Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-07-01
Y. Razuvaeva, E. A. Bayandueva, A. Toropova, I. G. Nikolaeva
{"title":"STUDYING OF THE ANTI-ISCHEMIC EFFECT OF OROSTACHYS SPINOSA DRY EXTRACT IN CAROTID ARTERIES BILATERAL OCCLUSION IN WHITE RATS","authors":"Y. Razuvaeva, E. A. Bayandueva, A. Toropova, I. G. Nikolaeva","doi":"10.29296/25877313-2022-07-01","DOIUrl":"https://doi.org/10.29296/25877313-2022-07-01","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85217753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-10-07
E. Ryskina, O. A. Magsumova, M. Postnikov, S. Chigarina, O.E. Simanovskaya, M. Korchagina, V. Polkanova
{"title":"Biochemical and spectral analysis of the impact of office teeth whitening on the organic composition of oral fluid","authors":"E. Ryskina, O. A. Magsumova, M. Postnikov, S. Chigarina, O.E. Simanovskaya, M. Korchagina, V. Polkanova","doi":"10.29296/25877313-2022-10-07","DOIUrl":"https://doi.org/10.29296/25877313-2022-10-07","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79705874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-12-01
A. Skalny, V. Nikolenko, T. Fatkhudinov, Jung-Su Chang, G.D. Morozova, G. Zolotenkova, Shih-Yi Huang, A. Tinkov
{"title":"Chemometric approach to investigation of the role of adipose tissue as a target for toxic metal effects","authors":"A. Skalny, V. Nikolenko, T. Fatkhudinov, Jung-Su Chang, G.D. Morozova, G. Zolotenkova, Shih-Yi Huang, A. Tinkov","doi":"10.29296/25877313-2022-12-01","DOIUrl":"https://doi.org/10.29296/25877313-2022-12-01","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80282953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-07-08
K. V. Quyet, H. Nguyen, E. Kalashnikova, R. Kirakosyan
{"title":"EXPERIMENTAL MORPHOGENESIS OF AMOMUM TSAO-KO CREVOST & LEMARIE. IN VITRO CULTURE","authors":"K. V. Quyet, H. Nguyen, E. Kalashnikova, R. Kirakosyan","doi":"10.29296/25877313-2022-07-08","DOIUrl":"https://doi.org/10.29296/25877313-2022-07-08","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89762154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-03-04
E. Okladnikova, T. Potupchik, L. Evert, O. Veselova, Y. Shirobokov
This article provides a literary review of domestic and foreign sources reflecting the prevalence of selenium (Se) in the environment, its metabolism in the human body. It has been shown that Se deficiency is associated with cardiovascular diseases, disorders in the endocrine and reproductive system. The role of Se in the antioxidant defense system that supports the redox homeostasis of the cell and the body, for example, in viral infections, one of the causes of which is oxidative stress, is presented. The above sources also reflect the positive role of Se in viral infections, including, with a new coronavirus infection caused by the SARS-CoV-2 virus, since Se is necessary for the differentiation and proliferation of a number of immune cells involved in the processes of innate and adaptive immunity. It has been proven that in moderate doses, the Se supplement increases the proliferation of T cells and the activity of natural killer cells. In this regard, it is possible to recommend taking dietary supplements containing Se in high-risk areas and /or shortly after suspected infection with SARS-CoV-2. Positive research results, as well as a good safety profile, indicate the possibility of using biologically active food additives containing Se in complex therapy, in particular SELENBIO for women in disorders of the cardiovascular, endocrine, reproductive system, as well as in infectious diseases. (English) [ FROM AUTHOR] Представлен литературный обзор отечественных и зарубежных источников, отражающих распространенность селена (Se) в окружающей среде, его метаболизм в организме человека. Показано, что дефицит Se ассоциируется с сердечно-сосудистыми заболеваниями, нарушениями в эндокринной и репродуктивной системах. Представлена роль Se в системе антиоксидантной защиты, поддерживающей окислительно-восстановительный гомеостаз клетки и организма, например в случае вирусных инфекций, одной из причин которых является окислительный стресс. В приведенных источниках отражена также положительная роль Se при вирусных инфекциях, в том числе при новой коронавирусной инфекции, вызванной вирусом SARS-CoV-2, поскольку