Parkinsonism & related disorders最新文献_第7页

Audible tremor: Analysis of the validity of audible information in assessing tremor severity 可听震颤：可听信息评估震颤严重程度的有效性分析。

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders

Pub Date : 2025-01-16 DOI: 10.1016/j.parkreldis.2025.107291

Natalie Grill , Ethan Wainman , Vibhash D. Sharma , Padraig O'Suilleabhain , Elan D. Louis

Introduction

Assessing the severity of kinetic tremor is important in clinical and research settings. Archimedes spirals are often used to assess tremor severity. Rating tremor from spirals has been based solely on visual information. However, one can often “hear” tremor.

Objectives

We evaluated the type of information that could be gained from hearing tremors and assessed its validity using visualized tremor as a gold standard.

Methods

52 essential tremor cases (94 spirals), 11 Parkinson's disease patients and 11 controls (20 spirals each) were enrolled. During videotaping, cases drew Archimedes spirals in a standardized manner. Three experienced movement disorders neurologists first listened to videotaped spiral drawing (no visual) and assigned a tremor severity rating using Washington Heights Inwood Genetic Study of Essential Tremor (WHIGET) ratings (0, 0.5, 1, 1.5, 2, 3). Later, the neurologist rated the physical (i.e., visual) spiral and assigned a WHIGET tremor rating.

Results

The Spearman's correlation coefficient (visual vs. auditory rating) was 0.721 (p < 0.001) and the weighted kappa statistic was 0.674, a level of agreement that is considered good.

Conclusions

Auditory information provides in-time synchronous corroboration of what the rater is seeing. That is, it informs the visual data and provides construct validity. The results of this study have ramifications for observational and experimental therapeutic studies, which commonly rely on videotaped tremor examinations. Additional corroborative information is available if the sound is left on. Regardless of the decision to present sound to the rater or not, clear instructions and a standardized practice within the study are imperative.

在临床和研究中，评估动态性震颤的严重程度是很重要的。阿基米德螺旋常用于评估震颤的严重程度。从螺旋中评估震颤完全是基于视觉信息。然而，人们经常可以“听到”震颤。目的：我们评估了从听觉震颤中获得的信息类型，并以视觉震颤作为金标准评估了其有效性。方法：选取特发性震颤患者52例（94个螺旋），帕金森病患者11例，对照组11例（各20个螺旋）。在录像过程中，凯斯以标准化的方式画出了阿基米德螺旋。三位经验丰富的运动障碍神经科医生首先听了录像的螺旋图（无视觉），并使用华盛顿高地因伍德原发性震颤遗传研究（WHIGET）评级（0,0.5,1,1.5,2,3）分配震颤严重程度评级。随后，神经科医生对物理（即视觉）螺旋进行评级，并分配WHIGET震颤评级。结果：斯皮尔曼相关系数（视觉与听觉评分）为0.721 (p)。结论：听觉信息为评分者所看到的提供了及时的同步佐证。也就是说，它告知可视化数据并提供构造有效性。这项研究的结果对观察性和实验性治疗性研究有影响，这些研究通常依赖于录像震颤检查。如果声音一直开着，可以获得额外的确证信息。无论是否决定向评分者提供声音，在研究中明确的指示和标准化的做法都是必不可少的。

{"title":"Audible tremor: Analysis of the validity of audible information in assessing tremor severity","authors":"Natalie Grill , Ethan Wainman , Vibhash D. Sharma , Padraig O'Suilleabhain , Elan D. Louis","doi":"10.1016/j.parkreldis.2025.107291","DOIUrl":"10.1016/j.parkreldis.2025.107291","url":null,"abstract":"<div><h3>Introduction</h3><div>Assessing the severity of kinetic tremor is important in clinical and research settings. Archimedes spirals are often used to assess tremor severity. Rating tremor from spirals has been based solely on visual information. However, one can often “hear” tremor.</div></div><div><h3>Objectives</h3><div>We evaluated the type of information that could be gained from hearing tremors and assessed its validity using visualized tremor as a gold standard.</div></div><div><h3>Methods</h3><div>52 essential tremor cases (94 spirals), 11 Parkinson's disease patients and 11 controls (20 spirals each) were enrolled. During videotaping, cases drew Archimedes spirals in a standardized manner. Three experienced movement disorders neurologists first listened to videotaped spiral drawing (no visual) and assigned a tremor severity rating using Washington Heights Inwood Genetic Study of Essential Tremor (WHIGET) ratings (0, 0.5, 1, 1.5, 2, 3). Later, the neurologist rated the physical (i.e., visual) spiral and assigned a WHIGET tremor rating.</div></div><div><h3>Results</h3><div>The Spearman's correlation coefficient (visual vs. auditory rating) was 0.721 (p < 0.001) and the weighted kappa statistic was 0.674, a level of agreement that is considered good.</div></div><div><h3>Conclusions</h3><div>Auditory information provides <em>in-time synchronous corroboration</em> of what the rater is seeing. That is, it informs the visual data and provides construct validity. The results of this study have ramifications for observational and experimental therapeutic studies, which commonly rely on videotaped tremor examinations. Additional corroborative information is available if the sound is left on. Regardless of the decision to present sound to the rater or not, clear instructions and a standardized practice within the study are imperative.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107291"},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vibro-tactile stimulation of the neck induces head righting in people with cervical dystonia

