Pub Date : 2021-01-01DOI: 10.36253/978-88-5518-344-4
Dalila De Vita
Malformations of cortical development (MCDs) result from a disruption in the process of the human brain cortex formation: currently, there are no pharmacological treatments for diffuse MCDs. Next-generation sequencing has accelerated the identification of MCDs causing genes: in some cases, functional studies are needed to clarify the role of genetic variants. The aim of this PhD project has been to apply a multidisciplinary approach to identify causative mutations in patients with MCDs, validate the pathogenic role of the identified mutations, and assess the effectiveness of novel in vitro treatment for mTOR pathway related MCDs.
{"title":"Functional validation of genetic variants identified by next generation sequencing in malformations of cortical development","authors":"Dalila De Vita","doi":"10.36253/978-88-5518-344-4","DOIUrl":"https://doi.org/10.36253/978-88-5518-344-4","url":null,"abstract":"Malformations of cortical development (MCDs) result from a disruption in the process of the human brain cortex formation: currently, there are no pharmacological treatments for diffuse MCDs. Next-generation sequencing has accelerated the identification of MCDs causing genes: in some cases, functional studies are needed to clarify the role of genetic variants. The aim of this PhD project has been to apply a multidisciplinary approach to identify causative mutations in patients with MCDs, validate the pathogenic role of the identified mutations, and assess the effectiveness of novel in vitro treatment for mTOR pathway related MCDs.","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83701145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36253/978-88-5518-420-5
M. Di Rosa
In this work the central area of Corsica island was studied in order to reconstruct the tectono-metamorphic history of the continental and oceanic high pressure units that occupy the structurally deeper levels of the tectonic stacking of Alpine Corsica and their stratigraphic and structural relationship with the European margin (Hercynian Corsica). The study includes the geological mapping, the mesoscale and microscale structural analysis, the acquisition of chemical analyzes and micromaps with the microprobe, thermobarometric estimation through specific methodologies for metapelites, U-Th-Pb dating of zircons and allanites. The results obtained allows to reconstruct the geodynamic model of this sector of the Alpine belt from the Permian to the Burdigalian.
{"title":"Tectono-metamorphic evolution of the continental units along the edge between Alpine and Hercynian Corsica","authors":"M. Di Rosa","doi":"10.36253/978-88-5518-420-5","DOIUrl":"https://doi.org/10.36253/978-88-5518-420-5","url":null,"abstract":"In this work the central area of Corsica island was studied in order to reconstruct the tectono-metamorphic history of the continental and oceanic high pressure units that occupy the structurally deeper levels of the tectonic stacking of Alpine Corsica and their stratigraphic and structural relationship with the European margin (Hercynian Corsica). The study includes the geological mapping, the mesoscale and microscale structural analysis, the acquisition of chemical analyzes and micromaps with the microprobe, thermobarometric estimation through specific methodologies for metapelites, U-Th-Pb dating of zircons and allanites. The results obtained allows to reconstruct the geodynamic model of this sector of the Alpine belt from the Permian to the Burdigalian.","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89946542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36253/978-88-5518-380-2
L. Colzi
One of the most important tools to investigate the chemical history of our Galaxy and our own Solar System is to measure the isotopic fractionation of chemical elements. In the present study new astronomical observations devoted to the study of hydrogen and nitrogen fractionation (D/H and 14N/15N ratios) of molecules, towards massive star-forming regions in different evolutionary phases, have been presented. Moreover, a new detailed theoretical study of carbon fractionation, 12C/13C ratios, has been done. One of the main results was the confirmation that the 14N/15N ratio increases with the galactocentric distance, as predicted by stellar nucleosynthesis Galactic chemical evolution models. This work gives new important inputs on the understanding of local chemical processes that favor the production of molecules with different isotopes in star-forming regions.
