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Minimizing Medication Errors from Electronic Prescription Transmission—Digitizing Compounded Drug Preparations 最大限度地减少电子处方传输的用药错误——数字化复方药物制剂
Pub Date : 2019-11-07 DOI: 10.3390/pharmacy7040149
R. Parrish, Lucy Gilak, Donna Z. Bohannon, Steven Emrick, B. Serumaga, R. Guharoy
Lack of standardization related to compounded drug preparations, especially in the transition of care situations, threatens patient safety by facilitating medication error. This paper outlines progress to-date from the United States Pharmacopeia (USP) Expert Panel on the Exchange of Compounded Drug Preparation Information in Health IT Systems. The work plan developed for the group is focused on proposing a set of encoding rules that would govern how compounded nonsterile drug preparations (CNSPs) are digitized and exchanged, including patient electronic health records (EHR), pharmacy systems, e-prescribing (eRx), and other Health IT (HIT) systems to ensure a seamless compounding process tailored to the needs of an individual patient. Included in this work are identifying authorized compounding monographs, surveying provider and end-user groups for information about data specificity during e-prescribing, and generating guidelines for the development of a compatible data model for clinical formulation identifiers (CF-IDs). This paper will also discuss how evolving nomenclature standards for CNSPs within HIT systems are part of a quality assurance system for comprehensive medication management (CMM) in children, thereby minimizing medication errors across the continuum of care. Finally, a network approach for the design of medication management systems for children and their families/caregivers is proposed.
缺乏与复合药物制剂相关的标准化,特别是在护理情况的过渡中,通过促进用药错误威胁患者安全。本文概述了美国药典(USP)专家小组在卫生IT系统中交换复方药物制剂信息方面的最新进展。为该小组制定的工作计划侧重于提出一套编码规则,这些规则将管理如何将合成非无菌药物制剂(cnsp)数字化和交换,包括患者电子健康记录(EHR)、药房系统、电子处方(eRx)和其他健康信息技术(HIT)系统,以确保根据个体患者的需求量身定制无缝合成过程。这项工作包括识别授权的复方专著,调查供应商和最终用户群体,以获取电子处方期间数据特异性的信息,并为临床配方标识符(cf - id)的兼容数据模型的开发生成指南。本文还将讨论HIT系统中不断发展的cnsp命名标准如何成为儿童综合用药管理(CMM)质量保证系统的一部分,从而最大限度地减少整个护理过程中的用药错误。最后,提出了一种针对儿童及其家庭/照顾者的药物管理系统的网络设计方法。
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引用次数: 2
A Stepwise Pharmacist-Led Medication Review Service in Interdisciplinary Teams in Rural Nursing Homes 农村养老院跨学科团队中逐步药师主导的药物评价服务
Pub Date : 2019-11-05 DOI: 10.3390/pharmacy7040148
K. Halvorsen, Torunn Stadeløkken, B. Garcia
Background: The provision of responsible medication therapy to old nursing home residents with comorbidities is a difficult task and requires extensive knowledge about optimal pharmacotherapy for different conditions. We describe a stepwise pharmacist-led medication review service in combination with an interdisciplinary team collaboration in order to identify, resolve, and prevent medication related problems (MRPs). Methods: The service included residents from four rural Norwegian nursing homes during August 2016–January 2017. All residents were eligible if they (or next of kin) supplied oral consent. The interdisciplinary medication review service comprised four steps: (1) patient and medication history taking; (2) systematic medication review; (3) interdisciplinary case conference; and (4) follow-up of pharmaceutical care plan. The pharmacist collected information about previous and present medication use, and clinical and laboratory values necessary for the medication review. The nurses collected information about possible symptoms related to adverse drug reactions. The pharmacist conducted the medication reviews, identified medication-related problems (MRPs) which were discussed at case conferences with the responsible physician and the responsible nurses. The main outcome measures were number and types of MRPs, percentage agreement between pharmacists and physicians and factors associated with MRPs. Results: The service was delivered for 151 (94%) nursing home residents. The pharmacist identified 675 MRPs in 146 (97%) medication lists (mean 4.0, SD 2.6, range 0–13). The MRPs most frequently identified concerned ‘unnecessary drug’ (22%), ‘too high dosage’ (17%) and ‘drug interactions’ (16%). The physicians agreed upon 64% of the pharmacist recommendations, and action was taken immediately for 32% of these. We identified no association between the number of MRPs and sex (p = 0.485), but between the number of MRPs, and the number of medications and the individual nursing homes. Conclusion: The pharmacist-led medication review service in the nursing homes was highly successfully piloted with many solved and prevented MRPs in interdisciplinary collaboration between the pharmacist, physicians, and nurses. Implementation of this service as a standard in all four nursing homes seems necessary and feasible. If such a service is implemented, effects related to patient outcomes, interdisciplinary collaboration, and health economy should be studied.
