontic treatment. Since lesions are the first stage of caries formation, it is possible to stop caries development at this stage. Many methods, such as improving oral hygiene, regulating diets, fluoridated agents, laser, casein phosphopeptide, and microabrasion, are used in the treatment of white spot lesions. Preventive methods are of great importance in terms of preventing future tooth loss and reducing the treatment process. The purpose of this article is to manage white spot lesions in orthodontic treatment and to examine risk factors and preventive methods based on the latest evidence.","PeriodicalId":19603,"journal":{"name":"Oral Health Care [Working Title]","volume":"186 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76048869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.5772/intechopen.101495
David G. Gillam
The clinician faces numerous challenges when confronted with patients complaining of oro-facial pain, which can involve both dental and non-dental causes. Perhaps one of the most enigmatic clinical conditions that a clinician may encounter is that of dentine hypersensitivity (DH), dentine sensitivity (DS) or root sensitivity (RS), which is both problematic to identify and difficult to treat and may have a major effect on the patient’s quality of life (QoL). Ideally, the clinician needs to prevent or minimize these effects to reduce any unnecessary discomfort for the patient and this may be accomplished through preventive strategies, the provision of the required information about the procedures both pre- and post-treatments as well as reassuring the patient in the event of any subsequent discomfort. Furthermore, it is important for the clinician to be able to correctly diagnose the exact cause of the patient’s discomfort and have the confidence to successfully manage the problem. This chapter aims to cover the relevant aspects for both diagnosing and managing DH with an emphasis on adopting a preventive strategy that will attempt to minimize or eliminate the problem, thereby enabling the patient to have an improved quality of life.
{"title":"Management and Prevention Strategies for Treating Dentine Hypersensitivity","authors":"David G. Gillam","doi":"10.5772/intechopen.101495","DOIUrl":"https://doi.org/10.5772/intechopen.101495","url":null,"abstract":"The clinician faces numerous challenges when confronted with patients complaining of oro-facial pain, which can involve both dental and non-dental causes. Perhaps one of the most enigmatic clinical conditions that a clinician may encounter is that of dentine hypersensitivity (DH), dentine sensitivity (DS) or root sensitivity (RS), which is both problematic to identify and difficult to treat and may have a major effect on the patient’s quality of life (QoL). Ideally, the clinician needs to prevent or minimize these effects to reduce any unnecessary discomfort for the patient and this may be accomplished through preventive strategies, the provision of the required information about the procedures both pre- and post-treatments as well as reassuring the patient in the event of any subsequent discomfort. Furthermore, it is important for the clinician to be able to correctly diagnose the exact cause of the patient’s discomfort and have the confidence to successfully manage the problem. This chapter aims to cover the relevant aspects for both diagnosing and managing DH with an emphasis on adopting a preventive strategy that will attempt to minimize or eliminate the problem, thereby enabling the patient to have an improved quality of life.","PeriodicalId":19603,"journal":{"name":"Oral Health Care [Working Title]","volume":"9 36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78873626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-13DOI: 10.5772/intechopen.101956
Lavinia Cosmina Ardelean, L. Rusu, Codruta Victoria Tigmeanu
Traditionally, a denture base is manufactured using a heat-cured acrylic resin. This type of resin was first used in dental labs in 1936, being a great step forward. Because of the many disadvantages as increased porosity, high water sorption, polymerization shrinkage, allergenic potential and citotoxicity due to the residual monomer, awkward flasking and packaging, and difficult processing, alternatives were continuously searched. Monomer-free and high-impact acrylics were developed, and gold plating of the denture base was experienced, in order to provide an alternative to allergic patients. Once polymers developed, new types of resins, such as polyamides (nylon), acetal, epoxy resins, styrene, polycarbonate, vinyl, urethane, polyether ether ketone (PEEK), became available on the dental market, accompanied by modern technologies, such as injection. CAD/CAM milled and 3D printed denture bases represent the present state of the art in this domain. Our chapter aims to present these alternative materials, which are safe to use in cases of allergic patients and guarantee a healthy oral environment and a high degree of comfort.
