Pub Date : 2021-12-31DOI: 10.24966/and-9608/100058
Barry S Willer
Objective: Chronic pain is known to affect neurocognitive function- ing; retired professional athletes are at high risk of having chronic musculoskeletal pain. However, this relationship has not been in-vestigated in retired professional contact sport athletes who are sus- pected to have early neurocognitive decline due to repetitive head injuries during their careers. Participants: Twenty-one retired National Football League and National Hockey League players (Contact Sport, CS) and 21 age-matched non-contact sport athletic controls (Non-contact Sport, NS). Design: Case-control Main measures: Behavior Regulatory Index (BRI) and Metacogni- tive Index (MI) from Behavioral Rating Inventory of Executive Func-tion-Adult, anxiety from Beck Anxiety Index, depression from Beck Depression Inventory-II, and Pain Intensity and Interference from Patient Reported Outcome Measure Information System-43. Results: CS group reported significantly more pain intensity and interference (p<0.001) than NS. On exploratory binary logistic re-gressions, body mass index (p=0.039), pain interference (p=0.014), and anxiety (p=0.010) were significant predictors of BRI. Pain interference (p=0.002) was the sole significant predictor of MI. A history of playing contact sports was significant for neither. Conclusion: Our results suggest there may be important causes of early neurocognitive decline in this population other than just a history of playing contact sports.
{"title":"Case-Control Study Comparing the Relationship between Pain, Neurobehavioral Functioning and a History of Playing Professional Contact Sports","authors":"Barry S Willer","doi":"10.24966/and-9608/100058","DOIUrl":"https://doi.org/10.24966/and-9608/100058","url":null,"abstract":"Objective: Chronic pain is known to affect neurocognitive function- ing; retired professional athletes are at high risk of having chronic musculoskeletal pain. However, this relationship has not been in-vestigated in retired professional contact sport athletes who are sus- pected to have early neurocognitive decline due to repetitive head injuries during their careers. Participants: Twenty-one retired National Football League and National Hockey League players (Contact Sport, CS) and 21 age-matched non-contact sport athletic controls (Non-contact Sport, NS). Design: Case-control Main measures: Behavior Regulatory Index (BRI) and Metacogni- tive Index (MI) from Behavioral Rating Inventory of Executive Func-tion-Adult, anxiety from Beck Anxiety Index, depression from Beck Depression Inventory-II, and Pain Intensity and Interference from Patient Reported Outcome Measure Information System-43. Results: CS group reported significantly more pain intensity and interference (p<0.001) than NS. On exploratory binary logistic re-gressions, body mass index (p=0.039), pain interference (p=0.014), and anxiety (p=0.010) were significant predictors of BRI. Pain interference (p=0.002) was the sole significant predictor of MI. A history of playing contact sports was significant for neither. Conclusion: Our results suggest there may be important causes of early neurocognitive decline in this population other than just a history of playing contact sports.","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122094247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.24966/and-9608/100051
S. Huggenberger
{"title":"Longitudinal Assessment of tau Phosphorylation in the Brainstem of P301L tau-transgenic pR5 Mice","authors":"S. Huggenberger","doi":"10.24966/and-9608/100051","DOIUrl":"https://doi.org/10.24966/and-9608/100051","url":null,"abstract":"","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128365433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.24966/and-9608/100050
F. Costa
{"title":"The Use of a Musical Mnemonic Strategy to Support Verbal Memory Recall in People with Alzheimer’s Disease: A Review","authors":"F. Costa","doi":"10.24966/and-9608/100050","DOIUrl":"https://doi.org/10.24966/and-9608/100050","url":null,"abstract":"","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123052998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.24966/and-9608/100052
A. Mandas
{"title":"The Role of Peripheral Cells in Neurocognitive Disorders Detection","authors":"A. Mandas","doi":"10.24966/and-9608/100052","DOIUrl":"https://doi.org/10.24966/and-9608/100052","url":null,"abstract":"","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129477088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.24966/and-9608/100048
A. Sfera
{"title":"Are “Sartans” the Common Treatment for COVID-19 and Parkinson’s Disease?","authors":"A. Sfera","doi":"10.24966/and-9608/100048","DOIUrl":"https://doi.org/10.24966/and-9608/100048","url":null,"abstract":"","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"24 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116707948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.24966/and-9608/100046
T. Shimura
Objective: CWPT, which is able to detect a slight cognitive impair- ment in PCSD (Preclinical Stage of Dementia) or MCI (Mild Cognitive Impairment), is attracting attention as a neuropsychological test that allows screening at the stage where we must rely on expensive testing equipment such as PET, MRI and X-CT. CWPT is a test for identifying colors and remembering episodes while reading a story containing Color Words, so it can be easily translated and used in various languages. Therefore, the purpose of this paper is to show foreign researchers how to deriver the diagnostic criteria in Japan. Methods: Diagnostic criteria were derived by analyzing large-scale data. At this time, since it is impossible to perform MMSE on all the subjects, CKPT was performed after receiving a report that I was normal. As shown in the evidence in the previous paper, the CKPT results show a normal distribution for each age, so a method to check the distribution by subjecting the subjects who disturb the normal distribution of the resulting histogram to trial and error is achieved. Results: The total number of subjects used for the diagnostic criteria was 1325, and 199 subjects were excluded. The average value ± SD, and the average value ± 1.5SD were derived as the diagnostic criteria for male and female in their 60s, 70s, and 80s. Conclusion: Using the derived diagnostic criteria, we have gained a foothold to develop various CKPT applications.
{"title":"Derivation of Diagnostic Criteria for a Slight Cognitive Impairment using CKPT (Japanese Version of CWPT)","authors":"T. Shimura","doi":"10.24966/and-9608/100046","DOIUrl":"https://doi.org/10.24966/and-9608/100046","url":null,"abstract":"Objective: CWPT, which is able to detect a slight cognitive impair- ment in PCSD (Preclinical Stage of Dementia) or MCI (Mild Cognitive Impairment), is attracting attention as a neuropsychological test that allows screening at the stage where we must rely on expensive testing equipment such as PET, MRI and X-CT. CWPT is a test for identifying colors and remembering episodes while reading a story containing Color Words, so it can be easily translated and used in various languages. Therefore, the purpose of this paper is to show foreign researchers how to deriver the diagnostic criteria in Japan. Methods: Diagnostic criteria were derived by analyzing large-scale data. At this time, since it is impossible to perform MMSE on all the subjects, CKPT was performed after receiving a report that I was normal. As shown in the evidence in the previous paper, the CKPT results show a normal distribution for each age, so a method to check the distribution by subjecting the subjects who disturb the normal distribution of the resulting histogram to trial and error is achieved. Results: The total number of subjects used for the diagnostic criteria was 1325, and 199 subjects were excluded. The average value ± SD, and the average value ± 1.5SD were derived as the diagnostic criteria for male and female in their 60s, 70s, and 80s. Conclusion: Using the derived diagnostic criteria, we have gained a foothold to develop various CKPT applications.","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"529 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123360779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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