背景:为有合并症的养老院老人提供负责任的药物治疗是一项艰巨的任务,需要广泛的关于不同情况下最佳药物治疗的知识。我们描述了一种逐步药剂师主导的药物审查服务,结合跨学科团队合作,以识别、解决和预防药物相关问题(mrp)。方法:该服务包括2016年8月至2017年1月期间来自挪威四个农村养老院的居民。如果他们(或近亲)口头同意,所有居民都有资格。跨学科药物审查服务包括四个步骤:(1)患者和用药史的调查;(2)系统的用药评价;(3)跨学科案例会议;(4)药学服务计划的随访。药剂师收集以往和现在的用药信息,以及药物审查所需的临床和实验室值。护士收集与药物不良反应有关的可能症状的信息。药剂师进行药物审查,确定药物相关问题(mrp),并在病例会议上与负责的医生和负责的护士讨论。主要结局指标为mrp的数量和类型、药师和医师之间的一致性百分比以及与mrp相关的因素。结果:为151名(94%)养老院居民提供了服务。药剂师在146份(97%)药物清单中确定了675个mrp(平均4.0,标准差2.6,范围0-13)。最常见的mrp涉及“不必要的药物”(22%)、“剂量太高”(17%)和“药物相互作用”(16%)。医生同意了64%的药剂师建议,并立即采取了32%的行动。我们发现mrp的数量与性别之间没有关联(p = 0.485),但mrp的数量与药物数量和个体养老院之间存在关联。结论:药师主导的养老院用药审评服务在药师、医师和护士的跨学科合作中取得了较好的效果,解决和预防了许多mrp问题。将这项服务作为一项标准在所有四家养老院实施似乎是必要和可行的。如果实施这种服务,应研究与患者预后、跨学科合作和卫生经济相关的影响。
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引用次数: 8
BundlED Up: A Narrative Review of Antimicrobial Stewardship Initiatives and Bundles in the Emergency Department 捆绑:急诊科抗菌素管理倡议和捆绑的叙述性回顾
Pub Date : 2019-11-01 DOI: 10.3390/pharmacy7040145
Maressa Santarossa, Emily Kilber, E. Wenzler, Fritzie S. Albarillo, Ethan Sterk
Antimicrobial stewardship (ASP) is becoming an increasingly high priority worldwide, yet the emergency department (ED) is an area where stewardship is often neglected. Implementing care bundles, guidelines, and protocols appears to be a rational strategy for ED stewardship given the inherently dynamic and hectic environment of care. Multiple questions still exist such as whether to target certain disease states, optimal implementation of ASP interventions in the ED, and the benefit of unique ED-specific guidelines and protocols. A narrative review was performed on interventions, guidelines, and bundles implemented in the ED setting, in an effort to improve ASP or management of infectious diseases. This review is meant to serve as a framework for the reader to implement these practices at their own institution. We examined various studies related to ASP interventions or care bundles in the ED which included: CNS infections (one study), skin and soft-tissue infections (one study), respiratory infections (four studies), urinary tract infections and sexually transmitted infections (eight studies), sepsis (two studies), culture follow-up programs (four studies), and stewardship in general or multiple infection types (five studies). The interventions in this review were diverse, yet the majority showed a benefit in clinical outcomes or a decrease in antimicrobial use. Care bundles, guidelines, and antimicrobial stewardship interventions can streamline care and improve the management of common infectious diseases seen in the ED.
