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An Investigation into Audio Features and DTW Algorithms for Infant Cry Classification 婴儿哭声分类的音频特征和DTW算法研究
Xilin Yu, Laishuan Wang, Xian Zhao, Chunmei Lu, X. Long, Wei Chen
Cry is the most common phenomenon among infants, and it has been reported that babies cry for multiple reasons. Infant cry signals are thought to convey much useful information about the physiological and pathological state of the baby. Hence, in this work we analyzed these audio signals in order to classify different reasons of cries. Cry signals were especially collected for this study including three causes, namely hunger, pain and uncertainty. Modified MFCC features besides basic acoustic features were extracted from each recording. After intergroup variance examination, nine features were selected and subjected to a novel matching process based on Dynamic Time Warping (DTW) for separating infant cries. Experiment results show that nine selected features are effective to recognize cries caused by hunger, pain and other uncertain reasons. The proposed approach for infant cry analysis will provide useful information for designing towards an automatic system for detecting physiological and pathological state of the baby
哭泣是婴儿中最常见的现象,据报道,婴儿哭泣有多种原因。婴儿的哭声信号被认为传达了关于婴儿生理和病理状态的许多有用信息。因此,在这项工作中,我们分析了这些音频信号,以分类不同的哭泣原因。该研究特别收集了哭泣信号,包括三个原因,即饥饿,疼痛和不确定。从每段录音中提取除基本声学特征外的修正MFCC特征。通过组间方差检验,选取9个特征进行基于动态时间翘曲(DTW)的匹配处理,对婴儿哭声进行分类。实验结果表明,所选择的9个特征可以有效识别由饥饿、疼痛和其他不确定原因引起的哭声。提出的婴儿哭声分析方法将为设计婴儿生理和病理状态自动检测系统提供有用的信息
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引用次数: 2
Study on Physical Strength Reserves of Diver after Underwater Delivery 水下交付后潜水员体力储备的研究
Fan Wei, Fu Xue Zhi, Liu Ping, Z. Yu
Objective: This paper aims on the physical strength reserves of diver after long time underwater delivery, to find the reasonable underwater working time which can maintain diver's work ability. Method: Select 16 divers for underwater deliver experiment for different length of time, and carry out PWC170 measurement analysis. Result: After 2.5 hours underwater delivery, the diver still has a certain level of physical strength reserves. But after 3 hours underwater delivery, the physical strength reserves close to zero. Conclusion: Through the experiment, we conclude that the reasonable underwater delivery time is 2.5 hours, which can maintain diver's work ability.
目的:针对长时间水下交付后潜水员的体力储备,寻找能保持潜水员工作能力的合理水下作业时间。方法:选择16名潜水员进行不同时间的水下交付实验,并进行PWC170测量分析。结果:经过2.5小时的水下分娩,潜水员仍有一定的体力储备。但经过3小时的水下交付,体力储备接近于零。结论:通过实验,我们得出合理的水下交付时间为2.5小时,可以保持潜水员的工作能力。
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引用次数: 0
Encoding of Stimulus-driven and Intention-driven Actions in Monkey's Primary Motor Cortex 猴子初级运动皮层刺激驱动和意图驱动行为的编码
Keyi Liu, Wenjuan Hu, Yao Chen
Actions can be divided into two modes, one is driven by intention without stimulus, another is in response to external stimulus. Previous studies have shown that these two modes of movement may be manipulated by different physiological pathways in the brain. However, the neural coding of them in motor cortex is still unknown. In this study, we trained rhesus monkeys performing external stimulus-driven and internal intention-driven arm movement tasks, and recorded neuronal activity in primary motor cortex (M1). We aimed to compare the neuronal coding between stimulus-based and intention-based action modes. We found that neurons fired in different patterns while doing internal intention-driven arm movement. These neurons show no significant difference between intention-based and stimulus-based tasks during movement execution period. We also set up a general linear model to quantify the encoding strength of M1 neurons towards movement parameters in different action modes.
