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Isthmic spondylolisthesis: the current state of the problem 峡部滑脱:问题的现状
Pub Date : 2022-12-27 DOI: 10.17650/1683-3295-2022-24-4-101-10
B. R. Kinzyagulov, V. Lebedev, A. Zuev
Isthmic spondylolisthesis is a common pathology in the population, often diagnosed in people of working age. On the issues of etiopathogenesis, as well as the classification of this pathology, researchers have no consensus. Currently, the literature provides different opinions on clinical features, evaluation, and treatment tactics. The presented work includes current information from the world literature on the etiology, classification, clinics, diagnostics, and treatment of patients with isthmic spondylolisthesis.The purpose of the work is to present current information from the world literature on the features of etiology, classification, clinic, diagnosis, treatment of patients with isthmic spondylolisthesis.
峡部滑脱是人群中常见的一种病理,通常在工作年龄的人群中被诊断出来。在其发病机制及病理分类等问题上,研究者尚无共识。目前,文献对其临床特征、评价及治疗策略均有不同看法。所提出的工作包括目前的信息,从世界文献的病因,分类,临床,诊断和治疗的峡部滑脱患者。这项工作的目的是介绍目前的信息,从世界文献的特点,病因,分类,临床,诊断,治疗的峡部滑脱患者。
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引用次数: 0
A clinical case of a combined approach to restoring post-traumatic deformation of the bones of the arch and base of the skull, bones of the middle zone of the face 联合入路修复创伤后颅弓骨、颅底骨、面部中部骨变形的临床一例
Pub Date : 2022-12-26 DOI: 10.17650/1683-3295-2022-24-4-67-72
V. Komar, T. M. Yaroshchik, O. Dudich, K. V. Andryuk, A. A. Vecherskaya
Background. The article is extremely relevant due to growing traumatism, current condition of craniofacial traumatology, debatable and incomplete tactics of restoring traumatic defects and deformations of bones of the skull and face. Plastic surgery of the skull defects has developed from simple defect closure to restoring an aesthetically attractive area of the skull, which shape repeats the individual structure of the area lost due to trauma or surgical treatment (trepanation surgery, osteoplastic trepanation, treatment of a depressed skull fracture, etc.). To restore the defects specialists use auto‑ and allografts. In recent years, materials to manufacture implants are simulated using a 3D‑shape.Aims. To describe the clinical case of a combined approach for the restoration of post‑traumatic deformation of the bones of the arch, base of the skull and bones of the middle zone of the face. To show the importance of multidisciplinary teams in providing assistance to this group of patients, as well as the use of individual 3D simulated titanium plates for reconstructive operations. Emphasize the need to perform reconstructive operations as soon as possible.Materials and methods. Patient Sh., 43 years old, was admitted to the neurosurgical department of the City Clinical Emergency Hospital (Minsk), in the long term severe traumatic brain injury, with defects of the arch and base of the skull and deformation of the bones of the facial skull on the left. Titanium implants were modeled on a 3D printer, which were used during the operation performed by a multidisciplinary team consisting of a neurosurgeon, maxillofacial surgeon and ophthalmologist‑surgeon. Us for closing defects in the cranial vault, the bottom wall of the orbit and in eliminating deformation skeleton midface line. Titanium implants are made by specialists of Medbiotech SP LLC, Minsk, Republic of Belarus.Results. The late postoperative period proceeded without peculiarities, the wounds healed by primary tension. Post-operative CT showed that the condition of the implants is satisfactory.Conclusion. This clinical observation demonstrated the need for a multidisciplinary approach, as well as the priority in using 3D simulated titanium implants to restore post‑traumatic deformation of the bones of the arch and base of the skull and midline bones.