Se необходим для дифференцировки и пролиферации ряда иммунных клеток, участвующих в процессах врожденного и адаптивного иммунитета. Доказано, что в умеренных дозах добавка Se увеличивает пролиферацию Т-клеток и активность естественных клеток-киллеров. В связи с этим можно рекомендовать прием пищевых добавок, содержащих Se, в зонах высокого риска и/или вскоре после подозрения на инфицирование SARS-CoV-2. Положительные результаты исследований, а также хороший профиль безопасности свидетельствуют о возможности применения в комплексной терапии биологически активных пищевых добавок, содержащих Se, в частности препарат «SELENBIO for women» при нарушениях сердечно-сосудистой, эндокринной, репродуктивной систем, а также при инфекционных заболеваниях. (Russian) [ FROM AUTHOR] Copyright of Problems of Biological, Medical & Pharmaceutical Chemistry is the proper
本文综述了反映环境中硒含量及其在人体内代谢的国内外文献。研究表明，硒缺乏与心血管疾病、内分泌和生殖系统紊乱有关。硒在抗氧化防御系统中的作用，支持细胞和身体的氧化还原稳态，例如，在病毒感染中，其原因之一是氧化应激，被提出。上述来源也反映了硒在病毒感染中的积极作用，包括SARS-CoV-2病毒引起的新型冠状病毒感染，因为硒是参与先天免疫和适应性免疫过程的许多免疫细胞分化和增殖所必需的。已经证明，在中等剂量下，硒补充剂可以增加T细胞的增殖和自然杀伤细胞的活性。在这方面，有可能建议在高风险地区和/或疑似感染SARS-CoV-2后不久服用含硒膳食补充剂。积极的研究结果以及良好的安全性表明，有可能在综合治疗中使用含硒的生物活性食品添加剂，特别是用于治疗心血管、内分泌、生殖系统疾病和传染病的妇女的SELENBIO。(英语)(从作者)Представленлитературныйобзоротечественныхизарубежныхисточников,отражающихраспространенностьселена(Se)вокружающейсреде,егометаболизмворганизмечеловека。,чПоказанотодефицитSeассоциируетсяссердечно——сосудистымизаболеваниями,нарушениямивэндокриннойирепродуктивнойсистемах。ПредставленарольSeвсистемеантиоксидантнойзащиты,поддерживающейокислительно——восстановительныйгомеостазклеткииорганизма,напримервслучаевирусныхинфекций,однойизпричинкоторыхявляетсяокислительныйстресс。ВприведенныхисточникахотраженатакжеположительнаярольSeпривирусныхинфекциях,втомчислеприновойкоронавируснойинфекции,вызваннойвирусомSARS-CoV-2,посколькуSeнеобходимдлядифференцировкиипролиферациирядаиммунныхклеток,участвующихвпроцессахврожденногоиадаптивногоиммунитета。,чДоказанотовумеренныхдозахдобавкаSeувеличиваетпролиферациюТ-клетокиактивностьестественныхклеток-киллеров。Всвязисэтимможнорекомендоватьприемпищевыхдобавок。содержащихSe,взонахвысокогорискаи/иливскорепослеподозрениянаинфицированиеSARS-CoV-2。Положительныерезультатыисследований,атакжехорошийпрофильбезопасностисвидетельствуютовозможностиприменениявкомплекснойтерапиибиологическиактивныхпищевыхдобавок。содержащихSe,вчастностипрепарат«女性SELENBIO»принарушенияхсердечно——сосудистой,эндокринной,репродуктивнойсистем,атакжеприинфекционныхзаболеваниях。(俄文)[来自作者]《生物、医学和药物化学问题》的版权是Russian Physician Public House Ltd.的财产，未经版权所有者的明确书面许可，不得复制或通过电子邮件将其内容发送到多个网站或发布到listserv。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这可以删节。对副本的准确性不作任何保证。用户应参阅原始出版版本的材料的完整。(版权适用于所有人。)
{"title":"Features of metabolism and spectrum of action of selenium, possibilities of application of selene-containing food supplements under SARS-CoV-2 pandemic conditions","authors":"E. Okladnikova, T. Potupchik, L. Evert, O. Veselova, Y. Shirobokov","doi":"10.29296/25877313-2022-03-04","DOIUrl":"https://doi.org/10.29296/25877313-2022-03-04","url":null,"abstract":"This article provides a literary review of domestic and foreign sources reflecting the prevalence of selenium (Se) in the environment, its metabolism in the human body. It has been shown that Se deficiency is associated with cardiovascular diseases, disorders in the endocrine and reproductive system. The role of Se in the antioxidant defense system that supports the redox homeostasis of the cell and the body, for example, in viral infections, one of the causes of which is oxidative stress, is presented. The above sources also reflect the positive role of Se in viral infections, including, with a new coronavirus infection caused by the SARS-CoV-2 virus, since Se is necessary for the differentiation and proliferation of a number of immune cells involved in the processes of innate and adaptive immunity. It has been proven that in moderate doses, the Se supplement increases the proliferation of T cells and the activity of natural killer cells. In this regard, it is possible to recommend taking dietary supplements containing Se in high-risk areas and /or shortly after suspected infection with SARS-CoV-2. Positive research results, as well as a good safety profile, indicate the