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Obesity promotes the global hypomethylation of CD4+ T cells in patients with systemic lupus erythematosus via downregulating DNMT1. 肥胖会通过下调 DNMT1 促进系统性红斑狼疮患者 CD4+ T 细胞的整体低甲基化。
IF 4.3 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Panminerva medica
Pub Date : 2024-09-01 Epub Date: 2020-06-23 DOI: 10.23736/S0031-0808.20.03990-7
Linxin Hou, Shasha Li, Mengmeng Zhao

Background: The global hypomethylation of CD4+ T cells in systemic lupus erythematosus (SLE) patients has been previously reported. However, potential influencing factors are unclear. This study aimed to uncover the potential influence of obese on hypomethylated CD4+ T cells in SLE patients.

Methods: Obese SLE patients with Body Mass Index (BMI)>30 (N.=15) and normal weight SLE patients with 18+ T cells isolated from SLE patients was assessed, as well as its correlation to BMI and Systemic Lupus Erythematosus Disease Activity Index (SLEADI) in SLE patients. Subsequently, relative level and catalytic activity of DNA (cytosine-5)-methyltransferase 1 (DNMT1) were examined. New Zealand black/white (NZB/W) mice were fed high-fat diet for generating obesity model or normal diet, followed by detection of antinuclear-ribonuclear-protein (nRNP) immunoglobulin G (IgG), antidouble-stranded (ds) DNA IgG, methylation rate of CD4+ T cells and DNMT1 level.

Results: SLEADI, nRNP and dsDNA levels were higher in obese SLE patients than normal weight cases. SLEADI was positively correlated to BMI in included SLE patients. Compared with normal weight SLE patients, methylation rate of CD4+ T cells was lower in obese patients. DNMT1 was downregulated in obese SLE patients, and its level was negatively correlated to BMI in SLE patients. Consistently, methylation rate of CD4+ T cells and DNMT1 level remained lower in obese SLE mice than those normally fed mice with SLE.

Conclusions: Hypomethylated CD4+ T cells extensively occur in SLE patients, which are much more pronounced in obese cases. DNMT1 level is found to be negatively correlated to the methylation rate of CD4+ T cells in SLE patients.

