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Intracapsular High-Grade Ductal Carcinoma In-Situ Ex Pleomorphic Adenoma of the Lacrimal Gland. 泪腺原位多形性腺瘤囊内高级别导管癌。
Pub Date : 2019-11-13 DOI: 10.1097/IOP.0000000000001491
Roya Garakani, R. Kersten, M. Pekmezci
Primary ductal adenocarcinoma of the lacrimal gland is an aggressive neoplasm and can be seen either as a de novo malignancy or in the setting of a carcinoma ex pleomorphic adenoma. Carcinoma ex pleomorphic adenoma carries an overall unfavorable outcome; however, prognosis depends on the type and grade of the malignant component, presence of retained myoepithelial component, and extend of invasion beyond the capsule. Herein, the authors describe a 78-year-old man diagnosed with an incidental, intracapsular, high-grade ductal adenocarcinoma in situ ex pleomorphic adenoma, who is free of disease at 9 months subsequent to complete resection. It is important to recognize the morphologic features of intraductal and intracapsular neoplasms to prevent unnecessary morbidities due to extensive surgical interventions or radiotherapy.
原发性泪腺导管腺癌是一种侵袭性肿瘤,既可视为新发恶性肿瘤,也可视为癌前多形性腺瘤。癌前多形性腺瘤具有总体上不利的结果;然而,预后取决于恶性成分的类型和分级,保留的肌上皮成分的存在,以及侵犯到囊外的范围。在此,作者描述了一位78岁的男性,被诊断为偶发的,囊内的,高级别导管腺癌原位多形性腺瘤,在完全切除后9个月无疾病。重要的是认识导管内和囊内肿瘤的形态学特征,以防止因广泛的手术干预或放疗而导致不必要的发病率。
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引用次数: 1
Proptosis in a Patient With Known Graft Versus Host Disease. 已知移植物抗宿主病患者的突起
Pub Date : 2019-11-01 DOI: 10.1097/IOP.0000000000001469
L. Tan, W. Hwang, A. Looi
A retrospective review of the medical reports of a patient who was undergoing treatment for graft versus host disease following bone marrow transplant for acute myeloid leukemia was conducted. The patient presented with persistent ocular irritation and injection. For an unclear period of time, he developed proptosis and binocular diplopia with limitation of extraocular motility insidiously. MRI revealed gross enlargement of extraocular muscles and bone marrow aspiration trephine confirmed relapse of leukemia. He then underwent chemotherapy with marked improvement of proptosis and extraocular motility. This case report highlights the importance of the eye care provider's careful assessment of patients with a history of malignancy. The presence of ocular irritation must not distract from the detection of other signs. Proptosis and extraocular motility limitation are rarely associated with graft versus host disease. The presence of these signs warrants orbital imaging to rule out recurrence of the primary malignancy.This case report highlights how proptosis and extraocular motility limitation seen in a patient with graft versus host disease may point to recurrence of the primary malignancy.
对一例急性髓性白血病骨髓移植后接受移植物抗宿主病治疗的患者的医学报告进行回顾性分析。患者表现为持续的眼部刺激和注射。在不清楚的时间内,他出现了眼球突出和双眼复视,并伴有眼外运动不明显的限制。MRI显示眼外肌肿大及骨髓穿刺证实白血病复发。术后接受化疗,眼球突出和眼外运动明显改善。本病例报告强调了眼科保健提供者对有恶性肿瘤病史的患者进行仔细评估的重要性。眼部刺激的存在不能分散对其他体征的检测。眼球突出和眼外运动受限很少与移植物抗宿主病相关。这些征象的存在需要眼眶成像来排除原发恶性肿瘤的复发。本病例报告强调了移植物抗宿主病患者的突起和眼外运动限制如何可能表明原发恶性肿瘤复发。
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引用次数: 4
Re: "Ocular Cosmetics: . 回复:“眼部化妆品:。
Pub Date : 2019-11-01 DOI: 10.1097/iop.0000000000001487
Gabriella Schmuter
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引用次数: 0
Clinicopathological Features and Outcomes in Lymphoma of Extraocular Muscles. 眼外肌淋巴瘤的临床病理特征及预后。
Pub Date : 2019-11-01 DOI: 10.1097/IOP.0000000000001426
Edwina L Eade, T. Hardy, P. Mckelvie, A. McNab
PURPOSETo describe the clinicopathological features and report the outcomes of treatment in lymphoma involving the extraocular muscles (EOM), the largest reported case-series.METHODSA retrospective case series of patients with lymphoma involving the EOM from a single tertiary referral orbital center, between March 1992 and March 2018. Patients with other histopathologic diagnoses or who did not have an EOM biopsy were excluded. The main outcome measures were histologic evaluation and clinical follow-up including tumor response, recurrence, and survival.RESULTSTwenty-five patients were included, 16 female; 9 male; median age 64.7 years (range 33.8-92.6 years). Unilateral involvement was present in 23 cases (92%). Lymphoma was found to be primary in 15 patients (60%), and any EOM could be affected by disease. Fourteen patients (56%) displayed impaired duction in the direction of the affected muscle. The commonest histologic type was extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in 16 cases (64%) followed by follicular lymphoma in 3 cases (12%), diffuse large B-cell lymphoma in 2 cases (8%), gamma delta T-cell lymphoma in 2 cases (8%), small lymphocytic lymphom and lymphoplasmacytic lymphoma in 1 case each (4%). All 4 patients with high-grade lymphomas (diffuse large B-cell or T cell lymphoma) were found to have systemic disease. Patients were treated with combinations of radiotherapy, chemotherapy, or immunotherapy, with low toxicity. Two patients developed treatment-related complications. With a median follow-up of 26 months (range 3-108 months), there was only 1 recurrence, which was successfully salvaged with Rituximab, and no deaths due to lymphoma.CONCLUSIONSLymphoma of the EOM is a rare tumor with good response to treatment, few treatment-related complications and low risk of recurrence or mortality.
