{"title":"First report of anaphylaxis to miswak (Salvadora persica).","authors":"Mohammed Osman Hussein, Abdullah A Alangari","doi":"10.1111/pai.14256","DOIUrl":"https://doi.org/10.1111/pai.14256","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"35 10","pages":"e14256"},"PeriodicalIF":4.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Atopic dermatitis (AD) has the highest disease burden among all skin diseases. However, reports on AD prevalence trends in China are limited. This study aimed to investigate the time trends of AD prevalence in China from 1990 to 2021 and to explore the age and sex differences.
Methods: Data were obtained from the Global Burden of Disease Study, 2021. We analyzed the annual percentage change in the crude prevalence rate and age-standardized prevalence rate (ASPR) of AD from 1990 to 2021 using the Joinpoint model. We predicted the future prevalence of AD from 2022 to 2030 using the Bayesian age-period-cohort model.
Results: The total ASPR decreased slightly from 1990 (1357.93 per 100,000) to 2021 (1347.11 per 100,000). The ASPR of females (1457.64 per 100,000) was higher than that of males (1247.04 per 100,000) in 2021. The prevalence rate of AD was highest in the under 5 years old age group (3455.56 per 100,000) and the 5-9 years old age group (3360.31 per 100,000). By 2030, the predicted ASPR of AD will be 1394.36 (per 100,000) in males and 1603.69 in females (per 100,000). The predicted prevalence rate in the under 5 years old (3996.14 per 100,000 in males and 3990.68 per 100,000 in females) and 5-9 years old (3714.61 per 100,000 in males and 3963.96 per 100,000 in females) age groups will be higher than those in other age groups.
Conclusion: Despite a slight decrease from 1990 to 2021, there has been an increasing trend since 2015 in the total AD burden. Given the increasing burden of AD on Chinese children and females, healthcare practitioners should enhance community education, improve disease management abilities of patients and caregivers, and reduce the burden and healthcare costs of AD.
{"title":"Trends in atopic dermatitis prevalence among the Chinese population (1990-2021) with projections for 2022-2030.","authors":"Jingjing Zhou, Huijing Chen, Shangcheng Zhou, Ailing Liu, Shanshan Liang, Xiaoning Sun, Kaiyue He","doi":"10.1111/pai.14271","DOIUrl":"10.1111/pai.14271","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) has the highest disease burden among all skin diseases. However, reports on AD prevalence trends in China are limited. This study aimed to investigate the time trends of AD prevalence in China from 1990 to 2021 and to explore the age and sex differences.</p><p><strong>Methods: </strong>Data were obtained from the Global Burden of Disease Study, 2021. We analyzed the annual percentage change in the crude prevalence rate and age-standardized prevalence rate (ASPR) of AD from 1990 to 2021 using the Joinpoint model. We predicted the future prevalence of AD from 2022 to 2030 using the Bayesian age-period-cohort model.</p><p><strong>Results: </strong>The total ASPR decreased slightly from 1990 (1357.93 per 100,000) to 2021 (1347.11 per 100,000). The ASPR of females (1457.64 per 100,000) was higher than that of males (1247.04 per 100,000) in 2021. The prevalence rate of AD was highest in the under 5 years old age group (3455.56 per 100,000) and the 5-9 years old age group (3360.31 per 100,000). By 2030, the predicted ASPR of AD will be 1394.36 (per 100,000) in males and 1603.69 in females (per 100,000). The predicted prevalence rate in the under 5 years old (3996.14 per 100,000 in males and 3990.68 per 100,000 in females) and 5-9 years old (3714.61 per 100,000 in males and 3963.96 per 100,000 in females) age groups will be higher than those in other age groups.</p><p><strong>Conclusion: </strong>Despite a slight decrease from 1990 to 2021, there has been an increasing trend since 2015 in the total AD burden. Given the increasing burden of AD on Chinese children and females, healthcare practitioners should enhance community education, improve disease management abilities of patients and caregivers, and reduce the burden and healthcare costs of AD.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"35 10","pages":"e14271"},"PeriodicalIF":4.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam Klocperk, Petr Říha, Renata Formánková, Martin Kynčl, Anna Šedivá, Petr Sedláček
