Pub Date : 2023-04-14DOI: 10.1080/10426507.2023.2196078
Jie Li, Lu Yu, Lingling Xiao, Mingwei Yang, Tianli Wu, Liqun Zhang, Shuming Tan, Pei Li
Abstract A series of novel botanical active component 4-chromanone derivatives incorporating carboxamide and 1,3,4-thiadiazole thioether moieties were synthesized and evaluated for their in vitro antibacterial and activities antifungal against Xanthomonas axonopodis pv. citri (Xac), Xanthomonas oryzae pv. oryzicolaby (Xoc) and Mucor bainieri (M. bainieri), Mucor fragilis (M. fragilis), Trichoderma atroviride (T. atroviride), respectively. Antibacterial screening results suggested that the target compounds showed moderate to good antibacterial activities against Xac and Xoc, to the contrary, had lower inhibitory effects on M. fragilis, M. bainieri, and T. atroviride. Among the target compounds, compound 6-chloro-N-(5-(methylthio)-1,3,4-thiadiazol-2-yl)-4-oxochromane-2-carboxamide (6f) had the best inhibition rates against Xac (85.15% and 72.41%, respectivelty) and Xoc (95.14% and 82.09%) at 200 and 100 μg/mL, which were superior to Bismerthiazol and Thiodiazole copper. As far as we know, it is the first report on the design, synthesis, and bioactivity evaluation of novel 4-chromanone-derived compounds incorporating carboxamide and 1,3,4-thiadiazole thioether moieties. Graphical Abstract
摘要合成了一系列含有羧基酰胺和1,3,4-噻二唑硫醚的新型植物活性成分4-铬酮衍生物，并对其体外抗菌和抗真菌活性进行了评价。柑桔(Xac)，米黄单胞菌;分别为米霉霉(Xoc)和白僵霉(M. bainieri)、脆弱毛霉(M. fragilis)、atroviride木霉(T. atroviride)。抑菌筛选结果表明，目标化合物对Xac和Xoc具有中等至良好的抑菌活性，而对脆弱支原体、白僵菌和阿托维绿杆菌的抑菌作用较低。目标化合物中，化合物6-氯- n -(5-(甲基硫)-1,3,4-噻二唑-2-基)-4-氧铬-2-羧酰胺(6f)在200和100 μg/mL下对Xac(分别为85.15%和72.41%)和Xoc(分别为95.14%和82.09%)的抑制率最高，优于双巯噻唑和硫代二唑铜。据我们所知，这是第一个设计、合成含有羧基酰胺和1,3,4-噻二唑硫醚的新型4-铬罗曼酮衍生化合物并进行生物活性评价的报道。图形抽象
{"title":"Design, synthesis, antibacterial, and antifungal evaluation of novel 4-chromanone-derived compounds incorporating carboxamide and 1,3,4-thiadiazole thioether moieties","authors":"Jie Li, Lu Yu, Lingling Xiao, Mingwei Yang, Tianli Wu, Liqun Zhang, Shuming Tan, Pei Li","doi":"10.1080/10426507.2023.2196078","DOIUrl":"https://doi.org/10.1080/10426507.2023.2196078","url":null,"abstract":"Abstract A series of novel botanical active component 4-chromanone derivatives incorporating carboxamide and 1,3,4-thiadiazole thioether moieties were synthesized and evaluated for their in vitro antibacterial and activities antifungal against Xanthomonas axonopodis pv. citri (Xac), Xanthomonas oryzae pv. oryzicolaby (Xoc) and Mucor bainieri (M. bainieri), Mucor fragilis (M. fragilis), Trichoderma atroviride (T. atroviride), respectively. Antibacterial screening results suggested that the target compounds showed moderate to good antibacterial activities against Xac and Xoc, to the contrary, had lower inhibitory effects on M. fragilis, M. bainieri, and T. atroviride. Among the target compounds, compound 6-chloro-N-(5-(methylthio)-1,3,4-thiadiazol-2-yl)-4-oxochromane-2-carboxamide (6f) had the best inhibition rates against Xac (85.15% and 72.41%, respectivelty) and Xoc (95.14% and 82.09%) at 200 and 100 μg/mL, which were superior to Bismerthiazol and Thiodiazole copper. As far as we know, it is the first report on the design, synthesis, and bioactivity evaluation of novel 4-chromanone-derived compounds incorporating carboxamide and 1,3,4-thiadiazole thioether moieties. Graphical Abstract","PeriodicalId":20043,"journal":{"name":"Phosphorus Sulfur and Silicon and The Related Elements","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72870019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-08DOI: 10.1080/10426507.2023.2196079
M. Hearn, Catherine D. Pugh, M. Cynamon
Abstract Using up-to-date methods for synthesis and analysis, 51 sulfonamides were prepared for use as tools in antitubercular drug discovery. The synthetic efforts were centered on varying substituents at three key structural units implicated in antimicrobial activity, namely the sulfonyl group, nitrogen N1 and nitrogen N4. Procedures were specific to the sites of functionalization. Preliminary biological assessments are included here on selected compounds. The results suggest that the compounds may be useful in the exploration of the likely interactions of sulfa drugs with enzymes found in tuberculosis (dihydropteroate synthase) or its human host (N-acetyltransferase), interactions that result in drug activity or drug de-activation, respectively. GRAPHICAL ABSTRACT