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders

Pub Date : 2025-01-16 DOI: 10.1016/j.parkreldis.2025.107263

Laura Avanzino , Jiapeng Xu , Davide Martino , Antonella Conte , Stephanie Standal , Parisa Salehi , Sara Terranova , Gaia Bonassi , Parisa Alizadeh , Janet Adesewa Adeoti , Daniele Belvisi , Matteo Costanzo , Jinseok Oh , Jürgen Konczak

Introduction

Cervical dystonia (CD) is characterized by involuntary neck muscle spasms that lead to abnormal head movements or postures. It is associated with somatosensory (tactile and proprioceptive) dysfunction. Here we tested whether vibro-tactile stimulation (VTS) of the cervical muscles constitutes a non-invasive form of neuromodulation of the somatosensory system that can provide temporary symptom relief for people with CD.

Material and method

In a multi-centre study, 67 CD patients (44 female) received VTS to sternocleidomastoid and/or trapezius muscles for up to 45 min under 9 different stimulation conditions. Retention was assessed 1, 5 and 20 min past VTS. Head angles and neck muscle EMG were recorded. The primary outcome measure was a head angle index (HAI), a composite measure reflecting the head deviation across the three axes of the head.

Results

After identifying the most effective VTS condition for each participant, analysis showed that 85 % (57/67) of participants experienced an improvement in HAI of at least 10 % during the application of VTS. HAI improved by 50 % or higher in 26/67 of participants. For those responding to VTS, the effects tended to decay within 20 min. For the different CD phenotypes several stimulation sites could induce similarly large relative improvements in head posture.

Conclusion

The study provides first systematic evidence that cervical VTS can induce fast-acting improvements in abnormal head posture in patients with CD. It demonstrates that a stimulation of somatosensory afferent networks modulates the innervation of dystonic muscles. It highlights the potential of cervical VTS as an adjuvant, non-invasive neuromodulation treatment in CD.

{"title":"Vibro-tactile stimulation of the neck induces head righting in people with cervical dystonia","authors":"Laura Avanzino , Jiapeng Xu , Davide Martino , Antonella Conte , Stephanie Standal , Parisa Salehi , Sara Terranova , Gaia Bonassi , Parisa Alizadeh , Janet Adesewa Adeoti , Daniele Belvisi , Matteo Costanzo , Jinseok Oh , Jürgen Konczak","doi":"10.1016/j.parkreldis.2025.107263","DOIUrl":"10.1016/j.parkreldis.2025.107263","url":null,"abstract":"<div><h3>Introduction</h3><div>Cervical dystonia (CD) is characterized by involuntary neck muscle spasms that lead to abnormal head movements or postures. It is associated with somatosensory (tactile and proprioceptive) dysfunction. Here we tested whether vibro-tactile stimulation (VTS) of the cervical muscles constitutes a non-invasive form of neuromodulation of the somatosensory system that can provide temporary symptom relief for people with CD.</div></div><div><h3>Material and method</h3><div>In a multi-centre study, 67 CD patients (44 female) received VTS to sternocleidomastoid and/or trapezius muscles for up to 45 min under 9 different stimulation conditions. Retention was assessed 1, 5 and 20 min past VTS. Head angles and neck muscle EMG were recorded. The primary outcome measure was a head angle index (HAI), a composite measure reflecting the head deviation across the three axes of the head.</div></div><div><h3>Results</h3><div>After identifying the most effective VTS condition for each participant, analysis showed that 85 % (57/67) of participants experienced an improvement in HAI of at least 10 % during the application of VTS. HAI improved by 50 % or higher in 26/67 of participants. For those responding to VTS, the effects tended to decay within 20 min. For the different CD phenotypes several stimulation sites could induce similarly large relative improvements in head posture.</div></div><div><h3>Conclusion</h3><div>The study provides first systematic evidence that cervical VTS can induce fast-acting improvements in abnormal head posture in patients with CD. It demonstrates that a stimulation of somatosensory afferent networks modulates the innervation of dystonic muscles. It highlights the potential of cervical VTS as an adjuvant, non-invasive neuromodulation treatment in CD.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107263"},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term, continuous, subcutaneous levodopa/carbidopa infusion with ND0612 in Parkinson's disease: 3-year outcomes from the open-label BeyoND study

