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In the "Drivers'" Seat: How to Improve Drivers of Health, from Vision to Impact. 坐在 "驾驶员 "的位置上:如何改善健康的驱动因素,从愿景到影响。
IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-12-01 Epub Date: 2024-11-19 DOI: 10.1089/pop.2024.0148
Ann Somers Hogg, Alexandra Schweitzer

Despite focusing on drivers of health, or social determinants of health, for more than a decade, health care organizations have made minimal progress in improving these factors and associated health outcomes. This data- and theory-driven analysis looks at (1) why that is the case and (2) how organizational leaders and operators can go about correcting it. The authors' research finds that lack of progress is often due to ill-fit, entrenched business models that were optimized for a fee-for-service environment and cannot easily pivot to focus on drivers of health. Additionally, leaders are often unclear about what to change and overwhelmed by how to do it. The authors propose a 5-step strategy and execution process to address these challenges, laying out an end-to-end road map that enables health care leaders to meaningfully improve drivers of health and associated health outcomes for their patients and communities.

尽管十多年来一直关注健康的驱动因素或健康的社会决定因素,但医疗机构在改善这些因素和相关健康结果方面取得的进展微乎其微。这篇以数据和理论为导向的分析报告探讨了:(1)为什么会出现这种情况;(2)组织领导者和运营者如何纠正这种情况。作者的研究发现,缺乏进展往往是由于业务模式不合适、根深蒂固,这些模式针对收费服务环境进行了优化,不能轻易转向关注健康驱动因素。此外,领导者往往不清楚要改变什么,也不知如何改变。作者提出了应对这些挑战的五步战略和执行流程,列出了端到端的路线图,使医疗保健领导者能够切实改善健康驱动因素,并为患者和社区带来相关的健康成果。
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引用次数: 0
The Social Risk ACTIONS Framework: Characterizing Responses to Social Risks by Health Care Delivery Organizations. 社会风险行动框架:社会风险行动框架:描述医疗服务机构应对社会风险的措施。
IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI: 10.1089/pop.2024.0162
Mayuree Rao, Matthew L Maciejewski, Karin Nelson, Alicia J Cohen, Hill L Wolfe, Leah Marcotte, Donna M Zulman

Social risks refer to individuals' social and economic conditions shaped by underlying social determinants of health. Health care delivery organizations increasingly screen patients for social risks given their potential impact on health outcomes. However, it can be challenging to meaningfully address patients' needs. Existing frameworks do not comprehensively describe and classify ways in which health care delivery organizations can address social risks after screening. Addressing this gap, the authors developed the Social Risk ACTIONS framework (Actionability Characteristics To Inform Organizations' Next steps after Screening) describing 4 dimensions of actionability: Level of action, Actor, Purpose of action, and Action. First, social risk actions can occur at 3 organizational levels (ie, patient encounter, clinical practice/institution, community). Second, social risk actions are initiated by different staff members, referred to as "actors" (ie, clinical care professionals with direct patient contact, clinical/institutional leaders, and researchers). Third, social risk actions can serve one or more purposes: strengthening relationships with patients, tailoring care, modifying the social risk itself, or facilitating population health, research, or advocacy. Finally, specific actions on social risks vary by level, actor, and purpose. This article presents the Social Risk ACTIONS framework, applies its concepts to 2 social risks (food insecurity and homelessness), and discusses its broader applications and implications. The framework offers an approach for leaders of health care delivery organizations to assess current efforts and identify additional opportunities to address social risks. Future work should validate this framework with patients, clinicians, and health care leaders, and incorporate implementation challenges to social risk action.

