Pub Date : 2018-10-11DOI: 10.19080/jtmp.2018.03.555616
H. Çubukçu
{"title":"Trifolium pratense: A New Activator of Purine Degradation","authors":"H. Çubukçu","doi":"10.19080/jtmp.2018.03.555616","DOIUrl":"https://doi.org/10.19080/jtmp.2018.03.555616","url":null,"abstract":"","PeriodicalId":198850,"journal":{"name":"Journal of Tumor Medicine & Prevention","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131859884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-09DOI: 10.19080/JTMP.2018.03.555615
N. Hamed
The determinants of treatment success and failure remain partly understood. A combination of patient-related and specific disease-related factors are more common among this aging population and correlate markedly with treatment failure (i.e., primary resistance and relapse after induction therapy). They include comorbid conditions, performance status, decreased drug clearance and prolonged exposure to chemotherapeutics resulting from pharmacokinetic and pharmacodynamic changes, less tolerability to infections due to decreased immune competence of elderly patients, psychosocial factors (cognitive decline, social isolation, and, often, lack of caretakers), multidrug resistant abilities of the leukemia cells to expel the chemotherapeutics, antecedent hematologic disorders [3] (previous MDS, chronic myelomonocytic leukemia, myeloproliferative neoplasm), prior exposure to cytotoxic therapy for other disorders [4] and higher frequencies of adverse cytogenetics and unfavorable molecular aberrations [3].
{"title":"Acute Myeloid Leukemia in Patients Older than 60 Year","authors":"N. Hamed","doi":"10.19080/JTMP.2018.03.555615","DOIUrl":"https://doi.org/10.19080/JTMP.2018.03.555615","url":null,"abstract":"The determinants of treatment success and failure remain partly understood. A combination of patient-related and specific disease-related factors are more common among this aging population and correlate markedly with treatment failure (i.e., primary resistance and relapse after induction therapy). They include comorbid conditions, performance status, decreased drug clearance and prolonged exposure to chemotherapeutics resulting from pharmacokinetic and pharmacodynamic changes, less tolerability to infections due to decreased immune competence of elderly patients, psychosocial factors (cognitive decline, social isolation, and, often, lack of caretakers), multidrug resistant abilities of the leukemia cells to expel the chemotherapeutics, antecedent hematologic disorders [3] (previous MDS, chronic myelomonocytic leukemia, myeloproliferative neoplasm), prior exposure to cytotoxic therapy for other disorders [4] and higher frequencies of adverse cytogenetics and unfavorable molecular aberrations [3].","PeriodicalId":198850,"journal":{"name":"Journal of Tumor Medicine & Prevention","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132944711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-26DOI: 10.33552/acrci.2018.01.000503
C. D. L. Pinta, R. Hernánz, T. Muñoz, A. Polo, Á. Montero, S. Sancho
Pericardial Synovial Sarcoma (PSS) is a rare malignant soft-tissue tumor. Early diagnosis and multimodal management could be improving patient outcome. PSS diagnose is difficult due to localization but and aggressive disease. Using all the available medical methods is important to avoid progression and recurrence of this kind of tumors. Multidisciplinary treatment is necessary and radiotherapy is a good and safe option. We present our experience of a forty-year-old man with this tumor.
{"title":"Pericardial Synovial Sarcoma: A Case Report and Review of Literature","authors":"C. D. L. Pinta, R. Hernánz, T. Muñoz, A. Polo, Á. Montero, S. Sancho","doi":"10.33552/acrci.2018.01.000503","DOIUrl":"https://doi.org/10.33552/acrci.2018.01.000503","url":null,"abstract":"Pericardial Synovial Sarcoma (PSS) is a rare malignant soft-tissue tumor. Early diagnosis and multimodal management could be improving patient outcome. PSS diagnose is difficult due to localization but and aggressive disease. Using all the available medical methods is important to avoid progression and recurrence of this kind of tumors. Multidisciplinary treatment is necessary and radiotherapy is a good and safe option. We present our experience of a forty-year-old man with this tumor.","PeriodicalId":198850,"journal":{"name":"Journal of Tumor Medicine & Prevention","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124329951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-24DOI: 10.19080/JTMP.2018.03.555613
R. R. Nair
Antibodies are immunoglobulins that are part of the humoral immune response and are secreted by the B-cells (plasma cells). Antibodies act by binding to either soluble antigens or ligands that are expressed on the surface of organisms or cells. In terms of structure, antibodies are Y-shaped glycoproteins made up of two heavy chain polypeptides and two light chain polypeptides that are held together by disulfide bridges. The light and the heavy chain are made up of constant regions and variable regions with light chain having one variable and one constant region and the heavy chain having one variable and three to four constant regions (part of which forms the Fc, crystallizable portion). The variable region of the light chain and the heavy chain together forms the antigenbinding site (Fab, antigen binding portion). At the end of each variable region is the hypervariable region (CDR, complementary determining region) and it is this region that allows for numerous conformations for infinite antibody-antigen binding probability.
