Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-07-03
O. V. Mushkina, N. Gurina
{"title":"EVALUATION OF ANTI-ULCER ACTIVITY OF BIOLOGICALLY ACTIVE COMPOUNDS IN ALDER LEAVES","authors":"O. V. Mushkina, N. Gurina","doi":"10.29296/25877313-2022-07-03","DOIUrl":"https://doi.org/10.29296/25877313-2022-07-03","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"76 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86397760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-12-08
F. Vagabova, A. Aliev
{"title":"Studying the chemical composition of the essential oil of the aboveground part of Artemisia marschalliana Spreng. Natural populations of Dagestan","authors":"F. Vagabova, A. Aliev","doi":"10.29296/25877313-2022-12-08","DOIUrl":"https://doi.org/10.29296/25877313-2022-12-08","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84249103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-05-06
N. Popov, V. Balabanyan, M. B. Petrova, N. Kolgina, G. A. Petrov
{"title":"The use of HPLC-MS/MS for the quantitative analysis of neuroactive amino acids in rat brain homogenates after derivatization with 9-fluorenylmethyl chloroformate","authors":"N. Popov, V. Balabanyan, M. B. Petrova, N. Kolgina, G. A. Petrov","doi":"10.29296/25877313-2022-05-06","DOIUrl":"https://doi.org/10.29296/25877313-2022-05-06","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85500451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-03-06
I. Lupanova, O. L. Saybel, E. V. Ferubko, E. N. Kurmanova, A.I. Radimitch, V. Kolkhir, P. G. Mizina
{"title":"Pharmacological screening of Serratula coronata L. herbal extract","authors":"I. Lupanova, O. L. Saybel, E. V. Ferubko, E. N. Kurmanova, A.I. Radimitch, V. Kolkhir, P. G. Mizina","doi":"10.29296/25877313-2022-03-06","DOIUrl":"https://doi.org/10.29296/25877313-2022-03-06","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90745494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-06-01
O. Somonova, A. Elizarova, T. V. Davydova, V. N. Blindar, N. Borisenko, M. M. Dobrovolskaya, U. Kornyushenko, E. Golovnya, J.A. Nesterova
{"title":"Disorders in the blood system in cancer patients with purulent-septic complications","authors":"O. Somonova, A. Elizarova, T. V. Davydova, V. N. Blindar, N. Borisenko, M. M. Dobrovolskaya, U. Kornyushenko, E. Golovnya, J.A. Nesterova","doi":"10.29296/25877313-2022-06-01","DOIUrl":"https://doi.org/10.29296/25877313-2022-06-01","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90276703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-02-08
P. Povarnina, D. M. Nikiforov, O. N. Vorontsova, T. Gudasheva
Relevance. Depression and cognitive impairment are common complications of acute cerebrovascular accidents. Disorders of hippocampal neuroplasticity associated with a decrease in BDNF expression are considered as one of the causes of these complicatio ns. A dimeric dipeptide mimetic of the BDNF loop 4, (bis (N - monosuccinyl -L- seryl -L- lysine) hexamethylenediamide) (GS B-106) was created at the V.V. Zakusov Research Institute of Pharmacology. GSB - 106 demonstrated antidepressant, neuroprotective and neuroregenera-tive properties in in vivo experiments. Objective . Experiments were performed on 40 male rats Wistar weighing 2 40–280 g. Purpose of the study is to investigate the effect of GSB - 106 on depression - like behavior and memory impairments in rats induced by middle cerebral artery occlusion (MCAO). Material and methods . GSB - 106 was injected intraperitoneally at a dose of 0.1 mg/kg for 21 days after surgery. Depressive - like behavior was detected in the forced swimming test, and memory impairments – in the novel object recognition test. Conclusions . GSB - 106 is a promising compound for further development as a drug for the treatment of post - stroke depression and cognitive impairment.
{"title":"Dipeptide BDNF mimetic GSB-106 prevents depression-like behavior and cognitive impairment caused by ischemic stroke in rats","authors":"P. Povarnina, D. M. Nikiforov, O. N. Vorontsova, T. Gudasheva","doi":"10.29296/25877313-2022-02-08","DOIUrl":"https://doi.org/10.29296/25877313-2022-02-08","url":null,"abstract":"Relevance. Depression and cognitive impairment are common complications of acute cerebrovascular accidents. Disorders of hippocampal neuroplasticity associated with a decrease in BDNF expression are considered as one of the causes of these complicatio ns. A dimeric dipeptide mimetic of the BDNF loop 4, (bis (N - monosuccinyl -L- seryl -L- lysine) hexamethylenediamide) (GS B-106) was created at the V.V. Zakusov Research Institute of Pharmacology. GSB - 106 demonstrated antidepressant, neuroprotective and neuroregenera-tive properties in in vivo experiments. Objective . Experiments were performed on 40 male rats Wistar weighing 2 40–280 g. Purpose of the study is to investigate the effect of GSB - 106 on depression - like behavior and memory impairments in rats induced by middle cerebral artery occlusion (MCAO). Material and methods . GSB - 106 was injected intraperitoneally at a dose of 0.1 mg/kg for 21 days after surgery. Depressive - like behavior was detected in the forced swimming test, and memory impairments – in the novel object recognition test. Conclusions . GSB - 106 is a promising compound for further development as a drug for the treatment of post - stroke depression and cognitive impairment.","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90522309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-01-08
O. Puzikova, I. Ralchenko
{"title":"Determination of the free radical reactions in whole blood of Wistar rats under stress-induced physical exercise","authors":"O. Puzikova, I. Ralchenko","doi":"10.29296/25877313-2022-01-08","DOIUrl":"https://doi.org/10.29296/25877313-2022-01-08","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78915119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-02-04
S. Zolotov, E. Ponomarev, I. A. Dain, N. Demina, A. Zolotova, V. M. Retivov, G. A. Buzanov
{"title":"The study of the physico-chemical properties of the substance efavirenz","authors":"S. Zolotov, E. Ponomarev, I. A. Dain, N. Demina, A. Zolotova, V. M. Retivov, G. A. Buzanov","doi":"10.29296/25877313-2022-02-04","DOIUrl":"https://doi.org/10.29296/25877313-2022-02-04","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75837042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-09-03
O. Semkina, V. I. Zvereva, M. A. Dzhavakhyan, N.P. Pavets
{"title":"Physical, chemical and technological aspects of a gel for oral administration Lycopus europaeus L. herb dry extract","authors":"O. Semkina, V. I. Zvereva, M. A. Dzhavakhyan, N.P. Pavets","doi":"10.29296/25877313-2022-09-03","DOIUrl":"https://doi.org/10.29296/25877313-2022-09-03","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82757712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29296/25877313-2022-02-05
Balloul Ghadeer, D. Martceva, E. Zhilyakova, N. Boyko, A. B. Abdulhadi, Mahmoud Dawood alrubaye Wissam
{"title":"Comparison of the rate of release of active substances from solutions of hydroxymethylpropyl cellulose and hydroxyethyl cellulose for selecting the optimal polymer for the development of ear drops","authors":"Balloul Ghadeer, D. Martceva, E. Zhilyakova, N. Boyko, A. B. Abdulhadi, Mahmoud Dawood alrubaye Wissam","doi":"10.29296/25877313-2022-02-05","DOIUrl":"https://doi.org/10.29296/25877313-2022-02-05","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87327494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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