目的描述眼外肌淋巴瘤(EOM)的临床病理特征和治疗结果,这是报道的最大的病例系列。方法回顾性分析1992年3月至2018年3月间来自单一三级转诊眼眶中心的累及EOM的淋巴瘤患者。有其他组织病理学诊断或没有EOM活检的患者被排除在外。主要观察指标为组织学评价和临床随访,包括肿瘤反应、复发和生存。结果共纳入25例患者,其中女性16例;9男;中位年龄64.7岁(33.8-92.6岁)。单侧受累23例(92%)。15例患者(60%)发现原发性淋巴瘤,任何EOM都可能受到疾病的影响。14例患者(56%)表现为受累肌肉方向的诱导功能受损。最常见的组织学类型为结外粘膜相关淋巴组织边缘区淋巴瘤16例(64%),其次为滤泡性淋巴瘤3例(12%),弥漫性大b细胞淋巴瘤2例(8%),γ δ t细胞淋巴瘤2例(8%),小淋巴细胞淋巴瘤和淋巴浆细胞淋巴瘤各1例(4%)。所有4例高级别淋巴瘤(弥漫性大b细胞或T细胞淋巴瘤)患者均发现有全身性疾病。患者采用低毒性的放疗、化疗或免疫治疗联合治疗。两名患者出现治疗相关并发症。中位随访26个月(范围3-108个月),只有1例复发,利妥昔单抗成功挽救,无淋巴瘤死亡。结论EOM淋巴瘤是一种罕见的肿瘤,治疗效果好,治疗相关并发症少,复发和死亡风险低。
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引用次数: 2
Myopathic Blepharoptoses: A New Classification System. 肌病性上睑下垂:一个新的分类系统。
Pub Date : 2019-11-01 DOI: 10.1097/IOP.0000000000001405
M. Burnstine, Christine Greer, Diana K. Lee, Jonathan W. Kim
PURPOSEMyopathic blepharoptoses (ptoses) is a complex group of disorders. To date, no formal categorization scheme has been developed based on associated ocular and systemic findings, genetic fingerprint, treatment, and prognosis for each ptosis in this group. We report a new classification scheme for myopathic ptoses.METHODSLiterature review and classification development.RESULTSA new classification scheme of myopathic ptoses includes isolated static myopathic ptosis (congenital ptosis), static myopathic ptosis associated with aberrant innervation and those associated with periocular abnormalities, and progressive myopathic ptoses that affect the levator muscle and other muscle groups in childhood and adulthood.CONCLUSIONSMaking the distinction of myopathic ptosis type early will maximize patient outcomes by optimizing surgical and systemic management and facilitating the recruitment of subspecialists to care for patients with these challenging conditions.