抗菌药物管理(ASP)正在成为世界范围内越来越高的优先事项,然而急诊科(ED)是一个管理往往被忽视的领域。鉴于急诊科固有的动态和繁忙的护理环境,实施护理包、指导方针和协议似乎是急诊科管理的合理策略。多个问题仍然存在,如是否针对某些疾病状态,在ED中最佳实施ASP干预措施,以及独特的ED特异性指南和方案的益处。对在急诊科环境中实施的干预措施、指南和一揽子措施进行了叙述性回顾,以努力改善ASP或传染病管理。这篇综述的目的是为读者在他们自己的机构中实现这些实践提供一个框架。我们检查了ED中与ASP干预措施或护理包相关的各种研究,包括:中枢神经系统感染(一项研究)、皮肤和软组织感染(一项研究)、呼吸道感染(四项研究)、尿路感染和性传播感染(八项研究)、败血症(两项研究)、培养随访计划(四项研究)和一般或多种感染类型的管理(五项研究)。本综述中的干预措施多种多样,但大多数干预措施在临床结果或减少抗菌药物使用方面显示出益处。护理包、指南和抗菌药物管理干预措施可以简化护理并改善急诊科常见传染病的管理。
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引用次数: 7
Impact of Diabetes Perceptions on Medication Adherence in Japan 日本糖尿病认知对药物依从性的影响
Pub Date : 2019-10-29 DOI: 10.3390/pharmacy7040144
Koki Urata, Kana Hashimoto, R. Horiuchi, Kiichi Fukui, K. Arai
Background: Patients’ perception of diabetes mellitus is one of the psychosocial factors influencing diabetic behavior. This patients’ perception of the disease is a mental image formed from the experience of patients with type 2 diabetes mellitus and reportedly reflects the aspect of recuperation. We investigated the relationship between changes in the patients’ perception of the disease and medication adherence, as influenced by the active involvement of community pharmacists. Methods: A prospective cohort study that used patient registry based in community pharmacies was conducted in patients with type 2 diabetes using oral antidiabetic agents at a pharmacy in Ishikawa Prefecture in Japan. Patients responded to the questionnaire at the time of enrollment and at the end of the one-year intervention period. The pharmacist confirmed the patient's medication status and treatment problems via telephone calls at least once every two weeks for one year. Main outcome measures: Type 2 diabetes patients’ perception of the disease related to medication adherence. Results: The study enrolled 113 patients. Among the seven diabetes image factors, “Living an orderly life” and “Feeling of fear” were significantly associated with medication adherence. “Feeling of neglect of health” was significantly associated at the subscale level. Conclusion: All the three factors related to medication adherence indicated self-care ability. To enhance the self-care ability of the patient, pharmacists should assist in self-care interventions for the patients.
背景:患者对糖尿病的认知是影响糖尿病行为的社会心理因素之一。该患者对疾病的感知是由2型糖尿病患者的经历形成的心理形象,据报道反映了疗养方面。我们调查了在社区药师积极参与的影响下,患者对疾病的认知变化与药物依从性之间的关系。方法:对日本石川县一家药店使用口服降糖药的2型糖尿病患者进行前瞻性队列研究,该研究采用基于社区药房的患者登记。患者在入组时和一年干预期结束时回答问卷。药剂师通过至少每两周一次的电话确认患者的用药状况和治疗问题,持续一年。主要观察指标:2型糖尿病患者对疾病的认知与药物依从性的关系。结果:研究入组113例患者。7个糖尿病形象因素中,“生活有序”和“恐惧感”与药物依从性显著相关。“忽视健康的感觉”在亚量表水平上显著相关。结论:三个因素均与服药依从性有关,反映了患者的自理能力。为提高患者的自我护理能力,药师应协助患者进行自我护理干预。
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引用次数: 6
Anticholinergic Burden, Sleep Quality and Health Outcomes in Malaysian Aged Care Home Residents 马来西亚老年护理院居民的抗胆碱能负担、睡眠质量和健康结果
Pub Date : 2019-10-23 DOI: 10.3390/pharmacy7040143
Suresh Kumar, S. Hasan, P. Wong, D. Chong, T. Kairuz
The use of anticholinergic medications by residents in aged care homes is associated with increased risk of adverse effects. These include cognitive impairment, sleep disturbances, and falls, and necessitate increased healthcare visits and the associated burden on healthcare systems. The objective of this study was to investigate associations between anticholinergic burden and health outcomes such as independence in activities for daily living, frailty, quality of life, and sleep quality. The study was conducted among residents in Malaysian aged care homes, aged 60 years and above. Anticholinergic burden was calculated using the Anticholinergic Cognitive Burden (ACB) scale. Health outcome measures included independence, assessed using the Katz Activities for Daily Living scale (Katz ADL); quality of life, assessed using the Older People’s Quality of Life Questionnaire (OPQOL); frailty, assessed using the Groningen Frailty Index (GFI); and sleep quality, measured using the Pittsburg Sleep Quality Index (PSQI). Just over one-third (36%) of the study population was exposed to at least one medication with anticholinergic effect. An increased anticholinergic cognitive burden was associated with frailty (p = 0.031), sleep latency (p = 0.007), and sleep disturbances (p = 0.015). Further studies are required to assess the effect of prolonged exposure to anticholinergic medications on health outcomes.
