Peritoneal Dialysis International最新文献

Peritoneal dialysis (PD) provides independence and quality of life comparable to in-center hemodialysis, but its long-term success depends on comprehensive training and sustained support. This editorial underscores the pivotal role of PD nurses as educators, partners, and motivators in empowering patients and caregivers. Beyond clinical skills, effective training must also address psychosocial stressors, as patient and caregiver burnout is an overlooked barrier to technique survival and adherence. Drawing on ISPD and NKF-KDOQI guidance, we highlight strategies such as early education, routine assessment of well-being, peer mentorship, retraining, and remote patient monitoring to foster resilience, prevent isolation, and reduce dropout. By prioritizing holistic, patient-centered training, healthcare systems can strengthen outcomes, enhance sustainability, and ensure PD remains a lifestyle-enabling therapy.

BackgroundThe stability of antimicrobials in peritonitis during peritoneal dialysis (PD) solutions is a critical factor influencing treatment success. This study investigated the stability of daptomycin (DAP) when combined with icodextrin-based PD solution, by measuring DAP concentrations and observing any structural changes.MethodsA dose of DAP (350 mg) was dissolved in 7 mL of saline in a clean bench. The solution was then injected into the large compartment (1,260 mL) of NICOPELIQ^® Peritoneal Dialysis Solution and thoroughly mixed. Samples were collected at intervals ranging from 0 to 336 h (7 points in total). The concentration of DAP was quantified using high-performance liquid chromatography (HPLC). The structure of any unidentified peaks was determined using HPLC coupled with electrospray ionization tandem mass spectrometry.ResultsDAP maintained 90% of the initial concentration in NICOPELIC^® for 72 h at room temperature and 12 h at 37 °C. Unidentified peaks, distinct from DAP, were detected during analysis. Further investigation indicated that these peaks corresponded to anhydrated DAP.ConclusionsThe findings from this stability study are expected to enhance the effectiveness of outpatient management and preparation for treating peritonitis using DAP.

Scrotal and penile edema is a noninfectious complication of peritoneal dialysis (PD). A tear in the Spigelian fascia is occasionally recognized as a Spigelian hernia. However, there is no documented evidence that this is a contributing factor for scrotal edema in individuals undergoing PD. We encountered a case of scrotal edema in a patient undergoing PD due to bilateral metachronous tears in the Spigelian fascia, which was successfully treated through surgical repair. A 20-year-old man with end-stage kidney disease due to Alport syndrome underwent PD. Eight months after induction of PD, he heard a rupture sound in the left inguinal region after coughing and developed genital edema. A computed tomography scan showed a tear in the left Spigelian fascia. Surgical repair was successful and there was no recurrence after PD was resumed. Seven months after surgery, he heard a rupture sound in the right inguinal region after coughing and developed genital edema. A computed tomography scan showed a tear in the right Spigelian fascia. Surgical repair was successful and there has been no recurrence since. It is important to recognize that the development of scrotal edema in a patient undergoing PD may be indicative of a tear in the Spigelian fascia.

BackgroundStaff-assisted peritoneal dialysis (PD) can help overcome barriers to self-care but is not yet available in the United States (US). We developed and implemented a staff-assisted PD program that fits within current regulatory and cost restraints in the US healthcare environment.MethodsPatient care technicians (PCTs) were trained on PD procedures and troubleshooting common problems. The program expanded from two centers in August 2020 to sixteen by October 2022. We described the logistic elements of program delivery, and patient and treatment outcomes for patients discharged by end of April 2023, with a cohort follow up until October 2023.ResultsA total of 121 patients were referred to the program. The most common indications for referral were physical function limitations, cognitive impairment, and psychosocial challenges. Staff assistance was provided for 73 patients. Mean age was 72 (standard deviation 14) years. A total of 604 visits were delivered, with a median 5 (interquartile range [IQR] 3-10, range: 1-49) visits per patient. Median duration of assistance was 8 (IQR: 2-21, range: 1-84) days. Assistance was most frequently needed for PD treatment setup and for observing and directing the technique. No peritonitis events or exit-site infections were reported. Sixty-eight patients (93%) were discharged on PD without staff assistance. The 6- and 12-month survival of PD without assistance was 71% and 57%, respectively.ConclusionsStaff-assisted PD for limited time periods is operationally feasible with PCTs in the US and can support transitioning and maintaining patients on PD.ClinicalTrials.gov Identifier: NCT04319185.

Cloudiness in peritoneal dialysate is a key clinical indicator of peritonitis. However, distinguishing between turbidity caused by peritonitis and that induced by drug administration can be challenging. To better understand this phenomenon, data were collected between April 2020 and March 2023 from 287 peritoneal dialysis (PD) patients undergoing benidipine-controlled blood pressure management in our PD center. Among these patients, 25 cases (8.71%) developed non-infectious chyloperitoneum as an adverse reaction to benidipine. Turbidity appeared, on average, 25.28 ± 60.55 days after starting benidipine. Switching to another antihypertensive drug cleared the dialysate within 12 to 36 hours. Laboratory results, including smears and cultures, were consistent with a non-infectious state. Elevated triglyceride (TG) levels were observed in the turbid dialysate (p < 0.0001), with a mean TG of 0.28 ± 0.17 mmol/L in cloudy samples, compared to 0.07 ± 0.03 mmol/L in clear samples. No significant changes in cholesterol or peripheral blood TG levels were found before or after the occurrence of turbidity. This study confirms that benidipine can cause non-infectious chyloperitoneum, underscoring the need for attention to adverse drug reactions to avoid unnecessary resource use. Further investigation is required to guide antihypertensive medication choices in PD patients.