{"title":"Resolution of granulomatous lesions in a Nijmegen breakage syndrome patient with severe immunodeficiency after hematopoietic stem cell transplantation","authors":"Adam Klocperk, Petr Říha, Renata Formánková, Martin Kynčl, Anna Šedivá, Petr Sedláček","doi":"10.1111/pai.14247","DOIUrl":"https://doi.org/10.1111/pai.14247","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"38 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prabal Barman, Sanchi Chawla, Jyoti Sharma, Rahul Tyagi, Adil Karim, Amit Rawat, Biman Saikia, Ankur Kumar Jindal
{"title":"Cold abscess and high IgE beyond Job's syndrome: Four cases of IL‐6R deficiency","authors":"Prabal Barman, Sanchi Chawla, Jyoti Sharma, Rahul Tyagi, Adil Karim, Amit Rawat, Biman Saikia, Ankur Kumar Jindal","doi":"10.1111/pai.14244","DOIUrl":"https://doi.org/10.1111/pai.14244","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"194 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonio Bognanni, Philippe Eigenmann, Julia E. M. Upton
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{"title":"Editorial comment on “Current options in the management of tree nut allergy: A systematic review and narrative synthesis”","authors":"Antonio Bognanni, Philippe Eigenmann, Julia E. M. Upton","doi":"10.1111/pai.14227","DOIUrl":"https://doi.org/10.1111/pai.14227","url":null,"abstract":"<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/pai14227-fig-0001-m.png\"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"8 1","pages":"e14227"},"PeriodicalIF":4.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship of advanced glycation end products with disease severity in breast‐fed infants with atopic dermatitis","authors":"Şenay Burçin Alkan, Tuğba Güler, İlknur Külhaş Çelik, Hasibe Artaç","doi":"10.1111/pai.14238","DOIUrl":"https://doi.org/10.1111/pai.14238","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"21 1","pages":"e14238"},"PeriodicalIF":4.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberto Berni Canani, Laura Carucci, Serena Coppola, Enza D'Auria, Liam O'Mahony, Franziska Roth‐Walter, Emilia Vassilopolou, Carlo Agostoni, Iaona Agache, Cezmi Akdis, Fiorenza De Giovanni Di Santa Severina, Gaby Faketea, Matt Greenhawt, Karin Hoffman, Karin Hufnagel, Rosan Meyer, Gregorio Paolo Milani, Anna Nowak‐Wegrzyn, Bright Nwaru, Ines Padua, Lorella Paparo, Peroni Diego, Imke Reese, Caroline Roduit, Peter K. Smith, Alexandra Santos, Eva Untersmayr, Berber Vlieg‐Boerstra, Carina Venter
BackgroundConsumption of ultra‐processed foods [UPFs] may be associated with negative health outcomes. Limited data exist regarding the potential role of UPFs in the occurrence of allergic diseases. The underlying mechanisms underpinning any such associations are also poorly elucidated.MethodsWe performed a systematic review and narrative evidence synthesis of the available literature to assess associations between UPF consumption and pediatric allergy outcomes (n = 26 papers), including data on the association seen with the gut microbiome (n = 16 papers) or immune system (n = 3 papers) structure and function following PRISMA guidelines.ResultsDietary exposure to fructose, carbonated soft drinks, and sugar intake was associated with an increased risk of asthma, allergic rhinitis, and food allergies in children. Commercial baby food intake was associated with childhood food allergy. Childhood intake of fructose, fruit juices, sugar‐sweetened beverages, high carbohydrate UPFs, monosodium glutamate, UPFs, and advanced glycated end‐products (AGEs) was associated with the occurrence of allergic diseases. Exposure to UPFs and common ingredients in UPFs seem to be associated with increased occurrence of allergic diseases such as asthma, wheezing, food allergies, atopic dermatitis, and allergic rhinitis, in many, but not all studies.ConclusionMore preclinical and clinical studies are required to better define the link between UPF consumption and the risk of allergies and asthma. These observational studies ideally require supporting data with clearly defined UPF consumption, validated dietary measures, and mechanistic assessments to definitively link UPFs with the risk of allergies and asthma.