{"title":"Alternative Denture Base Materials for Allergic Patients","authors":"Lavinia Cosmina Ardelean, L. Rusu, Codruta Victoria Tigmeanu","doi":"10.5772/intechopen.101956","DOIUrl":"https://doi.org/10.5772/intechopen.101956","url":null,"abstract":"Traditionally, a denture base is manufactured using a heat-cured acrylic resin. This type of resin was first used in dental labs in 1936, being a great step forward. Because of the many disadvantages as increased porosity, high water sorption, polymerization shrinkage, allergenic potential and citotoxicity due to the residual monomer, awkward flasking and packaging, and difficult processing, alternatives were continuously searched. Monomer-free and high-impact acrylics were developed, and gold plating of the denture base was experienced, in order to provide an alternative to allergic patients. Once polymers developed, new types of resins, such as polyamides (nylon), acetal, epoxy resins, styrene, polycarbonate, vinyl, urethane, polyether ether ketone (PEEK), became available on the dental market, accompanied by modern technologies, such as injection. CAD/CAM milled and 3D printed denture bases represent the present state of the art in this domain. Our chapter aims to present these alternative materials, which are safe to use in cases of allergic patients and guarantee a healthy oral environment and a high degree of comfort.","PeriodicalId":19603,"journal":{"name":"Oral Health Care [Working Title]","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85985505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-12DOI: 10.5772/intechopen.101043
Irma Fabiola Díaz-García, Dinorah Munira Hernández-Santos, Julio Alberto Díaz-Ramos, Neyda Ma. Mendoza-Ruvalcaba
The most prevalent oral diseases such as tooth decay and chronic periodontitis, are the main responsible for tooth loss, this causes a disability in the chewing function, which alters the selection of food, the pleasure of eating, and the state of nutrition. Even the use of total prostheses to replace this loss is not always satisfactory. In the emotional sphere, poor oral health causes discomfort and a decrease in self-esteem. Unfortunately, this continues to occur in older people despite the great scientific and technological advances in dentistry today. Health promotion, which includes health education and prevention, must be present in the course of people’s lives. In the prevention of oral diseases, consider not only biological factors as the only causes, but also alleviate and modify the social determinants of the disease. All those involved in the care of the older adults must promote prevention as the most important tool in favor of oral health, and make older people enjoy life with quality. Oral health is an invaluable asset and reward at this stage of life.
{"title":"Oral Health and Prevention in Older Adults","authors":"Irma Fabiola Díaz-García, Dinorah Munira Hernández-Santos, Julio Alberto Díaz-Ramos, Neyda Ma. Mendoza-Ruvalcaba","doi":"10.5772/intechopen.101043","DOIUrl":"https://doi.org/10.5772/intechopen.101043","url":null,"abstract":"The most prevalent oral diseases such as tooth decay and chronic periodontitis, are the main responsible for tooth loss, this causes a disability in the chewing function, which alters the selection of food, the pleasure of eating, and the state of nutrition. Even the use of total prostheses to replace this loss is not always satisfactory. In the emotional sphere, poor oral health causes discomfort and a decrease in self-esteem. Unfortunately, this continues to occur in older people despite the great scientific and technological advances in dentistry today. Health promotion, which includes health education and prevention, must be present in the course of people’s lives. In the prevention of oral diseases, consider not only biological factors as the only causes, but also alleviate and modify the social determinants of the disease. All those involved in the care of the older adults must promote prevention as the most important tool in favor of oral health, and make older people enjoy life with quality. Oral health is an invaluable asset and reward at this stage of life.","PeriodicalId":19603,"journal":{"name":"Oral Health Care [Working Title]","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83736871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-05DOI: 10.5772/intechopen.101506
Diego Romário da Silva, Tahyná Duda Deps, Otavio Akira Souza Sakaguchi, Edja Maria Melo de Brito Costa, Carlus Alberto Oliveira dos Santos, Joanilda Paolla Raimundo e Silva, Bruna Dantas da Silva, Frederico Favaro Ribeiro, Francisco Jaime Bezerra Mendonça-Júnior, Andréa Cristina Barbosa da Silva
Streptococcus mutans (S. mutans) is the most prevalent and most associated with dental caries. Here we aim to identify, through an in silico study, potential bioactive molecules against S. mutans. Twenty-four bioactive molecules with proven action against S. mutans were selected: 1-methoxyficifolinol; 5,7,2′,4′-tetrahydroxy-8-lavandulylflavanone (sophoraflavanone G); 6,8-diprenylgenistein; apigenin; artocarpesin; artocarpin; darbergioidin; dihydrobiochanin A; dihydrocajanin (5,2′,4′-trihydroxy-7-methoxyisoflavanone); erycristagallin; Erystagallin; ferreirin; fisetin; kaempferol; licoricidin; licorisoflavan A; licorisoflavan C; licorisoflavan E; luteolin (3′,4′,5,7-tetrahydroxyflavone); malvidin-3,5-diglucoside; myricetin; orientanol B; quercetin; and quercitrin. Moreover, we selected nine important target proteins for the virulence of this microorganism to perform as drug targets: antigen I/II (region V) (PDB: 1JMM); Antigen I/II (carbox-terminal region) (PDB: 3QE5); Spap (PDB: 3OPU); UA159sp signaling peptide (PDB: 2I2J); TCP3 signaling peptide (PDB: 2I2H); ATP-binding protein ComA (PDB: 3VX4); glucanosucrase (PDB: 3AIC); dextranase (PDB: 3VMO), and Hemolysin (PDB: 2RK5). Five molecules were revealed to be the best ligands for at least three target proteins, highlighting the following compounds: 11 (erystagallin), 10 (erycristagallin), 1 (methoxyficifonilol), 20 (malvidin-3,5-diglucoside), and 2 (sophoraflavanone G), which indicates a possible multi-target action of these compounds. Therefore, based on these findings, in vitro and in vivo tests should be performed to validate the effectiveness of these compounds in inhibiting S. mutans virulence factors. Furthermore, the promising results of these assays will allow the incorporation of these phytoconstituents in products for oral use for the control of tooth decay.