{"title":"Isotopic fractionation study towards massive star-forming regions across the Galaxy","authors":"L. Colzi","doi":"10.36253/978-88-5518-380-2","DOIUrl":"https://doi.org/10.36253/978-88-5518-380-2","url":null,"abstract":"One of the most important tools to investigate the chemical history of our Galaxy and our own Solar System is to measure the isotopic fractionation of chemical elements. In the present study new astronomical observations devoted to the study of hydrogen and nitrogen fractionation (D/H and 14N/15N ratios) of molecules, towards massive star-forming regions in different evolutionary phases, have been presented. Moreover, a new detailed theoretical study of carbon fractionation, 12C/13C ratios, has been done. One of the main results was the confirmation that the 14N/15N ratio increases with the galactocentric distance, as predicted by stellar nucleosynthesis Galactic chemical evolution models. This work gives new important inputs on the understanding of local chemical processes that favor the production of molecules with different isotopes in star-forming regions.","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72652759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36253/978-88-5518-397-0
Rasha Al Owaidi
This work focuses on the research and identification of the existence of Arabic traces, both formal and substantial, within the works of Andrea da Barberino. The critical analysis was based on the elaboration of an exhaustive register of terms of Arabic origin conducted on the six novels attributed with certainty to the author. The survey highlighted the substantial absence of a direct relationship between Barberino and the Arab world, both from the lexical point of view and as regards the mythographic aspects.
{"title":"La letteratura cavalleresca e il mondo arabo: il caso di Andrea da Barberino","authors":"Rasha Al Owaidi","doi":"10.36253/978-88-5518-397-0","DOIUrl":"https://doi.org/10.36253/978-88-5518-397-0","url":null,"abstract":"This work focuses on the research and identification of the existence of Arabic traces, both formal and substantial, within the works of Andrea da Barberino. The critical analysis was based on the elaboration of an exhaustive register of terms of Arabic origin conducted on the six novels attributed with certainty to the author. The survey highlighted the substantial absence of a direct relationship between Barberino and the Arab world, both from the lexical point of view and as regards the mythographic aspects.","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75613623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36253/978-88-5518-374-1
C. Ricci
The topic of this publication is the Camaldolese monastery of Santa Maria degli Angeli, located in the historic center of Florence, in an area between via degli Alfani, via del Castellaccio and piazza Brunelleschi. The study of the religious complex, founded in 1295, was tackled with the dual purpose to reconstruct the historical-architectural events of the last four centuries and to identify the causes of the fractionation following its suppression in 1866. The fractionation between different properties resulted in the current loss of architectural legibility of the Camaldolese monastery; for this reason one of the most important religious and cultural centers of the Florentine fourteenth-fifteenth century was almost “forgotten” not only by the citizens, but also by historiography.
本出版物的主题是Santa Maria degli Angeli的Camaldolese修道院，位于佛罗伦萨的历史中心，位于via degli Alfani, via del Castellaccio和布鲁内莱斯基广场之间的区域。对这座建于1295年的宗教建筑群的研究有两个目的，一是重建过去四个世纪的历史建筑事件，二是确定1866年被镇压后分裂的原因。不同属性之间的分割导致Camaldolese修道院目前的建筑可读性下降;正因为如此，这个14 - 15世纪佛罗伦萨最重要的宗教和文化中心之一，不仅被市民们“遗忘”了，而且也被史学界“遗忘”了。
{"title":"Santa Maria degli Angeli: un monastero camaldolese “dimenticato” nel centro di Firenze","authors":"C. Ricci","doi":"10.36253/978-88-5518-374-1","DOIUrl":"https://doi.org/10.36253/978-88-5518-374-1","url":null,"abstract":"The topic of this publication is the Camaldolese monastery of Santa Maria degli Angeli, located in the historic center of Florence, in an area between via degli Alfani, via del Castellaccio and piazza Brunelleschi. The study of the religious complex, founded in 1295, was tackled with the dual purpose to reconstruct the historical-architectural events of the last four centuries and to identify the causes of the fractionation following its suppression in 1866. The fractionation between different properties resulted in the current loss of architectural legibility of the Camaldolese monastery; for this reason one of the most important religious and cultural centers of the Florentine fourteenth-fifteenth century was almost “forgotten” not only by the citizens, but also by historiography.","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77084005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36253/978-88-5518-368-0
A. Galante
Over the past several years, constitutional, supreme and human rights courts had to deal with the problem of adjudicative retroactivity in criminal law with ever-greater intensity. Following the case Contrada c. Italie, in which the European Court of Human Rights found a violation of the legality principle under Art. 7 due to an unforeseeable retrospective application of a judicially created criminal offence, the issue of citizens’ safeguard upon an overruling occurrence is even more in the foreground. What temporal effect is best given to an unfavorable overruling decision? Should its application be limited to acts and conduct occurring after it or should it operate retrospectively and subject to criminal responsibility those who, acting in reliance on an earlier decision, did only what courts declared to be lawful? A limited prohibition of adjudicative retroactivity in criminal law seems to help foster an up-to-date relationship between the individual and the state.