背景。由于创伤的不断扩大,颅面创伤学的现状,修复颅骨和面部创伤性骨缺损的策略有争议和不完整,这篇文章是非常相关的。颅骨缺损的整形手术已经从简单的缺损闭合发展到恢复颅骨美观的区域,该区域的形状重复了因创伤或手术治疗(钻孔手术,骨塑钻孔手术,凹陷性颅骨骨折治疗等)而丢失的区域的个体结构。为了修复缺陷,专家们使用自体和同种异体移植。近年来,制造植入物的材料使用3D - shape.Aims进行模拟。描述一种联合方法修复创伤后弓骨、颅底骨和面部中部骨变形的临床病例。为了展示多学科团队在为这组患者提供帮助方面的重要性,以及在重建手术中使用单个3D模拟钛板。强调需要尽快进行重建手术。材料和方法。患者Sh., 43岁,长期严重创伤性脑损伤,入院于市临床急救医院(明斯克)神经外科,颅骨弓和底部缺损,左侧面部颅骨骨变形。钛植入物在3D打印机上建模,由神经外科医生、颌面外科医生和眼科医生组成的多学科团队在手术过程中使用。用于闭合颅穹窿、眶底壁缺损及消除骨中线变形。钛植入物是由白俄罗斯共和国明斯克Medbiotech SP LLC的专家制造的。术后后期无特殊情况,伤口因原发张力愈合。术后CT显示种植体状况良好。这一临床观察表明需要多学科的方法,以及优先使用3D模拟钛植入物来恢复创伤后变形的弓骨、颅底骨和中线骨。
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引用次数: 0
Endoscopic lavage of the cerebral ventricular system for ventriculitis treatment in a patient with complicated new coronavirus infection (COVID‑19) 内镜下脑室系统灌洗治疗1例合并新型冠状病毒感染(COVID - 19)的脑室炎
Pub Date : 2022-12-26 DOI: 10.17650/1683-3295-2022-24-4-73-83
K. E. Poshataev, D. L. Paskhin, A. M. Dorodov, R. V. Zabolotnyy, S. Mironov, P. V. Kuzmin, A. Avdalyan, E. Shtemplevskaya
Introduction. The new coronavirus infection (COVID‑19) has a wide spectrum of complications. Frequency of neurological symptoms varies between 17.3 and 36.4 %. In 8 % of cases, COVID‑19 can be accompanied by bacterial or fungal infection. Since few descriptions of bacterial meningitis in adult patients with COVID‑19 and a single description of surgical treatment of purulent meningitis complicated by empyema of the 4th ventricle in a patient with COVID‑19 were found, and there are no meta‑analyses in this area, descriptions of such cases are of high scientific and practical value.Aim. The describe a case of surgical treatment of purulent ventriculitis in an adult (during treatment of the new coronavirus infection COVID‑19).Materials and methods. A man, 69 years old, with previously established diagnosis of the new coronavirus infection COVID‑19 and a comorbid pathology was admitted to the Moscow City Clinical Hospital No. 40 with newly diagnosed seizure disorder. Computed tomography imaging showed ventriculitis confirmed by MRI with obstructive hypertensive triventricular hydrocephalus.Results. The patient underwent treatment: three‑time endoscopic lavage of the ventricular system, removal of newly formed fibrin membranes with interventricular septostomy, removal of obstruction at the level of the Sylvian aqueduct; the surgery was concluded by external draining of the lateral ventricles, administration of an antibiotic intro the ventricular system and intravenously. Cerebrospinal fluid flow was restored, ventriculitis manifestations completely negated.Conclusion. Development of ventriculitis as one of the first signs of bacterial infection accompanying COVID‑19 is a very rare and life‑threatening complication requiring active surgical intervention. In was shown that endoscopic lavage of the ventricular system for ventriculitis treatment is an effective action against infection and cerebrospinal fluid flow disorders. Use of intraventricular endoscopy for ventriculitis treatment has several advantages compared to needle ventriculostomy. Further studies and analysis of treatment of bacterial ventriculitis using endoscopic surgical techniques in patients with and without the new coronavirus infection are needed.
介绍。新型冠状病毒感染(COVID - 19)具有广泛的并发症。神经症状的发生频率在17.3%到36.4%之间。在8%的病例中,COVID - 19可伴有细菌或真菌感染。由于对成年COVID - 19患者细菌性脑膜炎的描述较少,对1例COVID - 19患者化脓性脑膜炎合并第四脑室脓肿的手术治疗的描述单一,且该领域未进行meta分析,故对此类病例的描述具有较高的科学和实用价值。报告1例成人化脓性脑室炎的手术治疗(在治疗新型冠状病毒感染COVID - 19期间)。材料和方法。一名69岁男性,先前确诊为新型冠状病毒感染COVID - 19,并伴有共病病理,因新诊断的癫痫发作而入住莫斯科市第40临床医院。计算机断层扫描显示脑室炎,MRI证实阻塞性高血压性三室脑积水。患者接受了以下治疗:三次内窥镜灌洗脑室系统,采用室间隔造口术去除新形成的纤维蛋白膜,去除Sylvian导水管水平的阻塞;手术通过侧脑室外引流,脑室系统内和静脉注射抗生素结束。脑脊液恢复正常,脑室炎症状完全消失。脑室炎作为伴随COVID - 19的细菌感染的最初迹象之一,是一种非常罕见的危及生命的并发症,需要积极的手术干预。结果表明,脑室炎的内窥镜灌洗是治疗脑脊液感染和脑脊液流动障碍的有效手段。与脑室针造口术相比,使用脑室内窥镜治疗脑室炎有几个优点。需要进一步研究和分析新型冠状病毒感染患者和非感染患者应用内窥镜手术技术治疗细菌性脑室炎的情况。
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引用次数: 0
Commentary 评论
Pub Date : 2022-12-26 DOI: 10.17650/1683-3295-2022-24-4-84
Иван Михайлович Годков
.
