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Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering最新文献

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A World Camera for Recording the Game Tactics in Martial Arts using Bamboo Swords 记录竹剑武术比赛战术的世界摄像机
K. Hoshino, Maki Nakamura, Yuya Nakai, Yoshimasa Ozone, Satoshi Shimanoe, Yuki Noguchi
The proposed system was designed for tankendo, kendo, or Japanese fencing using bamboo swords that also use a mask. First, a lightweight, miniaturized world-camera that is 3mm square, or smaller than the width of the vertical bar in the mask, is attached to the center of the vertical bar. This keeps the world-camera out of the field of vision of the competitor and protects the camera from damage. Second, a lengthened signal cable is connected to the control computer and compact power supply attached to the competitor's waist. This minimizes any discomfort a competitor might feel when using the system.
拟议的系统是为剑道设计的,剑道或日本剑术使用竹剑,也使用面具。首先,将一个3毫米见方的轻型微型世界相机(比面罩中竖条的宽度还小)安装在竖条的中心。这样可以使世界相机远离竞争对手的视野,并保护相机免受损坏。其次,将一根加长的信号电缆连接到控制计算机上,并将紧凑型电源连接到参赛者的腰部。这将最大限度地减少选手在使用系统时可能感到的不适。
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引用次数: 4
Synthesis of Lower Limbs Exoskeleton for the Rehabilitation of Patients with Disorders of Motor and Proprioceptive Systems 运动和本体感觉系统障碍患者下肢外骨骼的合成与康复
A. Poliakov, V. Pakhaliuk, M. Kolesova, Nikolay Lozinskiy, P. Bugayov, D. Koshevaya, P. Shtanko
In this work is presented a new design of a rehabilitation exoskeleton intended for the rehabilitation of disabled people and patients with impaired motor functions. A distinctive feature of this design is that the auxiliary legs used in it, in addition to rotational motion drives that simulate the work of the hip joints, are equipped with controlled artificial knee joints, providing biologically natural kinematics of patient during the rehabilitation process. In addition, to solve the problem of motor redundancy in the algorithms of the exoskeleton control system, synergistic quality criteria are used, which also contribute to the realization of biologically natural movements, and, consequently, the quality of rehabilitation effects. The drive control of joints is carried out using commands generated by a hierarchical control system operating based on information from inertial and resistor sensors mounted directly on the exoskeleton elements.
在这项工作中,提出了一种用于残疾人和运动功能受损患者康复的康复外骨骼的新设计。该设计的一个显著特点是辅助腿,除了模拟髋关节工作的旋转运动驱动器外,还配备了可控制的人工膝关节,在康复过程中为患者提供生物学上自然的运动学。此外,为了解决外骨骼控制系统算法中的运动冗余问题,使用了协同质量标准,这也有助于实现生物自然运动,从而提高康复效果的质量。关节的驱动控制是由一个基于直接安装在外骨骼元件上的惯性和电阻传感器信息的分层控制系统生成的命令来执行的。
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引用次数: 1
Growth Characteristics and Lipid Content of Black Soldier Fly (Hermetia illucens) Larva Reared in Milkfish Offal and Mixed Vegetable Wastes 遮目鱼内脏和混合蔬菜废弃物中黑虻幼虫生长特性及脂质含量
K. Pamintuan, Judy Ann B. Cajayon, Gecille B. Dableo
Black soldier fly larva (Hermetia illucens) of BSFL has long been eyed as a potential waste-to-energy bioconversion tool to convert organic waste into biomass (lipids) which would then be converted into biofuel. The effect of different feeds, namely, chick starter mash (control), milkfish offal, and mixed vegetable waste, on the growth characteristics and nutritional profile of black soldier fly larvae were determined in this study. Daily measurements of length, width, and mass of the larvae were done from hatching to the pre-pupal stage. The gathered mass of the larva as a function of time was fitted through a Gompertz growth equation. The growth experiment with these substrates showed that larvae reared in milkfish offal rendered the highest growth rate and largest terminal mass, length, and width. Furthermore, they also showed significantly higher efficiency of conversion of digested feed and survival rate than the other two substrates (control and vegetable waste). The nutritional profile was determined as fractions of crude protein, crude fat, carbohydrate, and ash. The proximate analysis reported the highest protein and carbohydrate content of the larvae reared in milkfish offal at 38.95% and 44.45%, respectively. Meanwhile, larvae raised in vegetable waste obtained the highest fat and ash content at 40.55% and 15.2%, respectively. The results dictated by the proximate analysis implies a potential for the rearing of black soldier fly in vegetable waste substrates as source of lipids for biodiesel feedstock through a low-cost waste-to-energy system.
