Pub Date : 2021-06-14DOI: 10.37219/2528-8253-2021-3-71
O. Semenyuk, Oksana Moskalyk
Topicality: The problem of diagnosis and treatment of otitis externa (OE) has been posed to doctors for a long time, and until the discovery of antibiotics (AB) and antifungal drugs (AFD) remained unresolved. OE can affect up to 10% of people at different periods of their lives, manifesting itself in the form of acute OE (AOE) in 95% of cases after the age of 2 years. There is a reduction in the number of patients admittance to the ENT specialist with the onset of the COVID-19 pandemic while maintaining the structure of the pathology, where AOE - in the top three of frequency. At the same time, there are a reports of an increasing amount of AOE cases in patients with COVID-19. Aim: To evaluate the dynamics of pain, the need for additional analgesia, systemic antibacterial therapy (ABT) or topical antifungal therapy (TAT), the level of compliance in patients with AOE in empirical treatment with a complex drug «Candibiotic» in comparison with protocol treatment. Material and methods: The study included adults and children from 2 years of age with a diagnosis of AOE: 30 patients in the main (17 adults, 13 children) and 25 patients in the control (15 adults, 10 children) groups. Patients in the main group as a basic treatment received topical ear drops «Candibiotic». Patients in the control group received protocol treatment. If necessary, patients were additionally prescribed analgesic therapy (ibuprofen in the appropriate dose), systemic ABT or TAT. For subjective pain asses, a visual analog scale (VAS) was used. Compliance was assessed using the Morisky-Green questionnaire. The obtained results were processed by common statistical methods. Results and discussion: In the main group of patients receiving «Candibiotic», there were fewer needs for additional systemic analgesia, systemic ABT, no one needed additional TAT. Comparison of the obtained results (percentage) in the form of arbitrary tables using the chi-squared test established that the relationship between factor and performance traits is not statistically significant (p>0.05). The mean compliance score between the two study groups differed significantly as a whole and separately between the groups of adults and children (p<0.05). Conclusion: In patients of adult and pediatric age with a diagnosis of AOE at the initial empirical appointment of the drug «Candibiotic» there was less need for additional analgesia, the appointment of systemic ABT and AFT. Such results did not differ statistically significantly from the results in adult and pediatric patients who were prescribed protocol treatment of AOE. Patients with «Candibiotic» monotherapy had a significantly higher average compliance score compared with the control group, especially among parents of children with AOE. The complex composition of ear drops «Candibiotic» contributes to a high adherence to treatment in patients, and the lack of an absolute analogue makes it the means of choice for the initial empirical treatment of AOE in adult
{"title":"Ways to increase compliance in patients with acute otitis externa","authors":"O. Semenyuk, Oksana Moskalyk","doi":"10.37219/2528-8253-2021-3-71","DOIUrl":"https://doi.org/10.37219/2528-8253-2021-3-71","url":null,"abstract":"Topicality: The problem of diagnosis and treatment of otitis externa (OE) has been posed to doctors for a long time, and until the discovery of antibiotics (AB) and antifungal drugs (AFD) remained unresolved. OE can affect up to 10% of people at different periods of their lives, manifesting itself in the form of acute OE (AOE) in 95% of cases after the age of 2 years. There is a reduction in the number of patients admittance to the ENT specialist with the onset of the COVID-19 pandemic while maintaining the structure of the pathology, where AOE - in the top three of frequency. At the same time, there are a reports of an increasing amount of AOE cases in patients with COVID-19.\u0000Aim: To evaluate the dynamics of pain, the need for additional analgesia, systemic antibacterial therapy (ABT) or topical antifungal therapy (TAT), the level of compliance in patients with AOE in empirical treatment with a complex drug «Candibiotic» in comparison with protocol treatment.\u0000Material and methods: The study included adults and children from 2 years of age with a diagnosis of AOE: 30 patients in the main (17 adults, 13 children) and 25 patients in the control (15 adults, 10 children) groups. Patients in the main group as a basic treatment received topical ear drops «Candibiotic». Patients in the control group received protocol treatment. If necessary, patients were additionally prescribed analgesic therapy (ibuprofen in the appropriate dose), systemic ABT or TAT. For subjective pain asses, a visual analog scale (VAS) was used. Compliance was assessed using the Morisky-Green questionnaire. The obtained results were processed by common statistical methods.