{"title":"Molecular Docking of Phytochemicals against Streptococcus mutans Virulence Targets: A Proteomic Insight into Drug Planning","authors":"Diego Romário da Silva, Tahyná Duda Deps, Otavio Akira Souza Sakaguchi, Edja Maria Melo de Brito Costa, Carlus Alberto Oliveira dos Santos, Joanilda Paolla Raimundo e Silva, Bruna Dantas da Silva, Frederico Favaro Ribeiro, Francisco Jaime Bezerra Mendonça-Júnior, Andréa Cristina Barbosa da Silva","doi":"10.5772/intechopen.101506","DOIUrl":"https://doi.org/10.5772/intechopen.101506","url":null,"abstract":"Streptococcus mutans (S. mutans) is the most prevalent and most associated with dental caries. Here we aim to identify, through an in silico study, potential bioactive molecules against S. mutans. Twenty-four bioactive molecules with proven action against S. mutans were selected: 1-methoxyficifolinol; 5,7,2′,4′-tetrahydroxy-8-lavandulylflavanone (sophoraflavanone G); 6,8-diprenylgenistein; apigenin; artocarpesin; artocarpin; darbergioidin; dihydrobiochanin A; dihydrocajanin (5,2′,4′-trihydroxy-7-methoxyisoflavanone); erycristagallin; Erystagallin; ferreirin; fisetin; kaempferol; licoricidin; licorisoflavan A; licorisoflavan C; licorisoflavan E; luteolin (3′,4′,5,7-tetrahydroxyflavone); malvidin-3,5-diglucoside; myricetin; orientanol B; quercetin; and quercitrin. Moreover, we selected nine important target proteins for the virulence of this microorganism to perform as drug targets: antigen I/II (region V) (PDB: 1JMM); Antigen I/II (carbox-terminal region) (PDB: 3QE5); Spap (PDB: 3OPU); UA159sp signaling peptide (PDB: 2I2J); TCP3 signaling peptide (PDB: 2I2H); ATP-binding protein ComA (PDB: 3VX4); glucanosucrase (PDB: 3AIC); dextranase (PDB: 3VMO), and Hemolysin (PDB: 2RK5). Five molecules were revealed to be the best ligands for at least three target proteins, highlighting the following compounds: 11 (erystagallin), 10 (erycristagallin), 1 (methoxyficifonilol), 20 (malvidin-3,5-diglucoside), and 2 (sophoraflavanone G), which indicates a possible multi-target action of these compounds. Therefore, based on these findings, in vitro and in vivo tests should be performed to validate the effectiveness of these compounds in inhibiting S. mutans virulence factors. Furthermore, the promising results of these assays will allow the incorporation of these phytoconstituents in products for oral use for the control of tooth decay.","PeriodicalId":19603,"journal":{"name":"Oral Health Care [Working Title]","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88649933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-22DOI: 10.5772/intechopen.101477
Tracey Lynn Harney
Periodontitis is a globally prevalent inflammation-mediated disease that can result in varying degrees of destruction to the tissues supporting the teeth. The microbial pathogenic dysbiosis, oxidative stress, and deregulated inflammation, found in patients with periodontitis, make it a multifaceted condition that is difficult to fully resolve. Further to this, periodontitis has been associated with other systemic inflammatory conditions. Trans-resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a plant-derived molecule present in many foods, which have been shown to exhibit antimicrobial, antioxidant, anti-inflammatory, and regenerative properties. However, trans-resveratrol has been reported to have physicochemical shortcomings, which make its clinical translation a challenge. This review outlines a critical analysis of identified samples from the scientific literature that was conducted to assess the potential of RES as a viable therapeutic for periodontitis. The potential for the improvement of the limiting pharmacological profile of trans-resveratrol via nanoformulation is also explored.
