Pub Date : 2019-02-01DOI: 10.33945/SAMI/PCBR.2019.2.1319
Mital K. Aadesariya, V. Ram, P. Dave
The current study was carried out on the extraction, isolation, and identification of phytochemical constituents existing in the Abutilon pannosum and Grewia tenax leaves extract collected from Kachchh region of Gujarat state, India. The main aim of this study was to expose important polar phytochemicals in locally available medicinal plants using LC-Q-TOF-MS analytical techniques. The main analytical tool is liquid chromatography quadrupole time of flight mass spectrometry (LC-Q-TOF-MS) which is one of the most sophisticated and sensitive instruments that gives qualitative as well as quantitative information accurately with respect to constituents present in the sample. The continuous extraction of plant leaves was commenced by Soxhlet extractor utilizing methanol as a solvent. The crude methanolic extracts were inserted in LC-Q-TOF-MS for identification and isolation of useful phytochemicals. The results of phytochemical analysis displayed that there were significant phytochemicals found in methanol extracts of A. pannosum leaves (APL) such as alkaloids, photoproteins, antibioticand in G. tenax leaves (GTL) like alkaloids, photoproteins, glycoside, terpenoids, fatty amides, steroids, fatty alcohols, saponins, flavones, flavonols, steroid etc. Hence, methanolic extract of GTL gives good medicinal activity as compared to the APL.
{"title":"Investigation of phytochemicals in methanolic leaves extracts of Abutilon pannosum and Grewia tenax by Q-TOF LC/MS","authors":"Mital K. Aadesariya, V. Ram, P. Dave","doi":"10.33945/SAMI/PCBR.2019.2.1319","DOIUrl":"https://doi.org/10.33945/SAMI/PCBR.2019.2.1319","url":null,"abstract":"The current study was carried out on the extraction, isolation, and identification of phytochemical constituents existing in the Abutilon pannosum and Grewia tenax leaves extract collected from Kachchh region of Gujarat state, India. The main aim of this study was to expose important polar phytochemicals in locally available medicinal plants using LC-Q-TOF-MS analytical techniques. The main analytical tool is liquid chromatography quadrupole time of flight mass spectrometry (LC-Q-TOF-MS) which is one of the most sophisticated and sensitive instruments that gives qualitative as well as quantitative information accurately with respect to constituents present in the sample. The continuous extraction of plant leaves was commenced by Soxhlet extractor utilizing methanol as a solvent. The crude methanolic extracts were inserted in LC-Q-TOF-MS for identification and isolation of useful phytochemicals. The results of phytochemical analysis displayed that there were significant phytochemicals found in methanol extracts of A. pannosum leaves (APL) such as alkaloids, photoproteins, antibioticand in G. tenax leaves (GTL) like alkaloids, photoproteins, glycoside, terpenoids, fatty amides, steroids, fatty alcohols, saponins, flavones, flavonols, steroid etc. Hence, methanolic extract of GTL gives good medicinal activity as compared to the APL.","PeriodicalId":20668,"journal":{"name":"Progress in Chemical and Biochemical Research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83286474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative study on different horizontal subsurface substrates in flow wetlands","authors":"A. EL-Khateeb, M. Mahmoud, M. Fakih","doi":"10.33945/sami/pcbr.2019.2.2023","DOIUrl":"https://doi.org/10.33945/sami/pcbr.2019.2.2023","url":null,"abstract":"Article history: Received: 14 December 2018 Accepted: 12 February 2019 Available online: 14 March 2019 Manuscript ID: PCBR-1810-1008","PeriodicalId":20668,"journal":{"name":"Progress in Chemical and Biochemical Research","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80803017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33945/sami/pcbr.2019.2.3439
Masomeh Aghazadeh
The reaction of indoles with the complex formed from tertiary cyclic amides and phosphorus oxychloride, followed by basification using sodium hydroxide, was studied. In the case of five member amide rings, 3-(1-alkyl-pyrrolidine-2-ylidene)3H-indoles were obtained but in the case of six and seven member amide rings, ring opening was occurred and amino ketones were obtained.