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders

Pub Date : 2025-01-16 DOI: 10.1016/j.parkreldis.2025.107293

Aaron L. Ellenbogen , Werner Poewe , Alberto J. Espay , Tanya Simuni , Tanya Gurevich , Tami Yardeni , Nelson Lopes , Nissim Sasson , Ryan Case , Fabrizio Stocchi

Introduction

ND0612 is being investigated as a continuous, subcutaneous levodopa/carbidopa infusion, in combination with oral levodopa/carbidopa, for motor fluctuations in Parkinson's disease (PD). One-year data from the ongoing BeyoND study (NCT02726386) showed that the ND0612 regimen was safe and well tolerated and provided a sustained ≥2-h improvement in daily Good ON-time through 12 months of treatment.

Methods

We describe 3-year safety and efficacy outcomes for participants who completed 12 months of ND0612 treatment in the core study period and entered the extension phase.

Results

Of the 214 enrolled participants, 120 completed the core 1-year period, and 114 participants continued into the extension phase. Of these, 95/114 (83.3 %) completed 2 years and 77/114 (67.5 %) completed 3 years of study treatment. Key reasons for discontinuation were treatment-emergent adverse events (TEAEs) (n = 5 and n = 11 after 2 and 3 years, respectively) and withdrawal of consent (n = 9 and n = 5, respectively). TEAEs were reported by 105/114 (92.1 %) participants in Year 1, 77/114 (67.5 %) in Year 2, and 73/95 (76.8 %) in Year 3. While most participants experienced infusion site reactions, these led to discontinuation in only five participants during this extension. At Month 36, the mean reduction in OFF-time from baseline was 2.81 h and the increase in Good ON-time was 2.79 h.

Conclusions

Three-year results from this open-label study support the long-term safety, tolerability, and efficacy of ND0612. For participants who entered the extension phase, the high rate of retention supports a favorable benefit-risk ratio of the ND0612 regimen for patients with PD experiencing motor fluctuations.

{"title":"Long-term, continuous, subcutaneous levodopa/carbidopa infusion with ND0612 in Parkinson's disease: 3-year outcomes from the open-label BeyoND study","authors":"Aaron L. Ellenbogen , Werner Poewe , Alberto J. Espay , Tanya Simuni , Tanya Gurevich , Tami Yardeni , Nelson Lopes , Nissim Sasson , Ryan Case , Fabrizio Stocchi","doi":"10.1016/j.parkreldis.2025.107293","DOIUrl":"10.1016/j.parkreldis.2025.107293","url":null,"abstract":"<div><h3>Introduction</h3><div>ND0612 is being investigated as a continuous, subcutaneous levodopa/carbidopa infusion, in combination with oral levodopa/carbidopa, for motor fluctuations in Parkinson's disease (PD). One-year data from the ongoing BeyoND study (NCT02726386) showed that the ND0612 regimen was safe and well tolerated and provided a sustained ≥2-h improvement in daily Good ON-time through 12 months of treatment.</div></div><div><h3>Methods</h3><div>We describe 3-year safety and efficacy outcomes for participants who completed 12 months of ND0612 treatment in the core study period and entered the extension phase.</div></div><div><h3>Results</h3><div>Of the 214 enrolled participants, 120 completed the core 1-year period, and 114 participants continued into the extension phase. Of these, 95/114 (83.3 %) completed 2 years and 77/114 (67.5 %) completed 3 years of study treatment. Key reasons for discontinuation were treatment-emergent adverse events (TEAEs) (n = 5 and n = 11 after 2 and 3 years, respectively) and withdrawal of consent (n = 9 and n = 5, respectively). TEAEs were reported by 105/114 (92.1 %) participants in Year 1, 77/114 (67.5 %) in Year 2, and 73/95 (76.8 %) in Year 3. While most participants experienced infusion site reactions, these led to discontinuation in only five participants during this extension. At Month 36, the mean reduction in OFF-time from baseline was 2.81 h and the increase in Good ON-time was 2.79 h.</div></div><div><h3>Conclusions</h3><div>Three-year results from this open-label study support the long-term safety, tolerability, and efficacy of ND0612. For participants who entered the extension phase, the high rate of retention supports a favorable benefit-risk ratio of the ND0612 regimen for patients with PD experiencing motor fluctuations.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107293"},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling distinct clinical manifestations of primary familial brain calcifications in Asian and European patients: A study based on 10-year individual-level data 揭示亚洲和欧洲患者原发性家族性脑钙化的独特临床表现：一项基于10年个体水平数据的研究。

