Pub Date : 2020-12-30DOI: 10.24966/and-9608/100049
S. Goradia
{"title":"The Scientific Search for the Soul in the Higgs Field","authors":"S. Goradia","doi":"10.24966/and-9608/100049","DOIUrl":"https://doi.org/10.24966/and-9608/100049","url":null,"abstract":"","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116598644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-12DOI: 10.24966/AND-9608/100026
F. Nikbakht, Cellular
Introduction: Metformin, the most commonly prescribed antidiabetic drug, has been shown to be effective in controlling seizures in some studies. However, there are some reports of proconvulsant activity of metformin in diabetic patients. The aim of the present study was to investigate the effects of metformin dosage on anti-seizure and neuronal protective activity. Method: Male Wistar rats were randomly divided into 5 groups as follows: 1-control/vehicle group, 2Kainic acid (KA), 3-metformin+KA (50 mg/kg), 4-metformin+KA (100 mg/kg), 5metformin+KA (200 mg/ kg). Temporal lobe epilepsy (TLE) was induced by injection of 0.5 μg kainite into the left lateral ventricle. Metformin was administered orally for two weeks before the induction of TLE. Results: We found that metformin at higher doses (100 and 200 mg/ kg) significantly suppressed the progression of seizure in TLE and ameliorated the neuronal loss in the hippocampus induced by KA. However, the low dose of metformin had no effect. Conclusion: We concluded that metformin may be a potential agent for the treatment of epilepsy and seizure and this effect is dose-dependent.
{"title":"Dose-Dependent Anticonvulsant and Protective Effects of Metformin in Kainate Induced Temporal Lobe Epilepsy","authors":"F. Nikbakht, Cellular","doi":"10.24966/AND-9608/100026","DOIUrl":"https://doi.org/10.24966/AND-9608/100026","url":null,"abstract":"Introduction: Metformin, the most commonly prescribed antidiabetic drug, has been shown to be effective in controlling seizures in some studies. However, there are some reports of proconvulsant activity of metformin in diabetic patients. The aim of the present study was to investigate the effects of metformin dosage on anti-seizure and neuronal protective activity. Method: Male Wistar rats were randomly divided into 5 groups as follows: 1-control/vehicle group, 2Kainic acid (KA), 3-metformin+KA (50 mg/kg), 4-metformin+KA (100 mg/kg), 5metformin+KA (200 mg/ kg). Temporal lobe epilepsy (TLE) was induced by injection of 0.5 μg kainite into the left lateral ventricle. Metformin was administered orally for two weeks before the induction of TLE. Results: We found that metformin at higher doses (100 and 200 mg/ kg) significantly suppressed the progression of seizure in TLE and ameliorated the neuronal loss in the hippocampus induced by KA. However, the low dose of metformin had no effect. Conclusion: We concluded that metformin may be a potential agent for the treatment of epilepsy and seizure and this effect is dose-dependent.","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114004705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-12DOI: 10.24966/and-9608/100025
Peng-chong Liang
{"title":"The Relationship between Perioperative Gut Microbiome and POCD","authors":"Peng-chong Liang","doi":"10.24966/and-9608/100025","DOIUrl":"https://doi.org/10.24966/and-9608/100025","url":null,"abstract":"","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125614207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-12DOI: 10.24966/and-9608/100028
T. Shimura
Objective: Before concept of mild cognitive impairment (MCI) and preclinical stage of dementia (PCSD) our study started to detect slight declines in the brain. The purpose of this study is to clarify the basis of the ability of the devised CWPT (Color Word Pick-out Test) to detect slight disorder and classify it at the MCI and PCSD. Methods: CWPT is an application of Stroop effect and is including an examination of episodic memory to obtain the evidence and 1 activation of the prefrontal lobe using an inferred spectroscopy, 2 criterion-related validity using CWPT, WCST, HCL, FAB and MMSE 3 sensitivity and specificity using MMSE and CWPT are examined. Results: 1 It is found using a near infrared spectroscopy that CWPT is the most effective test for the brain activation, in comparison with quick repetition of 4-5numbers in order, in reverse order, Kawashima arithmetic drill and KPT (Kana Pick-out Test). 2 among the histograms obtained from 22 healthy aging people, only CWPT and WCST show normal distributions besides CWPT has good correlation with WCST. 3 Sensitivity and specificity are calculated using MMSE as a true condition and CWPT as a predicted condition for 29 subjects with dementia. Sensitivity becomes 0.963 and specificity becomes 1.0 by the cutoff of the average-1.5SD of CWPT. Conclusion: As a result of these analyses, it has been suggested that CWPT can be used to classify the level of disorder during MCI and the preclinical stage of dementia.
{"title":"CWPT (Color Words Pick-Out Test) Available for Classifying the Slight Disorder on the Preclinical Stage of Dementia","authors":"T. Shimura","doi":"10.24966/and-9608/100028","DOIUrl":"https://doi.org/10.24966/and-9608/100028","url":null,"abstract":"Objective: Before concept of mild cognitive impairment (MCI) and preclinical stage of dementia (PCSD) our study started to detect slight declines in the brain. The purpose of this study is to clarify the basis of the ability of the devised CWPT (Color Word Pick-out Test) to detect slight disorder and classify it at the MCI and PCSD. Methods: CWPT is an application of Stroop effect and is including an examination of episodic memory to obtain the evidence and 1 activation of the prefrontal lobe using an inferred spectroscopy, 2 criterion-related validity using CWPT, WCST, HCL, FAB and MMSE 3 sensitivity and specificity using MMSE and CWPT are examined. Results: 1 It is found using a near infrared spectroscopy that CWPT is the most effective test for the brain activation, in comparison with quick repetition of 4-5numbers in order, in reverse order, Kawashima arithmetic drill and KPT (Kana Pick-out Test). 2 among the histograms obtained from 22 healthy aging people, only CWPT and WCST show normal distributions besides CWPT has good correlation with WCST. 3 Sensitivity and specificity are calculated using MMSE as a true condition and CWPT as a predicted condition for 29 subjects with dementia. Sensitivity becomes 0.963 and specificity becomes 1.0 by the cutoff of the average-1.5SD of CWPT. Conclusion: As a result of these analyses, it has been suggested that CWPT can be used to classify the level of disorder during MCI and the preclinical stage of dementia.","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130124447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-12DOI: 10.24966/and-9608/100027
Changgui Chen
{"title":"A Commentary about the Function of Selenoprotein SELENOK for the Prevention and Treatment of Alzheimer’s Disease","authors":"Changgui Chen","doi":"10.24966/and-9608/100027","DOIUrl":"https://doi.org/10.24966/and-9608/100027","url":null,"abstract":"","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131707464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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