Pediatric Surgery International最新文献

Purpose: This study aims to explore maternal and pregnancy-related risk factors for colonic atresia (CA) and assess the national total prevalence, mortality, and frequency of co-occurring anomalies of this rare malformation in 2004-2017.

Methods: This case-control study involved 36 cases with congenital CA identified from several Finnish registers. All cases were identified based on the ICD-9/ICD-10 codes and classified based on co-occurring anomalies. Five controls without gastrointestinal congenital malformations matched for residence and time of conception (± 1 year) were randomly selected for each case. Maternal risk factors were analyzed with data from the same registers.

Results: Total prevalence of CA was 0.45/10,000, birth prevalence was 0.37/10,000 and live birth prevalence was 0.36/10,000. The overall prevalence trend did not change (p = 0.11) during the study period. There were 15 (41.7%) isolated cases, 3 (8.3%) were associated with known syndromes and 18 (50.0%) had multiple congenital anomalies. Together there were 19.4% (n = 7) terminations or neonatal mortalities. An association was observed with maternal diabetes and CA (p = 0.03).

Conclusion: The prevalence of CA in Finland is low with no significant change over the study period. Despite the high frequency of associated anomalies, the overall survival of CA is very high, 97%.

Objective: To explore the therapeutic efficacy and technical characteristics of pneumovesical Cohen ureteral reimplantation (PCUR) versus laparoscopic dismembered Lich-Gregoir ureteral reimplantation (LLGR) in the treatment of primary obstructive megaureter (POM) in Paediatric Patients.

Methods: A retrospective analysis was performed on 94 paediatric patients with unilateral POM who were admitted to the Department of Paediatric Surgery, The First Affiliated Hospital of Zhengzhou University between October 2017 and October 2023. Based on the surgical approach, patients were allocated into two groups: 51 cases underwent PCUR, constituting the PCUR group; the remaining 43 cases underwent LLGR, forming the LLGR group. Preoperative baseline characteristics, intraoperative metrics, and postoperative outcomes were compared between the cohorts. The study specifically evaluated the changes in the renal pelvis anteroposterior diameter (APD), the maximum distal ureteral diameter (MDUD), and differential renal function (DRF) on the affected side, comparing preoperative and postoperative values.

Results: No significant differences were observed in preoperative baseline characteristics between the PCUR and LLGR groups. Compared to the PCUR group, the LLGR group was associated with a significantly shorter operative time (Z=-1.473, P = 0.015) and a reduced duration of postoperative haematuria (Z = -4.843, P < 0.001). Preoperative and postoperative measurements of the affected-side APD, MDUD, DRF and RCT were comparable between the two groups, with no statistically significant differences identified. However, intragroup analysis demonstrated a significant postoperative improvement in all three parameters (APD, MDUD, DRF and RCT) within both surgical cohorts. Furthermore, the magnitude of improvement, defined as the delta (Δ) values for APD (ΔAPD; t = -0.310, P = 0.758), MDUD (ΔMDUD; t = -0.418, P = 0.678), DRF (ΔDRF; t = -1.526, P = 0.129), and RCT(△RC; t = -0.431, P = 0.668), did not differ significantly between the groups.

Conclusion: Both PCUR and LLGR are safe and effective in treating paediatric POM. Compared with PCUR, LLGR offers advantages including shorter operative time, reduced duration of postoperative haematuria, broader age range applicability, more spacious surgical field, lower technical difficulty in ureteral tailoring, and no compromise to subsequent endoscopic interventions.

Purpose: Congenital inguinal hernia is a common condition treated by Pediatric Surgeons. Despite laparoscopy being the preferred method for many, there is still debate on its efficacy compared to the open technique. We compared our outcomes of laparoscopic percutaneous internal ring suturing with peritoneal thermal injury to open repairs.

Methods: Retrospective, cohort study from 2014 to 2023 at Dayton Children's Hospital of children aged 17 years or less who had an inguinal hernia repair by a Pediatric Surgeon via either of the two techniques. Demographics, operative technique, complications, hernia recurrence or metachronous contralateral hernia development, and follow-up length were collected.

Results: 1,141 children were included, of which 61.5% (n = 702) had an open repair and 38.5% (n = 439) had a laparoscopic repair. Demographics were similar, except infants comprised a greater proportion of the laparoscopic group (45.1% vs. 36.2%, p = 0.002). There were more bilateral repairs in the laparoscopic group (p < 0.001). Post-operative complications were similar. The recurrence rate was 2.5% with laparoscopic repairs and 1.1% with open repairs (p = 0.079).