{"title":"Tertiary cyclic amides in Vilsmeier type reaction with indoles","authors":"Masomeh Aghazadeh","doi":"10.33945/sami/pcbr.2019.2.3439","DOIUrl":"https://doi.org/10.33945/sami/pcbr.2019.2.3439","url":null,"abstract":"The reaction of indoles with the complex formed from tertiary cyclic amides and phosphorus oxychloride, followed by basification using sodium hydroxide, was studied. In the case of five member amide rings, 3-(1-alkyl-pyrrolidine-2-ylidene)3H-indoles were obtained but in the case of six and seven member amide rings, ring opening was occurred and amino ketones were obtained.","PeriodicalId":20668,"journal":{"name":"Progress in Chemical and Biochemical Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86344450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33945/SAMI/PCBR.2019.2.612
Amira Salem Zaek, Balsam Ali Benhamed, Mabroka Ali Al shahomy, Ruwida Kamour, Akram Eshames
Generic drugs have increased in their popularity as the cost of their brand counterparts have arisen. Post-marketing testing of some drugs is used to assure quality, efficacy and safety of those drugs made available for public use. This is to give evidence of their effectiveness. This study was undertaken to justify the use of generic substitution of metoprolol, spironolactone and verapamil brands marketed in Tripoli-Libya. This evaluation was achieved through QC tests for hardness, disintegration time and chemical content according to British Pharmacopoeial standards. The results of these tests were found to comply with pharmacopoial range indicating their efficiency to be used as a substituent for brands of higher price.
{"title":"Comparative study of pharmaceutical content of three different cardio vascular system drugs marketed in Tripoli- Libya","authors":"Amira Salem Zaek, Balsam Ali Benhamed, Mabroka Ali Al shahomy, Ruwida Kamour, Akram Eshames","doi":"10.33945/SAMI/PCBR.2019.2.612","DOIUrl":"https://doi.org/10.33945/SAMI/PCBR.2019.2.612","url":null,"abstract":"Generic drugs have increased in their popularity as the cost of their brand counterparts have arisen. Post-marketing testing of some drugs is used to assure quality, efficacy and safety of those drugs made available for public use. This is to give evidence of their effectiveness. This study was undertaken to justify the use of generic substitution of metoprolol, spironolactone and verapamil brands marketed in Tripoli-Libya. This evaluation was achieved through QC tests for hardness, disintegration time and chemical content according to British Pharmacopoeial standards. The results of these tests were found to comply with pharmacopoial range indicating their efficiency to be used as a substituent for brands of higher price.","PeriodicalId":20668,"journal":{"name":"Progress in Chemical and Biochemical Research","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79454294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33945/SAMI/PCBR.2019.2.2433
Walaa Haider Elobeid, A. Elbashir
An improvement to the performance of the bare pencil graphite electrode (PGE) was made by modifying it utilizing p-amino benzene sulfonic acid (p-ABSA), benzo-18-crown-6 and multi-walled carbon nanotubes (CNTs) to detect lead (II) ions in water samples using differential pulse anodic stripping voltammetric technique. The presence of p-ABSA serves as ionic conductor while the good adsorption ability and electrical conductivity of multi-walled CNTs enhanced the sensitivity through increasing the electrochemical active surface area. Furthermore, using benzo-18-crown-6 as a molecular scavenger improved the selectivity for lead (II) ions. After optimizing the experimental and chemical parameters, the proposed electrode demonstrated linearity toward the lead (II) ions in a concentration range of 15-200 µM, and 0.99852 correlation factor at 5 sec accumulation time. The detection and qualification limits were statistically calculated based on ICH guidelines as 5.72 µM and 17.32 µM, respectively. The sensor demonstrated a very good selectivity over heavy metals for instance Zn (II), Fe (III), Cr (III), Cu (II) and Mn (VI). The developed method was adequately applied for the determination of Pb (II) ions in water samples. The results obtained by the current method were compared to the acquired results utilizing ICP-OES. According to the statistical consideration, the two methods were considered identical.