{"title":"Synthesis of functionalized sulfonamides as antitubercular agents","authors":"M. Hearn, Catherine D. Pugh, M. Cynamon","doi":"10.1080/10426507.2023.2196079","DOIUrl":"https://doi.org/10.1080/10426507.2023.2196079","url":null,"abstract":"Abstract Using up-to-date methods for synthesis and analysis, 51 sulfonamides were prepared for use as tools in antitubercular drug discovery. The synthetic efforts were centered on varying substituents at three key structural units implicated in antimicrobial activity, namely the sulfonyl group, nitrogen N1 and nitrogen N4. Procedures were specific to the sites of functionalization. Preliminary biological assessments are included here on selected compounds. The results suggest that the compounds may be useful in the exploration of the likely interactions of sulfa drugs with enzymes found in tuberculosis (dihydropteroate synthase) or its human host (N-acetyltransferase), interactions that result in drug activity or drug de-activation, respectively. GRAPHICAL ABSTRACT","PeriodicalId":20043,"journal":{"name":"Phosphorus Sulfur and Silicon and The Related Elements","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81226316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-08DOI: 10.1080/10426507.2023.2195651
H. Yuasa, Tomohiro Yube, T. Kanamori
Abstract Here, we serendipitously found that photoirradiation of nitrobenzene derivatives with alkyl thiols produced sulfonamides in low yields without the addition of other reagents. We proposed a new photoreaction mechanism, in which the photo-excited nitrobenzene biradical abstracts a hydrogen atom from H-S, the resultant thiyl radical undergoes the coupling with the nitrogen atom in the nitro group, and the two oxygen atoms in the nitro group are transferred onto the sulfur atom. The photoreaction by-produced p-sulfanyl, aniline, and o-sulfonyl derivatives presumably through SRN1 mechanism from the p-substituted nitrobenzene, photo-desulfonylation, and photo-Fries rearrangement from the sulfonamide, respectively. Discovery of this photoreaction will expand the scope of the chemistry of nitro and thiol compounds, since the sulfonamides are expected to find extensive applications. GRAPHICAL ABSTRACT
{"title":"Photoreaction of nitrobenzene derivatives with alkyl thiols giving sulfonamides and derivatives","authors":"H. Yuasa, Tomohiro Yube, T. Kanamori","doi":"10.1080/10426507.2023.2195651","DOIUrl":"https://doi.org/10.1080/10426507.2023.2195651","url":null,"abstract":"Abstract Here, we serendipitously found that photoirradiation of nitrobenzene derivatives with alkyl thiols produced sulfonamides in low yields without the addition of other reagents. We proposed a new photoreaction mechanism, in which the photo-excited nitrobenzene biradical abstracts a hydrogen atom from H-S, the resultant thiyl radical undergoes the coupling with the nitrogen atom in the nitro group, and the two oxygen atoms in the nitro group are transferred onto the sulfur atom. The photoreaction by-produced p-sulfanyl, aniline, and o-sulfonyl derivatives presumably through SRN1 mechanism from the p-substituted nitrobenzene, photo-desulfonylation, and photo-Fries rearrangement from the sulfonamide, respectively. Discovery of this photoreaction will expand the scope of the chemistry of nitro and thiol compounds, since the sulfonamides are expected to find extensive applications. GRAPHICAL ABSTRACT","PeriodicalId":20043,"journal":{"name":"Phosphorus Sulfur and Silicon and The Related Elements","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86538281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.1080/10426507.2023.2197646
Z. Ramzi, W. Nachit, L. El Gaini, S. Touhtouh, K. Benkhouja