老年护理院里的居民使用抗胆碱能药物会增加不良反应的风险。这些障碍包括认知障碍、睡眠障碍和跌倒,需要增加医疗保健就诊次数,并给医疗保健系统带来相关负担。本研究的目的是调查抗胆碱能负担与健康结果之间的关系,如日常生活活动的独立性、虚弱、生活质量和睡眠质量。这项研究是在马来西亚养老院的60岁及以上的居民中进行的。采用抗胆碱能认知负荷(ACB)量表计算抗胆碱能负荷。健康结果测量包括独立性,使用Katz日常生活活动量表(Katz ADL)进行评估;生活质量,使用老年人生活质量问卷(OPQOL)进行评估;脆弱性,使用格罗宁根脆弱性指数(GFI)进行评估;睡眠质量,使用匹兹堡睡眠质量指数(PSQI)来衡量。超过三分之一(36%)的研究人群暴露于至少一种具有抗胆碱能作用的药物。抗胆碱能认知负担的增加与虚弱(p = 0.031)、睡眠潜伏期(p = 0.007)和睡眠障碍(p = 0.015)相关。需要进一步的研究来评估长期接触抗胆碱能药物对健康结果的影响。
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引用次数: 7
Advancing Pharmacist Collaborative Care within Academic Health Systems 在学术卫生系统内推进药剂师协作护理
Pub Date : 2019-10-11 DOI: 10.3390/pharmacy7040142
L. Awdishu, Renu Singh, Ila M. Saunders, Felix K. Yam, J. Hirsch, S. Lorentz, Rabia S. Atayee, Joseph D. Ma, S. Tsunoda, Jennifer M. Namba, Christina Mnatzaganian, N. Painter, J. Watanabe, Kelly C. Lee, C. Daniels, C. Morello
Introduction: The scope of pharmacy practice has evolved over the last few decades to focus on the optimization of medication therapy. Despite this positive impact, the lack of reimbursement remains a significant barrier to the implementation of innovative pharmacist practice models. Summary: We describe the successful development, implementation and outcomes of three types of pharmacist collaborative care models: (1) a pharmacist with physician oversight, (2) pharmacist–interprofessional teams and (3) physician–pharmacist teams. The outcome measurement of these pharmacist care models varied from the design phase to patient volume measurement and to comprehensive quality dashboards. All of these practice models have been successfully funded by affiliated health systems or grants. Conclusions: The expansion of pharmacist services delivered by clinical faculty has several benefits to affiliated health systems: (1) significant improvements in patient care quality, (2) access to experts in specialty areas, and (3) the dissemination of outcomes with national and international recognition, increasing the visibility of the health system.
导言:在过去的几十年里,药学实践的范围已经发展到专注于药物治疗的优化。尽管有这种积极的影响,缺乏报销仍然是实施创新药剂师实践模式的重大障碍。摘要:我们描述了三种类型的药剂师合作护理模式的成功发展,实施和结果:(1)药剂师监督,(2)药剂师-跨专业团队和(3)医生-药剂师团队。这些药剂师护理模型的结果测量从设计阶段到患者量测量和综合质量仪表板各不相同。所有这些实践模式都成功地由附属卫生系统或赠款资助。结论:扩大临床教师提供的药剂师服务对附属卫生系统有几个好处:(1)显著改善患者护理质量;(2)获得专业领域的专家;(3)传播国内和国际认可的结果,提高卫生系统的知名度。
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引用次数: 13
Pharmacist Services 药剂师服务
Pub Date : 2019-10-10 DOI: 10.3390/pharmacy7040141
J. Schommer, Anthony W. Olson
Welcome to the "Pharmacist Services" special issue in the journal Pharmacy, an open access journal with a focus on pharmacy education and practice [...].
