Pub Date : 2021-07-31DOI: 10.12771/emj.2021.44.3.89
H. Choi, Yongil Kim
{"title":"Use of Olive Oil for the Treatment of a Phytobezoar: A Case Report","authors":"H. Choi, Yongil Kim","doi":"10.12771/emj.2021.44.3.89","DOIUrl":"https://doi.org/10.12771/emj.2021.44.3.89","url":null,"abstract":"","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125215995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-31DOI: 10.12771/emj.2021.44.3.93
S. Hong, S. Park, B. Ye, Suk-Kyun Yang
{"title":"Differentiating between Intestinal Tuberculosis and Crohn’s Disease May Be Complicated by Multidrug-resistant Mycobacterium tuberculosis","authors":"S. Hong, S. Park, B. Ye, Suk-Kyun Yang","doi":"10.12771/emj.2021.44.3.93","DOIUrl":"https://doi.org/10.12771/emj.2021.44.3.93","url":null,"abstract":"","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126885447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-30DOI: 10.12771/EMJ.2021.44.2.46
Young Choi, Ji Hyen Lee, Jung Won Lee
Primary vesicoureteral reflux is a common genetically determined condition that is associated with varying degrees of renal scarring and represents one of the main causes of chronic kidney disease in children. Usually vesicoureteral reflux is common in urinary tract infection patient under 5 years of age. However, we report a rare case of high-grade vesicoureteral reflux and chronic kidney disease in a 10-year-old boy who was referred to the pediatric department for incidentally detected asymptomatic bacteriuria. Our case demonstrated that high grade vesicoureteral reflux patient with reduced renal function, bladder and bowel dysfunction at presentation is more likely to progress to chronic kidney disease. (Ewha Med J 2021;44(2):46-49)
{"title":"Unusual Case of Vesicoureteral Reflux and Chronic Kidney Disease in a 10-Year-old Boy with Asymptomatic Bacteriuria","authors":"Young Choi, Ji Hyen Lee, Jung Won Lee","doi":"10.12771/EMJ.2021.44.2.46","DOIUrl":"https://doi.org/10.12771/EMJ.2021.44.2.46","url":null,"abstract":"Primary vesicoureteral reflux is a common genetically determined condition that is associated with varying degrees of renal scarring and represents one of the main causes of chronic kidney disease in children. Usually vesicoureteral reflux is common in urinary tract infection patient under 5 years of age. However, we report a rare case of high-grade vesicoureteral reflux and chronic kidney disease in a 10-year-old boy who was referred to the pediatric department for incidentally detected asymptomatic bacteriuria. Our case demonstrated that high grade vesicoureteral reflux patient with reduced renal function, bladder and bowel dysfunction at presentation is more likely to progress to chronic kidney disease. (Ewha Med J 2021;44(2):46-49)","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116268724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-30DOI: 10.12771/EMJ.2021.44.2.37
Jong kyu Kim, H. Kwon, W. Lim, B. Moon, N. Paik
Active surveillance (AS) of papillary thyroid microcarcinoma was first suggested by Dr. Akira Miyauchi at Kuma Hospital in 1993. Based on several subsequent evidences, AS was approved by the American Thyroid Association in 2015. AS is no longer an experimental treatment but has become an acceptable standard of care for patients with low-risk thyroid cancers. No molecular markers, such as BRAF mutations, have been identified to predict the prognosis of papillary thyroid cancer. However, future molecular studies may reveal the relationship between genetic mutations and thyroid cancer prognosis. AS involves closely monitoring thyroid cancer over time, instead of immediately treating it with surgery. Patients and medical doctors should consider these two options: observation or surgery. (Ewha Med J 2021;44(2):37-40)