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引用次数: 0
Surgical treatment of cerebrovascular diseases in a hybrid operating room 混合手术室脑血管病的外科治疗
Pub Date : 2022-12-26 DOI: 10.17650/1683-3295-2022-24-4-12-21
A. V. Sergeev, V. Cherebillo, A. Savello, F. Chemurzieva
Background. Surgical treatment of complex neurovascular pathology remains an important problem requiring use of a combination of various techniques. Utilization of a hybrid operating room allows to simultaneously or sequentially combine microsurgical and endovascular surgical methods which can improve treatment outcomes.Aim. To improve surgical treatment of patients with cerebrovascular pathology by utilizing the capabilities of a hybrid operating room.Materials and methods. Surgical interventions were performed in a hybrid operating room with a combination of endovascular and microsurgical methods for treating the following cerebrovascular pathologies: complex dural fistulas, complex aneurysms, arteriovenous malformations. The type of surgical intervention – hybrid, combined, staged – was chosen in accordance with the nature of the pathology.Results. In 5 years, 41 patients underwent surgery in the hybrid operating room. Among them, 33 patients had arteriovenous malformations, 6 had complex aneurysms, 2 had complex dural fistulas. Combination interventions were performed in 27 patients, staged – in 12, hybrid – in 2. According to the Modified Rankin Scale (mRS) the following outcomes were observed: no complications in cases of complex aneurysms (6 patients) – mRS 0 (points), as well as in cases of dural fistulas (2 patients) – mRS 0 (points); in arteriovenous malformation, 30 patients did not have any complications – mRS 0; 3 patients had complications (of different types) – mRS 1.Conclusions. The combination of microsurgical and endovascular methods of treatment in a hybrid operating room allows to combine the positive features of the two methods in accordance with surgical needs which improves the outcomes of neurosurgical interventions in complex neurovascular pathology.
背景。复杂神经血管病理的外科治疗仍然是一个重要的问题,需要使用各种技术的组合。利用混合手术室可以同时或依次结合显微外科和血管内手术方法,提高治疗效果。目的:利用混合手术室的功能,提高脑血管病变患者的手术治疗水平。材料和方法。采用血管内与显微手术相结合的混合手术室,对复杂硬脑膜瘘、复杂动脉瘤、动静脉畸形等脑血管病变进行手术治疗。手术干预的类型-混合,联合,分期-是根据病理性质选择的。5年内,41例患者在混合手术室接受手术。其中动静脉畸形33例,复杂动脉瘤6例,复杂硬膜瘘2例。联合干预27例,分阶段干预12例,混合干预2例。根据改良Rankin量表(mRS)观察以下结果:复杂动脉瘤(6例)无并发症- mRS 0(分),硬膜瘘管(2例)- mRS 0(分);动静脉畸形30例无并发症,mRS 0;3例患者出现不同类型的并发症。在混合手术室中结合显微外科和血管内治疗方法,可以根据手术需要结合两种方法的优点,提高神经外科干预复杂神经血管病理的效果。
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引用次数: 0
Metabolic navigation during brain tumor surgery: analysis of a series of 403 patients 脑肿瘤手术中的代谢导航:403例患者的分析
Pub Date : 2022-12-26 DOI: 10.17650/1683-3295-2022-24-4-46-58
S. Goryaynov, A. Potapov, V. Okhlopkov, A. Batalov, R. Afandiev, A. Belyaev, A. Aristov, T. A. Caveleva, V. Zhukov, V. Loshchenov, D. Gusev, N. E. Zakharova
Introduction. Metabolic navigation with 5‑ALA is one of methods for intraoperative imaging in neuro‑oncology.Aim. To perform a comparative analysis of sensitivity of metabolic navigation with 5‑ALA during surgery of primary and secondary brain tumors of various histological nature and degree of malignancy.Materials and methods. During the period from 2013 to 2020, our group have performed surgery to 403 patients using metabolic navigation: microsurgical resections were performed in 384 people with brain tumors, 220 of them were with glial tumors, 101 were with intracranial meningiomas, 63 were with metastatic brain damage. Among patients with metastases, 39 patients had a solitary injury, 16 had a multi‑focal injury, so 72 cases of metastatic nodes were considered in this group. Stereotactic biopsies with 5‑ALA‑assistance were performed in 19 people. Metabolic navigation was performed with the drug 5‑ALA, which was taken orally at a dose of 20 mg/kg 2 hours before surgery. Intraoperative fluorescence was evaluated using microscope with a fluorescent module.Results. Metabolic navigation using microscope has a high sensitivity when employed during microsurgery (including repeated implementation of surgery) in cases of anaplastic gliomas (65 % in total, 58 % with bright glow), glioblastomas (94 % in total, 53 % with bright glow), intracranial meningiomas (94 % in total, 64 % – with bright glow). The use of 5‑ALA has significant limitations in sensitivity in cases of diffuse gliomas (46 % – in total, 27 % – with bright glow) and brain metastases (in total 87 % – for the solid part, 52 % – for the bed, with bright glow – 51 %). In diffuse gliomas, the glow areas had significantly higher proliferative index and cell nuclei density than the fluoronegative zones. Among the most important factors affecting the glow of gliomas it can be noted: the status of the IDH1 mutation, the volume of the contrasting part of the glioma according to MRI data, the methionine accumulation index according to positron emission tomography, the tumor blood flow indicators according to the arterial spin marking method – ASL perfusion.Conclusions. Implementation of 5‑ALA navigation with the use of microscope provides high sensitivity in cases of glioblastomas, anaplastic gliomas (especially for detecting of non‑contrasting part of tumor that is not visually altered in the white light of operating microscope) and brain meningiomas. The method is less effective in low‑grade gliomas and intracranial metastases.