欢迎来到《药学》杂志的“药剂师服务”特刊,这是一本关注药学教育和实践的开放获取期刊。
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引用次数: 3
Swedish Pharmacy Students’ Expectations and Perceptions of Their Education and Future Pharmacy Profession 瑞典药学学生对其教育和未来药学专业的期望和看法
Pub Date : 2019-09-25 DOI: 10.3390/pharmacy7040139
M. Gustafsson, Sofia Mattsson
Distance education is becoming more and more common, and today distance education is well established within academic settings. The aim was to investigate first-year pharmacy students’ expectations and perceptions of web-based pharmacy programs and of their future profession. Furthermore, student characteristics were compared over time. A questionnaire was distributed to all first-year students admitted to the pharmacy programs at Umeå University in 2017. The students were asked questions about their background, motives for choosing pharmacy education, and their expectations and perceptions of their education and profession. Factors of most importance when choosing the education were: the education is interesting, leads to an interesting job, and is web-based. The students’ expectations of the education were high, and they want to learn as much as possible and be well prepared for their future profession. Regarding the students’ perception of their future profession, three themes were identified: to help other people, professional development, and employment related issues. Student characteristics have changed over the years, suggesting that the web-based pharmacy education and the flexibility it entails attracts other groups of students today compared with when the programs started.
远程教育正变得越来越普遍,今天远程教育在学术环境中已经很好地建立起来了。目的是调查药学一年级学生对基于网络的药学课程和他们未来职业的期望和看法。此外,随着时间的推移,对学生的特征进行了比较。2017年,一份调查问卷被分发给了所有进入尤梅夫大学药学专业的一年级学生。这些学生被问及他们的背景、选择药学教育的动机,以及他们对自己的教育和职业的期望和看法。选择教育时最重要的因素是:教育是有趣的,导致一个有趣的工作,是基于网络的。学生们对教育的期望很高,他们希望尽可能多地学习,为未来的职业做好准备。关于学生对未来职业的看法,确定了三个主题:帮助他人、专业发展和就业相关问题。多年来,学生的特点已经发生了变化,这表明,与项目开始时相比,基于网络的药学教育及其灵活性吸引了今天其他群体的学生。
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引用次数: 1
Examining the Pharmacist Labor Supply in the United States: Increasing Medication Use, Aging Society, and Evolution of Pharmacy Practice 考察美国的药剂师劳动力供给:增加药物使用,老龄化社会和药学实践的演变
Pub Date : 2019-09-01 DOI: 10.3390/pharmacy7030137
J. Watanabe
The increasing number of pharmacists in the US has generated concern regarding potential oversupply. A 2018 analysis from the National Center for Health Workforce Analysis (NCHWA) in the US projected a best case scenario of an oversupply of more than 18,000 pharmacists in the year 2030. In this commentary, the limitations of this general health labor force analysis by the NCHWA are described. The goal of this work was to provide a more nuanced examination of the pharmacist labor demand in the US. Data from the US Bureau of Labor Statistics (BLS) and the US Medical Expenditure Panel Survey (MEPS) were utilized to examine, annually over a ten year period ending in 2017, the number of pharmacists, the ratio of pharmacists to persons living in the US, the ratio of pharmacists to older adults living in the US, and the ratio of medications to pharmacists. The number of pharmacists grew from 266,410 in 2008 to 309,330 in 2017. As anticipated, despite a growing US population, the ratio of people living in the US per pharmacist dropped unabated from 1141 to 1053 from 2008 to 2017, respectively. However, the reverse trend was observed for the ratio of persons 65 years or older per pharmacist. This ratio increased from 146.1 older adults to each pharmacist in 2008 to 164.3 in 2017. The accelerating demographic shift to an older population is also reversing an overall trend in the number of medications to pharmacist that will continue for the foreseeable future. While the ratio of medications to pharmacist dropped overall from 2008 to 2016, it has begun to rise again from 2016 to 2017. Beyond the increasing number of medications attributable to a rapidly aging population, there is a growing demand for clinical care from pharmacists due to the maturing environment of complex, costly medications for chronic disease treatment. As the portion of total health expenditure is increasingly devoted to medications and the US health delivery system continues its movement to community-based care, the demand for pharmacist care will require a larger number of pharmacists trained for advanced-practice care.