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders

Pub Date : 2025-01-16 DOI: 10.1016/j.parkreldis.2025.107290

Dehao Yang , Honghao Huang , Tian Zeng , Lebo Wang , Chenxin Ying , Xinhui Chen , Xinbo Zhou , Fangyue Sun , Yilin Chen , Shengqi Li , Bo Wang , Sheng Wu , Fei Xie , Zhidong Cen , Wei Luo

Background

Primary Familial Brain Calcification (PFBC) can manifest clinically with a complex and heterogeneous array of symptoms, including parkinsonism, dysarthria, and cognitive impairment. However, the distinct presentations of PFBC in Asian and European populations remain unclear.

Methods

We conducted a systematic search of PubMed for studies involving genetically confirmed PFBC patients. Demographic data, genetic information, radiological examinations, and clinical characteristics were extracted for each case.

Results

The study included 120 publications and 564 genetically confirmed PFBC patients. Asian and European PFBC populations represented 54 % and 37 % of global patients, respectively. While calcification patterns showed no significant differences between Asian and European PFBC patients, European autosomal dominant PFBC variant carriers were more likely to exhibit clinical symptoms compared to their Asian counterparts (OR = 2.90, 95 % CI 1.55–5.60) and had an earlier estimated age of onset (median age 42 vs 58).

Conclusion

The interaction between regional differences and genetically determined calcification severity may collectively influence PFBC symptom progression. Future research should further explore the potential roles of gene modifiers, ethnic background, socioeconomic and environmental exposure factors underlying regional differences in PFBC progression.

背景：原发性家族性脑钙化（PFBC）在临床上表现为一系列复杂且异质性的症状，包括帕金森症、构音障碍和认知障碍。然而，PFBC在亚洲和欧洲人群中的不同表现仍不清楚。方法：我们对PubMed中涉及基因证实的PFBC患者的研究进行了系统检索。提取每个病例的人口统计资料、遗传信息、放射学检查和临床特征。结果：该研究包括120篇出版物和564例基因证实的PFBC患者。亚洲和欧洲PFBC人群分别占全球患者的54%和37%。虽然钙化模式在亚洲和欧洲PFBC患者之间没有显着差异，但与亚洲患者相比，欧洲常染色体显性PFBC变异携带者更有可能表现出临床症状（OR = 2.90, 95% CI 1.55-5.60），并且估计发病年龄更早（中位年龄42岁对58岁）。结论：区域差异和基因决定的钙化严重程度之间的相互作用可能共同影响PFBC症状的进展。未来的研究应进一步探讨基因修饰剂、种族背景、社会经济和环境暴露因素在PFBC进展地区差异中的潜在作用。