{"title":"Development of chemically modified pencil graphite electrode based on benzo-18-crown-6 and multi-walled CNTs for determination of lead in water samples","authors":"Walaa Haider Elobeid, A. Elbashir","doi":"10.33945/SAMI/PCBR.2019.2.2433","DOIUrl":"https://doi.org/10.33945/SAMI/PCBR.2019.2.2433","url":null,"abstract":"An improvement to the performance of the bare pencil graphite electrode (PGE) was made by modifying it utilizing p-amino benzene sulfonic acid (p-ABSA), benzo-18-crown-6 and multi-walled carbon nanotubes (CNTs) to detect lead (II) ions in water samples using differential pulse anodic stripping voltammetric technique. The presence of p-ABSA serves as ionic conductor while the good adsorption ability and electrical conductivity of multi-walled CNTs enhanced the sensitivity through increasing the electrochemical active surface area. Furthermore, using benzo-18-crown-6 as a molecular scavenger improved the selectivity for lead (II) ions. After optimizing the experimental and chemical parameters, the proposed electrode demonstrated linearity toward the lead (II) ions in a concentration range of 15-200 µM, and 0.99852 correlation factor at 5 sec accumulation time. The detection and qualification limits were statistically calculated based on ICH guidelines as 5.72 µM and 17.32 µM, respectively. The sensor demonstrated a very good selectivity over heavy metals for instance Zn (II), Fe (III), Cr (III), Cu (II) and Mn (VI). The developed method was adequately applied for the determination of Pb (II) ions in water samples. The results obtained by the current method were compared to the acquired results utilizing ICP-OES. According to the statistical consideration, the two methods were considered identical.","PeriodicalId":20668,"journal":{"name":"Progress in Chemical and Biochemical Research","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75769132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.33945/SAMI/PCBR.2019.2.15
K. Alisher, Toshov S. Khamza, Yuldashev Sh. Ikbol
The most important aspect of modern chemistry lies in the fact that along with instrumental (physical) methods, computer modelling plays an increasing role in it. The role of molecular modelling in chemistry is quite large, despite the obvious priority of experimental research in this field of natural science. The most significant ones are theoretical results that are impossible, extremely difficult or too expensive to be obtained by experimental means.
{"title":"Quantum-chemical study of geometric and energy characteristics of some bases of shiff gossipol","authors":"K. Alisher, Toshov S. Khamza, Yuldashev Sh. Ikbol","doi":"10.33945/SAMI/PCBR.2019.2.15","DOIUrl":"https://doi.org/10.33945/SAMI/PCBR.2019.2.15","url":null,"abstract":"The most important aspect of modern chemistry lies in the fact that along with instrumental (physical) methods, computer modelling plays an increasing role in it. The role of molecular modelling in chemistry is quite large, despite the obvious priority of experimental research in this field of natural science. The most significant ones are theoretical results that are impossible, extremely difficult or too expensive to be obtained by experimental means.","PeriodicalId":20668,"journal":{"name":"Progress in Chemical and Biochemical Research","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75634958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.29088/SAMI/PCBR.2018.1.110
S. Mohammadi, A. Taheri, Zeinab Rezayati-Zad
A new enzymeless glucose sensor has been fabricated and its electrocatalytic oxidation has been investigated in alkaline medium directly on the Pt Electrode modified by Activated carbon nanotubes @ graphene oxide/ nickel hydroxide-Nafion hybrid composite (PtACNT@GONHNPsNf). Under the optimized condition, the calibration curve is linear in the concentration range of 5-1100 µM using cyclic voltammetric method. The detection limit and sensitivity are 0.75 µM and 40 nA, respectively. The glucose sensor can be renewed easily in a reproducible manner by a simple polishing step and it has a long operational lifetime and short response time t90% < 1 s. In addition, the fabrication of Pt with nafion and nickel hydroxide powder was employed to eliminate the interference of ascorbic acid during the catalytic oxidation of glucose. The biosensor was used for determination of glucose in human blood serum and the oxidant with satisfactory results.