社会风险指的是个人的社会和经济状况,由潜在的健康社会决定因素所决定。鉴于社会风险对健康结果的潜在影响,医疗服务机构越来越多地对患者进行社会风险筛查。然而,要有意义地满足患者的需求可能具有挑战性。现有的框架并没有对医疗服务机构在筛查后应对社会风险的方式进行全面的描述和分类。针对这一空白,作者开发了社会风险 ACTIONS 框架(筛查后告知组织下一步行动的可操作性特征),描述了可操作性的 4 个维度:行动级别、行动者、行动目的和行动。首先,社会风险行动可发生在 3 个组织层面(即患者就诊、临床实践/机构、社区)。第二,社会风险行动由不同的工作人员发起,这些工作人员被称为 "行动者"(即直接接触患者的临床护理专业人员、临床/机构领导和研究人员)。第三,社会风险行动可以达到一个或多个目的:加强与患者的关系,量身定制护理,改变社会风险本身,或促进人口健康、研究或宣传。最后,针对社会风险的具体行动因级别、参与者和目的而异。本文介绍了社会风险行动框架,将其概念应用于两种社会风险(粮食不安全和无家可归),并讨论了其更广泛的应用和影响。该框架为医疗保健服务机构的领导者提供了一种评估当前工作的方法,并确定了应对社会风险的更多机会。未来的工作应与患者、临床医生和医疗保健领导者一起验证该框架,并将实施社会风险行动所面临的挑战纳入其中。
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引用次数: 0
Design and Framework of a Technology-Based Closed-Loop Referral Project for Care Coordination of Social Determinants of Health. 基于技术的闭环转诊项目的设计和框架,以协调健康的社会决定因素。
IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-12-01 Epub Date: 2024-11-28 DOI: 10.1089/pop.2024.0129
Shreela V Sharma, Heidi McPherson, Micaela Sandoval, David Goodman, Carol Paret, Kallol Mahata, Junaid Husain, James Gallagher, Eric Boerwinkle

Screening for social determinants of health (SDOH) has been mandated by health systems nationwide. However, a gap exists in closed-loop referral for care coordination between health care and social services. This article presents the framework of a technology-based project to facilitate closed-loop referral between health care and social service agencies in Greater Houston by leveraging and connecting the existing care coordination technology infrastructure. Ten health care and social service organizations in Greater Houston participated in the demonstration project initiated in January 2023. The authors leveraged and linked regional health information exchange (HIE) technology with a master patient index of >18 million, and sector-specific care coordination platforms to build closed-loop referral capacity between HIE-participating health care organizations and social service organizations to meet patient SDOH needs. Evaluation efforts will assess the reach, adoption, implementation, and the effectiveness of the closed-loop framework in improving social and health outcomes. The framework comprised the following 4 components: (1) establishment of collaborative governance for shared decision-making processes, fostering trust, alignment, and transparency among organizations; (2) development of technology linkages between existing platforms to facilitate seamless referrals between organizations and ensure visibility of referral outcomes; (3) integration of regional resource directories into technology infrastructure to ensure resource accessibility/quality; and (4) evaluation of the system's impact on health equity, efficiency, and cost reduction. This project aimed to close the loop for care coordination between health care and social service agencies, enable data evaluation to determine care coordination effectiveness, and lay the foundation for SDOH-related research/practice equitably.

全国的医疗系统都已强制要求对健康的社会决定因素(SDOH)进行筛查。然而,在医疗保健与社会服务之间的闭环转介护理协调方面还存在差距。本文介绍了一个基于技术的项目框架,通过利用和连接现有的护理协调技术基础设施,促进大休斯顿地区医疗保健和社会服务机构之间的闭环转介。大休斯顿地区的十家医疗和社会服务机构参与了 2023 年 1 月启动的示范项目。作者利用并连接了拥有超过 1800 万患者主索引的区域医疗信息交换 (HIE) 技术和特定部门的护理协调平台,在参与 HIE 的医疗机构和社会服务机构之间建立闭环转诊能力,以满足患者的 SDOH 需求。评估工作将对闭环框架的覆盖范围、采用、实施以及在改善社会和健康成果方面的有效性进行评估。该框架由以下 4 个部分组成:(1)建立共同决策过程的合作治理,促进组织间的信任、协调和透明;(2)开发现有平台间的技术链接,促进组织间的无缝转诊,确保转诊结果的可见性;(3)将区域资源目录整合到技术基础设施中,确保资源的可获得性/质量;以及(4)评估系统对健康公平、效率和成本降低的影响。该项目旨在为医疗保健和社会服务机构之间的护理协调提供闭环,使数据评估能够确定护理协调的有效性,并为与 SDOH 相关的研究/公平实践奠定基础。
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引用次数: 0
Measuring Stakeholder Engagement in Statewide Primary Care Cardiovascular Health Improvement Cooperatives. 衡量利益相关者在全州初级保健心血管健康改善合作组织中的参与度。
IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-26 DOI: 10.1089/pop.2024.0175
Kimberly A Smith, Adam T Perzynski, Cori C Grant, Demetria Hubbard, Larry R Hearld, James E Bailey, Satya Surbhi, Umar Kabir, Andrea L Cherrington