背景：以前曾有报道称，系统性红斑狼疮（SLE）患者的 CD4+ T 细胞存在全球性的低甲基化。然而，潜在的影响因素尚不清楚。本研究旨在揭示肥胖对系统性红斑狼疮患者 CD4+ T 细胞低甲基化的潜在影响：方法：纳入体重指数（BMI）大于 30 的肥胖系统性红斑狼疮患者（15 人）和体重指数小于 25 的正常体重系统性红斑狼疮患者（20 人）。检测他们体内的 SLEADI、nRNP 和 dsDNA 水平。评估了从系统性红斑狼疮患者体内分离出的 CD4+ T 细胞的甲基化率及其与系统性红斑狼疮患者体重指数和系统性红斑狼疮疾病活动指数（SLEADI）的相关性。随后，研究人员检测了 DNA（胞嘧啶-5）甲基转移酶 1（DNMT1）的相对水平和催化活性。给新西兰黑/白（NZB/W）小鼠喂食高脂饮食以产生肥胖模型或正常饮食，然后检测抗核-核蛋白（nRNP）免疫球蛋白G（IgG）、抗双链（ds）DNA IgG、CD4+ T细胞甲基化率和DNMT1水平：结果：肥胖系统性红斑狼疮患者的SLEADI、nRNP和dsDNA水平均高于正常体重病例。在纳入的系统性红斑狼疮患者中，SLEADI 与体重指数呈正相关。与体重正常的系统性红斑狼疮患者相比，肥胖患者 CD4+ T 细胞的甲基化率较低。肥胖系统性红斑狼疮患者的 DNMT1 下调，其水平与系统性红斑狼疮患者的体重指数呈负相关。肥胖系统性红斑狼疮小鼠的CD4+ T细胞甲基化率和DNMT1水平始终低于正常喂养的系统性红斑狼疮小鼠：结论：在系统性红斑狼疮患者中广泛存在 CD4+ T 细胞甲基化过高的现象，肥胖病例中更为明显。DNMT1水平与系统性红斑狼疮患者CD4+T细胞的甲基化率呈负相关。
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引用次数: 0
Application effect of evidence-based nursing in patients with diabetic foot. 循证护理在糖尿病足患者中的应用效果。
IF 4.3 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Panminerva medica
Pub Date : 2024-09-01 Epub Date: 2021-09-21 DOI: 10.23736/S0031-0808.21.04477-3
Guimei Feng, Juanjuan Meng, Mei Zhang
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引用次数: 0
Exploring the relationship between triglyceride and fasting blood glucose based on the combination of mendelian randomization and NHANES data analysis. 基于门德尔随机化和 NHANES 数据分析的结合，探索甘油三酯与空腹血糖之间的关系。
IF 4.3 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Panminerva medica
Pub Date : 2024-09-01 Epub Date: 2023-09-15 DOI: 10.23736/S0031-0808.23.04969-8
Yafen Hu, Lin Hua
{"title":"Exploring the relationship between triglyceride and fasting blood glucose based on the combination of mendelian randomization and NHANES data analysis.","authors":"Yafen Hu, Lin Hua","doi":"10.23736/S0031-0808.23.04969-8","DOIUrl":"10.23736/S0031-0808.23.04969-8","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"337-339"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10298686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the diagnosis and pathogenic relationship of primary spontaneous pneumothorax with the expression of TRACP5b and 25-OH VD assisted chest CT. TRACP5b和25-OH VD辅助胸部CT表达对原发性自发性肺气肿的诊断及发病关系的研究。
IF 4.3 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Panminerva medica
Pub Date : 2024-09-01 Epub Date: 2023-09-28 DOI: 10.23736/S0031-0808.23.04966-2
Lixin Yu, Zhenkui Zhang, Zhijian Wang, Fenghua Sun
{"title":"Study on the diagnosis and pathogenic relationship of primary spontaneous pneumothorax with the expression of TRACP5b and 25-OH VD assisted chest CT.","authors":"Lixin Yu, Zhenkui Zhang, Zhijian Wang, Fenghua Sun","doi":"10.23736/S0031-0808.23.04966-2","DOIUrl":"10.23736/S0031-0808.23.04966-2","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"339-341"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41146569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of baicalin combined with adipose stem cells on promoting angiogenesis and improving wound healing in diabetes. 黄芩苷联合脂肪干细胞对促进血管生成和改善糖尿病患者伤口愈合的影响
IF 4.3 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Panminerva medica
Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI: 10.23736/S0031-0808.24.05068-7
Zhibing Ma, Jin Ding, Jia Liu, Zhijie Zhao, Qiuzi Long, Tianqi Zhang, Jinlong Huang
{"title":"Effect of baicalin combined with adipose stem cells on promoting angiogenesis and improving wound healing in diabetes.","authors":"Zhibing Ma, Jin Ding, Jia Liu, Zhijie Zhao, Qiuzi Long, Tianqi Zhang, Jinlong Huang","doi":"10.23736/S0031-0808.24.05068-7","DOIUrl":"10.23736/S0031-0808.24.05068-7","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"324-326"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative management of medications for psychiatric disorders. 精神疾病术前药物管理。
IF 4.3 4区 医学 N/A MEDICINE, GENERAL & INTERNAL
Panminerva medica
Pub Date : 2024-09-01 Epub Date: 2024-05-17 DOI: 10.23736/S0031-0808.24.05151-6
Claudia R Fernandez Robles, Carlos G Fernandez-Robles, Adriana D Oprea

Perioperative medication management is a complex topic. Physicians working in the perioperative space are frequently called upon to make decisions regarding continuing or stopping certain medications. For patients with psychiatric disorders, the overwhelming recommendation is to continue therapy with heightened awareness of anesthesiologists regarding potential side effects or medication interactions.