黑兵蝇幼虫(Hermetia illucens)长期以来一直被视为一种潜在的废物-能源生物转化工具,将有机废物转化为生物质(脂质),然后转化为生物燃料。本试验研究了不同饲料(鸡发酵剂(对照)、遮目鱼内脏和混合蔬菜废弃物)对黑虻幼虫生长特性和营养状况的影响。从孵化到蛹前,每天测量幼虫的长度、宽度和质量。通过Gompertz生长方程拟合了幼虫聚集质量随时间的函数。试验结果表明,以遮目鱼内脏饲养的幼鱼生长速率最高,终端质量、长度和宽度最大。此外,它们的消化饲料转化效率和成活率也显著高于其他两种基质(对照和植物废物)。营养成分由粗蛋白质、粗脂肪、碳水化合物和灰分组成。经近似分析,遮目鱼内脏中蛋白质和碳水化合物含量最高,分别为38.95%和44.45%。而在蔬菜废弃物中饲养的幼虫脂肪和灰分含量最高,分别为40.55%和15.2%。近似分析的结果表明,通过低成本的废物转化能源系统,在植物废物基质中饲养黑兵蝇作为生物柴油原料的脂质来源的潜力。
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引用次数: 7
A Study on the Texture Quality of Vietnamese Catfish (Pangasius Hypophthalmus) Fillets after Different Freezing Processes 越南鲶鱼(Pangasius Hypophthalmus)鱼片不同冷冻工艺后质地品质的研究
T. N. Nguyen, Q. P. Pham, Q. K. Do, C. C. Vo, T. V. Nguyen
In recent years, food safety and quality have become critical issues of great concern throughout the world. Although the food freezing process is a very complex process, the emergence of novel freezing processes and technologies has been able to bring high benefits improving the final quality of food frozen products. This study aims at evaluating the texture quality of Vietnamese catfish fillet products after different freezing processes. Experimental samples were carried out with the fresh Vietnamese catfish. These catfish fillet samples were frozen from 12°C to -18°C by conventional air blast freezing (ABF) and magnetic assisted freezing (MAF). The evaluation method for their textural quality is texture profile analysis (TPA). The mechanical-physical properties of catfish fillet samples, which include the frozen ones from different freezing processes and the fresh unfrozen ones, were investigated and analyzed with shear and compressive tests to identify their hardness, gumminess, stringiness, etc. Results obtained from both shear and compressive tests show that catfish fillet samples frozen by MAF were able to maintain the mechanical-physical properties better than ones frozen by ABF. Therefore, applying the innovative freezing processes such as MAF processes could improve the final textural quality of Vietnamese catfish fillet products.
近年来,食品安全和质量问题在世界范围内引起了广泛关注。虽然食品冷冻过程是一个非常复杂的过程,但新的冷冻工艺和技术的出现已经能够带来很高的效益,提高食品冷冻产品的最终质量。本研究旨在评价越南鲶鱼鱼片经过不同冷冻工艺后的口感品质。以新鲜的越南鲶鱼为实验样本。这些鲶鱼鱼片样品采用传统的风吹冷冻(ABF)和磁辅助冷冻(MAF)在12°C至-18°C之间冷冻。其纹理质量的评价方法是纹理轮廓分析(TPA)。对不同冷冻工艺冷冻后的鲶鱼鱼片和未冷冻后的新鲜鲶鱼鱼片进行了机械物理性能的研究,并通过剪切和压缩试验对其硬度、粘性、粘稠度等进行了表征。剪切和压缩试验结果表明,MAF冷冻的鲶鱼鱼片比ABF冷冻的鲶鱼鱼片能更好地保持鱼片的力学物理性能。因此,采用创新的冷冻工艺,如MAF工艺,可以提高越南鲶鱼鱼片产品的最终质地质量。
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引用次数: 1
Numerical Study on Flow Behavior of Red Blood Cells through Symmetric Capillary Bifurcations 红细胞通过对称毛细血管分岔流动特性的数值研究
M. Hirono, T. Hyakutake
The red blood cell (RBC) partitioning properties at microvascular bifurcation are largely related to heterogeneous oxygen distributions in the microcirculatory networks. Here, three-dimensional, T-type symmetric capillary bifurcation models have been prepared and the flow behavior of RBCs through the capillary bifurcations has been investigated. Simulated blood flow was computed using the lattice Boltzmann method, in conjunction with the immersed boundary method, for incorporating fluid-membrane interactions between the flow field and deformable RBCs. To do this, first the straight vessel flow was simulated to determine the RBC flow at a parent vessel of the bifurcation model. The simulation results indicated two types of RBC arrangements according to the hematocrit: (i) zigzag-slipper and (ii) aligned-parachute shapes. Next, by adopting the RBC arrangements obtained from the straight vessel analysis, RBC partitioning in the capillary bifurcation was investigated. The simulation results were in agreement with the Pries' empirical model at high hematocrit. On the other hand, the bias of RBC flux for the parachute shape was larger than that of the empirical model at low hematocrit. These results suggest that the partitioning properties of RBCs in the microvascular bifurcation depend largely on the RBC arrangement in the parent vessel.
