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Biomaterials for Organoid Modeling and Tumor Spheroids 类器官建模和肿瘤球体生物材料
Pub Date : 2022-08-30 DOI: 10.54565/jphcfum.1143395
Ş. Berk
Organoids are miniature forms of organs to demonstrate spatio-temporal cellular structure and tissue function. The organoids creation revolutionized developmental biology and provided the opportunity to study and modify human development and disease in laboratory setting. Recently, new biomaterial-guided culture systems have represented the versatility for designing and producing of organoids in a constant and reproducible manner. Since 2D cell culture models often lack in vivo tissue architecture, recent detailed research has allowed many 3D culture models development demonstrating the characteristics of in vivo organ structure and function. Organoid models are able to create 3D structures complex that maintain multiple cell types and also hide the relevant organ functions in vivo, and therefore, the development of organoids in particular has revolutionized developmental biology, disease modeling, and drug discovery. The new biomaterials production has been important for development of in vitro 3D models. Further work with biomaterials has been on the creation of hybrid polymers that combine the advantages of both synthetic and natural polymers to take place of communal materials such as Matrigel and polydimethylsiloxane (PDMS). The creation of 3D culture systems has also revolutionized in vitro drug testing. Furthermore, recreating the three-dimensional environment of tumors and the functional arrangement of cancer cells has been a major motivation for developing new tumor models. Under defined culture conditions, cancer cells can form three-dimensional structures known as spheroids and advances in development of embryonic to self-organize into three-dimensional cultures known as organoids. These newly designed biomaterials using for tumor modeling will make an important contribution to understand the main mechanisms of cancer.
类器官是展示时空细胞结构和组织功能的微缩器官。类器官的创造彻底改变了发育生物学,并提供了在实验室环境中研究和修改人类发育和疾病的机会。近年来,新的生物材料引导培养系统代表了以恒定和可复制的方式设计和生产类器官的多功能性。由于二维细胞培养模型往往缺乏体内组织结构,最近的详细研究使许多三维培养模型得以发展,展示了体内器官结构和功能的特征。类器官模型能够创建复杂的3D结构,维持多种细胞类型,并隐藏体内相关的器官功能,因此,类器官的发展特别是已经彻底改变了发育生物学,疾病建模和药物发现。新型生物材料的生产对体外3D模型的发展具有重要意义。与生物材料的进一步合作是创建混合聚合物,结合合成和天然聚合物的优点,以取代常用材料,如Matrigel和聚二甲基硅氧烷(PDMS)。3D培养系统的创建也彻底改变了体外药物测试。此外,重建肿瘤的三维环境和癌细胞的功能排列已成为开发新肿瘤模型的主要动力。在特定的培养条件下,癌细胞可以形成被称为球体的三维结构,胚胎发育的进展可以自组织成被称为类器官的三维培养物。这些新设计的用于肿瘤建模的生物材料将为了解癌症的主要机制做出重要贡献。
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引用次数: 0
Theoretical inhibitor Calculation for Synthesis of Two New thiazole Derivatives 两种新型噻唑衍生物合成的理论抑制剂计算
Pub Date : 2022-06-14 DOI: 10.54565/jphcfum.1121438
P. Koparir
Abstract: Two newly thiazole (1-(4-(3-methyl-3-phenylcyclobutyl)thiazol-2-yl)-3-(4-nitrophenyl)thiourea and 1-(4-methoxyphenyl)-3-(4-(3-methyl-3-phenylcyclobutyl)thiazol-2-yl)thiourea were synthesise. The molecular formula was characterized using Fourier-Transform Infrared (FT-IR) spectroscopy and Nuclear Magnetic Resonance (NMR). Theoretical vibration was calculated using Gaussian 09W software, and corrosion inhibiting activity was calculated using quantum chemical calculations. Furthermore, the GaussView 5.0 package on the B3LYP/6-311G(d,p) method was used to calculate the energy of the highest occupied molecular orbital (EHOMO), the energy lowest unoccupied molecular orbital (ELUMO)the energy gap (E = ELUMO - EHOMO), the dipole moment (µ), and the percent of transmitted electrons (ΔN). Based on the results of inhibitor activity, other molecular properties such as hardness (ɳ), softness (σ), and electronegativity (χ) were calculated. Quantum chemical calculations were used to predict the corrosion inhibiting activities of the derivatives. As a result, the corrosion inhibitor behavior can be predicted without the need for an experimental study. The results show a strong relationship between organic-based corrosion inhibitors and the process's quantum chemical parameters.