行为可以分为两种模式,一种是在没有刺激的情况下由意图驱动的行为,另一种是对外界刺激的反应。先前的研究表明,这两种运动模式可能是由大脑中不同的生理途径控制的。然而,它们在运动皮层中的神经编码尚不清楚。在这项研究中,我们训练恒河猴进行外部刺激驱动和内部意图驱动的手臂运动任务,并记录初级运动皮层(M1)的神经元活动。我们的目的是比较基于刺激和基于意图的行为模式之间的神经元编码。我们发现,在进行内部意图驱动的手臂运动时,神经元以不同的模式放电。在运动执行阶段,这些神经元在意图型任务和刺激型任务之间没有显著差异。我们还建立了一般线性模型来量化M1神经元在不同动作模式下对运动参数的编码强度。
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引用次数: 0
Reference-free Correction for the Nyquist Ghost in Echo-planar Imaging using Deep Learning 利用深度学习对回波平面成像中奈奎斯特幽灵进行无参考校正
Xudong Chen, Yufei Zhang, H. She, Yiping P. Du
Echo-planar imaging suffers from Nyquist ghost (i.e., N/2 ghost) because of the imperfection of the gradient system and gradient delays. The phase mismatch between even and odd echoes can be eliminated by an extra reference scan without the phase encoding. However, due to the non-linear and time-varying local magnetic field changes or movement of the patients, the reference-based methods may have incorrect correction results. Other correction methods like parallel imaging reconstruction may suffer from the image noise amplification and signal-to-noise ratio penalty. In this study, a deep learning method is proposed to eliminate the phase error in k-space and correct the mismatch between even and odd echoes without reference scan and SNR penalty. The Fourier transform layer is introduced into the conventional U-Net structure, and the distortion-free images are directly reconstructed from the k-space EPI data. Turbo spin echo data and single-shot EPI data are tested using this network. The results show that this method has a good performance in ghost correction, and the ghost-to-signal ratio is effectively reduced compared to other state-of-the-art correction methods. The proposed deep learning method is reference-free and effective to correct Nyquist ghost in EPI, and can also combine with parallel imaging to achieve additional acceleration.
由于梯度系统的不完善和梯度延迟,回波平面成像存在奈奎斯特鬼影(即N/2鬼影)。在不进行相位编码的情况下,通过额外的参考扫描可以消除奇偶回波之间的相位不匹配。然而,由于局部磁场的非线性和时变变化或患者的运动,基于参考的方法可能会产生不正确的校正结果。其他校正方法如并行成像重建可能会受到图像噪声放大和信噪比损失的影响。本研究提出了一种深度学习方法,在不需要参考扫描和信噪比损失的情况下消除k空间的相位误差,纠正奇偶回波不匹配。在传统的U-Net结构中引入傅里叶变换层,直接从k空间EPI数据重构无畸变图像。利用该网络测试了Turbo自旋回波数据和单次EPI数据。结果表明,该方法具有良好的鬼信号校正性能,与其他先进的校正方法相比,能有效降低鬼信号比。所提出的深度学习方法不需要参考,可以有效地校正EPI中的Nyquist鬼影,并且可以结合并行成像实现额外的加速。
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引用次数: 1
Control Algorithm for an Active Ankle-Foot Orthosis (AAFOs): Adaptative Admittance Control 主动踝足矫形器的控制算法:自适应导纳控制
Joseph Tsongo Vughuma, O. Verlinden
Most of current prostheses and orthoses use physical springs and dampers with various control strategies to replicate the compliant behavior of a normal ankle during the gait. The springs, dampers and the control strategies are usually tuned for a single patient and for a fixed gait speed which does not allow adaptation to another patient or another gait speed. In this work, we propose a control strategy that overcomes those adaptation problems. The algorithm is based on an admittance control and replicates the ankle torque-angle curve to assist level-ground gait. The particularity of this control comes from the fact that the physical spring is replaced by a mechatronic spring. It uses principally force and position sensors in order to replicate the behavior of a physical spring. Thanks to the use of a mechatronic spring, the orthosis and the control strategy can easily be adapted to any individual and can adapt themselves to any gait speed.