{"title":"Introduction to Therapeutic Antibodies","authors":"R. R. Nair","doi":"10.19080/JTMP.2018.03.555613","DOIUrl":"https://doi.org/10.19080/JTMP.2018.03.555613","url":null,"abstract":"Antibodies are immunoglobulins that are part of the humoral immune response and are secreted by the B-cells (plasma cells). Antibodies act by binding to either soluble antigens or ligands that are expressed on the surface of organisms or cells. In terms of structure, antibodies are Y-shaped glycoproteins made up of two heavy chain polypeptides and two light chain polypeptides that are held together by disulfide bridges. The light and the heavy chain are made up of constant regions and variable regions with light chain having one variable and one constant region and the heavy chain having one variable and three to four constant regions (part of which forms the Fc, crystallizable portion). The variable region of the light chain and the heavy chain together forms the antigenbinding site (Fab, antigen binding portion). At the end of each variable region is the hypervariable region (CDR, complementary determining region) and it is this region that allows for numerous conformations for infinite antibody-antigen binding probability.","PeriodicalId":198850,"journal":{"name":"Journal of Tumor Medicine & Prevention","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131768865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-28DOI: 10.19080/jtmp.2017.02.555576
A. Yordanov
Primary malignant tumors of the vagina are extremely rare, accounting for only about 2% of all gynecologic malignancies. About 140 Leiomyosarcoma in the vagina have been reported during the past 40 years [1]. There are no guidelines or standards established for the treatment of this disease. Vaginal Leiomyosarcoma usually originates from the smooth muscle tissue of the posterior vaginal wall, but they may also develop from smooth muscle cells in tissues near the vagina. This disease is diagnosed only histopatho logically.
{"title":"A Rare Case of Vaginal Leiomyosarcoma","authors":"A. Yordanov","doi":"10.19080/jtmp.2017.02.555576","DOIUrl":"https://doi.org/10.19080/jtmp.2017.02.555576","url":null,"abstract":"Primary malignant tumors of the vagina are extremely rare, accounting for only about 2% of all gynecologic malignancies. About 140 Leiomyosarcoma in the vagina have been reported during the past 40 years [1]. There are no guidelines or standards established for the treatment of this disease. Vaginal Leiomyosarcoma usually originates from the smooth muscle tissue of the posterior vaginal wall, but they may also develop from smooth muscle cells in tissues near the vagina. This disease is diagnosed only histopatho logically.","PeriodicalId":198850,"journal":{"name":"Journal of Tumor Medicine & Prevention","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124990434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-28DOI: 10.19080/JTMP.2017.01.555575
W. Nowicky
Surgery, chemotherapy and radiotherapy are the three most important types of cancer treatment. However, each of them have their limitations and as well as considerable ad-verse effects. Surgery is the oldest treatment option and, if possible, is still frequently the method of first choice. Unfortunately curative surgical intervention is only possible in few cases; the residual tumour usually remains unrecognized, leading to tumour recurrence and metastazing. Additional treatment then comes into consideration [1,2].