围手术期用药管理是一个复杂的话题。在围手术期工作的医生经常需要就继续使用或停用某些药物做出决定。对于患有精神疾病的患者，绝大多数的建议是继续治疗，但麻醉医生要提高对潜在副作用或药物相互作用的认识。
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引用次数: 0
Evaluation of surgical resection combined with interstitial sustained-release chemotherapy in the treatment of recurrent malignant gliomas. 评估手术切除联合间质持续释放化疗治疗复发性恶性胶质瘤的效果。
IF 4.3 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Panminerva medica
Pub Date : 2024-09-01 Epub Date: 2021-06-11 DOI: 10.23736/S0031-0808.21.04422-0
Xiaoshan Huang, Guang Yan, Baisheng Li, Gang Zhu
{"title":"Evaluation of surgical resection combined with interstitial sustained-release chemotherapy in the treatment of recurrent malignant gliomas.","authors":"Xiaoshan Huang, Guang Yan, Baisheng Li, Gang Zhu","doi":"10.23736/S0031-0808.21.04422-0","DOIUrl":"10.23736/S0031-0808.21.04422-0","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"361-363"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39084599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of individual case management model on adherence to medical advice and Quality of Life in patients with diabetic nephropathy. 个体个案管理模式对糖尿病肾病患者遵医嘱和生活质量的影响。
IF 4.3 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Panminerva medica
Pub Date : 2024-09-01 Epub Date: 2024-02-06 DOI: 10.23736/S0031-0808.24.05094-8
Li Dong, Ke Pang, Zhen Zeng, Lian Tan
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引用次数: 0
Budesonide aqueous nasal spray: an updated review in managing chronic rhinosinusitis with nasal polyps. 布地诺苷水溶液鼻腔喷雾剂：治疗伴有鼻息肉的慢性鼻窦炎的最新综述。
IF 4.3 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Panminerva medica
Pub Date : 2024-09-01 Epub Date: 2024-07-17 DOI: 10.23736/S0031-0808.24.05200-5
Giorgio Ciprandi

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a frequent medical condition. Type 2 inflammation signs CRSwNP in western countries. Type 2 inflammation leads to nasal airflow limitation. Budesonide aqueous nasal spray (BANS) is an intranasal corticosteroid (INCS); it has been launched in the early 1980s. BANS is indicated for treating allergic rhinitis, nonallergic rhinitis, and nasal polyps (both as treatment and prevention after surgery). Consolidated evidence documented its efficacy in treating CRSwNP. In addition, BANS is safe with negligible local and systemic side effects. Recent guidelines for patients with CRSwNP recommend using INCS as the first line in many situations. In particular, patients may assess the perception of symptoms' severity using the Visual Analog Scale (VAS). A score >5/10 means uncontrolled symptoms in both diseases and requires adequate treatment. BANS could appropriately be used in patients with uncontrolled symptoms and/or moderate/severe nasal obstruction. In addition, BANS may adequately integrate surgery and biologics for CRSwNP management. In conclusion, BANS represents a valuable option in managing patients with type 2-mediated CRSwNP.

慢性鼻炎伴鼻息肉（CRSwNP）是一种常见的内科疾病。在西方国家，2 型炎症是 CRSwNP 的特征。2 型炎症会导致鼻腔气流受限。布地奈德水鼻喷雾剂（BANS）是一种鼻内皮质类固醇（INCS），于 20 世纪 80 年代初上市。BANS 适用于治疗过敏性鼻炎、非过敏性鼻炎和鼻息肉（包括治疗和术后预防）。综合证据表明，它对治疗 CRSwNP 具有疗效。此外，BANS 是安全的，对局部和全身的副作用微乎其微。最近针对 CRSwNP 患者的指南建议在许多情况下将 INCS 作为一线治疗方案。尤其是，患者可使用视觉模拟量表（VAS）评估症状的严重程度。评分 >5/10 意味着这两种疾病的症状均未得到控制，需要进行适当的治疗。BANS 可适当用于症状无法控制和/或中度/重度鼻阻塞的患者。此外，BANS 还可将手术和生物制剂充分结合起来，用于 CRSwNP 的治疗。总之，BANS 是治疗 2 型介导的 CRSwNP 患者的重要选择。
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引用次数: 0
Clinical study of stereotactic technology in the treatment of chyloma-induced intraventricular hemorrhage. 立体定向技术治疗乳糜泻引起的脑室出血的临床研究。
IF 4.3 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Panminerva medica
Pub Date : 2024-09-01 Epub Date: 2024-02-02 DOI: 10.23736/S0031-0808.24.05103-6
Jianbin Sun, Junhui Zhao, Jianan Zheng, Chuixian Zhou
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引用次数: 0
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