{"title":"Active Surveillance of Papillary Thyroid Cancer: Past, Present, and Future","authors":"Jong kyu Kim, H. Kwon, W. Lim, B. Moon, N. Paik","doi":"10.12771/EMJ.2021.44.2.37","DOIUrl":"https://doi.org/10.12771/EMJ.2021.44.2.37","url":null,"abstract":"Active surveillance (AS) of papillary thyroid microcarcinoma was first suggested by Dr. Akira Miyauchi at Kuma Hospital in 1993. Based on several subsequent evidences, AS was approved by the American Thyroid Association in 2015. AS is no longer an experimental treatment but has become an acceptable standard of care for patients with low-risk thyroid cancers. No molecular markers, such as BRAF mutations, have been identified to predict the prognosis of papillary thyroid cancer. However, future molecular studies may reveal the relationship between genetic mutations and thyroid cancer prognosis. AS involves closely monitoring thyroid cancer over time, instead of immediately treating it with surgery. Patients and medical doctors should consider these two options: observation or surgery. (Ewha Med J 2021;44(2):37-40)","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129534017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-30DOI: 10.12771/EMJ.2021.44.2.41
J. E. Shim, Juhui Kim, Mi Kyung Kim, Y. Kim, Seung Cheol Kim
Lymphomas that originate from the female genital tract are very rare. Primary cervical lymphoma only accounts for less than 1% of all extra-nodal lymphomas. Clinical mani-festations of primary cervical lymphoma can be nonspecific, vaginal bleeding being the most common symptom, and this makes timely diagnosis often difficult. Prognosis and optimal treatment have yet been established due to the rarity of the disease. In this article, a rare case of primary diffuse large B-cell lymphoma of cervix is reported with a review of the available literature. (Ewha Med J 2021;44(2):41-45)
{"title":"Primary Lymphoma of Cervix","authors":"J. E. Shim, Juhui Kim, Mi Kyung Kim, Y. Kim, Seung Cheol Kim","doi":"10.12771/EMJ.2021.44.2.41","DOIUrl":"https://doi.org/10.12771/EMJ.2021.44.2.41","url":null,"abstract":"Lymphomas that originate from the female genital tract are very rare. Primary cervical lymphoma only accounts for less than 1% of all extra-nodal lymphomas. Clinical mani-festations of primary cervical lymphoma can be nonspecific, vaginal bleeding being the most common symptom, and this makes timely diagnosis often difficult. Prognosis and optimal treatment have yet been established due to the rarity of the disease. In this article, a rare case of primary diffuse large B-cell lymphoma of cervix is reported with a review of the available literature. (Ewha Med J 2021;44(2):41-45)","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132237623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-30DOI: 10.12771/EMJ.2021.44.2.34
Eun Mee Kim
{"title":"Vision of Ewha in the COVID-19 Pandemic Era: A Note from the President","authors":"Eun Mee Kim","doi":"10.12771/EMJ.2021.44.2.34","DOIUrl":"https://doi.org/10.12771/EMJ.2021.44.2.34","url":null,"abstract":"","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126907748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-31DOI: 10.12771/EMJ.2021.44.1.19
Bu Yong Kim, Na Yun Bang, Da In Baik, K. Jung, Junbeom Park
Objectives: This study aimed to characteristic the systolic blood pressure (SBP), diastolic pressure, pulse pressure, glucose, creatine, and lipid profile. This study also aimed to investigate the prevalence of hypertension and the relationship between hypertension and the lipid profile in Uzbekistan. Methods: The subjects consisted of 58 Uzbekistan subjects recruited from Ewha Medical Care patients. Blood samples were collected from the patients for the lipid profile and random glucose and creatinine levels. Paired t tests were used for the group means and a chi-square or Fisher’s exact test for categorical variables. A multiple logistic regression analysis was performed. Results: Among the 58 patients constituting the baseline population, hypertension de-veloped in 42 patients. Among them, the triglyceride (TG) level was significantly higher in the hypertension group than normal group (173.19 vs. 127.06 mg/dL, P=0.014). The SBP had a positive correlation with the TG (r=0.979, P<0.01) and creatinine (r=0.002, P<0.05) levels and also, the pulse pressure had a positive correlation with the cholesterol level (r=0.539, P<0.05). A multivariate analysis (adjusted for age and sex) indicated that there was a positive correlation between the SBP and TG level (r=0.941, P<0.05). Conclusion: There was a positive correlation between the SBP and TG level in the Uzbekistan population according to this study. (Ewha Med J 2021;44(1):19-25)