在过去几年中，宪法法院、最高法院和人权法院不得不更加认真地处理刑法中的裁决溯及既往的问题。在Contrada c. italy一案中，欧洲人权法院裁定，由于不可预见地追溯适用司法创造的刑事犯罪而违反了第7条规定的合法性原则，在此之后，公民在被推翻的情况下的保障问题更加突出。什么样的时间效应对一个不利的否决决定是最好的?它的适用是否应限于在它之后发生的行为，或者它是否应追溯地适用，并对那些依靠先前的决定而只做法院宣布为合法的事情的人追究刑事责任?刑法中对判决溯及既往的有限禁止似乎有助于促进个人与国家之间的最新关系。
{"title":"Legalità e mutamenti giurisprudenziali nel diritto penale","authors":"A. Galante","doi":"10.36253/978-88-5518-368-0","DOIUrl":"https://doi.org/10.36253/978-88-5518-368-0","url":null,"abstract":"Over the past several years, constitutional, supreme and human rights courts had to deal with the problem of adjudicative retroactivity in criminal law with ever-greater intensity. Following the case Contrada c. Italie, in which the European Court of Human Rights found a violation of the legality principle under Art. 7 due to an unforeseeable retrospective application of a judicially created criminal offence, the issue of citizens’ safeguard upon an overruling occurrence is even more in the foreground. What temporal effect is best given to an unfavorable overruling decision? Should its application be limited to acts and conduct occurring after it or should it operate retrospectively and subject to criminal responsibility those who, acting in reliance on an earlier decision, did only what courts declared to be lawful? A limited prohibition of adjudicative retroactivity in criminal law seems to help foster an up-to-date relationship between the individual and the state.","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89095056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.36253/978-88-5518-061-0
L. Talluri
The Tesla expander was first developed by N. Tesla at the beginning of the 20th century. In recent years, due to the increasing appeal towards micro power generation and energy recovery from wasted flows, this cost effective expander technology rose a renovated interest. In the present study, a 2D numerical model is realized and a design procedure of a Tesla turbine for ORC applications is proposed. A throughout optimization method is developed by evaluating the losses of each component. The 2D model results are further exploited through the development of 3D computational investigation, which allows an accurate comprehension of the flow characteristics. Finally, two prototypes are designed, realized and tested. The former one is designed to work with air as working fluid. The second prototype is designed to work with organic fluids. The achieved experimental results confirmed the validity and the large potential applicative chances of this emerging technology in the field of micro sizes, low inlet temperature and low expansion ratios.
{"title":"Micro turbo expander design for small scale ORC","authors":"L. Talluri","doi":"10.36253/978-88-5518-061-0","DOIUrl":"https://doi.org/10.36253/978-88-5518-061-0","url":null,"abstract":"The Tesla expander was first developed by N. Tesla at the beginning of the 20th century. In recent years, due to the increasing appeal towards micro power generation and energy recovery from wasted flows, this cost effective expander technology rose a renovated interest. In the present study, a 2D numerical model is realized and a design procedure of a Tesla turbine for ORC applications is proposed. A throughout optimization method is developed by evaluating the losses of each component. The 2D model results are further exploited through the development of 3D computational investigation, which allows an accurate comprehension of the flow characteristics. Finally, two prototypes are designed, realized and tested. The former one is designed to work with air as working fluid. The second prototype is designed to work with organic fluids. The achieved experimental results confirmed the validity and the large potential applicative chances of this emerging technology in the field of micro sizes, low inlet temperature and low expansion ratios.","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84046119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.36253/978-88-6453-781-8
L. Pattelli
Paper, milk, clouds and white paint share a common property: they are opaque disordered media through which light scatters randomly rather than propagating in a straight path. For very thick and turbid media, indeed, light eventually propagates in a ‘diffusive’ way, i.e. similarly to how tea infuses through hot water. Frequently though, a material is neither perfectly opaque nor transparent and the simple diffusion model does not hold. In this work, we developed a novel optical-gating setup that allowed us to observe light transport in scattering media with sub-ps time resolution. An array of unexplored aspects of light propagation emerged from this spatio-temporal description, unveiling transport regimes that were previously inaccessibile due to the extreme time scales involved and the lack of analytical models.