Abstract Strontium phosphate glasses containing bismuth oxide were prepared using conventional melt-quenching technique. X-ray diffraction and differential scanning calorimetry (DSC) analysis suggests that stable ternary glasses of composition 70 P2O5-(30-x)SrO-xBi2O3 can be obtained for x = 5–25 mol%. This study examines such physical properties as the density, molar volume (Vm), glass transition temperature (Tg), and structural properties in the interest of explaining the effect on these glasses of Bi-Sr substitution. An almost linear increase in the density when the concentration of bismuth increases between x = 5 and x = 10 mol% followed by monotonic decreasing is noted. However, the calculated molar volume (Vm) behaves in exactly the opposite way. DSC curves showed that the glass transition temperature (Tg) decreases by 555 °C down to 490 °C as the concentration of Bi2O3 increases, due to the increase in the number of bridging oxygens. Structural investigations performed using IR spectroscopy revealed that the structure of the phosphate network contains predominately meta-phosphate (Q2) units, with contributions from pyrophosphate (Q1) and orthophosphate (Q0). The infrared spectra also revealed depolymerization of the phosphate chains in the glass system, with increased Bi2O3 concentration and the formation of P–O–Bi bonds. The study of the gamma ray shielding parameters showed that the prepared glasses can be used for shielding radiation applications. GRAPHICAL ABSTRACT
{"title":"Effect of Bi2O3 on the physical, structural and gamma ray shielding properties of phosphate glasses inside the ternary P2O5-SrO-Bi2O3 system","authors":"Z. Ramzi, W. Nachit, L. El Gaini, S. Touhtouh, K. Benkhouja","doi":"10.1080/10426507.2023.2197646","DOIUrl":"https://doi.org/10.1080/10426507.2023.2197646","url":null,"abstract":"Abstract Strontium phosphate glasses containing bismuth oxide were prepared using conventional melt-quenching technique. X-ray diffraction and differential scanning calorimetry (DSC) analysis suggests that stable ternary glasses of composition 70 P2O5-(30-x)SrO-xBi2O3 can be obtained for x = 5–25 mol%. This study examines such physical properties as the density, molar volume (Vm), glass transition temperature (Tg), and structural properties in the interest of explaining the effect on these glasses of Bi-Sr substitution. An almost linear increase in the density when the concentration of bismuth increases between x = 5 and x = 10 mol% followed by monotonic decreasing is noted. However, the calculated molar volume (Vm) behaves in exactly the opposite way. DSC curves showed that the glass transition temperature (Tg) decreases by 555 °C down to 490 °C as the concentration of Bi2O3 increases, due to the increase in the number of bridging oxygens. Structural investigations performed using IR spectroscopy revealed that the structure of the phosphate network contains predominately meta-phosphate (Q2) units, with contributions from pyrophosphate (Q1) and orthophosphate (Q0). The infrared spectra also revealed depolymerization of the phosphate chains in the glass system, with increased Bi2O3 concentration and the formation of P–O–Bi bonds. The study of the gamma ray shielding parameters showed that the prepared glasses can be used for shielding radiation applications. GRAPHICAL ABSTRACT","PeriodicalId":20043,"journal":{"name":"Phosphorus Sulfur and Silicon and The Related Elements","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79451615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.1080/10426507.2023.2194651
Hamid Mohammadzadeh Dovvom, B. Akhlaghinia