Cardiovascular disease (CVD) remains a major national health challenge with significant disparities linked to socioeconomic status, race, ethnicity, sex, and geography, prompting federal efforts to build statewide primary care quality improvement (QI) cooperatives to improve heart health. To be effective, cooperatives require high levels of member engagement and leaders need ways to assess engagement. The objective of this study was to develop and validate a novel Cooperative Member Survey to assess cooperative member engagement and assess the value of the cooperative to members across three statewide heart health QI cooperatives. The 14-item survey included fixed-response and open-ended questions and was developed through multiple iterative rounds across the three cooperatives to gain consensus on the wording of final items using a Delphi process. The survey then was administered to the key stakeholders in the three cooperatives. Findings from both the quantitative and qualitative items were analyzed and reported based on frequencies and emerging themes. The survey was then analyzed to determine factor structure and validity. Analysis revealed a two-factor structure which the research team identified as: (1) Cooperative Engagement, consisting of 11 items that measured how well the cooperative functioned overall, and (2) Cooperative Value, consisting of two items that assessed the perceived value of mutual learning and respect within the cooperative. This two-factor structure indicated that the Cooperative Member Survey successfully captured both the practical aspects of how the cooperative operates and the members' perceived benefits of their involvement. Successful QI cooperatives not only require efficient operations but also a sense of shared value among members. These findings suggest that cooperatives designed to improve public health outcomes may benefit from focusing not only on practical aspects of engagement but also on cultivating mutual respect and collective learning.

心血管疾病(CVD)仍然是全国健康面临的一大挑战,与社会经济地位、种族、民族、性别和地理位置等因素相关的显著差异,促使联邦政府努力在全州范围内建立初级医疗质量改进(QI)合作社,以改善心脏健康状况。合作社要想取得成效,需要成员的高度参与,而领导者则需要评估参与度的方法。本研究的目的是开发并验证一种新颖的合作社成员调查,以评估合作社成员的参与度,并评估三个全州范围内心脏健康 QI 合作社的合作社对成员的价值。该调查问卷共有 14 个项目,包括固定回答式问题和开放式问题,在三个合作社中经过多轮迭代开发,以通过德尔菲流程就最终项目的措辞达成共识。然后,对三个合作社的主要利益相关者进行了调查。根据频率和新出现的主题,对定量和定性项目的结果进行了分析和报告。然后对调查进行分析,以确定因子结构和有效性。分析表明,研究小组确定了双因素结构,即(1) 合作参与,由 11 个项目组成,衡量合作社的整体运作情况;(2) 合作价值,由两个项目组成,评估合作社内部相互学习和尊重的感知价值。这种双因素结构表明,合作社成员调查成功地捕捉到了合作社运作方式的实际方面以及成员对参与合作社所带来的益处的感知。成功的质量创新合作社不仅需要高效的运营,还需要成员之间的价值共享意识。这些研究结果表明,旨在改善公共卫生成果的合作社不仅要注重参与的实际方面,还要注重培养相互尊重和集体学习,这样才能从中受益。
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引用次数: 0
Scoping Review of Indices to Measure a Community's Health Status. 衡量社区健康状况指标的范围审查。
IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-19 DOI: 10.1089/pop.2024.0138
Susan T Pastula, Lauren C Bylsma, Saumitra V Rege, R Jeffrey Lewis, Naimisha Movva

Composite health indicators are valuable tools to assess population health over time and identify areas for intervention. This scoping review (ScR) aimed to map the literature describing comprehensive health-related metrics used to assess community health. The Arksey and O'Malley framework was used to conduct the ScR, using the following steps: identifying the research question, identifying relevant studies, charting the data, collating and reporting results. United States-based studies that developed/utilized a composite health index using geographic information system (GIS) mapping capabilities to assess community health at the county level or more granular were identified through literature searches conducted in PubMed and EMBASE databases. Literature searches identified 5112 articles; of these, 8 studies describing composite health indices were included. The number of indicators used in each index ranged from 4 to 75 (median: 22). Health outcomes, health behaviors, education, and economics were incorporated into most indices. High school graduation rate (n = 6 indices), health insurance status (n = 5), commute time, median household income, unemployment, and obesity rates (n = 4 each) were the most common indicators across indices. All indicators were derived from publicly available data sources, such as the American Community Survey and US Census Bureau. Although a limited number of community health indices were identified in the ScR, the indices included a broad range of indicators covering both health outcomes and factors contributing to health vulnerabilities. The public data sources and GIS integration of the indices provide potential for broad, insightful applications to various contexts across the United States.