{"title":"Unveiling distinct clinical manifestations of primary familial brain calcifications in Asian and European patients: A study based on 10-year individual-level data","authors":"Dehao Yang , Honghao Huang , Tian Zeng , Lebo Wang , Chenxin Ying , Xinhui Chen , Xinbo Zhou , Fangyue Sun , Yilin Chen , Shengqi Li , Bo Wang , Sheng Wu , Fei Xie , Zhidong Cen , Wei Luo","doi":"10.1016/j.parkreldis.2025.107290","DOIUrl":"10.1016/j.parkreldis.2025.107290","url":null,"abstract":"<div><h3>Background</h3><div>Primary Familial Brain Calcification (PFBC) can manifest clinically with a complex and heterogeneous array of symptoms, including parkinsonism, dysarthria, and cognitive impairment. However, the distinct presentations of PFBC in Asian and European populations remain unclear.</div></div><div><h3>Methods</h3><div>We conducted a systematic search of PubMed for studies involving genetically confirmed PFBC patients. Demographic data, genetic information, radiological examinations, and clinical characteristics were extracted for each case.</div></div><div><h3>Results</h3><div>The study included 120 publications and 564 genetically confirmed PFBC patients. Asian and European PFBC populations represented 54 % and 37 % of global patients, respectively. While calcification patterns showed no significant differences between Asian and European PFBC patients, European autosomal dominant PFBC variant carriers were more likely to exhibit clinical symptoms compared to their Asian counterparts (OR = 2.90, 95 % CI 1.55–5.60) and had an earlier estimated age of onset (median age 42 vs 58).</div></div><div><h3>Conclusion</h3><div>The interaction between regional differences and genetically determined calcification severity may collectively influence PFBC symptom progression. Future research should further explore the potential roles of gene modifiers, ethnic background, socioeconomic and environmental exposure factors underlying regional differences in PFBC progression.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107290"},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency of anti-IgLON5 disease in patients with a typical clinical presentation of progressive supranuclear palsy/corticobasal syndrome.

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders

Pub Date : 2025-01-15 DOI: 10.1016/j.parkreldis.2025.107289

Yoya Ono, Hiroshi Takigawa, Akira Takekoshi, Nobuaki Yoshikura, Ikuko Aiba, Ritsuko Hanajima, Hisanori Kowa, Masato Kanazawa, Takahiko Tokuda, Aya Midori Tokumaru, Mitsuya Morita, Kazuko Hasegawa, Kenji Nakashima, Takeshi Ikeuchi, Akio Kimura, Takayoshi Shimohata

Serum anti-IgLON5 antibodies, which were tested in 223 patients meeting the diagnostic criteria for progressive supranuclear palsy/corticobasal syndrome (PSP/CBS), were negative in all patients. Our study suggests that the frequency of anti-IgLON5 disease is extremely rare in patients with typical presentation of PSP/CBS.

引用次数: 0

Cropland associated with risk of Parkinson's disease in the northern Great Plains

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders

Pub Date : 2025-01-14 DOI: 10.1016/j.parkreldis.2025.107288

Brittany Krzyzanowski , Kassu M. Beyene , Susan Searles Nielsen , Jordan A. Killion , Brad A. Racette

Introduction

We sought to identify regional associations between cropland density and crop types and PD in the U.S.

Methods

We conducted a population-based study of 21,639,190 Medicare beneficiaries, 89,790 with incident PD in 2009. We used county-level geographic weighted regression (GWR) to identify region(s) of the U.S. where the association between PD RR and cropland density was strongest. In a broad region identified by GWR in which cropland density was associated with PD, we performed logistic regression using individual-level beneficiary data (2733 cases and 805,984 non-cases) with high-resolution cropland density data. We adjusted for age, sex, race, smoking, healthcare utilization, and PM_2.5 (particulate matter <2.5 μm). We then explored PD-cropland associations for each type of crop within a subregion, in which the association was the strongest.

Results

GWR identified a 9-state region in the Great Plains in which county-level cropland density and PD RR were associated. Within this region, the strongest GWR coefficients centered around the Williston Basin. High-resolution analysis demonstrated an association between cropland density within a 5-mile radius of residential zip+4 and PD. When comparing the highest to lowest quartile of cropland density, the odds ratio (OR) for PD was 1.14 (95 % confidence interval [CI] 1.01–1.27) in the 9-state region and 1.99 (95 % CI 1.09–3.61) in the Williston Basin. In the Williston Basin, percentage of sunflowers, winter wheat, and alfalfa within 5 miles of a beneficiary's zip+4 was associated with PD.

Conclusion

We identified a region-specific association between cropland and crop type and PD in the Williston Basin.