目前大多数假肢和矫形器使用物理弹簧和阻尼器,并采用各种控制策略来复制正常踝关节在步态中的顺应行为。弹簧,阻尼器和控制策略通常是针对单个患者和固定的步态速度进行调整的,不允许适应另一个患者或另一个步态速度。在这项工作中,我们提出了一种克服这些适应问题的控制策略。该算法基于导纳控制,通过复制踝关节转角曲线来辅助平地步态。这种控制的特殊性来自于物理弹簧被机电弹簧取代的事实。它主要使用力和位置传感器来复制物理弹簧的行为。由于使用了机电弹簧,矫形器和控制策略可以很容易地适应任何个体,并且可以适应任何步态速度。
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引用次数: 1
McBel-Plnc: A Deep Learning Model for Multiclass Multilabel Classification of Protein-lncRNA Interactions McBel-Plnc:蛋白质- lncrna相互作用多类多标签分类的深度学习模型
Natsuda Navamajiti, Thammakorn Saethang, D. Wichadakul
One main function of long non-coding RNAs (lncRNAs) is to act as a scaffold facilitating multiple proteins to form complexes. Most of available prediction models for protein-RNA interactions, however, were proposed as a binary classifier, which limited on predicting the interaction between the non-coding RNAs and each individual RNA-binding protein (RBP). Hence, to predict if a lncRNA is acting as a scaffold, we consider this problem as a multiclass multilabel classification problem. To solve this problem, the high confident CLIP-seq data were selected from the POSTAR2 database with an augmentation of the data for the RBP classes with a small number of interacting lncRNAs. We then constructed a deep learning model for multiclass multilabel classification, called McBel-Plnc, based on the convolutional neural network (CNN) and long-short term memory (LSTM) using each of the five datasets randomly generated from the prepared data. Based on macro average, the test results showed the high precision of 0.9151 ± 0.0038 averaged from the five models with the lower recall of 0.5786 ± 0.0208. The small standard deviations confirmed the model stability. Comparing with iDeepE with a binary relevance method, iDeepE got the higher recall with the significantly lower precision (0.6912 and 0.1987, respectively). This result suggested that our model is competent to predict the protein-lncRNA interactions, especially with the lncRNAs targeted by multiple proteins. This suggested the potential to infer the insights of lncRNA functions and molecular mechanisms.
长链非编码rna (lncRNAs)的一个主要功能是作为一个支架,促进多种蛋白质形成复合物。然而,大多数现有的蛋白质- rna相互作用预测模型都是作为二分类器提出的,其局限于预测非编码rna与每个rna结合蛋白(RBP)之间的相互作用。因此,为了预测lncRNA是否起到支架的作用,我们将这个问题视为一个多类别多标签分类问题。为了解决这个问题,我们从POSTAR2数据库中选择了高可信度的CLIP-seq数据,并增加了具有少量相互作用lncrna的RBP类的数据。然后,我们基于卷积神经网络(CNN)和长短期记忆(LSTM),使用从准备数据随机生成的五个数据集中的每一个,构建了一个用于多类多标签分类的深度学习模型,称为McBel-Plnc。在宏观平均的基础上,5个模型的平均精度为0.9151±0.0038,召回率为0.5786±0.0208。小的标准差证实了模型的稳定性。与二值相关方法的iDeepE相比,iDeepE的查全率更高,查准率显著低于前者(分别为0.6912和0.1987)。这一结果表明,我们的模型能够预测蛋白质与lncrna的相互作用,特别是与多种蛋白质靶向的lncrna的相互作用。这表明有可能推断lncRNA的功能和分子机制。
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引用次数: 4
In Vitro Safety Assessment and Permeation Study of Topical Lidocaine Solution for Ocular Administration 利多卡因眼用外用溶液体外安全性评价及渗透研究
Sirikool Thamnium, V. Panapisal, J. Luckanagul
In this research, topical lidocaine solution for ocular administration was assessed for biocompatibility as a non-invasive anesthetic drug delivery. The study aimed to investigate the cytotoxicity against human corneal epithelial cells (HCECs) and to evaluate drug permeation. In the case of cytotoxicity, HCECs were treated with drug solution, analyzed for percent viability. For permeation study, the modified-franz diffusion method was used to study permeation partition coefficient of lidocaine solution; moreover, the drug retained on the sclera was also determined. HCECs were treated with lidocaine solutions with the concentration range of 0.781 -100 g/L. Significantly decrease in cell viability with the concentration above 12 g/L was detected by Resazurin metabolic rate assay. The permeation coefficient of lidocaine hydrochloride solution could not be determined because of drug absence in the receptor chamber. The entire drug loaded remained in the donor chamber and adsorbed on the surface of sclera tissue. The results suggested that topical lidocaine solution showed reasonably safe and lidocaine drops did not absorbed through the sclera. In present study, local topical anesthetic delivery of lidocaine was considered safe for ophthalmologic treatment.