介绍。5 - ALA代谢导航是神经肿瘤术中成像的方法之一。比较分析5 - ALA在不同组织学性质和恶性程度的原发性和继发性脑肿瘤手术中代谢导航的敏感性。材料和方法。2013年至2020年,我组利用代谢导航技术共手术403例,其中脑肿瘤384例,其中神经胶质瘤220例,颅内脑膜瘤101例,转移性脑损伤63例。在转移患者中,39例为单发性损伤,16例为多灶性损伤,故本组考虑72例转移淋巴结。在5 - ALA辅助下对19人进行立体定向活检。代谢导航使用药物5‑ALA进行,该药物在手术前2小时以20mg /kg的剂量口服。用带荧光模块的显微镜观察术中荧光。显微镜下的代谢导航在显微手术(包括重复手术)中对间变性胶质瘤(总65%,亮光58%)、胶质母细胞瘤(总94%,亮光53%)、颅内脑膜瘤(总94%,亮光64%)具有很高的灵敏度。5 - ALA在弥漫性胶质瘤(总共46%,27% -伴有明亮的发光)和脑转移瘤(实体部分总共87%,床部52%,伴有明亮的发光- 51%)的敏感性上有明显的限制。在弥漫性胶质瘤中,荧光区增殖指数和细胞核密度明显高于阴性区。影响胶质瘤发光的最重要因素包括:IDH1突变的状态,MRI数据显示胶质瘤对比部分的体积,正电子发射断层扫描显示蛋氨酸积累指数,动脉自旋标记法- ASL灌注显示肿瘤血流指标。使用显微镜实施5 - ALA导航,在胶质母细胞瘤、间变性胶质瘤(特别是用于检测肿瘤的非对比部分,在操作显微镜的白光下没有视觉改变)和脑膜瘤的情况下提供了高灵敏度。该方法在低级别胶质瘤和颅内转移瘤中效果较差。
{"title":"Metabolic navigation during brain tumor surgery: analysis of a series of 403 patients","authors":"S. Goryaynov, A. Potapov, V. Okhlopkov, A. Batalov, R. Afandiev, A. Belyaev, A. Aristov, T. A. Caveleva, V. Zhukov, V. Loshchenov, D. Gusev, N. E. Zakharova","doi":"10.17650/1683-3295-2022-24-4-46-58","DOIUrl":"https://doi.org/10.17650/1683-3295-2022-24-4-46-58","url":null,"abstract":"Introduction. Metabolic navigation with 5‑ALA is one of methods for intraoperative imaging in neuro‑oncology.Aim. To perform a comparative analysis of sensitivity of metabolic navigation with 5‑ALA during surgery of primary and secondary brain tumors of various histological nature and degree of malignancy.Materials and methods. During the period from 2013 to 2020, our group have performed surgery to 403 patients using metabolic navigation: microsurgical resections were performed in 384 people with brain tumors, 220 of them were with glial tumors, 101 were with intracranial meningiomas, 63 were with metastatic brain damage. Among patients with metastases, 39 patients had a solitary injury, 16 had a multi‑focal injury, so 72 cases of metastatic nodes were considered in this group. Stereotactic biopsies with 5‑ALA‑assistance were performed in 19 people. Metabolic navigation was performed with the drug 5‑ALA, which was taken orally at a dose of 20 mg/kg 2 hours before surgery. Intraoperative fluorescence was evaluated using microscope with a fluorescent module.Results. Metabolic navigation using microscope has a high sensitivity when employed during microsurgery (including repeated implementation of surgery) in cases of anaplastic gliomas (65 % in total, 58 % with bright glow), glioblastomas (94 % in total, 53 % with bright glow), intracranial meningiomas (94 % in total, 64 % – with bright glow). The use of 5‑ALA has significant limitations in sensitivity in cases of diffuse gliomas (46 % – in total, 27 % – with bright glow) and brain metastases (in total 87 % – for the solid part, 52 % – for the bed, with bright glow – 51 %). In diffuse gliomas, the glow areas had significantly higher proliferative index and cell nuclei density than the fluoronegative zones. Among the most important factors affecting the glow of gliomas it can be noted: the status of the IDH1 mutation, the volume of the contrasting part of the glioma according to MRI data, the methionine accumulation index according to positron emission tomography, the tumor blood flow indicators according to the arterial spin marking method – ASL perfusion.Conclusions. Implementation of 5‑ALA navigation with the use of microscope provides high sensitivity in