{"title":"Ultra‐processed foods, allergy outcomes and underlying mechanisms in children: An EAACI task force report","authors":"Roberto Berni Canani, Laura Carucci, Serena Coppola, Enza D'Auria, Liam O'Mahony, Franziska Roth‐Walter, Emilia Vassilopolou, Carlo Agostoni, Iaona Agache, Cezmi Akdis, Fiorenza De Giovanni Di Santa Severina, Gaby Faketea, Matt Greenhawt, Karin Hoffman, Karin Hufnagel, Rosan Meyer, Gregorio Paolo Milani, Anna Nowak‐Wegrzyn, Bright Nwaru, Ines Padua, Lorella Paparo, Peroni Diego, Imke Reese, Caroline Roduit, Peter K. Smith, Alexandra Santos, Eva Untersmayr, Berber Vlieg‐Boerstra, Carina Venter","doi":"10.1111/pai.14231","DOIUrl":"https://doi.org/10.1111/pai.14231","url":null,"abstract":"BackgroundConsumption of ultra‐processed foods [UPFs] may be associated with negative health outcomes. Limited data exist regarding the potential role of UPFs in the occurrence of allergic diseases. The underlying mechanisms underpinning any such associations are also poorly elucidated.MethodsWe performed a systematic review and narrative evidence synthesis of the available literature to assess associations between UPF consumption and pediatric allergy outcomes (<jats:italic>n</jats:italic> = 26 papers), including data on the association seen with the gut microbiome (<jats:italic>n</jats:italic> = 16 papers) or immune system (<jats:italic>n</jats:italic> = 3 papers) structure and function following PRISMA guidelines.ResultsDietary exposure to fructose, carbonated soft drinks, and sugar intake was associated with an increased risk of asthma, allergic rhinitis, and food allergies in children. Commercial baby food intake was associated with childhood food allergy. Childhood intake of fructose, fruit juices, sugar‐sweetened beverages, high carbohydrate UPFs, monosodium glutamate, UPFs, and advanced glycated end‐products (AGEs) was associated with the occurrence of allergic diseases. Exposure to UPFs and common ingredients in UPFs seem to be associated with increased occurrence of allergic diseases such as asthma, wheezing, food allergies, atopic dermatitis, and allergic rhinitis, in many, but not all studies.ConclusionMore preclinical and clinical studies are required to better define the link between UPF consumption and the risk of allergies and asthma. These observational studies ideally require supporting data with clearly defined UPF consumption, validated dietary measures, and mechanistic assessments to definitively link UPFs with the risk of allergies and asthma.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"100 1","pages":"e14231"},"PeriodicalIF":4.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachelle A. Pretorius, Elizabeth McKinnon, Debra J. Palmer
BackgroundA mother's diet during pregnancy may influence her infant's immune development. However, as potential interactions between components of our dietary intakes can make any nutritional analysis complex, here we took a multi‐component dietary analysis approach.MethodsNutritional intake data was collected from 639 pregnant women using a validated semi‐quantitative food frequency questionnaire to reflect their dietary intakes during 32–36 weeks of gestation. To investigate their dietary intake pattern, we calculated Dietary Inflammatory Index scores. Maternal consumption of 12 food groups, 20 individual whole foods, and 18 specific nutrient intakes, along with any vitamin and mineral supplementation, were determined. Infant outcomes included eczema, allergen sensitization, and IgE‐mediated food allergy. Regression‐based analyses with covariates adjustment were applied.ResultsWomen with higher white bread consumption were more likely to have an infant with doctor‐diagnosed eczema (adjusted relative risk [aRR] 1.16; 95% CI 1.08, 1.24; p < .001) and IgE‐mediated food allergy (aRR 1.14; 95% CI 1.02, 1.28; p = .02). Higher maternal intakes of fiber‐rich bread (aRR 1.14; 95% CI 1.04, 1.25; p = .01) and legumes (aRR 1.11; 95% CI 1.02, 1.21; p = .02) were also associated with infant doctor‐diagnosed eczema. Higher maternal thiamine intakes were associated with increased parent‐reported infant eczema (aRR 1.08; 95% CI 1.03, 1.12; p < .001).ConclusionIn Australia, where bread flour is fortified with thiamine, we identified consistent links between higher maternal thiamine‐rich diets and increased risk of infant eczema and food allergy. Our results highlight a need for further investigation of potential effects of high thiamine exposures on immune development, especially in‐utero.