{"title":"Ultrasensitive and selective non-enzymatic glucose detection based on pt electrode modified by carbon nanotubes@ graphene oxide/ nickel hydroxide-Nafion hybrid composite in alkaline media","authors":"S. Mohammadi, A. Taheri, Zeinab Rezayati-Zad","doi":"10.29088/SAMI/PCBR.2018.1.110","DOIUrl":"https://doi.org/10.29088/SAMI/PCBR.2018.1.110","url":null,"abstract":"A new enzymeless glucose sensor has been fabricated and its electrocatalytic oxidation has been investigated in alkaline medium directly on the Pt Electrode modified by Activated carbon nanotubes @ graphene oxide/ nickel hydroxide-Nafion hybrid composite (PtACNT@GONHNPsNf). Under the optimized condition, the calibration curve is linear in the concentration range of 5-1100 µM using cyclic voltammetric method. The detection limit and sensitivity are 0.75 µM and 40 nA, respectively. The glucose sensor can be renewed easily in a reproducible manner by a simple polishing step and it has a long operational lifetime and short response time t90% < 1 s. In addition, the fabrication of Pt with nafion and nickel hydroxide powder was employed to eliminate the interference of ascorbic acid during the catalytic oxidation of glucose. The biosensor was used for determination of glucose in human blood serum and the oxidant with satisfactory results.","PeriodicalId":20668,"journal":{"name":"Progress in Chemical and Biochemical Research","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85002505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.29088/SAMI/PCBR.2018.1.5059
A. Itodo, O. M. Itodo, E. Iornumbe, Michael Omotola Fayomi
Synthesis and Characterization of Inorganic–organic hybrid Tungsten oxide-ethylenediamine (WOx–EDA) nanowires have been carried out by a simple, low-cost and high-yield solvo-thermal method. The WOx–EDA nanowire adsorbent was characterized using, Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Energy Dispersive X-ray spectroscopy (EDX). Adsorptive potential of the hybrid for aqueous phase copper and lead removal was investigated using batch adsorption process. The equilibrium data were subjected to various isotherm models. The Langmuir model shows high applicability (R2 of 0.921) for lead uptake. Other R2 values include 0.882 (for Freundlich model), 0.947 (Temkin) and 0.972 (Dubinin- Radushkevich). Similarly, adsorption experimental runs for Cu uptake gave correlation coefficient (R2) values of 0.972, 0.584, 0.906 and 0.899 for the Langmuir, Freundlich, Temkin and Dubinin- Radushkevich isotherm models respectively. Overall, Tungsten oxide ethylenediamine adsorbent proved its potential candidature for the chelating treatment of Pb and Cu poisoning as well as purifications of water containing such metals. Sorptive chelation of metals by inorganic functionalized organic WOx–EDA nanowires: adsorbent characterization and isotherm studies
{"title":"Sorptive chelation of metals by inorganic functionalized organic WOx–EDA nanowires: adsorbent characterization and isotherm studies","authors":"A. Itodo, O. M. Itodo, E. Iornumbe, Michael Omotola Fayomi","doi":"10.29088/SAMI/PCBR.2018.1.5059","DOIUrl":"https://doi.org/10.29088/SAMI/PCBR.2018.1.5059","url":null,"abstract":"Synthesis and Characterization of Inorganic–organic hybrid Tungsten oxide-ethylenediamine (WOx–EDA) nanowires have been carried out by a simple, low-cost and high-yield solvo-thermal method. The WOx–EDA nanowire adsorbent was characterized using, Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Energy Dispersive X-ray spectroscopy (EDX). Adsorptive potential of the hybrid for aqueous phase copper and lead removal was investigated using batch adsorption process. The equilibrium data were subjected to various isotherm models. The Langmuir model shows high applicability (R2 of 0.921) for lead uptake. Other R2 values include 0.882 (for Freundlich model), 0.947 (Temkin) and 0.972 (Dubinin- Radushkevich). Similarly, adsorption experimental runs for Cu uptake gave correlation coefficient (R2) values of 0.972, 0.584, 0.906 and 0.899 for the Langmuir, Freundlich, Temkin and Dubinin- Radushkevich isotherm models respectively. Overall, Tungsten oxide ethylenediamine adsorbent proved its potential candidature for the chelating treatment of Pb and Cu poisoning as well as purifications of water containing such metals. Sorptive chelation of metals by inorganic functionalized organic WOx–EDA nanowires: adsorbent characterization and isotherm studies","PeriodicalId":20668,"journal":{"name":"Progress in Chemical and Biochemical Research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85181100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.29088/SAMI/PCBR.2018.1.4049
G. Vinodhkumar, R. Ramya, M. Vimalan, I. Potheher, Cyrac Peter
Reduced graphene oxide (rGO) is synthesized using strong oxidizing agents with the help of chemical reduction method. Structural and physiochemical properties of the prepared sample are studied by ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). UV-Vis spectra of GO exhibit maximum absorption peak attributable to restoration of sp2carbon. Electrochemical study performed for bare and rGO modified glassy carbon electrode. Electrochemical sensing of Dopamine (DA) and Uric Acid (UA) was examined by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and square wave voltammetry (SWV) were conducted in phosphate buffer solution (PBS) at pH = 7.0 done for both simultaneous and individual determination of DA and UA in the range of 500nM – 1mM exhibit a wide linear range of detection and having low limit of detection (LOD) of 0.67µM for DA, and 0.69µM for UA estimated for simultaneous determination and in individual determination it was found to be 0.51µM and 0.42µM for DA and UA respectively. Additionally, the modified electrode exhibits good reproducibility, selectivity, sensitivity and stability. The proposed sensor could be applied for the determination of DA and UA in real samples.