cases of glioblastomas, anaplastic gliomas (especially for detecting of non‑contrasting part of tumor that is not visually altered in the white light of operating microscope) and brain meningiomas. The method is less effective in low‑grade gliomas and intracranial metastases.","PeriodicalId":197162,"journal":{"name":"Russian journal of neurosurgery","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130908446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Feasibility of safe posterior C1–2 transarticular screw fixation: CT morphometric study 安全后路C1-2经关节螺钉固定的可行性:CT形态学研究
Pub Date : 2022-12-26 DOI: 10.17650/1683-3295-2022-24-4-59-66
I. Lvov, A. Grin, A. Talypov, S. Y. Roshchin, V. A. Sharifullin, Z. Barbakadze, E. E. Alekhin, A. V. Tupikin, E. A. Sosnovskiy, R. A. Nikogosyan, D. A. Talypova, N. B. Zhadova, O. A. Minkina, D. V. Shmeleva, L. T. Khamidova
Background. C1–2 transarticular fixation according to the F. Magerl technique is one of the most reliable methods of C1–2 screw stabilization. An important aspect of the precise placement of implants during transarticular fixation under X‑ray control is the use of correct selection of start‑ and end‑points of the installation trajectory. At certain values of the height and width of C2 isthmus some screw installation trajectories may be accompanied by a zero probability of vertebral artery damage that might be due to the screw malposition.Aim. To evaluate CT morphometric characteristics of the C2 vertebra to assess the possibility of safe C1–2 transarticular fixation.Materials and methods. The analysis performed was based on the data obtained from 7672 patients having admitted with suspected injury to the N.V. Sklifosovsky Research Institute of Emergency Medicine during the period from 01.01.2019 to 31.07.2019. The study involved 6 neurosurgeons and 6 medical doctors of the X‑ray diagnostics department. The measurements were carried out in 2 stages. Each parameter (isthmus height – IsthH, isthmus width – IsthW, lateral mass height – LmH) was measured 2 times. In case of high intraclass correlation, the mean value of the measurements was calculated, which was included in the final analysis.Results. The intraclass correlation coefficient for all measurements approached an excellent correlation values and was 0.852 (95 % CI 0.844–0.860). Morphometric characteristics were calculated basing on data from 795 patients. The IsthH value was 7.45 ± 1.66, IsthW – 8.56 ± 1.48, LmH – 5.56 ± 1.84 mm. In men, the transarticular fixation was significantly more likely to be performed without injury of the vertebral artery (in 66.1 % of cases; χ2‑test, p <0.000001), whereas in women – only in 29.9 % of cases.Conclusions. The results obtained suggest that percutaneous bilateral transarticular fixation with the use of posterior spinolaminar point and middle of the atlas anterior arch as landmarks potentially serves as a method of choice in 88.3 % of patients. Of all patients with normal anatomy of C2 isthmus, men are twice more likely to undergo transarticular fixation without damage of vertebral artery than women, the probability exceeds 66 %. However, the risk of injury of this blood vessel in other patients does not exceed 2.3 %, which is comparable with outcomes of other methods of C1–2 screw stabilization.