红细胞(RBC)在微血管分叉处的分配特性很大程度上与微循环网络中氧的不均匀分布有关。本文建立了三维t型对称毛细血管分岔模型,并研究了红细胞在毛细血管分岔中的流动行为。为了考虑流场与可变形红细胞之间的流膜相互作用,采用点阵玻尔兹曼法结合浸入边界法计算模拟血流。为了做到这一点,首先模拟了直血管流动,以确定分岔模型的母血管中的红细胞流动。模拟结果表明,根据红细胞比容,红细胞排列有两种类型:(i)之字形拖鞋形和(ii)对齐降落伞形。接下来,采用直血管分析得到的红细胞排列,研究了红细胞在毛细血管分叉中的分配。在高红细胞压积条件下,模拟结果与Pries的经验模型一致。另一方面,低红细胞压积时,降落伞形状对红细胞通量的偏差大于经验模型。这些结果表明,红细胞在微血管分叉中的分配特性在很大程度上取决于红细胞在母血管中的排列。
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引用次数: 0
An Improved Intermittent Electrical Stimulation Therapy for Penicillin-induced Seizure Suppression 一种改进的间歇性电刺激疗法用于青霉素诱导的癫痫抑制
Long-Bin Liu, Jiacheng Zhang, Shuming Ye, Kedi Xu
Neuromodulation is a promising treating therapy for drug-resistant epilepsy. Studies have shown that electrical stimulation could induce post-stimulus inhibition of neural activity, making it available for aborting seizure. Considering the long-term safety, intermittent open loop electrical stimulations are commonly employed in both experimental studies and clinical trials. Commonly applied stimulations were alternation sequences between stimulation ONs and OFFs, during which both stimulation pulse trains and interval periods lasted several minutes. The long periods of stimulations may lead to damage to both tissue and electrode itself. To optimize treatment efficacy, in current study, a new stimulation paradigm was designed. To reduce charge accumulation, two pairs of cross-located electrodes were implanted for interleaved stimulation delivering. Besides, brief pulse trains with short intervals were applied instead of relatively long stimulation cycle. Key stimulation parameters were tested for efficacy comparison. And long-term seizure suppression effects were monitored and estimated by LFP signals. The results showed that in acute Penicillin-induced seizure model, the new stimulation therapy could significantly reduce seizure durations by 80.3%. The counts of seizure were also found to be reduced by 80.7%. These results demonstrated that with shortened stimulation sequences, seizures could still be suppressed efficiently, providing a new possible stimulation paradigm for seizure treatment.
神经调节是治疗耐药癫痫的一种很有前途的治疗方法。研究表明,电刺激可以诱导刺激后神经活动的抑制,使其可用于中止癫痫发作。考虑到长期的安全性,间歇开环电刺激在实验研究和临床试验中都是常用的。通常应用的刺激是在刺激on和off之间交替序列,在此过程中刺激脉冲序列和间隔时间都持续几分钟。长时间的刺激可能导致组织和电极本身的损伤。为了优化治疗效果,本研究设计了一种新的刺激模式。为了减少电荷积累,植入了两对交叉位置的电极,以交错传递刺激。此外,采用短间隔脉冲序列代替较长的刺激周期。测试关键刺激参数进行疗效比较。并通过LFP信号监测和评估长期癫痫发作抑制效果。结果表明,在急性青霉素致癫痫模型中,新刺激疗法可使癫痫发作时间明显缩短80.3%。检获毒品的数目亦减少了80.7%。这些结果表明,缩短刺激序列仍然可以有效地抑制癫痫发作,为癫痫发作治疗提供了一种新的可能的刺激范式。
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引用次数: 0
Predicting the Types of Striking and Thrusting Motions by using Deep Learning 利用深度学习预测击打和插入动作的类型
K. Hoshino, Yuki Noguchi, Yuya Nakai, Yoshimasa Ozone, Maki Nakamura
The final goal is to make a "tankendo machine" that is easy to use, safe, fun, and can provide a mechanical competitor for humans. First, deep learning technology was used to install an image processing system that could detect the start (initial motion) of striking and thrusting motions by humans and quickly predict the type of technique used.