综合健康指标是评估不同时期人口健康状况和确定干预领域的重要工具。本次范围界定综述(ScR)旨在绘制描述用于评估社区健康的综合健康相关指标的文献。范围界定研究采用 Arksey 和 O'Malley 框架,具体步骤如下:确定研究问题、确定相关研究、绘制数据图表、整理并报告结果。通过在 PubMed 和 EMBASE 数据库中进行文献检索,确定了利用地理信息系统 (GIS) 制图功能制定/使用综合健康指数来评估县级或更细粒度的社区健康状况的美国研究。文献检索确定了 5112 篇文章;其中包括 8 项描述综合健康指数的研究。每个指数中使用的指标数量从 4 个到 75 个不等(中位数:22 个)。大多数指数都包含了健康结果、健康行为、教育和经济因素。高中毕业率(6 个指数)、医疗保险状况(5 个指数)、通勤时间、家庭收入中位数、失业率和肥胖率(各 4 个指数)是各指数中最常见的指标。所有指标均来自美国社区调查和美国人口普查局等公开数据源。尽管在 ScR 中确定的社区健康指数数量有限,但这些指数包含了广泛的指标,既有健康结果,也有导致健康脆弱性的因素。这些指数的公共数据来源和地理信息系统(GIS)集成为在全美各种情况下广泛而深入的应用提供了可能。
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引用次数: 0
Community-Based Mental Health Improvement Initiatives: A Narrative Review and Indiana Case Study. 基于社区的心理健康改善计划:叙述性回顾和印第安纳州案例研究》。
IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-07 DOI: 10.1089/pop.2024.0153
William M Tierney, Cassidy McNamee, Sydney S Harris, Stephen M Strakowski

There is a global mental health crisis: mental illness is underrecognized, underdiagnosed, and undertreated with adverse effects on mental, physical, and social health. In the United States, there is an insufficient number of traditional psychiatric and psychological resources to provide the mental health care needed to solve this crisis. Community-based interventions could be an important adjunct to traditional mental health care. An evaluation of peer-reviewed articles was performed describing community-based interventions and identified 3 approaches with some evidence of effectiveness: (1) interventions that enhance community mental health literacy to improve recognition of early signs of mental illness for early engagement and provide community, family, and peer support; (2) community clinics providing social, medical, and mental health care and support to transition-age youth (15-25 years); and (3) social networking activities to enhance interactions among elders suffering from social isolation and loneliness. Multisector, multidisciplinary, and multicomponent interventions involving health care providers and community-based organizations had the best evidence of effectiveness and should target transition-age youth and elders.

目前存在着全球性的心理健康危机:人们对心理疾病的认识不足、诊断不足、治疗不 足,从而对心理、生理和社会健康造成了不良影响。在美国,传统的精神病学和心理学资源不足,无法提供解决这一危机所需的心理保健服务。基于社区的干预措施可以成为传统心理保健的重要辅助手段。我们对同行评议文章中描述的社区干预措施进行了评估,发现有三种方法具有一定的有效性:(1) 加强社区心理健康知识普及的干预措施,以提高对精神疾病早期征兆的识别能力,从而及早参与,并提供社区、家庭和同伴支持;(2) 社区诊所为过渡年龄青年(15-25 岁)提供社会、医疗和心理健康护理和支持;(3) 开展社交网络活动,以加强遭受社会隔离和孤独的老年人之间的互动。涉及医疗服务提供者和社区组织的多部门、多学科和多成分干预措施具有最佳的有效性证据,并应以过渡年龄青年和老年人为目标。
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引用次数: 0
Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for Population Health Management. 罗莎琳德-富兰克林学会自豪地宣布 2023 年人口健康管理奖得主。
IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-01 DOI: 10.1089/pop.2024.12337.rfs2023
Marik Moen
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引用次数: 0
Profiling Social Needs Activities in Publicly Traded Medicare Advantage Organizations. 剖析公开交易的医疗保险优势组织的社会需求活动。
IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-08-27 DOI: 10.1089/pop.2024.0045
Khyathi Gadag, Fred Ullrich, Keith J Mueller

