{"title":"Review of biological activities and medicinal significance of quercetin","authors":"Ana D. Amic, Marija Mirosavljević","doi":"10.3390/ecmc2021-11509","DOIUrl":"https://doi.org/10.3390/ecmc2021-11509","url":null,"abstract":"","PeriodicalId":20499,"journal":{"name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90053326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediciton of skin permeability of compounds using IAM chromatographic and calculated descriptors","authors":"A. Sobańska, E. Brzezińska","doi":"10.3390/ecmc2021-11493","DOIUrl":"https://doi.org/10.3390/ecmc2021-11493","url":null,"abstract":"","PeriodicalId":20499,"journal":{"name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90208546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Jacinto, and C. Santos, M. Dionísio, Miguel M. Santos, Luís Branco, Ž. Petrovski
{"title":"Development of ionic liquids and eutectic systems for drug-formulations","authors":"M. Jacinto, and C. Santos, M. Dionísio, Miguel M. Santos, Luís Branco, Ž. Petrovski","doi":"10.3390/ecmc2021-11568","DOIUrl":"https://doi.org/10.3390/ecmc2021-11568","url":null,"abstract":"","PeriodicalId":20499,"journal":{"name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89771151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel of (‒)-menthone and (+)-camphor hydrazones as promising agents with dual effects","authors":"M. Nesterkina, Y. Boiko, I. Kravchenko","doi":"10.3390/ecmc2021-11559","DOIUrl":"https://doi.org/10.3390/ecmc2021-11559","url":null,"abstract":"","PeriodicalId":20499,"journal":{"name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87771008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Colon specific delivery system based on ethylcellulose-alginates microspheres loaded with mesalazine","authors":"Merir Roufaida","doi":"10.3390/ecmc2021-11500","DOIUrl":"https://doi.org/10.3390/ecmc2021-11500","url":null,"abstract":"","PeriodicalId":20499,"journal":{"name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87876073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Le Borgne, N. Lebouvier, F. Pagniez, Y. Na, Angélique Mularoni, Marie Brossier, J. Guillon, C. Simons, R. Abagyan, R. Hartmann, P. Le Pape
Invasive fungal infections have increased in frequency and severity over the last twenty years as a result of an increasing number of immunocompromised hosts due to cancer chemotherapy, organ and bone marrow transplantation, or therapy against autoimmune and inflammatory disorders. Candida species (spp.) are among the most common pathogens. Candida albicans is the main cause of candidiasis. In addition non-albicans Candida spp. are becoming more and more involved in nosocomial infections. The emergence of resistance to conventional treatments (e.g. fluconazole) make healing successes weaker. It is therefore urgent to continue efforts to develop new antifungal agents. A series of 2-aryl-3-azolyl-1indolyl-propan-2-ols was designed as new analogs of fluconazole by replacing one of its two triazole moieties by an indole scaffold. Two different chemical pathways were developed; the first one included seven steps and the second one only three. The pharmacomodulation works have enabled us to identify a molecule with a strong biological impact on fungi. Numerous experiments progressively confirmed the high potential of this hybrid molecule as antifungal agent. In this presentation, all aspects of medicinal chemistry will be addressed.
{"title":"Triazole-indole hybrid molecules as antifungal agents: Design, synthesis and biological activity, and beyond","authors":"M. Le Borgne, N. Lebouvier, F. Pagniez, Y. Na, Angélique Mularoni, Marie Brossier, J. Guillon, C. Simons, R. Abagyan, R. Hartmann, P. Le Pape","doi":"10.3390/ecmc2021-11577","DOIUrl":"https://doi.org/10.3390/ecmc2021-11577","url":null,"abstract":"Invasive fungal infections have increased in frequency and severity over the last twenty years as a result of an increasing number of immunocompromised hosts due to cancer chemotherapy, organ and bone marrow transplantation, or therapy against autoimmune and inflammatory disorders. Candida species (spp.) are among the most common pathogens. Candida albicans is the main cause of candidiasis. In addition non-albicans Candida spp. are becoming more and more involved in nosocomial infections. The emergence of resistance to conventional treatments (e.g. fluconazole) make healing successes weaker. It is therefore urgent to continue efforts to develop new antifungal agents. A series of 2-aryl-3-azolyl-1indolyl-propan-2-ols was designed as new analogs of fluconazole by replacing one of its two triazole moieties by an indole scaffold. Two different chemical pathways were developed; the first one included seven steps and the second one only three. The pharmacomodulation works have enabled us to identify a molecule with a strong biological impact on fungi. Numerous experiments progressively confirmed the high potential of this hybrid molecule as antifungal agent. In this presentation, all aspects of medicinal chemistry will be addressed.","PeriodicalId":20499,"journal":{"name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86861798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural Insight into the interaction of flavonoids with aldose reductase","authors":"Manivannan Elangovan, N. Moorthy, K. Chandra Bose","doi":"10.3390/ecmc2021-11497","DOIUrl":"https://doi.org/10.3390/ecmc2021-11497","url":null,"abstract":"","PeriodicalId":20499,"journal":{"name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79183234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carla Cruz, André Rico, F. Sousa, Bernardo Teixeira, D. Alexandre
{"title":"miRNA Detection for non-small cell lung cancer diagnosis","authors":"Carla Cruz, André Rico, F. Sousa, Bernardo Teixeira, D. Alexandre","doi":"10.3390/ecmc2021-11506","DOIUrl":"https://doi.org/10.3390/ecmc2021-11506","url":null,"abstract":"","PeriodicalId":20499,"journal":{"name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86199508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Selective inhibition of the iNOS by acetamidine derivatives","authors":"R. Amoroso","doi":"10.3390/ecmc2021-11491","DOIUrl":"https://doi.org/10.3390/ecmc2021-11491","url":null,"abstract":"","PeriodicalId":20499,"journal":{"name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85633691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miguel Oliveira, Filipa Morais, Mónica Almeida, I. Lopes
{"title":"Effects of propranolol and haloperidol on non-target organisms: A case study with amphibians","authors":"Miguel Oliveira, Filipa Morais, Mónica Almeida, I. Lopes","doi":"10.3390/ecmc2021-11540","DOIUrl":"https://doi.org/10.3390/ecmc2021-11540","url":null,"abstract":"","PeriodicalId":20499,"journal":{"name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85984158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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