Given the central importance of the peritoneal dialysis (PD) nurse in successfully training and supporting a patient with PD at home, as well as preventing complications as a result of the therapy, the International Society for Peritoneal Dialysis (ISPD) has provided guidance on the principles for training in two previous publications. Despite the lack of high certainty evidence in teaching PD, this ISPD 2025 Position Paper builds upon the two prior works to provide contemporary approaches to training a patient/care partner for PD to be performed at home, based upon an evolution in healthcare practices broadly and the cumulative evidence to support recommendations to date. A number of practice points have been provided. Suggestions are discussed on key areas in teaching PD which include: (a) Education, knowledge, skills and attributes for the PD nurse trainer; (b) Preparation for the training; (c) Methods of training/educational interventions; (d) Post training; and (e) Measures of outcomes. Areas for future research are suggested and include: best practices on educational interventions; knowledge and skills necessary for PD nurses; and how to best capture and measure the patient experience related to PD training.

A nurse new to home peritoneal dialysis (PD) undoubtedly has to learn all the steps for continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD) procedures, along with basics such as hand hygiene, ordering supplies, disposing of supplies, recognizing signs and symptoms of peritonitis. However, it is not always clear what else the new PD nurse needs to know in order to successfully teach a patient all that a patient (and care partner) starting home PD training need to know, as well as to support that patient overtime once the patient is performing PD at home. To answer this question, using a modified Delphi technique, members of the International Society for Peritoneal Dialysis (ISPD) Nursing and Allied Health Professional Committee identified the top 10 practice advice (tips) these nurse members thought all new home PD nurses should know and be aware of. For each tip, we justified the importance of the tip and how it could be implemented. The 10 tips were quite varied and highlighted both the breadth and the depth of knowledge a new PD nurse needs to acquire over and above basic knowledge and skills such as performing CAPD and APD and recognizing signs and symptoms of peritonitis. The members of the ISPD Nursing and Allied Health Professional Committee who compiled this list of the top 10 tips, believe that through understanding the importance, justification, and implementation of each of these tips, the nurse new to a home PD program can, in turn, appreciate more how to individualize home PD training sessions, improve the quality of life for patients on PD, as well as extend the patients' time on PD.

Women with kidney failure have impaired fertility challenges due to disruption of the hypothalamic gonadal axis and hormonal dysregulation, with pregnancy rates on home dialysis being much lower than those with normal kidney function. Pregnant women on dialysis are at high risk of hypertensive disorders, preterm birth, and fetal growth restriction, but intensified dialysis can mitigate these risks. Home dialysis offers advantages like flexibility, better hemodynamic stability, and improved fetal outcomes, but logistical and training challenges remain. Hybrid approaches combining hemodialysis and peritoneal dialysis may benefit select women during pregnancy. Effective management of pregnancy on dialysis requires treatment of anemia, optimized nutrition, close obstetric monitoring, and multi-disciplinary care. Postpartum care should focus on breastfeeding support, home dialysis prescription adjustment, and contraception counseling. Systematic capacity-building in home dialysis can lead to better pregnancy outcomes while alleviating in-center dialysis burdens.

BackgroundInfections can make it difficult to continue peritoneal dialysis (PD). Nontuberculous mycobacteria-associated PD (NTM-PD) infections, while rare, frequently pose a treatment challenge due to their intractable nature and the lack of established therapeutic guidelines. As a result, we aimed to investigate the clinical characteristics of NTM infections in patients undergoing PD.MethodsWe retrospectively examined consecutive patients with NTM-PD infections from 2012 to 2022. The cases were identified through microbiological records. The primary outcomes were all-cause mortality and transition to hemodialysis. Secondary outcomes included treatment duration and antimicrobial regimens. Outcomes were compared across different NTM species and between cases with and without infectious disease (ID) consultation.ResultsAmong 177 patients undergoing PD, we identified 22 NTM infections in 20 patients. The predominant species were M. chelonae (36%), M. fortuitum (36%), and M. abscessus (23%). Twelve patients were transitioned to hemodialysis, with no mortality. All M. abscessus infections (n = 5) required transition to hemodialysis, compared to 46% in other species. ID consultation (n = 15) was linked to more frequent antimicrobial susceptibility testing (60% vs. 0%, p < .05), longer treatment duration (5.7 vs. 1.2 months, p < .05), and increased use of combination therapies (100% vs. 43%, p < .05). However, ID consultation did not affect the frequency of transition to hemodialysis.ConclusionEarly identification of NTM species and timely ID consultation can help optimize management strategies for these challenging infections.