{"title":"Imaging light transport at the femtosecond scale","authors":"L. Pattelli","doi":"10.36253/978-88-6453-781-8","DOIUrl":"https://doi.org/10.36253/978-88-6453-781-8","url":null,"abstract":"Paper, milk, clouds and white paint share a common property: they are opaque disordered media through which light scatters randomly rather than propagating in a straight path. For very thick and turbid media, indeed, light eventually propagates in a ‘diffusive’ way, i.e. similarly to how tea infuses through hot water. Frequently though, a material is neither perfectly opaque nor transparent and the simple diffusion model does not hold. In this work, we developed a novel optical-gating setup that allowed us to observe light transport in scattering media with sub-ps time resolution. An array of unexplored aspects of light propagation emerged from this spatio-temporal description, unveiling transport regimes that were previously inaccessibile due to the extreme time scales involved and the lack of analytical models.","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83649746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.36253/978-88-6453-789-4
D. Verardi
Il volume è dedicato al tema degli ‘occulti segreti della natura’ nella magia naturale di Giovan Battista Della Porta (1535-1615). L’argomento è studiato in relazione sia ai dibattiti interni all’aristotelismo napoletano del XVI secolo, sia alle proposte della tradizione magica rinascimentale. Il libro affronta anche il problema della stregoneria, fenomeno non prettamente filosofico, ma storicamente connesso alla lotta che Della Porta conduce contro ogni forma di spiegazione superstiziosa dei segreti naturali, compresi quelli più scabrosi.
{"title":"La scienza e i segreti della natura a Napoli nel Rinascimento","authors":"D. Verardi","doi":"10.36253/978-88-6453-789-4","DOIUrl":"https://doi.org/10.36253/978-88-6453-789-4","url":null,"abstract":"Il volume è dedicato al tema degli ‘occulti segreti della natura’ nella magia naturale di Giovan Battista Della Porta (1535-1615). L’argomento è studiato in relazione sia ai dibattiti interni all’aristotelismo napoletano del XVI secolo, sia alle proposte della tradizione magica rinascimentale. Il libro affronta anche il problema della stregoneria, fenomeno non prettamente filosofico, ma storicamente connesso alla lotta che Della Porta conduce contro ogni forma di spiegazione superstiziosa dei segreti naturali, compresi quelli più scabrosi.\u0000\u0000","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83847001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.36253/978-88-6453-779-5
R. Valenti
Sporadic cerebral small vessel disease (SVD) is considered to be among the most commonly known neuropathological processes in the brain, hosting a crucial role in stroke, cognitive impairment, and functional loss in elderly subjects. We investigated clinical (neuroimaging and cognitive) biomarkers in the SVD, through a series of analyses from our five studies. Sporadic cerebral SVD is a complex ‘micro-world’ to be globally considered. All the relevant lesion types and SVD neuroimaging burden should be taken into account. The cumulative effects of microangiopathy burden in the brain of patients affected by SVD are crucial. Cognitive rehabilitation could represent a promising approach to prevent vascular dementia or to improve cognitive performances in patients with cerebral SVD. Longitudinal studies may provide more robust information about the progression and prognostic significance of our findings.
{"title":"Cerebral Small Vessel Disease and Cerebral Amyloid Angiopathy","authors":"R. Valenti","doi":"10.36253/978-88-6453-779-5","DOIUrl":"https://doi.org/10.36253/978-88-6453-779-5","url":null,"abstract":"Sporadic cerebral small vessel disease (SVD) is considered to be among the most commonly known neuropathological processes in the brain, hosting a crucial role in stroke, cognitive impairment, and functional loss in elderly subjects. We investigated clinical (neuroimaging and cognitive) biomarkers in the SVD, through a series of analyses from our five studies. Sporadic cerebral SVD is a complex ‘micro-world’ to be globally considered. All the relevant lesion types and SVD neuroimaging burden should be taken into account. The cumulative effects of microangiopathy burden in the brain of patients affected by SVD are crucial. Cognitive rehabilitation could represent a promising approach to prevent vascular dementia or to improve cognitive performances in patients with cerebral SVD. Longitudinal studies may provide more robust information about the progression and prognostic significance of our findings.\u0000","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76511956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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