最终的目标是制造一个“剑道机器”,它易于使用,安全,有趣,并且可以为人类提供机械竞争对手。首先,使用深度学习技术安装了一个图像处理系统,该系统可以检测人类击打和插入运动的开始(初始运动),并快速预测所使用的技术类型。
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引用次数: 3
Field Map Estimation in MRI using Compressed Sensing Algorithm 基于压缩感知算法的MRI场图估计
K. Yan, H. She
For non-cartesian magnetic resonance imaging, like spiral imaging, field inhomogeneity could cause image blurring, especially for long readout time. General correction method required field map estimation. However, when images are in low spin density, the estimated field map suffers from noise. A regularized method which utilizes the physical feature that field map is spatial smoothing, is proposed to estimate field map with little noise. The field map estimated by regularized method only have good performance while the images in low noise level. Once image suffers from severe noise, an accurate field map is still hard to obtain. In reality, to shorten scan time in spiral imaging, we would decrease the number of interleaves of sampling. As results of that, Signal-to-noise Ratio (SNR) of image gets lower, and effect of B0 inhomogeneity becomes serious problem. In such situation, a better way to calculate field map is required. In this paper, we propose optimized field map estimation method which employs compressed sensing algorithm. Actually, recovery expected signal of compressed sensing (CS) algorithm is noise reduction process, which could be used to estimate field map when images are in low SNR. The experiments show that using Wavelet transform as regularization term could perform better when images are in low Signal-to-Noise Ratio (SNR). To improve calculated field map further, both Total Variation (TV) term and Waveform term as regularization term are adapted. The method in this paper promises great field map estimation.
对于非笛卡儿磁共振成像,如螺旋成像,场的不均匀性可能导致图像模糊,特别是长时间读取。一般校正方法需要实地图估计。然而,当图像处于低自旋密度时,估计的场图受到噪声的影响。提出了一种利用场图空间平滑的物理特性进行场图估计的正则化方法。正则化方法估计的场图只有在低噪声条件下才有较好的性能。一旦图像受到严重的噪声影响,仍然难以获得准确的野外地图。在现实中,为了缩短螺旋成像的扫描时间,我们需要减少采样的交错次数。因此,图像的信噪比降低,B0不均匀性的影响变得严重。在这种情况下,需要一种更好的计算字段映射的方法。本文提出了一种采用压缩感知算法的优化场图估计方法。实际上,压缩感知(CS)算法的恢复期望信号是降噪过程,可用于图像低信噪比时的场图估计。实验表明,当图像信噪比较低时,采用小波变换作为正则化项能取得较好的效果。为了进一步改善计算的场图,采用了总变差项和波形项作为正则化项。本文所提出的方法具有很好的野外图估计效果。
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引用次数: 0
A Novel Method for Estimating Respiration Rate based on Ensemble Empirical Mode Decomposition and EKG Slope 基于集合经验模态分解和心电图斜率的呼吸速率估计新方法
Iau-Quen Chung, Jen-te Yu, Weichih Hu
The clinical monitor now mostly uses impedance IP (impedance pneumography) to measure respiratory signals. While in breathing, the movement of chest leads to position change of the EKG (Electrocardiogram) electrodes on the skin resulting in a change in impedance which can be used to estimate the respiratory rate. Measuring the EKG's impedance change for estimating the respiratory rate requires some specialized hardware. Other indirect methods for estimating respiratory rate, such as the EDR (EKG Derived Respiration), just simply utilize the EKG signal making use of the inherent variations in respiration wherein the respiratory rate is obtained from the parameter variations within the EKG waveform including RSA (Respiratory Sinus Arrhythmia) and R Peak Amplitude (RPA). This study proposes a new EDR method in which the square of the slope of the EKG waveform is calculated first and then followed by the moving average. The respiratory rate is obtained by the proposed algorithm that employs the modulated time series and compared to the results from RPA and RSA methods. The new method uses EEMD (Ensemble Empirical Mode Decomposition) to remove noise from EKG, reconstructs the respiratory signal by selecting the right IMF (Intrinsic Mode Function) as respiratory signal, and finally compares it with the nasal mouth pressure reference respiratory signal. The new RSS (R-peak Slope Square) method works with adaptive signal processing tool EEMD to obtain the EDR exploring the potential feasibility of clinical application in the future. The results demonstrate that the innovative methods proposed by this study are more accurate than that from RSA in elderly monitoring and nearly same performance as RPA (R-peak Amplitude) as well.
