Pain Practice最新文献

Background: Facet joint septic arthritis (FJSA) is an uncommon cause of neck pain, most frequently occurring in the lumbosacral spine. Cervical facet joint septic arthritis is particularly rare. Symptoms typically include spinal or paraspinal pain and tenderness, with severe infections potentially causing neurological impairments. This condition can progress to discitis and osteomyelitis. High clinical suspicion is required for accurate diagnosis and timely treatment.

Objective: To present the first known case of cervical spine FJSA caused by Moraxella species and provide an updated narrative review of cervical spine FJSA.

Methods: A case study of a 66-year-old male with cervical spine FJSA caused by Moraxella osloensis is detailed. Additionally, a librarian-assisted literature search was conducted on MEDLINE Pubmed, filtering for adult human trials and including various study types, resulting in the inclusion of 9 relevant manuscripts.

Results: The patient's symptoms included neck, right upper thoracic, and periscapular pain, with episodes of numbness and tingling. MRI revealed septic arthritis at the C7-T1 facet joint and associated osteomyelitis. Cultures identified Moraxella osloensis as the causative agent. The patient was successfully treated with antibiotics and experienced significant symptom improvement. Literature review highlights that Staphylococcus aureus is the most common causative agent of cervical FJSA, with diagnosis typically involving MRI and culture tests. Treatment generally includes long-term antibiotics, with some cases requiring surgical intervention.

Conclusions: This report underscores the need for high clinical suspicion in diagnosing FJSA and highlights the importance of early intervention. It documents the first known case of cervical spine FJSA caused by Moraxella osloensis, contributing valuable information to the limited literature on this rare condition.

Background: Low back pain (LBP) is a highly prevalent condition that comprise a large portion of outpatient practice, challenging the diagnosis and treatment. However, the diagnostic tools are limited to clinical history, physical examination and imaging. Degenerative disc disease (DDD) is a significant cause of LBP, and emerging literature confirms the elevated levels of biomarkers in the discs. These biomarkers may serve as a tool for diagnosis, but may also be useful in predicting the treatment outcome. Here, we examine the expression of various cytokines on 1-year recovery from patients with LBP.

Methods: Patient-reported outcome (PRO) in terms of pain intensity (VAS), disability (ODI), and quality of life (Eq-5D) is collected from 44 patients at baseline and 12 months after surgery to study the influence of baseline TNF-α, IL-1β, and IL-6 mRNA expression in both annulus fibrosus (AF) and nucleus pulposus (NP).

Results: Between baseline and follow-up, our cohort showed improvement in VAS back pain (p < 0.001), VAS leg pain (p < 0.001), ODI (p = 0.02), and Eq-5D (p = 0.01). Baseline levels of IL-1 β was positively correlated with VAS back pain scores in AF (p = 0.05) and NP (p = 0.01) at 1-year follow-up. TNF-α expression at baseline was also positively correlated to ODI scores (p = 0.01) at follow-up and inversely correlated to improvements in ODI score between baseline and follow-up, suggesting that high TNF-α expression at baseline is associated with poor outcomes from surgery.

Conclusion: The results from our study support that TNF-α expression at baseline can serve as a very important predictor of treatment response from lumbar fusion surgery.

A

Abd Elsayed A.OP-06

Ahmadi R.PP-58

Ahmed R.S.PP-38

Akar O. OP-08

Akbaş M. OP-27, SP-31, SP-32

Akin Takmaz S. PP-62

Akkaya Ömer T. OP-01

Aksoy M.E. SP-18

Alimian M. PP-31

Allet M. PP-25

Allet S. PP-25

Anitescu M. OP-11

Anwar S. PP-05

Arkan Tuna H.OP-04, OP-25, PP-13, PP-29

Asik I.OP-08

Aşik I.OP-22

Aşkin Turan S.OP-15, OP-20, PP-16

Aslam M.PP-05

Asmara Y.R.Y.PP-03

Atallah J.OP-26, PP-44

Aukes H.PP-59

Aydin Ş.OP-15, OP-20

B

Bakir M.PP-63

Bakshi S.G.OP-10, PP-30, PP-61

Balaban D.OP-22

Baranidharan G.OP-24

Barat J.L.OP-24

Barrett S.PP-04

Batra A.PP-14, PP-34

Batra J.PP-14, PP-34

Battilana M.PP-35

Bayerl S.PP-56

Belaid H.PP-54

Bendel M.OP-07

Benedetti F.SP-01, SP-02

Berg A.PP-50

Bergmans T.PP-39

Bhaskar A.OP-24

Bhoi D.OP-23

Biesemans T.PP-48

Bode B.PP-04

Bojrab L.PP-20

Bonavina G.PP-35

Bougeard R.PP-54

Brewer R.PP-20

Bruehl S.SP-03, SP-04

Buschman R.PP-04

Buyse K.PP-39

C

Cadide D.M.OP-14

Calodney A.OP-07, PP-53

Camolesi E.PP-25

Canos Verdecho M.A.PP-54, PP-56

Capello M.G.MOP-14

Caraway D.OP-07

Cassini F.OP-24, PP-42, PP-43

Castellani G.B.PP-35

Çelik Ilhan S.OP-04

Cervera S.B.OP-13

Chair M.PP-08

Chatterjee A.PP-30

Chaudhari N.PP-40

Chauhan H.PP-14, PP-34

Chen L.OP-21, PP-42, PP-43, PP-53, PP-54, PP-55, PP-56

Chua N.H.PP-37

Cohen S.P.SP-15, SP-16, SP-17

Cömert A.OP-01

Comlek S.PP-19

D

Dağistan G.OP-12, OP-27, SP-30, SP-33

Dankerlui R.PP-32

Danko M.OP-26, PP-44

Dann T.PP-04

Darmawan G.PP-08

Darnall B.OP-18

De Andrés J.PP-49

De Andres ARES J.SP-19, SP-20, SP-22

De Andrés ARES J.OP-24

De Minkelis J.PP-59

De Negri P.PP-54

De Ridder D.SP-17, SP-26

Deligoz O.OP-04

Deri D.PP-29

Devor M.SP-36, SP-37, SP-38, SP-39, SP-40

Di Mauro L.PP-36

Dorenkamp C.PP-57

Durmuşoğlu Ü.OP-16

E

Eerlings S.PP-45

Eggington S.PP-60

Eglseer D.OP-17

El Tallawy S.N.PP-38

Eldabe S.OP-24

Elkholy A.PP-11

Elkholy W.PP-11

Elzinga L.PP-59

Emami A.PP-31

Erdine S.SP-34, SP-35

Ergisi M.PP-40

Ertargin M.PP-17, PP-47, PP-63

Esen K.PP-47

Eyigor C.OP-09

F

Fallatah S.M.A.OP-05

Fernández A.PP-49

Ferro R.PP-51, PP-52, PP-57

Figueiras G.PP-02

Fishman M.OP-06, PP-04

Fonseca C.B.PP-12

Franco M.S.OP-13

G

Gage E.PP-52

Gemae M.R.PP-09

Generoso L.POP-14