目的:痉挛性上睑下垂是一组复杂的疾病。到目前为止,还没有正式的分类方案是基于相关的眼部和全身的发现,遗传指纹,治疗和预后的每一个上睑下垂组。我们报告一种新的肌病性上睑下垂的分类方案。方法文献复习和分类发展。结果新的肌病性上睑下垂分类方案包括孤立性静态肌病性上睑下垂(先天性上睑下垂)、伴有神经支配异常和眼周异常的静态肌病性上睑下垂、儿童期和成人期影响提上肌和其他肌群的进行性肌病性上睑下垂。结论及早区分肌病性上睑下垂类型,通过优化手术和系统管理,促进招募专科医生来照顾这些具有挑战性的患者,可以最大限度地提高患者的预后。
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引用次数: 5
Visual Outcomes of Patients With Retrobulbar Hemorrhage Undergoing Lateral Canthotomy and Cantholysis. 球后出血患者行侧眦切开术和眦松解术的视觉效果。
Pub Date : 2019-11-01 DOI: 10.1097/IOP.0000000000001401
Lucy A. Bailey, Alexandra J van Brummen, Layla M Ghergherehchi, A. Chuang, K. Richani, M. Phillips
PURPOSEEvaluate visual outcomes in relation to time from injury to intervention in patients who undergo lateral canthotomy with cantholysis (LCC) for retrobulbar hemorrhage (RBH).METHODSRetrospective study of patients with orbital compartment syndrome (OCS) secondary to RBH who underwent LCC. OCS due to RBH was defined by a combination of decreased vision, proptosis, resistance to retropulsion, increased intraocular pressure, and relative afferent pupillary defect. Time from injury to intervention and change in visual acuity were calculated, with regression analysis identifying predictors of vision recovery.RESULTSFifteen participants were included. Three (20%) participants presented with no light perception, 7 (47%) with count fingers (CF) to light perception, and 5 (33%) with better than count fingers vision. All 5 participants who had LCC within 3 hours (twice the standard 90 minutes) gained some vision, and 6 of 10 participants who had LCC after 3 hours recovered some vision. The latest intervention with visual acuity improvement was performed 9 hours postinjury. Of 3 participants who presented with no light perception vision, 1 regained vision to 20/40 (intervention 1.7 hours postinjury), and 2 did not regain any vision (interventions at 5 and 8.7 hours postinjury). Duration from injury to intervention was associated with decreased amount of vision recovery (P = 0.03).CONCLUSIONSIncreased time to intervention with LCC was associated with less vision recovery after OCS from RBH. However, over half of participants with intervention more than 90 minutes after injury still showed visual acuity improvement. The authors recommend LCC in all patients who present with OCS regardless of the time since injury.Patients with orbital compartment syndrome may see visual recovery after lateral canthotomy and cantholysis, even if performed outside of the previously accepted 3-hour window.
目的评价因球后出血(RBH)而行侧眦切开术伴眦松解(LCC)治疗的患者从损伤到干预的时间与视力的关系。方法回顾性分析RBH继发眼眶间室综合征(OCS)行LCC的患者。RBH引起的OCS被定义为视力下降、眼球突出、抗后移、眼压升高和相对传入瞳孔缺损。计算从受伤到干预的时间和视力的变化,并通过回归分析确定视力恢复的预测因素。结果共纳入15例受试者。3名(20%)参与者没有光知觉,7名(47%)参与者有数指(CF)光知觉,5名(33%)参与者有数指以上的视觉。所有5名在3小时内(两倍于标准90分钟)患有LCC的参与者都恢复了一些视力,10名在3小时后患有LCC的参与者中有6人恢复了一些视力。视力改善的最新干预在损伤后9小时进行。在3名无光感视力的参与者中,1名视力恢复到20/40(损伤后1.7小时干预),2名未恢复任何视力(损伤后5小时和8.7小时干预)。从受伤到干预的持续时间与视力恢复的减少有关(P = 0.03)。结论LCC干预时间的延长与RBH OCS术后视力恢复的减少有关。然而,在受伤后超过90分钟的干预中,超过一半的参与者仍然表现出视力的改善。作者推荐对所有出现OCS的患者进行LCC治疗,无论损伤时间。眶间室综合征患者在侧眦切开术和眦松解术后,即使在先前接受的3小时窗口之外,也可以看到视力恢复。
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引用次数: 5
Surgical Management of a Recurrent Odontogenic Keratocyst With Orbital and Temporal Fossa Invasion. 侵袭眶颞窝复发性牙源性角化囊肿的手术治疗。
Pub Date : 2019-11-01 DOI: 10.1097/IOP.0000000000001477
C. Brookes, G. Harris
Odontogenic keratocyst is a benign locally aggressive odontogenic cyst with a high recurrence rate. This report presents an unusual case of a recurrent odontogenic keratocyst with zygomatic bone involvement and orbital and temporal extension resulting in globe compression. Odontogenic keratocyst is reviewed, and surgical management of the cyst is discussed.The authors present a case of a recurrent odontogenic keratocyst involving the zygoma with orbital and temporal invasion; aggressive surgical resection and reconstruction was required.