{"title":"Evaluation of Trans-Resveratrol as a Treatment for Periodontitis","authors":"Tracey Lynn Harney","doi":"10.5772/intechopen.101477","DOIUrl":"https://doi.org/10.5772/intechopen.101477","url":null,"abstract":"Periodontitis is a globally prevalent inflammation-mediated disease that can result in varying degrees of destruction to the tissues supporting the teeth. The microbial pathogenic dysbiosis, oxidative stress, and deregulated inflammation, found in patients with periodontitis, make it a multifaceted condition that is difficult to fully resolve. Further to this, periodontitis has been associated with other systemic inflammatory conditions. Trans-resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a plant-derived molecule present in many foods, which have been shown to exhibit antimicrobial, antioxidant, anti-inflammatory, and regenerative properties. However, trans-resveratrol has been reported to have physicochemical shortcomings, which make its clinical translation a challenge. This review outlines a critical analysis of identified samples from the scientific literature that was conducted to assess the potential of RES as a viable therapeutic for periodontitis. The potential for the improvement of the limiting pharmacological profile of trans-resveratrol via nanoformulation is also explored.","PeriodicalId":19603,"journal":{"name":"Oral Health Care [Working Title]","volume":"193 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75536171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-24DOI: 10.5772/intechopen.101116
T. Nakamoto, Alexander U. Falster, William B. Simmons Jr
Caffeine and theobromine are members of the xanthine family. Coffee and soft drinks contain caffeine, whereas, in cacao, theobromine is the main ingredient. The mineral contents of the tooth which sucked the caffeine-containing dam’s milk were decreased. To determine if caffeine would affect enamel, dams were fed with a caffeine and pups were killed and first and second molars were extracted. Enamel was exposed to the acid solution and dissolved minerals from the enamel were measured. Calcium, phosphorus and magnesium from the first molars of the caffeine group were significantly dissolved. To determine why minerals were released, enamel was separated. The crystallite size of the enamel from the caffeine group showed decreased. If the pups with the same dietary regimen, but given a cariogenic diet, the caffeine group should show a higher incidence of dental caries. The caffeine group revealed higher caries scores. An in vitro experiment to grow apatite crystals was conducted, adding the various members of the xanthine. Theobromine produced larger crystal sizes than caffeine. Theobromine was added to the maternal diet. Dissolution experiments revealed that these minerals were far less dissolved. Comparative studies of the various parameters between theobromine and fluoride were conducted. Theobromine was superior to fluoride in every aspect.
{"title":"The Contrasting Effects between Caffeine and Theobromine on Crystallization: How the Non-fluoride Dentifrice Was Developed","authors":"T. Nakamoto, Alexander U. Falster, William B. Simmons Jr","doi":"10.5772/intechopen.101116","DOIUrl":"https://doi.org/10.5772/intechopen.101116","url":null,"abstract":"Caffeine and theobromine are members of the xanthine family. Coffee and soft drinks contain caffeine, whereas, in cacao, theobromine is the main ingredient. The mineral contents of the tooth which sucked the caffeine-containing dam’s milk were decreased. To determine if caffeine would affect enamel, dams were fed with a caffeine and pups were killed and first and second molars were extracted. Enamel was exposed to the acid solution and dissolved minerals from the enamel were measured. Calcium, phosphorus and magnesium from the first molars of the caffeine group were significantly dissolved. To determine why minerals were released, enamel was separated. The crystallite size of the enamel from the caffeine group showed decreased. If the pups with the same dietary regimen, but given a cariogenic diet, the caffeine group should show a higher incidence of dental caries. The caffeine group revealed higher caries scores. An in vitro experiment to grow apatite crystals was conducted, adding the various members of the xanthine. Theobromine produced larger crystal sizes than caffeine. Theobromine was added to the maternal diet. Dissolution experiments revealed that these minerals were far less dissolved. Comparative studies of the various parameters between theobromine and fluoride were conducted. Theobromine was superior to fluoride in every aspect.","PeriodicalId":19603,"journal":{"name":"Oral Health Care [Working Title]","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84538784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-22DOI: 10.5772/intechopen.101187
G. Krishnamoorthy, Aparna I. Narayana, Dhanasekar Balakrishnan
As dental implant treatment has become a part of mainstream dental therapy, it is imperative to implement dental implant maintenance guidelines to achieve the long-term success of implant prostheses. Earlier, the success of a dental implant was mainly focused on the surgical phase to achieve good primary stability, with time, this belief has taken a major paradigm shift towards implementing and ensuring a periodic recall and following a maintenance phase for dental implants to achieve long-term success. As the dental team strives to attain and maintain the long-term success of implant prostheses, the patient should also recognize that their contribution towards the success of implant prostheses is also equally indispensable. This chapter highlights the importance of maintaining oral hygiene in implant rehabilitated patients and enumerates the implant maintenance protocol to be followed along with the different in-home and in-office procedures which can be implemented to achieve long-term success of the implant and peri-implant structures.
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