背景母亲在怀孕期间的饮食可能会影响婴儿的免疫发育。然而，由于膳食摄入成分之间的潜在相互作用可能会使任何营养分析变得复杂，因此我们在此采用了多成分膳食分析方法。方法：我们使用经过验证的半定量食物频率问卷收集了 639 名孕妇的营养摄入数据，以反映她们在妊娠 32-36 周期间的膳食摄入情况。为了调查她们的膳食摄入模式，我们计算了膳食炎症指数得分。我们还确定了孕妇对 12 种食物组、20 种单独的全食物和 18 种特定营养素的摄入量，以及是否补充了维生素和矿物质。婴儿的结果包括湿疹、过敏原致敏和 IgE 介导的食物过敏。结果白面包摄入量越高的女性，其婴儿更有可能被医生诊断为湿疹（调整后相对风险 [aRR] 1.16; 95% CI 1.08, 1.24; p <.001）和IgE介导的食物过敏（aRR 1.14; 95% CI 1.02, 1.28; p = .02）。母亲摄入更多富含纤维的面包（aRR 1.14；95% CI 1.04，1.25；p = .01）和豆类（aRR 1.11；95% CI 1.02，1.21；p = .02）也与医生诊断的婴儿湿疹有关。结论在澳大利亚，面包粉中强化了硫胺素，我们发现母亲摄入硫胺素较高的饮食与婴儿湿疹和食物过敏风险增加之间存在一致的联系。我们的研究结果表明，有必要进一步研究高硫胺素摄入对免疫系统发育的潜在影响，尤其是对胎儿的影响。
{"title":"Higher maternal bread and thiamine intakes are associated with increased infant allergic disease","authors":"Rachelle A. Pretorius, Elizabeth McKinnon, Debra J. Palmer","doi":"10.1111/pai.14237","DOIUrl":"https://doi.org/10.1111/pai.14237","url":null,"abstract":"BackgroundA mother's diet during pregnancy may influence her infant's immune development. However, as potential interactions between components of our dietary intakes can make any nutritional analysis complex, here we took a multi‐component dietary analysis approach.MethodsNutritional intake data was collected from 639 pregnant women using a validated semi‐quantitative food frequency questionnaire to reflect their dietary intakes during 32–36 weeks of gestation. To investigate their dietary intake pattern, we calculated Dietary Inflammatory Index scores. Maternal consumption of 12 food groups, 20 individual whole foods, and 18 specific nutrient intakes, along with any vitamin and mineral supplementation, were determined. Infant outcomes included eczema, allergen sensitization, and IgE‐mediated food allergy. Regression‐based analyses with covariates adjustment were applied.ResultsWomen with higher white bread consumption were more likely to have an infant with doctor‐diagnosed eczema (adjusted relative risk [aRR] 1.16; 95% CI 1.08, 1.24; <jats:italic>p</jats:italic> < .001) and IgE‐mediated food allergy (aRR 1.14; 95% CI 1.02, 1.28; <jats:italic>p</jats:italic> = .02). Higher maternal intakes of fiber‐rich bread (aRR 1.14; 95% CI 1.04, 1.25; <jats:italic>p</jats:italic> = .01) and legumes (aRR 1.11; 95% CI 1.02, 1.21; <jats:italic>p</jats:italic> = .02) were also associated with infant doctor‐diagnosed eczema. Higher maternal thiamine intakes were associated with increased parent‐reported infant eczema (aRR 1.08; 95% CI 1.03, 1.12; <jats:italic>p</jats:italic> < .001).ConclusionIn Australia, where bread flour is fortified with thiamine, we identified consistent links between higher maternal thiamine‐rich diets and increased risk of infant eczema and food allergy. Our results highlight a need for further investigation of potential effects of high thiamine exposures on immune development, especially in‐utero.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"3 1","pages":"e14237"},"PeriodicalIF":4.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emilio Nuñez‐Borque, Pablo Rodriguez del Rio, Virginia Di Paolo, Sergio Fernández‐Bravo, Angela Galardi, Raphaëlle Bazire, María Dolores Ibáñez‐Sandín, Alberto Benito‐Martín, Angela Di Giannatale, Vanesa Esteban
{"title":"Increased miR‐21‐3p levels in extracellular vesicles of children with food anaphylaxis","authors":"Emilio Nuñez‐Borque, Pablo Rodriguez del Rio, Virginia Di Paolo, Sergio Fernández‐Bravo, Angela Galardi, Raphaëlle Bazire, María Dolores Ibáñez‐Sandín, Alberto Benito‐Martín, Angela Di Giannatale, Vanesa Esteban","doi":"10.1111/pai.14241","DOIUrl":"https://doi.org/10.1111/pai.14241","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"355 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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