Abstract Dithioacetalization, as a well-known class of organic transformation, was carried out for protection of a wide variety of aromatic (with electron releasing and electron withdrawing substituents), heteroaromatic and aliphatic aldehydes as well as ketones by 1,2-ethanedithiol/or 1,3-propanedithiol in the presence of Fe3O4@MCM-41-GPTMS-Gu-CuIINPs. The corresponding 1,3-dithiolanes and 1,3-dithianes were obtained chemoselectively in the presence of Fe3O4@MCM-41-GPTMS-Gu-CuIINPs with hexagonal core-shell structure, superparamagnetic behavior, and average particle size of 8–25 nm under mild reaction conditions. The nanostructured catalyst could be separated easily from the reaction mixture using a magnetic bar and reused in several reaction runs without any remarkable reduction in its catalytic activity. Nearly neutral conditions, good to high yields of the products, operational simplicity, easy work-up procedure, compatibility with various functional groups make the present method valuable in addition to the known methodologies. GRAPHICAL ABSTRACT
{"title":"Facile chemoselective dithioacetalization of carbonyl compounds promoted by Fe3O4@MCM-41-GPTMS-Gu-CuIINPs as an efficient magnetic nanostructured catalyst","authors":"Hamid Mohammadzadeh Dovvom, B. Akhlaghinia","doi":"10.1080/10426507.2023.2194651","DOIUrl":"https://doi.org/10.1080/10426507.2023.2194651","url":null,"abstract":"Abstract Dithioacetalization, as a well-known class of organic transformation, was carried out for protection of a wide variety of aromatic (with electron releasing and electron withdrawing substituents), heteroaromatic and aliphatic aldehydes as well as ketones by 1,2-ethanedithiol/or 1,3-propanedithiol in the presence of Fe3O4@MCM-41-GPTMS-Gu-CuIINPs. The corresponding 1,3-dithiolanes and 1,3-dithianes were obtained chemoselectively in the presence of Fe3O4@MCM-41-GPTMS-Gu-CuIINPs with hexagonal core-shell structure, superparamagnetic behavior, and average particle size of 8–25 nm under mild reaction conditions. The nanostructured catalyst could be separated easily from the reaction mixture using a magnetic bar and reused in several reaction runs without any remarkable reduction in its catalytic activity. Nearly neutral conditions, good to high yields of the products, operational simplicity, easy work-up procedure, compatibility with various functional groups make the present method valuable in addition to the known methodologies. GRAPHICAL ABSTRACT","PeriodicalId":20043,"journal":{"name":"Phosphorus Sulfur and Silicon and The Related Elements","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81071651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-03DOI: 10.1080/10426507.2022.2099715
Tomasz Cierpiał, J. Drabowicz, P. Kiełbasiński
{"title":"Afterword: Twenty third international conference on phosphorus chemistry","authors":"Tomasz Cierpiał, J. Drabowicz, P. Kiełbasiński","doi":"10.1080/10426507.2022.2099715","DOIUrl":"https://doi.org/10.1080/10426507.2022.2099715","url":null,"abstract":"","PeriodicalId":20043,"journal":{"name":"Phosphorus Sulfur and Silicon and The Related Elements","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79041904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-03DOI: 10.1080/10426507.2022.2043636
M. Rudd
{"title":"Editor's Remarks for International Conference on Phosphorus Chemistry – ICPC 23","authors":"M. Rudd","doi":"10.1080/10426507.2022.2043636","DOIUrl":"https://doi.org/10.1080/10426507.2022.2043636","url":null,"abstract":"","PeriodicalId":20043,"journal":{"name":"Phosphorus Sulfur and Silicon and The Related Elements","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82926853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-09DOI: 10.1080/10426507.2022.2043640
Charles B Mckenna
{"title":"ICPC23, Czestochowa, POLAND: Opening Ceremony: Welcoming Remarks for ICPC23","authors":"Charles B Mckenna","doi":"10.1080/10426507.2022.2043640","DOIUrl":"https://doi.org/10.1080/10426507.2022.2043640","url":null,"abstract":"","PeriodicalId":20043,"journal":{"name":"Phosphorus Sulfur and Silicon and The Related Elements","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83189562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.1080/10426507.2022.2046572
Nevena I. Petkova-Yankova, R. Nikolova
Abstract Bromohydrins were prepared by ring opening of coumarinyl-1,2-epoxy phosphonate esters under acidic conditions. The chemical behavior of bromohydrins was examined under Michaelis–Becker reaction conditions using dialkylphosphites. Graphical Abstract