{"title":"Cropland associated with risk of Parkinson's disease in the northern Great Plains","authors":"Brittany Krzyzanowski , Kassu M. Beyene , Susan Searles Nielsen , Jordan A. Killion , Brad A. Racette","doi":"10.1016/j.parkreldis.2025.107288","DOIUrl":"10.1016/j.parkreldis.2025.107288","url":null,"abstract":"<div><h3>Introduction</h3><div>We sought to identify regional associations between cropland density and crop types and PD in the U.S.</div></div><div><h3>Methods</h3><div>We conducted a population-based study of 21,639,190 Medicare beneficiaries, 89,790 with incident PD in 2009. We used county-level geographic weighted regression (GWR) to identify region(s) of the U.S. where the association between PD RR and cropland density was strongest. In a broad region identified by GWR in which cropland density was associated with PD, we performed logistic regression using individual-level beneficiary data (2733 cases and 805,984 non-cases) with high-resolution cropland density data. We adjusted for age, sex, race, smoking, healthcare utilization, and PM<sub>2.5</sub> (particulate matter <2.5 μm). We then explored PD-cropland associations for <em>each type</em> of crop within a subregion, in which the association was the strongest.</div></div><div><h3>Results</h3><div>GWR identified a 9-state region in the Great Plains in which county-level cropland density and PD RR were associated. Within this region, the strongest GWR coefficients centered around the Williston Basin. High-resolution analysis demonstrated an association between cropland density within a 5-mile radius of residential zip+4 and PD. When comparing the highest to lowest quartile of cropland density, the odds ratio (OR) for PD was 1.14 (95 % confidence interval [CI] 1.01–1.27) in the 9-state region and 1.99 (95 % CI 1.09–3.61) in the Williston Basin. In the Williston Basin, percentage of sunflowers, winter wheat, and alfalfa within 5 miles of a beneficiary's zip+4 was associated with PD.</div></div><div><h3>Conclusion</h3><div>We identified a region-specific association between cropland and crop type and PD in the Williston Basin.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107288"},"PeriodicalIF":3.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case report -Cavernoma involving substantia nigra and nigrostriatal pathway as a rare cause of secondary parkinsonism with a 5 year follow up 病例报告-累及黑质和黑质纹状体通路的海绵状瘤是继发性帕金森病的罕见病因，随访5年。

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders

Pub Date : 2025-01-13 DOI: 10.1016/j.parkreldis.2025.107281

Sahana Sathyanarayana , Jacopo Pasquini , David Ledingham , Dipayan Mitra , Naomi Warren , Nicola Pavese

引用次数: 0

Filipinos and Parkinson's disease: A scoping review of the literature.

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders

Pub Date : 2025-01-13 DOI: 10.1016/j.parkreldis.2025.107271

Emma Krening, Alfand Marl F Dy Closas, Jeryl Ritzi T Yu, Todd B Seto, Lauren Terpak, Michiko K Bruno

Background: Filipinos are the third largest sub-group of Asian Americans in the United States and have greater socioeconomic and health disparities than many other Asian sub-groups [1,2,3,4,5,6,7,8]. Characteristics of Filipino patients with Parkinson's disease (PD) have not been adequately studied.

Objective: To scope the extent, range and nature of current knowledge on PD in Filipino-American (FA) patients in contrast to Filipino patients in general.

Methods: We undertook a scoping review including all types of research relating to PD in Filipinos. We searched the following electronic databases: MEDLINE via PubMed, Google Scholar, Cochrane Library, Herdin and Journals@OVID (searched 1944-November 2024). Criteria for inclusion were peer-reviewed empirical articles published in English that specifically included and described Filipino patients with PD. We reviewed all eligible articles and categorized them by general topical themes.

Results: The scoping review resulted in 48 eligible papers (Fig. 1). There were 7 papers that discussed PD in FA, and 35 papers that discussed PD in the Philippines. The main themes identified from the scoping review were: epidemiology/etiology (n = 19, 39 %), clinical manifestations and management (n = 20, 42 %), and access to PD care (n = 9, 19 %).

Conclusion: There is a paucity of information on PD in the FA population, with the majority of studies from the Philippines. Further studies on FA in the US, when compared to the studies from the Philippines, may shed light on how differences in the environment and sociodemographic factors may influence the nature and course of PD.