摘要:合成了两种新型噻唑(1-(4-(3-甲基-3-苯基环丁基)噻唑-2-基)-3-(4-硝基)硫脲和1-(4-甲氧基苯基)-3-(4-(3-甲基-3-苯基环丁基)噻唑-2-基)硫脲。利用傅里叶变换红外光谱(FT-IR)和核磁共振(NMR)对分子式进行了表征。理论振动计算采用Gaussian 09W软件,缓蚀活性计算采用量子化学计算。利用B3LYP/6-311G(d,p)方法上的GaussView 5.0软件包计算了最高已占据分子轨道(EHOMO)的能量、最低未占据分子轨道(ELUMO)的能量、能隙(E = ELUMO - EHOMO)、偶极矩(µ)和透射电子百分比(ΔN)。根据抑制剂活性的结果,计算了其他分子性质,如硬度(%)、柔软度(σ)和电负性(χ)。利用量子化学计算预测了衍生物的缓蚀活性。因此,不需要进行实验研究就可以预测缓蚀剂的行为。结果表明,有机基缓蚀剂与过程的量子化学参数之间存在很强的关系。
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引用次数: 0
KINETICS STUDY OF BBD OPTIMIZED ADSORPTION OF ERIOCHROME BLACK T DYE USING ALUMINA BEADS 氧化铝微球吸附铬黑t染料的动力学研究
Pub Date : 2022-05-25 DOI: 10.54565/jphcfum.1095968
A. bello, A. Hamisu, Naziru Muhammad Alhassan
Numerous approaches have been investigated for the development of cheaper and more effective technologies to improve the quality of industrial effluent. However, adsorption has been one of the most simplest and economical remediation technology in the treatment of wastewaters. In this study, commercial alumina beads (Al-beads) were utilized for the adsorption of Eriochrome Black T dye. The adsorption process was optimized using the RSM model by Box-Behnken Design (BBD). From the optimization result, the most influential variables are; the initial dye concentration, the interaction between adsorbent dosage with itself, and that of adsorbent dosage with initial dye concentration. The R2 value of 0.7743 implies that 77.43% on the percent dye removal could be due to the variation in the independent variable. Whereas the Adeq. precision of 6.493, and lack of fit (0.92) implies the model can be used to navigate the design space. Up to 98.28%, dye removal was attained using the Al-beads under the conditions; pH of 12.39, adsorbent dosage (1.25 g), and initial dye concentration (175 ppm). The sorption data indicated that the adsorption process was fitted to Freundlich and Temkin isotherm models, while for the kinetics study, the pseudo-second-order model was the best fit. Furthermore, the adsorption mechanism was found to be governed majorly by intra-particle diffusion with some contribution from external mass transfer diffusion.