背景。经关节内固定采用F. Magerl技术是最可靠的固定C1-2螺钉的方法之一。在X射线控制下经关节固定期间,植入物精确放置的一个重要方面是正确选择安装轨迹的起点和终点。在C2峡部高度和宽度的一定值下,一些螺钉安装轨迹可能伴随着零概率的椎动脉损伤,这可能是由于螺钉位置不当造成的。评估C2椎体的CT形态特征,以评估安全的C1-2经关节固定的可能性。材料和方法。分析基于2019年1月1日至2019年7月31日期间在N.V.斯克利福索夫斯基急诊医学研究所收治的7672名疑似受伤患者的数据。这项研究涉及6名神经外科医生和6名X射线诊断科医生。测量分两个阶段进行。每个参数(峡高- IsthH,峡宽- IsthW,侧块高度- LmH)测量2次。在类内相关性较高的情况下,计算测量值的平均值,并将其纳入最终分析。所有测量值的类内相关系数接近极好的相关值,为0.852 (95% CI 0.844-0.860)。根据795例患者的数据计算形态计量学特征。IsthH值为7.45±1.66 mm, IsthW - 8.56±1.48 mm, LmH - 5.56±1.84 mm。在男性中,经关节固定更有可能在不损伤椎动脉的情况下进行(66.1%的病例;χ2 - test, p <0.000001),而在女性中-仅为29.9%。结果表明,经皮双侧经关节固定,使用后棘椎板点和寰椎前弓中部作为标志,可能是88.3%患者的选择方法。在所有C2峡解剖结构正常的患者中,男性接受经关节固定而不损伤椎动脉的可能性是女性的两倍,概率超过66%。然而,在其他患者中,该血管损伤的风险不超过2.3%,这与其他C1-2螺钉稳定方法的结果相当。
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引用次数: 0
Radicality of lateral ventricular neoplasms removal and risk factors of postoperative hemorrhagic complications 侧脑室肿瘤切除的根治性及术后出血并发症的危险因素
Pub Date : 2022-12-26 DOI: 10.17650/1683-3295-2022-24-4-32-45
S. Maryashev, G. Danilov, Y. Strunina, A. I. Batalov, Y. Vologdina, I. Pronin, D. Pitskhelauri
Introduction. Lateral ventricular neoplasms (tumors, vascular neoplasms, cysts) are rare and according to different sources comprise between 0.64 and 3.5 % of all brain tumors. Due to relatively slow growth, tumors can reach significant size before patient develops neurological symptoms. Surgery is the main method of treatment of lateral ventricular neoplasms, and in many cases radical removal can be achieved. The main complications after surgery are hydrocephalus and hemorrhages. The later frequently lead to escalation of neurological symptoms and sometimes require repeat surgical intervention. The success of intraventricular surgery consists of reasonable radicality and absence of complications.Aims. To evaluate the radicality and safety of lateral ventricular tumor removal through traditional approaches–transcallosal and transcortical – using arterial spin labeling (ASL perfusion) and to analyze the risk of hemorrhagic complications in the early postoperative period in the context of tumor location and blood supply.Materials and methods. At the N.N. Burdenko National Medical Research Center of Neurosurgery between 2017 and 2019 48 patients with space‑occupying lesions of the lateral ventricles were examined and treated with surgery. All patients were examined using the same MRI protocol before and after surgery: Т1‑weighted, Т1‑weighed contrast‑enhanced, 3D SPGR, Т2‑weighted, Т2‑FLAIR, DWI, T2‑FLAIR CUBE, SWAN, ASL perfusion. In 28 (58 %) cases, transcortical approach was used (through the frontal lobe in 24 cases, through the upper temporal lobe in 2 cases, through the parietal lobe in 2 cases); transcallosal approach was used in 16 (33 %) cases; combination approach (for advanced tumors of the lateral ventricles) was used in 3 (6 %) cases; supracerebellar infratentorial approach was used in 1 (2 %) case. Radicality of lateral ventricular tumor removal and risk factors for postoperative hemorrhagic complications using different approaches were evaluated based on the following parameters: tumor volume and location, sex, blood flow characteristics, presence of hydrocephalus.Results. In the compared groups I and II, similar rates of radical tumor removal were observed: 63 % for transcortical approach and 71 % for transcallosal approach. Hematomas in the tumor bed were more frequently observed in patients operated through transcortical approach (64 % vs. 31 % in transcallosal) without statistical significance. Generally, there were no statistically significant differences between surgical treatment results in groups I and II (p >0.05); this conclusion was confirmed in pseudo‑randomized patient subgroups selected through propensity score matching. Analysis of the association between hematoma in the postoperative period and baseline blood flow level showed that in the group with such hematomas mean tumor blood flow prior to surgery was almost twice as high as in the group without hemorrhagic complications after resection (80.6 vs. 49.4 ml/100 g/min