The objective was to examine Medical Advantage (MA) organizations' commitment toward addressing social determinants of health (SDOH) through their health-related social benefit offerings, and the perceived impact of providing supplemental benefits associated with SDOH in their plans. Public reporting documents were reviewed from six of the largest MA firms: Humana, UnitedHealthcare, Cigna, Elevance Health, CVS Health, and Centene. Public reports were obtained from each company's website (eg, from the "Investor Relations" page). Quarterly reports for Q1 2023, annual reports for 2022, and proxy statements for 2023 for all companies were examined. Content analysis of the public reports was conducted under three constructs: (1) Growth of MA in the company, (2) SDOH-related activities in the company, and (3) SDOH-related activities in the MA plans of the company. Each of the three constructs was further analyzed for recurring themes and elements. The findings from content analysis suggests that plans are providing tailored benefits that may address the social needs of vulnerable and underserved populations. Companies that offered supplemental benefits and value-based arrangements that addressed social needs reported beneficiary clinical outcomes resulting in cost savings and increased revenue. Health insurance companies identify MA as a significant growth opportunity and a strategically important market for overall membership and revenue growth. Moreover, companies providing innovative social benefits through their MA plans reported witnessing increased value propositions by underserved and vulnerable populations, leading to increased revenue and cost containment.

目的是研究医疗优势(MA)组织通过提供与健康相关的社会福利来解决健康的社会决定因素(SDOH)的承诺,以及在其计划中提供与 SDOH 相关的补充福利的预期影响。我们审查了六家最大的医疗保险公司的公开报告文件:Humana、UnitedHealthcare、Cigna、Elevance Health、CVS Health 和 Centene。公开报告来自各公司的网站(如 "投资者关系 "页面)。对所有公司 2023 年第一季度的季度报告、2022 年的年度报告和 2023 年的代理声明进行了检查。公开报告的内容分析在三个结构下进行:(1)公司中医疗保险的增长,(2)公司中与 SDOH 相关的活动,(3)公司医疗保险计划中与 SDOH 相关的活动。对这三个结构中的每一个结构都进一步分析了重复出现的主题和要素。内容分析结果表明,医疗保险计划正在提供量身定制的福利,以满足弱势和服务不足人群的社会需求。提供满足社会需求的补充福利和基于价值的安排的公司报告了受益人的临床结果,从而节省了成本并增加了收入。医疗保险公司认为,医疗保险是一个重要的增长机会,也是一个对整体会员和收入增长具有重要战略意义的市场。此外,通过医疗保险计划提供创新性社会福利的公司报告称,服务不足和弱势群体的价值主张得到了提高,从而增加了收入并控制了成本。
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引用次数: 0
Association of Timely Outpatient Follow-Up and Readmission Risk in a Mobile Integrated Health Program. 移动综合医疗项目中门诊病人及时随访与再入院风险的关系。
IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-08-01 Epub Date: 2024-04-29 DOI: 10.1089/pop.2024.0020
Nicholas Brady, Yuanyuan Liang, Kristin L Seidl, David Marcozzi, Benoit Stryckman, Daniel B Gingold

The objective was to identify medical conditions associated with 30-day readmission, determine patient characteristics for which outpatient follow-up is most associated with reduced readmission, and evaluate how readmission risk changes with time to outpatient follow-up within a mobile integrated health-community paramedicine (MIH-CP) program. This retrospective observational study used data from 1,118 adult patient enrollments in a MIH-CP program operating in Baltimore, Maryland, from May 14, 2018, to December 21, 2021. Bivariate analysis identified chronic disease exacerbations associated with higher 30-day readmission risk. Kaplan-Meier curves and Cox proportional hazard regressions were used to measure how hazard of readmission changes with outpatient follow-up and how that association may vary with other factors. Receiver operating characteristic analysis was used to evaluate how well time to follow-up could predict 30-day readmission. Timely outpatient follow-up was associated with a significant reduction in hazard of readmission for patients aged 50 and younger and for patients with fewer than 5 social determinants of health needs identified. No significant association between readmission and specific chronic disease exacerbations was observed. An optimal follow-up time frame to reduce readmissions could not be identified. Timely outpatient follow-up may be effective for reducing readmissions in younger patients and patients who are less socially complex. Programs and policies aiming to reduce 30-day readmissions may have more success by expanding efforts to include these patients.