牙源性角化囊肿是一种局部侵袭性的良性牙源性囊肿,复发率高。本文报告一例罕见的复发性牙源性角化囊肿伴颧骨受累,眶部和颞部延伸导致眼球受压。本文回顾了牙源性角化囊肿,并讨论了囊肿的手术治疗。作者提出一个复发性牙源性角化囊肿累及眼眶和颞侵犯颧骨的病例;需要积极的手术切除和重建。
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引用次数: 1
Conjunctival Trichodiscoma of the Lower Eyelid. 下眼睑结膜毛状纤维瘤。
Pub Date : 2019-11-01 DOI: 10.1097/IOP.0000000000001470
N. Kasturi, P. Chavhan, Ghag Gaurav Ramakant, Athira Devaraj, R. Babu, Rajesh N G
Trichodiscomas are benign tumors of the skin which develop around a hair follicle. They usually present on the face, neck, or trunk region. The authors report a rare case of a 63-year-old man who presented with a tumor on the left lower eyelid that was histologically proven to be a trichodiscoma of conjunctival origin.
毛癣是发生在毛囊周围的良性皮肤肿瘤。它们通常出现在面部、颈部或躯干区域。作者报告了一例罕见的63岁男性左下眼睑肿瘤,经组织学证实为结膜起源的毛状纤维瘤。
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引用次数: 0
Scanning Electron Microscopic Features of the Canalicular Entrance Into the Lacrimal Sac. 泪囊小管入口的扫描电镜特征。
Pub Date : 2019-11-01 DOI: 10.1097/IOP.0000000000001467
M. Ali
PURPOSE The aim of this study was to examine the ultrastructural features of the canalicular entrance into the lacrimal sac. METHODS Ten openings of the common canaliculus into the lacrimal sac from 10 lacrimal sacs obtained during a dacryocystectomy were studied. Each of the openings were completely excised with 3-4 mm margins on all sides and transported to the laboratory in 2.5% glutaraldehyde. The analysis was performed using the standard protocols of scanning electron microscopy (SEM). The openings, their edges, canalicular lacrimal sac-mucosal folds, and internal surfaces were studied. RESULTS Of the 10 common canalicular openings studied, the upper and lower canaliculi opened into a common canaliculus in all the cases. The terminal portion of the 2 canaliculi had a common wall, which appeared like a septum, just proximal to the beginning of the dilated common canalicular portion. In 60% (6/10) of the cases, a diverticular or a type III sinus of Maier (SOM) was noted. The surface of this diverticulum was smooth and lined by stratified columnar epithelium, reflecting its lacrimal sac origins. Interestingly, the junction of the epithelial change from stratified squamous to columnar could be appreciated clearly in 80% (8/10) of the cases and was mostly located just within from the edge of the internal common opening (ICO). The canalicular lacrimal sac-mucosal folds could be appreciated in 70% (7/10) samples, being very defined and prominent in 30% (3/10). CONCLUSIONS The common merged wall of the 2 canaliculus is the most proximal and prominent structure noted on an end-on view of the ICO. Diverticular variant of the sinus of Maier is common. The junction of the epithelial change from stratified squamous to columnar is appreciated just within the edge of the ICO.
目的观察泪囊小管入口的超微结构特征。方法对泪囊切除术后获得的10个泪囊中泪小管的10个开口进行了研究。每个开口都完全切除,四周留有3-4 mm的边缘,用2.5%戊二醛运输到实验室。采用扫描电子显微镜(SEM)标准方案进行分析。研究了泪囊开口及其边缘、泪囊小管-粘膜褶皱和内部表面。结果所研究的10个小管开口均为上小管和下小管合开。2小管的末端部分有一个共同的壁,它看起来像隔膜,就在扩张的小管总部分开始的近端。在60%(6/10)的病例中,注意到憩室或III型迈尔窦(SOM)。憩室表面光滑,内衬层状柱状上皮,反映其泪囊起源。有趣的是,在80%(8/10)的病例中,上皮从分层鳞状变为柱状的交界处可以清楚地看到,并且大多数位于内共开口(ICO)边缘。70%(7/10)的样本可以看到泪管-粘膜褶皱,30%(3/10)的样本非常明确和突出。结论:2小管的共同合并壁是髂胫束的最近、最突出的结构。梅尔窦憩室变型是常见的。从分层鳞状上皮变为柱状上皮的交界处仅在ICO边缘内可见。
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引用次数: 8
Orbital Extension of a Frontal Bone Intradiploic Epidermoid Cyst. 额骨盆腔内表皮样囊肿的眼眶延伸。
Pub Date : 2019-11-01 DOI: 10.1097/iop.0000000000001358
S. Diniz, F. Chahud, A. Cruz
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引用次数: 2
期刊
Ophthalmic Plastic & Reconstructive Surgery
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