介绍。侧脑室肿瘤(肿瘤、血管肿瘤、囊肿)是罕见的,根据不同的来源,约占所有脑肿瘤的0.64 - 3.5%。由于肿瘤生长相对缓慢,在患者出现神经系统症状之前,肿瘤可达到显著的大小。手术是治疗侧脑室肿瘤的主要方法,在许多情况下可以根治性切除。术后主要并发症为脑积水和出血。后者经常导致神经系统症状的升级,有时需要重复手术干预。脑室内手术的成功在于合理的根治性和无并发症。目的评价经胼胝体和经皮质传统入路经动脉自旋标记术(ASL灌注)切除侧脑室肿瘤的根治性和安全性,并结合肿瘤位置和血供情况分析术后早期出血并发症的风险。材料和方法。2017年至2019年,在N.N. Burdenko国家神经外科医学研究中心,对48例侧脑室占位性病变患者进行了检查和手术治疗。所有患者在手术前和术后使用相同的MRI方案进行检查:Т1加权、Т1加权对比增强、3D SPGR、Т2加权、Т2‑FLAIR、DWI、T2‑FLAIR CUBE、SWAN、ASL灌注。28例(58%)采用经皮质入路(经额叶24例,经上颞叶2例,经顶叶2例);经胼胝体入路16例(33%);联合入路(晚期侧脑室肿瘤)3例(6%);1例(2%)采用小脑上幕下入路。根据肿瘤的体积和位置、性别、血流特征、是否存在脑积水等参数,评价不同入路切除侧脑室肿瘤的根治性及术后出血并发症的危险因素。在I组和II组中,观察到相似的肿瘤根治率:经皮质入路为63%,经胼胝体入路为71%。经皮质入路患者肿瘤床血肿发生率更高(64% vs.经胼胝体31%),但无统计学意义。总体而言,I组与II组手术治疗效果比较,差异无统计学意义(p >0.05);这一结论在通过倾向评分匹配选择的伪随机患者亚组中得到证实。对术后血肿与基线血流量水平的相关性分析显示,有血肿的组术前平均肿瘤血流量几乎是术后无出血并发症组的两倍(分别为80.6 ml/100 g/min和49.4 ml/100 g/min)。肿瘤床血肿发生的术后参数有统计学意义:脑积水的存在,术后早期Evans指数。考虑到肿瘤的解剖位置和进展、脑积水的存在和外科医生的喜好,正确和充分地选择手术入路,确保高根治性切除。影响术后早期出血性并发症风险的因素应考虑:性别、是否存在脑积水、肿瘤位置和血流水平。
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引用次数: 0
Surgical treatment of adenoid cystic carcinomas of sinonasal localization 鼻窦定位腺样囊性癌的手术治疗
Pub Date : 2022-12-26 DOI: 10.17650/1683-3295-2022-24-4-22-31
D. S. Spirinrin, I. Reshetov, V. Cherekaev, I. Chernov, G. Kobyakov, A. Golanov, M. Tlisova, A. Donskoy, E. Vetlova, V. Ivanov, P. Kalinin
Background. Tumors of the sinonasal region represent a large group of both benign and malignant formations affecting the nasal cavity, paranasal sinuses, structures of the anterior and middle cranial pits of the base of the skull.Aim. Evaluation of the results of surgical treatment of patients with adenoid cystic carcinomas of sinonasal localization treated in the period from 2007 to 2021.Material and methods. The present study is a retrospective analysis of the results of surgical treatment of patients with adenoid cystic cancer of the base of the skull operated at the N.N. Burdenko National Medical Research Center of Neurosurgery in the period from 2007 to 2021.Results. The radicality of tumor removal was assessed based on an MRI analysis performed no earlier than 3 months after surgery. Total (95–100 %) tumor removal was achieved in 8 (25 %), subtotal (80–95 %) in 15 (46.9 %), partial (50–80 %) in 5 (15.6 %) patients; extended biopsy was performed in 4 (12.5 %) cases. At the same time, total and subtotal removal was more often achieved with open surgery, which was due to the topographic and anatomical features of the location of tumors.Discussion. In this paper, we present an analysis of the results of treatment of 32 patients with adenocystic cancer of sinonasal localization.The main method of treatment is an integrated approach – radical surgical resection of the tumor together with adjuvant radiation therapy. Surgical treatment is aimed at the maximum possible resection of pathological tissues to prevent recurrence of the disease.One of the most common approaches is transfacial with or without bifrontal craniotomy, which includes craniofacial resection.Conclusion. Adenoid cystic carcinoma is an aggressive malignant tumor that requires a comprehensive approach to treatment. Important factors that positively affect the results of treatment are the conduct of chemoradiation treatment and the age of patients, as well as the initial stage of the disease at which treatment was initiated, which necessitates strengthening dispensary monitoring and raising awareness of the population about the possibility of developing such diseases for timely access to a doctor.