{"title":"Filipinos and Parkinson's disease: A scoping review of the literature.","authors":"Emma Krening, Alfand Marl F Dy Closas, Jeryl Ritzi T Yu, Todd B Seto, Lauren Terpak, Michiko K Bruno","doi":"10.1016/j.parkreldis.2025.107271","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107271","url":null,"abstract":"<p><strong>Background: </strong>Filipinos are the third largest sub-group of Asian Americans in the United States and have greater socioeconomic and health disparities than many other Asian sub-groups [1,2,3,4,5,6,7,8]. Characteristics of Filipino patients with Parkinson's disease (PD) have not been adequately studied.</p><p><strong>Objective: </strong>To scope the extent, range and nature of current knowledge on PD in Filipino-American (FA) patients in contrast to Filipino patients in general.</p><p><strong>Methods: </strong>We undertook a scoping review including all types of research relating to PD in Filipinos. We searched the following electronic databases: MEDLINE via PubMed, Google Scholar, Cochrane Library, Herdin and Journals@OVID (searched 1944-November 2024). Criteria for inclusion were peer-reviewed empirical articles published in English that specifically included and described Filipino patients with PD. We reviewed all eligible articles and categorized them by general topical themes.</p><p><strong>Results: </strong>The scoping review resulted in 48 eligible papers (Fig. 1). There were 7 papers that discussed PD in FA, and 35 papers that discussed PD in the Philippines. The main themes identified from the scoping review were: epidemiology/etiology (n = 19, 39 %), clinical manifestations and management (n = 20, 42 %), and access to PD care (n = 9, 19 %).</p><p><strong>Conclusion: </strong>There is a paucity of information on PD in the FA population, with the majority of studies from the Philippines. Further studies on FA in the US, when compared to the studies from the Philippines, may shed light on how differences in the environment and sociodemographic factors may influence the nature and course of PD.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107271"},"PeriodicalIF":3.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does exercise demonstrate a dose-dependent benefit with cognition in Parkinson's disease?

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders

Pub Date : 2025-01-13 DOI: 10.1016/j.parkreldis.2025.107277

Joseph Seemiller , Abhimanyu Mahajan , Christopher B. Morrow , Gregory M. Pontone , Kelly A. Mills

Background

Exercise confers motor benefits in Parkinson's disease (PD) and may even have disease modifying effects. While the impact of exercise on motor symptoms and quality of life is well-studied in PD, its relationship with cognitive performance warrants further attention.

Methods

In people with PD, self-reported exercise information was quantified using the Rapid Assessment of Physical Activity (RAPA). Cognitive performance was assessed using the symbol digit modalities test (SDMT) and Stroop tests. The association between test performance and intensity of physical exercise, as measured by the RAPA, was assessed using linear regression, adjusting for covariates of age and duration of Parkinson's disease.

Results

172 participants completed Stroop testing and 181 completed SDMT in both medication “off” and “on” states. Compared with participants reporting no exercise, those with mild activity (RAPA frequency/duration score 2–3) performed better on the SDMT (β = 1.31, p = 0.01) and Stroop color naming (β = 9.19, p = 0.02). Highly active participants (RAPA frequency/duration score 6–7) scored significantly higher than those with moderate activity (RAPA frequency/duration score 4–5) on the SDMT (β = 1.44, p < 0.01) and Stroop color naming (β = 4.66, p = 0.03).

Conclusion

Higher self-reported physical activity levels were associated with higher cognitive performance in a dose-dependent fashion in both the off-medication and on-medication states. The greatest difference in cognitive performance was seen between those reporting no exercise and those reporting at least some activity, suggesting that even small amounts of physical activity can benefit cognition.

{"title":"Does exercise demonstrate a dose-dependent benefit with cognition in Parkinson's disease?","authors":"Joseph Seemiller , Abhimanyu Mahajan , Christopher B. Morrow , Gregory M. Pontone , Kelly A. Mills","doi":"10.1016/j.parkreldis.2025.107277","DOIUrl":"10.1016/j.parkreldis.2025.107277","url":null,"abstract":"<div><h3>Background</h3><div>Exercise confers motor benefits in Parkinson's disease (PD) and may even have disease modifying effects. While the impact of exercise on motor symptoms and quality of life is well-studied in PD, its relationship with cognitive performance warrants further attention.</div></div><div><h3>Methods</h3><div>In people with PD, self-reported exercise information was quantified using the Rapid Assessment of Physical Activity (RAPA). Cognitive performance was assessed using the symbol digit modalities test (SDMT) and Stroop tests. The association between test performance and intensity of physical exercise, as measured by the RAPA, was assessed using linear regression, adjusting for covariates of age and duration of Parkinson's disease.</div></div><div><h3>Results</h3><div>172 participants completed Stroop testing and 181 completed SDMT in both medication “off” and “on” states. Compared with participants reporting no exercise, those with mild activity (RAPA frequency/duration score 2–3) performed better on the SDMT (β = 1.31, p = 0.01) and Stroop color naming (β = 9.19, p = 0.02). Highly active participants (RAPA frequency/duration score 6–7) scored significantly higher than those with moderate activity (RAPA frequency/duration score 4–5) on the SDMT (β = 1.44, p < 0.01) and Stroop color naming (β = 4.66, p = 0.03).</div></div><div><h3>Conclusion</h3><div>Higher self-reported physical activity levels were associated with higher cognitive performance in a dose-dependent fashion in both the off-medication and on-medication states. The greatest difference in cognitive performance was seen between those reporting no exercise and those reporting at least some activity, suggesting that even small amounts of physical activity can benefit cognition.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107277"},"PeriodicalIF":3.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability of remote video ratings of the scale for assessment and rating of ataxia 共济失调评定量表远程视频评分的可靠性。