Conclusions: The rate of hernia recurrence and other post-operative outcomes were similar for the two techniques, providing further evidence for the continued use of our laparoscopic technique.

Background: Biliary atresia (BA) is a progressive neonatal cholestatic liver disease that requires timely diagnosis and intervention. Differentiating BA from other causes of neonatal cholestasis remains a significant clinical challenge.

Methods: In this study, we retrospectively analyzed the clinical and biochemical data of 243 cholestatic neonates, comprising 61 with BA and 182 with non-BA. We utilized five supervised machine learning algorithms-logistic regression (LRM), decision tree (DET), multilayer perceptron (MLP), support vector machine (SVC), and random forest (RF)-to construct diagnostic models for BA. The performance of each model was evaluated based on its accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve (AUC). We then developed an online diagnostic tool based on the best-performing model.

Results: The BA and non-BA groups showed significant differences across multiple biochemical markers. All five models demonstrated good diagnostic performance, with the random forest (RF) model achieving the best results (AUC = 0.93, sensitivity = 88.5%, specificity = 85.2%). The combination of multiple biochemical parameters substantially improved diagnostic accuracy compared to using single indicators. The web-based tool provides an intuitive and user-friendly interface to support early BA screening in clinical practice.

Conclusion: Machine learning-based models, particularly the RF model, show great potential for the early diagnosis of BA in cholestatic neonates. The implementation of a dedicated online platform may facilitate timely identification and assist clinicians in decision-making.

Objective: Remote ischemic conditioning (RIC) potentially is an innovative therapeutic strategy for preterm infants with necrotizing enterocolitis (NEC). RIC appears safe in human premature neonates with NEC, as demonstrated by no adverse effects or complications due to RIC in our previous trial. The aim of the current study is to further assess the safety of RIC during its extended application in preterm infants with NEC.

Methods: A single center phase I non-randomized trial was conducted. Preterm (< 36 weeks gestational age at birth) infants with confirmed NEC were recruited and received RIC intervention. RIC consisted of four cycles of limb ischemia (5-min via cuff inflation) followed by reperfusion (5-min via cuff deflation), repeated on two consecutive days post enrollment. Demographic and clinical data were collected at enrollment. The primary endpoint of this study was safety defined as perfusion returning to baseline within 5 min after cuff deflation. Secondary endpoints included cutaneous injury and pain (measured by PIPP scores).

Results: A total of 6 neonates were recruited. All neonates were preterm with a birth weight ranging from 450 to 3150 g. NEC was diagnosed between 7 and 30 days and weight at RIC ranged from 780 to 3040 g. Two (33.3%) patients had medical NEC. Four (66.7%) patients underwent RIC postoperatively. RIC was completed in all neonates. Arterial flow and limb perfusion returned to baseline within 5 min in all patients. All patients had a normal grasp reflex both before and after RIC. No new-onset skin lesions were observed. There was no significant difference in PIPP score before and after RIC.

Conclusions: RIC intervention with 5-min ischemia-reperfusion cycles is safe. RIC is also safe when extended to extremely preterm neonates with confirmed medical or surgical NEC.

Background: Congenital duodenal obstruction (DO) is an anomaly which requires surgery shortly after birth. However, its long-term gastrointestinal (GI) sequelae remain unknown. Therefore, this study aimed to determine the long-term GI patient-reported outcome measurements (PROMs) using the Pediatric Quality of Life Inventory™ (PedsQL™) GI-Module in patients with DO compared to healthy controls. Secondly, we evaluated the PROMs comparing patients with DO with and without trisomy 21.

Methods: We performed a cross-sectional cohort study (September-December 2023). The PedsQL™ GI-Module questionnaire was sent to all patients who underwent DO surgery between 1999 and 2022. Data were compared with a published healthy control group (n = 513). Bonferroni correction was used to adjust for multiple tests.

Results: In total, 33/89 patients completed the PedsQL™ GI-Module questionnaire. The majority of the patients were female (N = 19/33) with a mean age of 13.3 years (SD ± 6.6). Trisomy 21 was diagnosed in seven patients. The DO group had a similar mean total score compared to healthy controls (84.5 ± 11.5 vs. 88.6 ± 12.9,p = 0.075). The mean score for constipation (77.2 ± 22.0 vs. 86.9 ± 17.6,p = 0.002) was significantly lower compared to the healthy controls, indicating a worse outcome, whilst all other domains were similar. Four patients used laxatives. Patients with DO and trisomy 21 had similar scores compared to patients with DO without trisomy 21.