possibility of using biologically active food additives containing Se in complex therapy, in particular SELENBIO for women in disorders of the cardiovascular, endocrine, reproductive system, as well as in infectious diseases. (English) [ FROM AUTHOR] Представлен литературный обзор отечественных и зарубежных источников, отражающих распространенность селена (Se) в окружающей среде, его метаболизм в организме человека. Показано, что дефицит Se ассоциируется с сердечно-сосудистыми заболеваниями, нарушениями в эндокринной и репродуктивной системах. Представлена роль Se в системе антиоксидантной защиты, поддерживающей окислительно-восстановительный гомеостаз клетки и организма, например в случае вирусных инфекций, одной из причин которых является окислительный стресс. В приведенных источниках отражена также положительная роль Se при вирусных инфекциях, в том числе при новой коронавирусной инфекции, вызванной вирусом SARS-CoV-2, поскольку Se необходим для дифференцировки и пролиферации ряда иммунных клеток, участвующих в процессах врожденного и адаптивного иммунитета. Доказано, что в умеренных дозах добавка Se увеличивает пролиферацию Т-клеток и активность естественных клеток-киллеров. В связи с этим можно рекомендовать прием пищевых добавок, содержащих Se, в зонах высокого риска и/или вскоре после подозрения на инфицирование SARS-CoV-2. Положительные результаты исследований, а также хороший профиль безопасности свидетельствуют о возможности применения в комплексной терапии биологически активных пищевых добавок, содержащих Se, в частности препарат «SELENBIO for women» при нарушениях сердечно-сосудистой, эндокринной, репродуктивной систем, а также при инфекционных заболеваниях. (Russian) [ FROM AUTHOR] Copyright of Problems of Biological, Medical & Pharmaceutical Chemistry is the proper","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79013789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-06-06
Hajjar Fadi, O. G. Potanina, R. Abramovich
{"title":"Benefits of composition combined herbal drug of sedative action","authors":"Hajjar Fadi, O. G. Potanina, R. Abramovich","doi":"10.29296/25877313-2022-06-06","DOIUrl":"https://doi.org/10.29296/25877313-2022-06-06","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75052977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-03-01
A.A. Balakireva, D. Panteleev, D. Malygina, D. Orekhov, I.V. Spitskaya, N. Melnikova
{"title":"Physicochemical properties of zinc oxide nanoparticles modified with betulin diphosphate","authors":"A.A. Balakireva, D. Panteleev, D. Malygina, D. Orekhov, I.V. Spitskaya, N. Melnikova","doi":"10.29296/25877313-2022-03-01","DOIUrl":"https://doi.org/10.29296/25877313-2022-03-01","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79469167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-10-08
V.V. Karabayeva, L. Krepkova, I. Lupanova, A. N. Babenko, P. G. Mizina
{"title":"A retrospective analysis of the experimental and clinical study of pasenin, a drug for the treatment of dyslipidemia in patients with diabetes mellitus","authors":"V.V. Karabayeva, L. Krepkova, I. Lupanova, A. N. Babenko, P. G. Mizina","doi":"10.29296/25877313-2022-10-08","DOIUrl":"https://doi.org/10.29296/25877313-2022-10-08","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79005835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-05-02
U. Saginbaev
{"title":"Production of interleukin-6 by resting hybridoma endothelial cells of the EA.HY926 line","authors":"U. Saginbaev","doi":"10.29296/25877313-2022-05-02","DOIUrl":"https://doi.org/10.29296/25877313-2022-05-02","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79909285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-03-03
I. T. Murkamilov, K. Aitbaev, Z. Murkamilova, V. Fomin, I. Kudaibergenova, F. Yusupov
{"title":"Remodeling of the left atrium in patients with 4-5 stage chronic kidney disease","authors":"I. T. Murkamilov, K. Aitbaev, Z. Murkamilova, V. Fomin, I. Kudaibergenova, F. Yusupov","doi":"10.29296/25877313-2022-03-03","DOIUrl":"https://doi.org/10.29296/25877313-2022-03-03","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"480 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77779263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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