目前临床监护主要采用阻抗性肺成像(impedance pneumography)来测量呼吸信号。在呼吸时,胸部的运动导致皮肤上的心电图电极的位置变化,从而导致阻抗的变化,这可以用来估计呼吸速率。测量心电图的阻抗变化来估计呼吸速率需要一些专门的硬件。其他估计呼吸频率的间接方法,如EDR (EKG衍生呼吸),只是简单地利用心电图信号,利用呼吸的固有变化,其中呼吸频率是从心电图波形中的参数变化中获得的,包括RSA(呼吸性窦性心律失常)和R峰值幅度(RPA)。本文提出了一种新的EDR方法,该方法首先计算eeg波形斜率的平方,然后计算移动平均。该算法采用调制时间序列得到呼吸频率,并与RPA和RSA方法的结果进行了比较。该方法利用集成经验模态分解(EEMD)去除心电图噪声,选取合适的本征模态函数(IMF)作为呼吸信号重构呼吸信号,最后与鼻口压力参考呼吸信号进行比较。新的RSS (R-peak Slope Square)方法与自适应信号处理工具EEMD一起获得EDR,探索未来临床应用的潜在可行性。结果表明,本研究提出的创新方法在老年人监测中比RSA方法更准确,并且与RPA (R-peak Amplitude)方法的性能几乎相同。
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引用次数: 0
RUN-ONCO: A Highly Extensible Software Platform for Cancer Precision Medicine RUN-ONCO:一个高度可扩展的癌症精准医疗软件平台
Neda Peyrone, D. Wichadakul
Precision medicine is a strategy to personalize disease identification and medical care decisions through genetics. The rapid development of -omics technologies e.g., DNA and RNA sequencing, which reveal specific gene mutations in a patient's tumor or profiling of gene expressions for drug responses helps oncologists find effective treatments for individual patients based on their genetics. Hence, besides the clinical records, -omics data become essential for personalized diagnosis and treatments. In this paper, a web-based standalone software platform for cancer precision medicine, called RUN-ONCO, is proposed aiming to help oncologists and researchers manage and make use of the available clinical and -omics data easily and efficiently. The platform allows the management of clinical records, biospecimens, and -omics data and enables various integrative data analyses together with public databases such as STRING and OncoKB. With the increasing number of published methods for various -omics data analyses together with the availability of numerous javascript libraries for data visualization, RUN-ONCO has also been designed to be highly extensible with plugins for both visualizations and analysis methods. A demo version of RUN-ONCO is available online at http://cucpbioinfo.cp.eng.chula.ac.th:6002 and the source code for local deployment is at https://gitlab.com/peyrone/run-onco.
精准医学是一种通过遗传学来个性化疾病识别和医疗护理决策的策略。快速发展的组学技术,例如DNA和RNA测序,可以揭示患者肿瘤中的特定基因突变或药物反应的基因表达谱,帮助肿瘤学家根据个体患者的遗传学找到有效的治疗方法。因此,除了临床记录外,组学数据对个性化诊断和治疗至关重要。本文提出了一个基于网络的癌症精准医疗独立软件平台RUN-ONCO,旨在帮助肿瘤学家和研究人员轻松高效地管理和利用现有的临床和组学数据。该平台允许管理临床记录、生物标本和组学数据,并支持与公共数据库(如STRING和OncoKB)一起进行各种综合数据分析。随着各种组学数据分析方法的发布数量的增加,以及用于数据可视化的大量javascript库的可用性,RUN-ONCO也被设计成具有高度可扩展性,可以使用可视化和分析方法的插件。RUN-ONCO的演示版本可在http://cucpbioinfo.cp.eng.chula.ac.th:6002上在线获得,本地部署的源代码可在https://gitlab.com/peyrone/run-onco上获得。
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引用次数: 2
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Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering
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