Conclusion: The results showed similar long-term GI PROMs in patients who underwent DO surgery compared to healthy controls. Patients with DO experienced constipation more frequently, emphasizing the need for attention during follow-up and education of (parents) of patients. Additionally, children with DO and trisomy 21 showed similar PROMs to those without trisomy 21.

Level of evidence: II.

Background: Pediatric spinal injuries refers to a medical condition characterized by structural or functional impairment of the spinal cord in children, resulting from trauma, infections, or other etiological factors, which may lead to severe consequences such as paraplegia or quadriplegia.​ METHODS: Epidemiological data on subtypes of spinal injuries in children were sourced from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, encompassing annual estimates from 1990 to 2021. We analyzed the disease burden and epidemiological trends of distinct spinal injuries subtypes in children. Using the nordpred model, we projected the global burden of pediatric spinal injuries through 2046.

Result: n 2021, the global incidence of pediatric spinal injury cases was 72,628 (55,829-94,283), including pediatric spinal cord lesion at neck level with 34,695 (25,206-49,063) incidence cases, and pediatric spinal cord lesion below neck level with 37,933 (27,349-51,354) incidence cases. The global ASIR of pediatric spinal injury cases was 3.60(2.70-4.83), including pediatric spinal cord lesion at neck level with an ASIR of 1.72(1.20-2.50), and pediatric spinal cord lesion below neck level with an ASIR of 1.88(1.30-2.71). The global prevalence of pediatric spinal injury cases was 593,486 (521,155-683,457) and the global ASPR of pediatric spinal injury cases was 28.65(24.88-33.18). The global Years Lived with Disability (YLDs) due to pediatric spinal injuries was 199,941 (139,710-265,960), and the global ASYR of pediatric spinal injury cases was 9.66(6.65-12.94). Based on Joinpoint Regression analysis, we found that from 1990 to 2021, the Average Annual Percent Change (AAPC) in the ASIR of Global Pediatric Spinal Injuries was - 1.4(-1.73 to -1.07)). The AAPC for the ASPR of Global Pediatric Spinal Injuries was - 1.32(-1.36 to -1.27). The AAPC for the ASYR of Global Pediatric Spinal Injuries was - 1.58(-1.62 to -1.52).Based on the Nordpred model, it is projected that by 2046, the global number of new pediatric spinal injuries cases would be 57,877 with an ASIR of 3.13. The global number of pediatric spinal injuries prevalent cases would be 472,447 with an ASPR of 24.69. The global YLDs from pediatric spinal injuries would be 153,221 with an ASYR of 8.01.

Conclusion: The global epidemiological curve of pediatric spinal injury incidence is trending downward, yet these injuries still impose severe YLDs and high prevalence worldwide.

Background: Chronic right lower quadrant (RLQ) abdominal pain in pediatric patients with a negative workup poses a diagnostic and therapeutic challenge. The role of laparoscopic appendectomy (LA) in this cohort remains controversial.

Methods: Patients ≤ 18 years old who underwent LA for chronic RLQ pain between 2010 and 2021 were reviewed across two academic centers. Clinical data, operative findings, and histopathological results were compared between those with resolved and persistent pain following appendectomy.

Results: 123 patients underwent LA for chronic RLQ pain. Patients were categorized based on resolution (n = 78) or persistence (n = 45) of their pain following LA. Neither median symptom duration (9.3 [IQR: 2.7-18.7] vs. 6.4 [2.9-18.6] months, p=0.75), presenting symptoms, nor incidence of prior abdominal surgery (14.1% vs. 17.8%, p = 0.58) differed between groups. There was a high incidence of psychiatric diagnoses in both groups (21.8% vs. 24.4%, p = 0.74). Histopathologic findings did not differ between responders and non-responders. Concomitant surgeries were performed in 14.1% of responders (6 planned cholecystectomies, 6 incidental pathologies) and 20.0% of non-responders (4 planned cholecystectomies, 7 incidental).

Conclusions: LA provided sustained pain relief for a large subset of pediatric patients with chronic RLQ pain, even though no objective findings could distinguish responders from non-responders. These findings underscore the need for additional research to optimize diagnostic and treatment strategies for these difficult patients.