为了开发更便宜、更有效的技术来改善工业废水的质量,已经研究了许多方法。而吸附是目前污水处理中最简单、最经济的修复技术之一。在本研究中,利用商业氧化铝珠(al -珠)吸附了铬黑T染料。采用Box-Behnken设计(BBD)的RSM模型对吸附过程进行优化。从优化结果来看,影响最大的变量是;染料初始浓度,吸附剂用量与自身的相互作用,吸附剂用量与染料初始浓度的相互作用。R2值为0.7743,说明77.43%的去除率可能是由自变量的变化引起的。而Adeq。精度为6.493,缺乏拟合(0.92)意味着该模型可以用于导航设计空间。在此条件下,铝珠的去除率高达98.28%;pH为12.39,吸附剂用量(1.25 g),初始染料浓度(175 ppm)。吸附数据表明,吸附过程符合Freundlich和Temkin等温模型,而在动力学研究中,拟二阶模型最适合。吸附机制主要受颗粒内扩散控制,外部传质扩散也有一定贡献。
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引用次数: 0
Study of the dynamic modulus of elasticity of sand concrete containing crushed sand 含碎砂砂混凝土动弹性模量的研究
Pub Date : 2022-04-06 DOI: 10.54565/jphcfum.1070879
Oday Z. Jaradat
This research work deals with study of the dynamic modulus of elasticity of sand concrete containing crushed sand. As the crushed sand was replaced by river sand in three different proportions which are 10%, 20% and 30% respectively. In this paper, the flexural strength, ultrasonic pulse velocity, and the dynamic modulus of elasticity will be examined. The results obtained showed that the sample consisting of 30%crushed sand +70% river sand, gave the best result for all the studied experiments.
本课题研究的是含碎砂砂混凝土的动弹性模量。采用河砂代替破碎砂,比例分别为10%、20%和30%。本文将对其抗弯强度、超声脉冲速度和动弹性模量进行检测。结果表明,30%破碎砂+70%河砂的试样在各试验中效果最好。
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引用次数: 0
A review on Physical Properties of CdS Thin Film CdS薄膜物理性质的研究进展
Pub Date : 2022-02-22 DOI: 10.54565/jphcfum.1026213
R. Hussei̇n, A. Jafir
CdS Cadmium Sulfide is the important semiconductor materials. Semiconductors are solids with conductivities ranged from 104 to 10-10 (n cm)-l. The properties of CdS are structural, Electrical and Optical. We examine a number of papers published between 1983 and 2015 that created CdS thin films in a variety of ways, including chemical bath deposition, spray pyrolysis, thermal evaporation, close spaced sublimation, and pulsed laser ablation. They found band gap energy in (eV), Refractive index (n) and Extension coefficient (k). X-ray diffraction, the researchers employed energy dispersive X-ray spectroscopy with scanning electron microscopy in this study. The crystallinity the quality of the movie improves after annealing, As a result, optical transmittance is reduced. The structure is hexagonal in general. All of the films are ideal as efficient for solar cell applications, there are a number of different window layers that may be used. Due to their high transmittance and low resistance values. These findings suggest that CBD films with a broad Low resistivity, high mobility, and a high carrier concentration are all characteristics of the band gap. Produced at pH 11 are ideal contenders for use in various optoelectronic devices.
硫化镉是重要的半导体材料。半导体是电导率在104到10-10 (n cm)- 1之间的固体。cd具有结构性质、电学性质和光学性质。我们研究了1983年至2015年间发表的一些论文,这些论文以各种方式制备了CdS薄膜,包括化学浴沉积、喷雾热解、热蒸发、紧密间隔升华和脉冲激光烧蚀。他们发现了带隙能量(eV),折射率(n)和延伸系数(k)。x射线衍射,研究人员在本研究中使用了扫描电子显微镜下的能量色散x射线光谱学。退火后薄膜的结晶度和质量得到改善,从而降低了透光率。结构一般是六边形的。所有的薄膜都是理想的高效太阳能电池应用,有许多不同的窗口层可以使用。由于其高透光率和低电阻值。这些发现表明,具有宽、低电阻率、高迁移率和高载流子浓度的CBD薄膜都是带隙的特征。pH值为11的产品是各种光电器件的理想竞争者。
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引用次数: 0
INVESTIGATION ON PROCESS OF THE WATER RADIOLYSIS IN THE NANO Si+H2O SYSTEM UNDER THE INFLUENCE OF GAMMA – QUANTA γ -量子影响下纳米Si+H2O体系水辐射分解过程的研究
Pub Date : 2022-02-19 DOI: 10.54565/jphcfum.1052234
G. Imanova
The radiation-chemical yield of the molecular hydrogen received under the influence of gamma quanta (60Co, P=22Rad/s, T=300K) to liquid water of constant volume (V=5 ml) in the process of a radiolysis of water at change of weight (m=0.01; 0.02; 0.06 and 0.12 g) and sizes of silicon particle (d=50 nanometers) is defined. It has been revealed that at increase in mass of the silicon added to water the radiation-chemical yield of the molecular hydrogen received in the process of a water radiolysis grows in direct ratio (m0.02 g) the stationary area is observed. In the Si+H2O system the maximum radiation-chemical yield of molecular hydrogen is equal to 10,9 molecules / 100eV at the sizes of silicon particle d=50 nanometer respectively. The mechanism explaining the received results is offered.