目的:本研究旨在确定收缩压(SBP)、舒张压、脉压、葡萄糖、肌酸和脂质特征。本研究还旨在调查乌兹别克斯坦的高血压患病率以及高血压与血脂的关系。方法:研究对象为从梨花女子医院患者中招募的58名乌兹别克斯坦人。采集患者的血液样本，测定血脂、随机葡萄糖和肌酐水平。对组均值采用配对t检验，对分类变量采用卡方检验或Fisher精确检验。进行多元逻辑回归分析。结果:在构成基线人群的58例患者中，42例患者发生高血压。其中，高血压组甘油三酯(TG)水平显著高于正常组(173.19 vs. 127.06 mg/dL, P=0.014)。收缩压与TG (r=0.979, P<0.01)、肌酐(r=0.002, P<0.05)呈正相关，脉压与胆固醇(r=0.539, P<0.05)呈正相关。多因素分析(调整年龄和性别)显示收缩压与TG水平呈正相关(r=0.941, P<0.05)。结论:根据本研究，乌兹别克斯坦人群的收缩压与TG水平呈正相关。(梨花医学杂志;2021;44(1):19-25)
{"title":"Correlation between Systolic Blood Pressure and Triglyceride Level in the Uzbekistan Population","authors":"Bu Yong Kim, Na Yun Bang, Da In Baik, K. Jung, Junbeom Park","doi":"10.12771/EMJ.2021.44.1.19","DOIUrl":"https://doi.org/10.12771/EMJ.2021.44.1.19","url":null,"abstract":"Objectives: This study aimed to characteristic the systolic blood pressure (SBP), diastolic pressure, pulse pressure, glucose, creatine, and lipid profile. This study also aimed to investigate the prevalence of hypertension and the relationship between hypertension and the lipid profile in Uzbekistan. Methods: The subjects consisted of 58 Uzbekistan subjects recruited from Ewha Medical Care patients. Blood samples were collected from the patients for the lipid profile and random glucose and creatinine levels. Paired t tests were used for the group means and a chi-square or Fisher’s exact test for categorical variables. A multiple logistic regression analysis was performed. Results: Among the 58 patients constituting the baseline population, hypertension de-veloped in 42 patients. Among them, the triglyceride (TG) level was significantly higher in the hypertension group than normal group (173.19 vs. 127.06 mg/dL, P=0.014). The SBP had a positive correlation with the TG (r=0.979, P<0.01) and creatinine (r=0.002, P<0.05) levels and also, the pulse pressure had a positive correlation with the cholesterol level (r=0.539, P<0.05). A multivariate analysis (adjusted for age and sex) indicated that there was a positive correlation between the SBP and TG level (r=0.941, P<0.05). Conclusion: There was a positive correlation between the SBP and TG level in the Uzbekistan population according to this study. (Ewha Med J 2021;44(1):19-25)","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125273706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-31DOI: 10.12771/EMJ.2021.44.1.11
J. Jo
Over the past decade, substantial advances have been made in the individualization of therapeutic strategies for metastatic colorectal cancer (mCRC). Treatment strategies have been developed and classified according to their molecular and genetic character-istics based on predictive biomarkers such as microsatellite instability, RAS and BRAF mutations, HER2 amplification, or NTRK fusions. As molecular and genetic predictive tests are routinely performed, new challenges for mCRC treatment strategies are al-lowed. For patients responding to anti-epithelial growth factor receptor treatments, expanded biomarkers panels enable customized treatment to be selected and the optimal treatment can be determined. Patients with mCRC with the BRAF V600E mutation who did not have effective targeted treatments have effective therapeutic options. Attractive but rare targets, such as HER2 amplification and NTRK fusions, could be a breakthrough and the use of immune checkpoint inhibitors in patients with mismatch repair deficiency/microsatellite instability is the striking revolution. In this review, we summarize the current landscape of targeted therapies for mCRC patients, with a focus on new developments for epithelial growth factor receptor blockade and emerging biomarkers. (Ewha Med J 2021;44(1):11-18)