在本研究中,我们评估了局部利多卡因溶液作为一种非侵入性麻醉药物给药的生物相容性。本研究旨在探讨药物对人角膜上皮细胞(HCECs)的细胞毒性,并评价药物的透性。在细胞毒性的情况下,用药物溶液处理HCECs,分析存活率。在渗透研究方面,采用改进的franz扩散法研究利多卡因溶液的渗透分配系数;此外,还测定了巩膜上残留的药物。采用浓度范围为0.781 ~ 100 g/L的利多卡因溶液处理HCECs。reazurin代谢率试验表明,浓度超过12 g/L时,细胞活力显著降低。由于受体腔内药物缺失,无法测定盐酸利多卡因溶液的渗透系数。全部载药留在供体腔内,并吸附在巩膜组织表面。结果表明,外用利多卡因溶液安全性较好,利多卡因滴剂不经巩膜吸收。本研究认为局部局部麻醉给药利多卡因用于眼科治疗是安全的。
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引用次数: 0
Improved Pathogen Recognition using Non-Euclidean Distance Metrics andWeighted kNN 利用非欧几里得距离度量和加权kNN改进病原体识别
M. Tharmakulasingam, Cihan Topal, Warnakulasuriya Anil Chandana Fernando, R. M. Ragione
The timely identification of pathogens is vital in order to effectively control diseases and avoid antimicrobial resistance. Non-invasive point-of-care diagnostic tools are recently trending in identification of the pathogens and becoming a helpful tool especially for rural areas. Machine learning approaches have been widely applied on biological markers for predicting diseases and pathogens. However, there are few studies in the literature that have utilized volatile organic compounds (VOCs) as non-invasive biological markers to identify bacterial pathogens. Furthermore, there is no comprehensive study investigating the effect of different distance and similarity metrics for pathogen classification based on VOC data. In this study, we compared various non-Euclidean distance and similarity metrics with Euclidean metric to identify significantly contributing VOCs to predict pathogens. In addition, we also utilized backward feature elimination (BFE) method to accurately select the best set of features. The dataset we utilized for experiments was composed from the publications published between 1977 and 2016, and consisted of associations in between 703 VOCs and 11 pathogens.We performed extensive set of experiments with five different distance metrics in both uniform and weighted manner. Comprehensive experiments showed that it is possible to correctly predict pathogens by using 68 VOCs among 703 with 78.6% accuracy using k-nearest neighbour classifier and Sorensen distance metric.