{"title":"The Selective Effect of NSC-631570 (UKRAIN)","authors":"W. Nowicky","doi":"10.19080/JTMP.2017.01.555575","DOIUrl":"https://doi.org/10.19080/JTMP.2017.01.555575","url":null,"abstract":"Surgery, chemotherapy and radiotherapy are the three most important types of cancer treatment. However, each of them have their limitations and as well as considerable ad-verse effects. Surgery is the oldest treatment option and, if possible, is still frequently the method of first choice. Unfortunately curative surgical intervention is only possible in few cases; the residual tumour usually remains unrecognized, leading to tumour recurrence and metastazing. Additional treatment then comes into consideration [1,2].","PeriodicalId":198850,"journal":{"name":"Journal of Tumor Medicine & Prevention","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124095873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-16DOI: 10.19080/JTMP.2018.03.555612
S. Passarella
One of the outstanding problems in biochemistry as well as in biological sciences is whether and how each research paper and in particular each review paper reports up-to date information on a specific topic. We suggest to resort to available data bases that sort publications by relevance (i.e. WEB of Sciences and SCOPUS) or by best match (i.e. PubMed). For instance, when searching for “lactate metabolism and cancer mitochondria” on July 9th2018, one finds more than 950 results that includes in the first 6, three publications from the Passarella Lab showing that cancer mitochondria can take up and metabolize externally added D and L-lactate [1-3]. This finding is further confirmed in the 14th and 15th papers on the list [4,5]. Surprisingly, the mitochondrial lactate metabolism in cancer cells is essentially ignored in all listed papers including the one published by the Gladden’s lab, which is listed at 43th place [6].
生物化学和生物科学中一个突出的问题是每一篇研究论文，特别是每一篇综述论文是否以及如何报告一个特定主题的最新信息。我们建议求助于可用的数据库，根据相关性(即WEB of Sciences和SCOPUS)或最佳匹配(即PubMed)对出版物进行排序。例如，当在2018年7月9日搜索“乳酸代谢和癌症线粒体”时，人们会发现超过950个结果，其中包括Passarella实验室的前6,3篇出版物，表明癌症线粒体可以吸收和代谢外部添加的D和l -乳酸[1-3]。这一发现在列表中的第14篇和第15篇论文中得到了进一步的证实[4,5]。令人惊讶的是，所有列出的论文基本上都忽略了癌细胞中的线粒体乳酸代谢，包括Gladden实验室发表的论文，该论文列在第43位[6]。
{"title":"Incorrect Use of The Web Databases Can Result in Incorrect Information for the Readers: The Case of Lactate-Mitochondria Affair","authors":"S. Passarella","doi":"10.19080/JTMP.2018.03.555612","DOIUrl":"https://doi.org/10.19080/JTMP.2018.03.555612","url":null,"abstract":"One of the outstanding problems in biochemistry as well as in biological sciences is whether and how each research paper and in particular each review paper reports up-to date information on a specific topic. We suggest to resort to available data bases that sort publications by relevance (i.e. WEB of Sciences and SCOPUS) or by best match (i.e. PubMed). For instance, when searching for “lactate metabolism and cancer mitochondria” on July 9th2018, one finds more than 950 results that includes in the first 6, three publications from the Passarella Lab showing that cancer mitochondria can take up and metabolize externally added D and L-lactate [1-3]. This finding is further confirmed in the 14th and 15th papers on the list [4,5]. Surprisingly, the mitochondrial lactate metabolism in cancer cells is essentially ignored in all listed papers including the one published by the Gladden’s lab, which is listed at 43th place [6].","PeriodicalId":198850,"journal":{"name":"Journal of Tumor Medicine & Prevention","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117116031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-15DOI: 10.19080/jtmp.2018.03.555611
R. T. Costa
We conducted an observational retrospective study in cancer patients assisted by the Hospital Medicine Department in a 480 beds Cancer Center in Brazil between January 2013 and December 2016. Data were retrieved from a prospectively collected database. We included a total of 4695 patients that were evaluated by the Hospitalist Department in the study period. The following clinical data were included: number of patients, age, Average Length of Stay (ALOS) and time from hospital admission to the beginning of co-management by a hospitalist. Linear regression was used to compare the ALOS during the study period. The surgical patients were divided in two groups according to the time from hospital admission to the first evaluation of the hospitalist team: early comanagement group (time to first evaluation ≤ 3 days) vs late comanagement group (time to first evaluation > 3 days). Age was described as mean ± standard deviation and mean age between groups were compared using the t-student test. Non-parametric variables were described as median (25-75% percentile). We used the Mann-Whitney test to analyze the non-parametric variables. The median hospital LOS (16 days) for the surgical population was used as the cutoff value to build a Kaplan-Meier curve considering a LOS higher than 16 days (high LOS) as endpoint. The primary outcome was the hospital length of stay (LOS) of the patients evaluated. P-values <.05 were considered to indicate statistical significance.