在γ量子(60Co, P=22Rad/s, T=300K)的影响下,水在质量变化(m=0.01;0.02;0.06和0.12 g)和硅颗粒尺寸(d=50纳米)的定义。结果表明,随着硅加入水中质量的增加,水辐射分解过程中接收到的分子氢的辐射化学产率成正比增长(m0.02 g)。在Si+H2O体系中,在硅颗粒尺寸d=50纳米时,分子氢的最大辐射化学产率分别为10,9分子/ 100eV。给出了解释接收结果的机制。
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引用次数: 0
A Review on DPA for computing radiation damage simulation 辐射损伤模拟计算的DPA研究进展
Pub Date : 2022-02-18 DOI: 10.54565/jphcfum.1027393
H. Qadr, D. Mamand
A Monte Carlo code is developed for the radiation damage in the metals which results from nuclear collisions that create energetic recoil atoms of the host material. The development of the simulation codes for the radiation damage method by neutrons and protons can be highly useful in technology of advanced nuclear systems and nuclear fusion reactors. The aim of this review is to investigate the impact of the radiation damage in the materials by the neutron and proton energy irradiation. The damage parameter used in the evaluation is displacement per atom (DPA) in material as a function of neutron and proton energy. For this purpose, there are some software codes used which are related to radiation damage because radiation damage can be measured as a function of DPA, which is one of the critical issues for high intensity beams, particularly, for protons and neutrons.
提出了一种蒙特卡罗代码,用于计算由核碰撞引起的金属辐射损伤,这种碰撞产生了宿主材料的高能反冲原子。中子和质子辐射损伤方法仿真代码的开发在先进核系统和核聚变反应堆技术中具有重要的应用价值。本文综述了中子和质子能量辐照对材料辐射损伤的影响。评估中使用的损伤参数是材料中每原子位移(DPA)作为中子和质子能量的函数。为此目的,使用了一些与辐射损伤有关的软件代码,因为辐射损伤可以作为DPA的函数来测量,这是高强度光束,特别是质子和中子的关键问题之一。
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引用次数: 3
Determination of Eigenvalues and Eigenvectors of the Orbital Angular Momentum. 轨道角动量特征值和特征向量的确定。
Pub Date : 2022-02-17 DOI: 10.54565/jphcfum.1026837
Kishwar Mohammed Wasman, S. Mawlud
The theory of angular momentum performance a significant position in the classical and quantum mechanical study of physical properties, such as studies into nuclear, atomic, and molecular processes, as well as other quantum problems, including spherical symmetry. In this analysis, angular momentum operators are described in multiple ways, based on the angular momentum operator's commutator, matrix, and geometric representation, The eigenvalue and eigenvector were also known for operatorsJ ̂_±,J ⃑ ̂^2, J ̂_x,J ̂_y and J ̂_zwithin the |j,┤ ├ m⟩ basis. Furthermore, in quantum mechanics, angular momentum is called quantized variable, meaning that it comes in discrete quantities. In contrast to the macroscopic system case where a continuous variable is angular momentum.