\u0000Results and discussion: In the main group of patients receiving «Candibiotic», there were fewer needs for additional systemic analgesia, systemic ABT, no one needed additional TAT. Comparison of the obtained results (percentage) in the form of arbitrary tables using the chi-squared test established that the relationship between factor and performance traits is not statistically significant (p>0.05). The mean compliance score between the two study groups differed significantly as a whole and separately between the groups of adults and children (p<0.05).\u0000Conclusion: In patients of adult and pediatric age with a diagnosis of AOE at the initial empirical appointment of the drug «Candibiotic» there was less need for additional analgesia, the appointment of systemic ABT and AFT. Such results did not differ statistically significantly from the results in adult and pediatric patients who were prescribed protocol treatment of AOE. Patients with «Candibiotic» monotherapy had a significantly higher average compliance score compared with the control group, especially among parents of children with AOE. The complex composition of ear drops «Candibiotic» contributes to a high adherence to treatment in patients, and the lack of an absolute analogue makes it the means of choice for the initial empirical treatment of AOE in adult","PeriodicalId":19612,"journal":{"name":"OTORHINOLARYNGOLOGY No3(4) 2021","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91091651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-14DOI: 10.37219/2528-8253-2021-3-22
O. Melnikov, D. Zabolotny, A. Bredun, V. Kishchuk
Experimental work carried out over the past 20 years to study the activity of various functional groups in tonsillar cells in patients with chronic tonsillitis (CT) under local exposure to various immune response modifiers showed that: - tonsillar cells from CT patients in 69.5% of cases are capable of increasing their immunofunctional activity under the influence of immune modifiers in vitro reactions; - the most active of the group of immunotropic immune response modifiers are T-activin and Thymogen; - it can be considered the optimal diagnostic technique to carry out a "stress" test on the tonsil tissue using nonspecific (alternating magnetic field of industrial (low) frequency and low-frequency ultrasound) and specific — a microbial vaccine when applied to the tonsil tissue; - a non-invasive method for recording changes in the tonsils after stimulation may be fluctuations in the level of secretory immunoglobulin A and α-interferon in saliva after the test; - an increase in the level of secretory immunoglobulin A and α-interferon by more than 1/3 of the initial level after the test is a clinically favorable sign and a recommendation for medical treatment to the managing of patients with CT.
{"title":"Immunodiagnostics, immunotherapy and immunoprophylaxis in otorhinolaryngological practice.\u0000Report 3. Diagnostic approaches to the palatine tonsils functional state assessment for selecting a treatment strategy for patients with chronic tonsillitis (analytical summary)","authors":"O. Melnikov, D. Zabolotny, A. Bredun, V. Kishchuk","doi":"10.37219/2528-8253-2021-3-22","DOIUrl":"https://doi.org/10.37219/2528-8253-2021-3-22","url":null,"abstract":"Experimental work carried out over the past 20 years to study the activity of various functional groups in tonsillar cells in patients with chronic tonsillitis (CT) under local exposure to various immune response modifiers showed that:\u0000- tonsillar cells from CT patients in 69.5% of cases are capable of increasing their immunofunctional activity under the influence of immune modifiers in vitro reactions;\u0000- the most active of the group of immunotropic immune response modifiers are T-activin and Thymogen;\u0000- it can be considered the optimal diagnostic technique to carry out a \"stress\" test on the tonsil tissue using nonspecific (alternating magnetic field of industrial (low) frequency and low-frequency ultrasound) and specific — a microbial vaccine when applied to the tonsil tissue;\u0000- a non-invasive method for recording changes in the tonsils after stimulation may be fluctuations in the level of secretory immunoglobulin A and α-interferon in saliva after the test;\u0000- an increase in the level of secretory immunoglobulin A and α-interferon by more than 1/3 of the initial level after the test is a clinically favorable sign and a recommendation for medical treatment to the managing of patients with CT.","PeriodicalId":19612,"journal":{"name":"OTORHINOLARYNGOLOGY No3(4) 2021","volume":"1999 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88282185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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