{"title":"Reducing the Length of Stay in Oncological Surgical Patients: Impact of Early Hospitalist Co-Management","authors":"R. T. Costa","doi":"10.19080/jtmp.2018.03.555611","DOIUrl":"https://doi.org/10.19080/jtmp.2018.03.555611","url":null,"abstract":"We conducted an observational retrospective study in cancer patients assisted by the Hospital Medicine Department in a 480 beds Cancer Center in Brazil between January 2013 and December 2016. Data were retrieved from a prospectively collected database. We included a total of 4695 patients that were evaluated by the Hospitalist Department in the study period. The following clinical data were included: number of patients, age, Average Length of Stay (ALOS) and time from hospital admission to the beginning of co-management by a hospitalist. Linear regression was used to compare the ALOS during the study period. The surgical patients were divided in two groups according to the time from hospital admission to the first evaluation of the hospitalist team: early comanagement group (time to first evaluation ≤ 3 days) vs late comanagement group (time to first evaluation > 3 days). Age was described as mean ± standard deviation and mean age between groups were compared using the t-student test. Non-parametric variables were described as median (25-75% percentile). We used the Mann-Whitney test to analyze the non-parametric variables. The median hospital LOS (16 days) for the surgical population was used as the cutoff value to build a Kaplan-Meier curve considering a LOS higher than 16 days (high LOS) as endpoint. The primary outcome was the hospital length of stay (LOS) of the patients evaluated. P-values <.05 were considered to indicate statistical significance.","PeriodicalId":198850,"journal":{"name":"Journal of Tumor Medicine & Prevention","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126089764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-18DOI: 10.19080/JTMP.2018.03.555609
Gilbert H. Smith
{"title":"Unipotent or Multipotent Mammary Stem/Progenitor Cells in Mouse Mammary Gland Development","authors":"Gilbert H. Smith","doi":"10.19080/JTMP.2018.03.555609","DOIUrl":"https://doi.org/10.19080/JTMP.2018.03.555609","url":null,"abstract":"","PeriodicalId":198850,"journal":{"name":"Journal of Tumor Medicine & Prevention","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134255309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-18DOI: 10.19080/jtmp.2018.03.555610
A. Mariniello
The era of communication we’re living has shrunk the world to a global village: digital reality is characterized by a constant stream of knowledge, and Internet articles are predominating over newspapers, radio and television. Therefore, for non-professionals, building a robust expertise on the access to information technologies and knowing how to discern between real and fake news, are contemporary and controversial issues. In this confusing scenario, the importance of educating general public to prevention is unequivocal and can be considered an ethical mission at all levels: either as primary prevention initiatives on healthy lifestyles or as secondary ones as well, promoting adherence to the screening programs. For Patient Organizations, communication facilities represent a golden opportunity to become promulgators of correct information: a beacon of positivism in the darkness of a new digital middle ages.
{"title":"Focus on Primary Prevention: A European Example of Prevention Strategies in the Digital Era","authors":"A. Mariniello","doi":"10.19080/jtmp.2018.03.555610","DOIUrl":"https://doi.org/10.19080/jtmp.2018.03.555610","url":null,"abstract":"The era of communication we’re living has shrunk the world to a global village: digital reality is characterized by a constant stream of knowledge, and Internet articles are predominating over newspapers, radio and television. Therefore, for non-professionals, building a robust expertise on the access to information technologies and knowing how to discern between real and fake news, are contemporary and controversial issues. In this confusing scenario, the importance of educating general public to prevention is unequivocal and can be considered an ethical mission at all levels: either as primary prevention initiatives on healthy lifestyles or as secondary ones as well, promoting adherence to the screening programs. For Patient Organizations, communication facilities represent a golden opportunity to become promulgators of correct information: a beacon of positivism in the darkness of a new digital middle ages.","PeriodicalId":198850,"journal":{"name":"Journal of Tumor Medicine & Prevention","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117267919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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