美国药剂师数量的增加引发了对潜在供应过剩的担忧。美国国家卫生人力分析中心(NCHWA) 2018年的一项分析预测,到2030年,最好的情况是超过1.8万名药剂师供过于求。在这篇评论中,描述了国家卫生和社会福利部的一般卫生劳动力分析的局限性。这项工作的目标是提供一个更细致入微的检查药剂师劳动力需求在美国。利用美国劳工统计局(BLS)和美国医疗支出小组调查(MEPS)的数据,在截至2017年的10年期间,每年检查药剂师的数量、药剂师与美国居民的比例、药剂师与美国老年人的比例,以及药物与药剂师的比例。药剂师的数量从2008年的266410人增加到2017年的309330人。正如预期的那样,尽管美国人口不断增长,但从2008年到2017年,美国每名药剂师的人口比例分别从1141人下降到1053人。然而,相反的趋势是观察65岁或65岁以上的人每名药剂师的比例。这一比例从2008年的146.1名老年人对每名药剂师增加到2017年的164.3名。人口结构向老年人口的加速转变也扭转了药剂师所需药物数量的总体趋势,这种趋势在可预见的未来将继续下去。虽然药物与药剂师的比例从2008年到2016年整体下降,但从2016年到2017年又开始上升。除了人口快速老龄化导致的药物数量不断增加之外,由于复杂、昂贵的慢性疾病治疗药物环境日趋成熟,对药剂师临床护理的需求也在不断增长。随着总卫生支出的一部分越来越多地用于药物治疗,美国卫生服务系统继续向社区护理转移,对药剂师护理的需求将需要更多受过高级实践护理培训的药剂师。
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引用次数: 6
Penicillin Allergy Assessment and Skin Testing in the Outpatient Setting 青霉素过敏评估和皮肤试验在门诊设置
Pub Date : 2019-09-01 DOI: 10.3390/pharmacy7030136
Wesley D. Kufel, Wesley D. Kufel, Wesley D. Kufel, J. Justo, P. Bookstaver, Lisa M. Avery, Lisa M. Avery
Penicillin allergies are among of the most commonly reported allergies, yet only 10% of these patients are truly allergic. This leads to potential inadvertent negative consequences for patients and makes treatment decisions challenging for clinicians. Thus, allergy assessment and penicillin skin testing (PST) are important management strategies to reconcile and clarify labeled penicillin allergies. While PST is more common in the inpatient setting where the results will immediately impact antibiotic management, this process is becoming of increasing importance in the outpatient setting. PST in the outpatient setting allows clinicians to proactively de-label and educate patients accordingly so beta-lactam antibiotics may be appropriately prescribed when necessary for future infections. While allergists have primarily been responsible for PST in the outpatient setting, there is an increasing role for pharmacist involvement in the process. This review highlights the importance of penicillin allergy assessments, considerations for PST in the outpatient setting, education and advocacy for patients and clinicians, and the pharmacist’s role in outpatient PST.
青霉素过敏是最常见的过敏症之一,但这些患者中只有10%真正过敏。这导致潜在的无意的负面后果,对患者和临床医生的治疗决策具有挑战性。因此,过敏评估和青霉素皮肤试验(PST)是协调和澄清标记青霉素过敏的重要管理策略。虽然PST在住院环境中更为常见,其结果将立即影响抗生素管理,但这一过程在门诊环境中变得越来越重要。门诊环境中的PST允许临床医生主动取消标签并相应地教育患者,以便在必要时为未来的感染适当开β -内酰胺类抗生素。虽然过敏症专家主要负责门诊环境中的PST,但药剂师在这一过程中的作用越来越大。这篇综述强调了青霉素过敏评估的重要性,门诊环境中PST的考虑,对患者和临床医生的教育和宣传,以及药剂师在门诊PST中的作用。
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引用次数: 16
期刊
Pharmacy: Journal of Pharmacy Education and Practice
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