角动量理论在物理性质的经典和量子力学研究中占有重要地位,例如对核、原子和分子过程的研究,以及其他量子问题,包括球对称。在这个分析中,角动量算符以多种方式描述,基于角动量算符的换向子,矩阵和几何表示,特征值和特征向量也为算符sj³±,J⃑³^2,J³x,J³y和J³³在| J,│├m⟩基中已知。此外,在量子力学中,角动量被称为量子化变量,这意味着它是离散量。与宏观系统的情况相反连续变量是角动量。
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引用次数: 0
Photodetectors Based on Doped-ZNO Nanoparticle: Synthesis and Optoelectrical Property 掺杂zno纳米粒子的光电探测器:合成及其光电性能
Pub Date : 2022-02-16 DOI: 10.54565/jphcfum.1026868
Kishwar Mohammed Wasman, Bestoon Hamadameen
Photodetection has been gained a lot of attention in last years biased on military wide range and civil application. With essential properties of Zno which has the wide band gap, strong radiation hardness, low cost and good chemical stabilities. ZnO are considered as the most successful candidate for UV photodetector. The study of our report is to review photodetectors based on doped Zno nanostructures and the new advances in ZnO nanostructured generation technique including adjustment and doping methods with modifications of ZnO photodetector. Final part of this review is about literature reviews were reported in recent years about optoelectrical property of Zno nanostructures, due to the fact that Zinc oxide is an important semiconductor material for optoelectronic and industrial applications, such solar cell, photosensors and photodetectors.
近年来,光探测技术得到了广泛的关注,并在军事和民用方面得到了广泛的应用。具有带隙宽、辐射硬度强、成本低、化学稳定性好等Zno的基本特性。氧化锌被认为是最成功的紫外光电探测器的候选材料。本文综述了基于掺杂Zno纳米结构的光电探测器,以及Zno纳米结构制备技术的最新进展,包括调整和掺杂方式对Zno光电探测器的修饰。由于氧化锌是一种重要的半导体材料,可用于太阳能电池、光传感器和光电探测器等光电和工业应用,因此本文最后对近年来氧化锌纳米结构的光电性能进行了文献综述。
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引用次数: 0
Surface Texturing Method for Solar Cell Efficiency Enhancement 提高太阳能电池效率的表面纹理化方法
Pub Date : 2022-01-02 DOI: 10.54565/jphcfum.1026209
R. Hussei̇n, Dilshad S. Ismael
Sun oriented cell are also known as Photoelectric (PE) cells, which labor to transform sunlight specifically into electricity, Photoelectric cells are attached electric powered and conveniently arranged within a wide outline known as a sun based board. The efficiency of the sun powered cell is turns on the number of consume photons which are absorbed in the consumer sheet of sun powered cell. However, the low absorption rate of the absorber material and light reflection in the surface of material and the material interfaces of the glass absorbers will reduce the conversion of solar energy. The effect of the energy conversion can be upgrade by modifying the surface morphology of the solar cell. In this article review of Exterior by different Texturing Method to increase efficiency enhancement, minimum waste energy of light of the sun and to get a maximum efficiency for the Sun Powered Cell Effective Upgrade has been investigated.
面向太阳的电池也被称为光电(PE)电池,它的工作是将阳光转化为电能,光电电池是附着在电力上的,并且方便地排列在一个被称为太阳基板的宽轮廓内。太阳能电池的效率取决于太阳能电池消耗片吸收的光子的数量。然而,吸收材料的低吸收率以及材料表面和玻璃吸收材料界面的光反射将降低太阳能的转换。通过改变太阳能电池的表面形态,可以提高能量转换的效果。本文综述了采用不同的外部纹理方法来提高效率,减少太阳光能的浪费,获得最大的效率,为太阳能电池的有效升级进行了研究。
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引用次数: 2
期刊
Journal of Physical Chemistry and Functional Materials
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