为了有效控制疾病和避免抗生素耐药性,及时鉴定病原体至关重要。非侵入性即时诊断工具最近在鉴定病原体方面有趋势,并成为一种有用的工具,特别是在农村地区。机器学习方法已广泛应用于生物标记物,用于预测疾病和病原体。然而,利用挥发性有机化合物(VOCs)作为非侵入性生物标志物来鉴定细菌性病原体的研究文献很少。此外,目前还没有全面研究不同距离和相似度指标对基于VOC数据的病原体分类的影响。在这项研究中,我们将各种非欧几里得距离和相似性度量与欧几里得度量进行了比较,以确定对预测病原体有重要贡献的voc。此外,我们还利用反向特征消除(BFE)方法来准确地选择最佳特征集。我们用于实验的数据集由1977年至2016年发表的出版物组成,包括703种挥发性有机化合物与11种病原体之间的关联。我们以均匀和加权的方式对五种不同的距离度量进行了广泛的实验。综合实验表明,采用k近邻分类器和Sorensen距离度量方法,对703种VOCs中的68种VOCs进行准确预测,准确率为78.6%。
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引用次数: 5
Comprehensive Prediction and Interpretation of Viral Protein Subcellular Localization 病毒蛋白亚细胞定位的综合预测和解释
Xiyu Liu
Determining the subcellular localization of viral proteins is indispensable for understanding the activity of the virus and inferring viral protein functions. Although previous studies about predicting viral protein subcellular localization have been developed, they often have the following disadvantages: (i) only focusing on a part of proteins of a species (ii) not considering the presence of multi-location proteins and (iii) lacking interpretability for the results. To address these problems, this paper is firstly predicting all the subcellular localization of the whole viral proteome in the UniProtKB and is interpretable for the results. This paper gives high prediction accuracy for the single-location and multi-location viral proteins by the FUEL-mLoc predictor. More importantly, we did deeply analysis and interpretation of the subcellular localization of all viral proteins. Finally, we have found some essential GO terms which are interpretable for the results and are significant in predicting the subcellular localization of the viral proteins.
确定病毒蛋白的亚细胞定位是了解病毒活性和推断病毒蛋白功能的必要条件。虽然之前关于预测病毒蛋白亚细胞定位的研究已经发展起来,但它们往往存在以下缺点:(i)只关注一个物种的一部分蛋白质(ii)没有考虑多位置蛋白质的存在(iii)缺乏结果的可解释性。为了解决这些问题,本文首先在UniProtKB中预测了整个病毒蛋白质组的所有亚细胞定位,并对结果进行了解释。本文给出了FUEL-mLoc预测器对单位点和多位点病毒蛋白具有较高的预测精度。更重要的是,我们对所有病毒蛋白的亚细胞定位进行了深入的分析和解释。最后,我们发现了一些基本的氧化石墨烯术语,这些术语可以解释结果,并且在预测病毒蛋白的亚细胞定位方面具有重要意义。
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引用次数: 0
Attitudinal Factors for Personal Health 个人健康的态度因素
B. Voon, Joachim Engan Sigau, Joshua E.H. Voon, Grace E. H. Voon
In this paper, the roles of attitudinal factors and fish were investigated to explore their relationships with the health performance of individuals. Specifically, the variables included were: Health Orientation (HO), Diet Orientation (DO), Life Satisfaction (LS), Attitude toward Fish (ATF), Fish Consumption (FC) Demographic variables and Health Performance (HP). A total of 300 respondents participated in the structured questionnaire survey. The data analyses included multi-item scale reliability, Chi-square, means, t-Test, ANOVA and multiple regression analyses. The influences of the various socio-demographic variables on attitudes and personal health were investigated accordingly. The attitudinal factors (i.e., Attitudes towards Health and Eating, Life Satisfaction and Attitudes towards Fish) had shown significant positive relationships with the personal health performance of individuals. The results suggested that the human factor engineering in biomedical sciences is essential. The attitudinal factors are potential determinants for personal health and should be managed effectively and efficiently.
本研究考察了态度因素和鱼的作用,探讨了态度因素和鱼对个体健康绩效的影响。具体变量包括:健康取向(HO)、饮食取向(DO)、生活满意度(LS)、对鱼的态度(ATF)、鱼的消费(FC)、人口统计学变量和健康表现(HP)。共有300名受访者参与了结构化问卷调查。资料分析包括多项目量表信度分析、卡方分析、均数分析、t检验、方差分析和多元回归分析。据此调查了各种社会人口变量对态度和个人健康的影响。态度因素(即对健康和饮食的态度、生活满意度和对鱼的态度)与个人健康表现呈显著正相关。结果表明,人因工程在生物医学科学中是必不可少的。态度因素是个人健康的潜在决定因素,应得到有效和高效的管理。
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引用次数: 0
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Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering
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