目的是确定与 30 天再入院相关的医疗条件,确定门诊随访与减少再入院最相关的患者特征,并评估在移动综合医疗-社区辅助医疗(MIH-CP)项目中,再入院风险如何随门诊随访时间的变化而变化。这项回顾性观察研究使用了 2018 年 5 月 14 日至 2021 年 12 月 21 日在马里兰州巴尔的摩市开展的一项 MIH-CP 计划的 1118 名成年患者注册数据。双变量分析确定了与较高的 30 天再入院风险相关的慢性疾病加重。Kaplan-Meier 曲线和 Cox 比例危险度回归用于测量再入院风险随门诊随访的变化情况,以及这种关联可能随其他因素的变化而变化。接受者操作特征分析用于评估随访时间对 30 天再入院的预测能力。对于年龄在 50 岁及以下的患者和确定了少于 5 项健康社会决定因素需求的患者来说,及时的门诊随访与再入院风险的显著降低有关。未观察到再入院与特定慢性疾病加重之间存在明显关联。无法确定减少再入院的最佳随访时间。及时的门诊随访可能会有效减少年轻患者和社会复杂性较低的患者的再入院率。旨在减少 30 天再入院率的计划和政策若能将这些患者纳入其中,可能会取得更大的成功。
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引用次数: 0
Long-Term HIV Pre-Exposure Prophylaxis Persistence and Reinitiation in Connecticut from 2012 to 2018. 2012 年至 2018 年康涅狄格州艾滋病毒暴露前预防的长期持续性和重新启动。
IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-08-01 Epub Date: 2024-07-09 DOI: 10.1089/pop.2024.0012
Jun Tao, Mofan Gu, Omar Galarraga, Jhanavi Kapadia, Harrison Martin, Hannah Parent, Philip A Chan

HIV pre-exposure prophylaxis (PrEP) is a highly effective biomedical prevention for HIV infections. PrEP persistence is critical to achieving optimal protection against HIV infection. However, little is known about PrEP persistence in the United States. This study utilized the Connecticut All-Payer Claims Database (APCD) to identify PrEP persistence among patients who filled their PrEP prescriptions in the state. The authors identified 1,576 PrEP patients who picked up PrEP prescriptions and extracted medical and pharmacy claims to evaluate a longitudinal cohort during 2012-2018 based on the Connecticut APCD. Patients who did not pick up medication for one consecutive month (ie, 30 days) were defined as discontinuing PrEP. Kaplan-Meier Survival Curve and proportional hazard regression were used to describe PrEP persistence. Of the 1,576 patients who picked up PrEP prescriptions, the median age was 32.0 (interquartile range [IQR]: 22.0-44.0). The majority were male individuals (93%). Of 1,040 patients who discontinued PrEP, 702 (67.5%) restarted PrEP at least once. The median time of PrEP persistence was 3 months (IQR: 1-6 months) for initial PrEP use. The median time on PrEP was also around 3 months in the following episodes of PrEP use. Being female, being on parent's insurance, and having high co-pays were associated with shorter periods of PrEP persistence. PrEP persistence was low among patients who picked up PrEP prescriptions. Although many patients restarted PrEP, persistence remained low during follow-up PrEP use and possibly led to periods of increased HIV risk. Effective interventions are needed to improve PrEP persistence and reduce HIV incidence.

艾滋病毒暴露前预防疗法(PrEP)是一种高效的预防艾滋病毒感染的生物医学疗法。PrEP 的持续性对于实现预防 HIV 感染的最佳效果至关重要。然而,人们对美国 PrEP 的持续性知之甚少。本研究利用康涅狄格州所有付费者索赔数据库(APCD),在该州开具 PrEP 处方的患者中识别 PrEP 的持续性。作者根据康涅狄格州 APCD 确定了 1576 名开具 PrEP 处方的 PrEP 患者,并提取了医疗和药房报销单,对 2012-2018 年期间的纵向队列进行了评估。连续一个月(即 30 天)未领取药物的患者被定义为停止 PrEP。Kaplan-Meier 生存曲线和比例危险回归用于描述 PrEP 的持续性。在 1576 名领取 PrEP 处方的患者中,年龄中位数为 32.0(四分位数间距 [IQR]:22.0-44.0)。大多数患者为男性(93%)。在 1040 名中断 PrEP 的患者中,有 702 人(67.5%)至少重新开始过一次 PrEP。在首次使用 PrEP 的患者中,坚持 PrEP 的中位时间为 3 个月(IQR:1-6 个月)。在随后的 PrEP 使用中,坚持 PrEP 的时间中位数也在 3 个月左右。女性、使用父母的保险以及高额自费与较短的 PrEP 持续时间有关。在领取 PrEP 处方的患者中,PrEP 的持续时间较短。尽管许多患者重新开始了 PrEP,但在后续的 PrEP 使用过程中,坚持率仍然很低,这可能会导致 HIV 风险增加。需要采取有效的干预措施来提高 PrEP 的持续性并降低艾滋病毒的发病率。
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Population Health Management
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