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders

Pub Date : 2025-01-13 DOI: 10.1016/j.parkreldis.2025.107278

Joaquin A. Vizcarra , Hannah L. Casey , Ali G. Hamedani , Christopher M. Gomez

Introduction

The Scale for Assessment and Rating of Ataxia (SARA) is a widely used clinical rating scale in ataxia. Remote video assessments of SARA examinations are increasingly used to reduce variability through centralized ratings. Remote video assessments have a high agreement with in-person ratings, but the intra- and inter-rater reliability of remote video ratings has not been examined. In this study, we compared the performance of live versus video SARA ratings and evaluated intra- and inter-rater reliability of SARA ratings via video review in patients with spinocerebellar ataxia (SCA) type 1, 2, 3, and 6.

Methods

We calculated the Bland-Altman analysis for average measures to assess the agreement between live and video ratings and the Intraclass Correlation Coefficient (ICC) for intra- and inter-rater reliability of video ratings.

Results

In all 15 participants, we found high agreement between live and video for all SARA items, with less than 0.5 point overestimation of video compared to live SARA total score, and excellent intra- and inter-rater reliability for the SARA total score rated by video revision, with an ICC of 0.98 and 0.95, respectively.

Conclusions

Our study highlights the ability to adopt SARA video ratings in clinical practice and research.

简介：共济失调评定量表（SARA）是临床上广泛使用的共济失调评定量表。SARA检查的远程视频评估越来越多地用于通过集中评分来减少可变性。远程视频评价与现场评价具有较高的一致性，但远程视频评价的内部和内部可靠性尚未得到检验。在这项研究中，我们比较了现场SARA评分与视频SARA评分的表现，并通过视频回顾评估了脊髓小脑性共济失调（SCA） 1、2、3和6型患者SARA评分的内部和内部可靠性。方法：我们计算了Bland-Altman分析的平均措施，以评估直播和视频评级之间的一致性，以及视频评级内部和内部可靠性的类内相关系数（ICC）。结果：在所有15名参与者中，我们发现所有SARA项目的现场和视频之间的一致性很高，与现场SARA总分相比，视频的高估不到0.5点，并且通过视频修订评定的SARA总分的内部和内部可靠性非常好，ICC分别为0.98和0.95。结论：我们的研究突出了SARA视频评分在临床实践和研究中的应用能力。

{"title":"Reliability of remote video ratings of the scale for assessment and rating of ataxia","authors":"Joaquin A. Vizcarra , Hannah L. Casey , Ali G. Hamedani , Christopher M. Gomez","doi":"10.1016/j.parkreldis.2025.107278","DOIUrl":"10.1016/j.parkreldis.2025.107278","url":null,"abstract":"<div><h3>Introduction</h3><div>The Scale for Assessment and Rating of Ataxia (SARA) is a widely used clinical rating scale in ataxia. Remote video assessments of SARA examinations are increasingly used to reduce variability through centralized ratings. Remote video assessments have a high agreement with in-person ratings, but the intra- and inter-rater reliability of remote video ratings has not been examined. In this study, we compared the performance of live versus video SARA ratings and evaluated intra- and inter-rater reliability of SARA ratings via video review in patients with spinocerebellar ataxia (SCA) type 1, 2, 3, and 6.</div></div><div><h3>Methods</h3><div>We calculated the Bland-Altman analysis for average measures to assess the agreement between live and video ratings and the Intraclass Correlation Coefficient (ICC) for intra- and inter-rater reliability of video ratings.</div></div><div><h3>Results</h3><div>In all 15 participants, we found high agreement between live and video for all SARA items, with less than 0.5 point overestimation of video compared to live SARA total score, and excellent intra- and inter-rater reliability for the SARA total score rated by video revision, with an ICC of 0.98 and 0.95, respectively.</div></div><div><h3>Conclusions</h3><div>Our study highlights the ability to adopt SARA video ratings in clinical practice and research.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107278"},"PeriodicalIF":3.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0