Pub Date : 2024-04-01DOI: 10.23736/S0031-0808.23.05040-1
V. Cirello, C. Gambale, Alyaksandr V. Nikitski, Chie Masaki, João Roque, Carla Colombo
Poorly differentiated thyroid carcinoma (PDTC) is a rare and extremely aggressive tumor, accounting for about 2-15% of all thyroid cancer. PDTC has a distinct biological behavior compared to well-differentiated and anaplastic thyroid carcinoma and, in last years, it has been classified as a separate entity from both anatomopathological and clinical points of view. Nevertheless, there is still a lack of consensus among clinicians regarding inclusion criteria and definition of PDTC that affects its diagnosis and clinical management. Due to its rarity and difficulty in classification compared to other tumors, very few studies are available to date and series often include different histotypes in addition to PDTC. This review focuses on main studies concerning PDTC summarizing the evolution in the definition of its diagnosis criteria, clinicopathological features, management, and outcome. The data available confirm that the pathological evaluation and classification of PDTC are crucial and should therefore be standardized. Since the clinical presentation and prognosis of PDTC may vary widely depending on the different stage of the disease at diagnosis, the patient's management may differ in treatment and should be tailored to each patient. Finally, this review discusses advances in molecular insights of PDTC that, together with the implementation of both in vitro and in vivo models, will provide valuable insights into biological mechanisms of progression, metastasis, and invasion of this aggressive thyroid carcinoma. Further studies on larger, carefully selected series are needed to better assess the peculiar features of PDTC and to better define its management by focusing on the best diagnostic and therapeutic approaches.
{"title":"Poorly differentiated thyroid carcinoma: molecular, clinico-pathological hallmarks and therapeutic perspectives.","authors":"V. Cirello, C. Gambale, Alyaksandr V. Nikitski, Chie Masaki, João Roque, Carla Colombo","doi":"10.23736/S0031-0808.23.05040-1","DOIUrl":"https://doi.org/10.23736/S0031-0808.23.05040-1","url":null,"abstract":"Poorly differentiated thyroid carcinoma (PDTC) is a rare and extremely aggressive tumor, accounting for about 2-15% of all thyroid cancer. PDTC has a distinct biological behavior compared to well-differentiated and anaplastic thyroid carcinoma and, in last years, it has been classified as a separate entity from both anatomopathological and clinical points of view. Nevertheless, there is still a lack of consensus among clinicians regarding inclusion criteria and definition of PDTC that affects its diagnosis and clinical management. Due to its rarity and difficulty in classification compared to other tumors, very few studies are available to date and series often include different histotypes in addition to PDTC. This review focuses on main studies concerning PDTC summarizing the evolution in the definition of its diagnosis criteria, clinicopathological features, management, and outcome. The data available confirm that the pathological evaluation and classification of PDTC are crucial and should therefore be standardized. Since the clinical presentation and prognosis of PDTC may vary widely depending on the different stage of the disease at diagnosis, the patient's management may differ in treatment and should be tailored to each patient. Finally, this review discusses advances in molecular insights of PDTC that, together with the implementation of both in vitro and in vivo models, will provide valuable insights into biological mechanisms of progression, metastasis, and invasion of this aggressive thyroid carcinoma. Further studies on larger, carefully selected series are needed to better assess the peculiar features of PDTC and to better define its management by focusing on the best diagnostic and therapeutic approaches.","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":"428 5","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.23736/S0031-0808.24.05122-X
Sarah Damanti, M. Cilla, Bruno Tuscano, Chiara Pomaranzi, Valeria Tiraferri, Rebecka Papaioannu, Giacomo Ponta, R. De Lorenzo, Filippo Chiabrando, G. Vitali, M. Tresoldi, Patrizia Rovere Querini
{"title":"Muscle quality assessment in COVID-19 survivors: agreement between echointensity and stiffness.","authors":"Sarah Damanti, M. Cilla, Bruno Tuscano, Chiara Pomaranzi, Valeria Tiraferri, Rebecka Papaioannu, Giacomo Ponta, R. De Lorenzo, Filippo Chiabrando, G. Vitali, M. Tresoldi, Patrizia Rovere Querini","doi":"10.23736/S0031-0808.24.05122-X","DOIUrl":"https://doi.org/10.23736/S0031-0808.24.05122-X","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":"190 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-12DOI: 10.23736/S0031-0808.24.05074-2
Mengxing Li, Chunfen Pang, Lei Wu, Jinjiao Li, Xiaoying Wu
{"title":"Effect of early mechanical ventilation positive end-expiratory pressure on blood pressure in patients with ARDS combined with septic shock.","authors":"Mengxing Li, Chunfen Pang, Lei Wu, Jinjiao Li, Xiaoying Wu","doi":"10.23736/S0031-0808.24.05074-2","DOIUrl":"https://doi.org/10.23736/S0031-0808.24.05074-2","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-06DOI: 10.23736/S0031-0808.24.05061-4
Ruipeng Jia, Cuimei Liu, Rui Zhang
{"title":"Study on the correlation between the treatment of osteoporosis and osteoarthritis.","authors":"Ruipeng Jia, Cuimei Liu, Rui Zhang","doi":"10.23736/S0031-0808.24.05061-4","DOIUrl":"https://doi.org/10.23736/S0031-0808.24.05061-4","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Outcome study of five cases receiving in-vitro fertilization after treatment of intrauterine platelet-rich plasma for chronic endometritis.","authors":"Fenghua Li, Yuanqing Cui, Dongmei Zhao, Hongchu Bao, Cuifang Hao","doi":"10.23736/S0031-0808.20.04247-0","DOIUrl":"10.23736/S0031-0808.20.04247-0","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"105-107"},"PeriodicalIF":4.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38838793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of free position midwifery combined with systematic education on labor control and pain of primipara.","authors":"Chunyan Wei, Liping Yu, Wei Yan, Hua Li, Wenjuan Wei, Lili Qi","doi":"10.23736/S0031-0808.21.04598-5","DOIUrl":"10.23736/S0031-0808.21.04598-5","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"84-86"},"PeriodicalIF":4.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40313355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2022-03-22DOI: 10.23736/S0031-0808.22.04661-4
Lin Xu, Fei Xie, Haiyang Zhou, Wenjun Chen, Weidong Chen, Yingtian Jia, Liang Ma, Wusheng Li
{"title":"Clinical application of laparoscopy and laparotomy in the treatment of colorectal cancer and its effect on immune function.","authors":"Lin Xu, Fei Xie, Haiyang Zhou, Wenjun Chen, Weidong Chen, Yingtian Jia, Liang Ma, Wusheng Li","doi":"10.23736/S0031-0808.22.04661-4","DOIUrl":"10.23736/S0031-0808.22.04661-4","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"103-105"},"PeriodicalIF":4.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40313356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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