{"title":"New Molecular Targeted Therapy of Metastatic Colorectal Cancer","authors":"J. Jo","doi":"10.12771/EMJ.2021.44.1.11","DOIUrl":"https://doi.org/10.12771/EMJ.2021.44.1.11","url":null,"abstract":"Over the past decade, substantial advances have been made in the individualization of therapeutic strategies for metastatic colorectal cancer (mCRC). Treatment strategies have been developed and classified according to their molecular and genetic character-istics based on predictive biomarkers such as microsatellite instability, RAS and BRAF mutations, HER2 amplification, or NTRK fusions. As molecular and genetic predictive tests are routinely performed, new challenges for mCRC treatment strategies are al-lowed. For patients responding to anti-epithelial growth factor receptor treatments, expanded biomarkers panels enable customized treatment to be selected and the optimal treatment can be determined. Patients with mCRC with the BRAF V600E mutation who did not have effective targeted treatments have effective therapeutic options. Attractive but rare targets, such as HER2 amplification and NTRK fusions, could be a breakthrough and the use of immune checkpoint inhibitors in patients with mismatch repair deficiency/microsatellite instability is the striking revolution. In this review, we summarize the current landscape of targeted therapies for mCRC patients, with a focus on new developments for epithelial growth factor receptor blockade and emerging biomarkers. (Ewha Med J 2021;44(1):11-18)","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127165239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-31DOI: 10.12771/EMJ.2021.44.1.1
Kyunghoon Lee
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), is a type of human coronavirus that causes severe pneumonia, similar to SARS-CoV-1 and Middle East respiratory syndrome coronavirus In Korea, the SARS-CoV-2 testing has started quickly from February 2020 to respond to the COVID-19 pandemic In this article, I would like to introduce the characteristics of coronavirus and PCR test methods that play a large role in COVID-19 quarantine measures Real-time reverse transcription (RT)-PCR is one of the molecular diagnostic method, and it detect SARS-CoV-2 RNA by amplifying SARS-CoV-2 specific RdRp (RNA-dependent RNA polymerase) gene and E (envelope) gene at the same time Real-time RT-PCR is currently the most reliable test that confirming COVID-19 and is in use worldwide Real-time RT-PCR test is recommended for COVID-19 confirmatory diagnosis in Korea, but this test requires dedicated equipment, reagents, experienced technicians and laboratory medicine specialists, and it takes about a few hours to a day to report Rapid molecular testing results in one to two hours with a simple procedure Antigen test is less sensitive than real-time RT-PCR and can only be used as a secondary role of diagnosis As the global COVID-19 pandemic progresses, diagnostic testing guidelines and recommendations may vary and will be updated as scientific evidence and experience of the COVID-19 accumulates
{"title":"Laboratory Diagnosis of COVID-19 in Korea","authors":"Kyunghoon Lee","doi":"10.12771/EMJ.2021.44.1.1","DOIUrl":"https://doi.org/10.12771/EMJ.2021.44.1.1","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), is a type of human coronavirus that causes severe pneumonia, similar to SARS-CoV-1 and Middle East respiratory syndrome coronavirus In Korea, the SARS-CoV-2 testing has started quickly from February 2020 to respond to the COVID-19 pandemic In this article, I would like to introduce the characteristics of coronavirus and PCR test methods that play a large role in COVID-19 quarantine measures Real-time reverse transcription (RT)-PCR is one of the molecular diagnostic method, and it detect SARS-CoV-2 RNA by amplifying SARS-CoV-2 specific RdRp (RNA-dependent RNA polymerase) gene and E (envelope) gene at the same time Real-time RT-PCR is currently the most reliable test that confirming COVID-19 and is in use worldwide Real-time RT-PCR test is recommended for COVID-19 confirmatory diagnosis in Korea, but this test requires dedicated equipment, reagents, experienced technicians and laboratory medicine specialists, and it takes about a few hours to a day to report Rapid molecular testing results in one to two hours with a simple procedure Antigen test is less sensitive than real-time RT-PCR and can only be used as a secondary role of diagnosis As the global COVID-19 pandemic progresses, diagnostic testing guidelines and recommendations may vary and will be updated as scientific evidence and experience of the COVID-19 accumulates","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131398139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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