背景。鼻窦区肿瘤是影响鼻腔、鼻旁窦、颅底前、中颅窝结构的一大类良性和恶性肿瘤。2007 - 2021年鼻窦定位腺样囊性癌手术治疗效果评价材料和方法。本研究回顾性分析2007年至2021年在N.N. Burdenko国家神经外科医学研究中心手术治疗的颅底腺样囊性癌患者的手术治疗结果。术后不早于3个月的MRI分析评估肿瘤切除的根治性。全部(95 - 100%)切除8例(25%),部分(80 - 95%)切除15例(46.9%),部分(50 - 80%)切除5例(15.6%);4例(12.5%)行延长活检。同时,由于肿瘤位置的地形和解剖特征,开放手术更常实现全切除和次全切除。本文报告32例鼻窦定位腺囊癌的治疗结果。主要的治疗方法是综合的方法-肿瘤根治性手术切除和辅助放射治疗。手术治疗的目的是尽可能切除病变组织,防止疾病复发。最常见的方法之一是经面联合或不联合双额开颅术,其中包括颅面切除术。腺样囊性癌是一种侵袭性恶性肿瘤,需要综合治疗。对治疗结果产生积极影响的重要因素是放化疗的实施和患者的年龄,以及开始治疗的疾病的初始阶段,这就需要加强医务室的监测,并提高民众对发生这类疾病的可能性的认识,以便及时就医。
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引用次数: 0
Surgical treatment of distal cerebral aneurysms 脑远端动脉瘤的外科治疗
Pub Date : 2022-10-05 DOI: 10.17650/1683-3295-2022-24-3-12-22
I. Senko, V. Krylov, V. Dashyan, I. Grigoriev
Background. Distal cerebral aneurysms are very rare. To date, there are very few publications on distal cerebral aneurysms and they are mostly limited to clinical case series.Aim. To analyze anatomical characteristics of distal cerebral aneurysms and surgical outcomes, as well as to identify risk factors for a poor outcome and develop a treatment algorithm on this basis; to determine the role of neuronavigation and revascularization in the surgical treatment of distal cerebral aneurysms.Materials and methods. We performed a retrospective analysis of surgical outcomes of 153 patients with distal cerebral aneurysms treated in N.V. Sklifosovsky Research Institute for Emergency Medicine (Moscow Healthcare Department) between January 1, 2000 and December 31, 2019.Results. Distal cerebral aneurysms were identified in 4.5 % cases of all cerebral aneurysms; 81.7 % of patients with distal cerebral aneurysms were admitted to the hospital with ruptured aneurysms. The most frequent locations of distal cerebral aneurysms were pericallosal and middle cerebral arteries. Distal cerebral aneurysms were usually small (77.5 %), had a wide neck (31.8 %), and fusiform structure (15.7 %). Aneurysm clipping was performed in 74.5 % cases; parent artery trapping, in 23.5 % of patients; revascularization, in 5.9 % of patients. The main risk factors for a poor outcome included aneurysm size and location, patient grade on the modified scale of the World Federation of Neurosurgical Societies (mWFNS), and presence of severe vasospasm.Conclusion. The developed surgical algorithm for distal cerebral aneurysms (based on the assessment of a poor outcome risk factors, the use of neuronavigation, arterial patency control, and revascularization) could improve surgical outcomes of patients with distal cerebral aneurysms.
背景。脑远端动脉瘤是非常罕见的。迄今为止,关于脑远端动脉瘤的文献很少,而且大多局限于临床病例系列。分析脑远端动脉瘤的解剖特征和手术结果,识别预后不良的危险因素,并在此基础上制定治疗算法;目的探讨神经导航和血管重建术在脑远端动脉瘤手术治疗中的作用。材料和方法。我们回顾性分析了2000年1月1日至2019年12月31日期间在N.V. Sklifosovsky急诊医学研究所(莫斯科卫生保健部)治疗的153例脑远端动脉瘤的手术结果。脑远端动脉瘤占所有脑动脉瘤的4.5%;81.7%的脑远端动脉瘤患者因动脉瘤破裂而入院。脑远端动脉瘤的多发部位为胼胝体周围动脉和大脑中动脉。脑远端动脉瘤多为小动脉瘤(77.5%),颈宽动脉瘤(31.8%),梭状结构动脉瘤(15.7%)。动脉瘤夹闭率为74.5%;23.5%的患者有母动脉夹闭;5.9%的患者有血运重建术。不良预后的主要危险因素包括动脉瘤的大小和位置、患者在世界神经外科学会联合会(mWFNS)修正评分中的分级以及是否存在严重的血管痉挛。开发的脑远端动脉瘤手术算法(基于不良预后危险因素的评估,使用神经导航,动脉通畅控制和血运重建术)可以改善脑远端动脉瘤患者的手术结果。
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引用次数: 1
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Russian journal of neurosurgery
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