{"title":"Current attempt on the transformations of coumarinyl-1,2-epoxyphosphonates","authors":"Nevena I. Petkova-Yankova, R. Nikolova","doi":"10.1080/10426507.2022.2046572","DOIUrl":"https://doi.org/10.1080/10426507.2022.2046572","url":null,"abstract":"Abstract Bromohydrins were prepared by ring opening of coumarinyl-1,2-epoxy phosphonate esters under acidic conditions. The chemical behavior of bromohydrins was examined under Michaelis–Becker reaction conditions using dialkylphosphites. Graphical Abstract","PeriodicalId":20043,"journal":{"name":"Phosphorus Sulfur and Silicon and The Related Elements","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80064183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-21DOI: 10.1080/10426507.2021.2017434
S. Varshney, A. Nigam, S. J. Pawar, N. Mishra
Abstract Silica has drawn the attention of many researchers from all over the world owing to its excellent biological, mechanical, and physiochemical properties. Different synthetic routes, reagents, characterization techniques, and applications of silica nanoparticles (SiO2 NPs) are discussed in this review article. A detailed discussion on sol-gel, ultrasonication, chemical precipitation, and hydrothermal route is presented. Biological synthesis of SiO2 NPs from bamboo leaves, rice husk, and sugarcane bagasse is also focused. Different characterization techniques including X-ray diffraction, dynamic light scattering, transmission electron microscopy, and Fourier transform infrared spectroscopy are discussed in detail. A study on SiO2 NPs conjugated with metallic oxides and polymers is also discussed. Being important materials with a wide variety and novel applications, these conjugates are used in agriculture, mechanical engineering, material science, electronics, and biomedical engineering. However, greater emphasis has been laid on biomedical aspects, including antibacterial applications and drug delivery along with its cytotoxic properties. The review article reflects that SiO2 NPs are potential candidates for several biomedical applications due to their biocompatibility and appreciable biological activity. Graphical Abstract
{"title":"An overview on biomedical applications of versatile silica nanoparticles, synthesized via several chemical and biological routes: A review","authors":"S. Varshney, A. Nigam, S. J. Pawar, N. Mishra","doi":"10.1080/10426507.2021.2017434","DOIUrl":"https://doi.org/10.1080/10426507.2021.2017434","url":null,"abstract":"Abstract Silica has drawn the attention of many researchers from all over the world owing to its excellent biological, mechanical, and physiochemical properties. Different synthetic routes, reagents, characterization techniques, and applications of silica nanoparticles (SiO2 NPs) are discussed in this review article. A detailed discussion on sol-gel, ultrasonication, chemical precipitation, and hydrothermal route is presented. Biological synthesis of SiO2 NPs from bamboo leaves, rice husk, and sugarcane bagasse is also focused. Different characterization techniques including X-ray diffraction, dynamic light scattering, transmission electron microscopy, and Fourier transform infrared spectroscopy are discussed in detail. A study on SiO2 NPs conjugated with metallic oxides and polymers is also discussed. Being important materials with a wide variety and novel applications, these conjugates are used in agriculture, mechanical engineering, material science, electronics, and biomedical engineering. However, greater emphasis has been laid on biomedical aspects, including antibacterial applications and drug delivery along with its cytotoxic properties. The review article reflects that SiO2 NPs are potential candidates for several biomedical applications due to their biocompatibility and appreciable biological activity. Graphical Abstract","PeriodicalId":20043,"journal":{"name":"Phosphorus Sulfur and Silicon and The Related Elements","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83285799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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