{"title":"Reduced graphene oxide based on simultaneous detection of neurotransmitters","authors":"G. Vinodhkumar, R. Ramya, M. Vimalan, I. Potheher, Cyrac Peter","doi":"10.29088/SAMI/PCBR.2018.1.4049","DOIUrl":"https://doi.org/10.29088/SAMI/PCBR.2018.1.4049","url":null,"abstract":"Reduced graphene oxide (rGO) is synthesized using strong oxidizing agents with the help of chemical reduction method. Structural and physiochemical properties of the prepared sample are studied by ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). UV-Vis spectra of GO exhibit maximum absorption peak attributable to restoration of sp2carbon. Electrochemical study performed for bare and rGO modified glassy carbon electrode. Electrochemical sensing of Dopamine (DA) and Uric Acid (UA) was examined by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and square wave voltammetry (SWV) were conducted in phosphate buffer solution (PBS) at pH = 7.0 done for both simultaneous and individual determination of DA and UA in the range of 500nM – 1mM exhibit a wide linear range of detection and having low limit of detection (LOD) of 0.67µM for DA, and 0.69µM for UA estimated for simultaneous determination and in individual determination it was found to be 0.51µM and 0.42µM for DA and UA respectively. Additionally, the modified electrode exhibits good reproducibility, selectivity, sensitivity and stability. The proposed sensor could be applied for the determination of DA and UA in real samples.","PeriodicalId":20668,"journal":{"name":"Progress in Chemical and Biochemical Research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75050592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.29088/SAMI/PCBR.2018.1.2939
Onoshe Solomon, W. R. S. Umar, H. Wara, A. Yakubu, Madusolumou Michael Azubuike, M. A. Mary, H. Louis
Peptic ulcer disease is one of the most prevalent gastrointestinal disorders causing tremendous human suffering worldwide. The present study was designed to evaluate the antiulcerogenic activity of the methanol and solvent stem bark fractions (hexane, ethyl acetate and butanol) and elucidate their possible antiulcerogenic mechanisms. The antiulcerogenic mechanisms were investigated by estimation of Superoxide dismutase (SOD), Glutathione (GSH), Catalase (CAT), Vitamins A, C and E, Malondialdehyde (MDA) and involvement of KATP channel. Pretreatment with the methanol extract and solvent fractions produce significant reductions in ulcer index in a dose dependent manner. Ethylacetate fraction (EtyAc) showed the highest antiulcer activity. Elevated MDA and decreased levels of SOD, GSH, CAT, Vitamin A, C and E observed in ulcer control groups were significantly decreased and increased respectively in the EtyAc fraction treated groups. Antiulcer activity of the EtyAc fraction was blocked upon coadministration with glibenclamide; a KATP channel blocker. The stem bark extract of Lannea acida possess antiulcerogenic activity and the mechanisms seems to involve antioxidant activity and KATP channel opening.
{"title":"Antiulcerogenic Activity of methanol extract and solvent fractions of Stem Bark of Lannea acida (A. Rich) Against Ethanol-Induced Gastric Mucosal Injury in Albino Rats","authors":"Onoshe Solomon, W. R. S. Umar, H. Wara, A. Yakubu, Madusolumou Michael Azubuike, M. A. Mary, H. Louis","doi":"10.29088/SAMI/PCBR.2018.1.2939","DOIUrl":"https://doi.org/10.29088/SAMI/PCBR.2018.1.2939","url":null,"abstract":"Peptic ulcer disease is one of the most prevalent gastrointestinal disorders causing tremendous human suffering worldwide. The present study was designed to evaluate the antiulcerogenic activity of the methanol and solvent stem bark fractions (hexane, ethyl acetate and butanol) and elucidate their possible antiulcerogenic mechanisms. The antiulcerogenic mechanisms were investigated by estimation of Superoxide dismutase (SOD), Glutathione (GSH), Catalase (CAT), Vitamins A, C and E, Malondialdehyde (MDA) and involvement of KATP channel. Pretreatment with the methanol extract and solvent fractions produce significant reductions in ulcer index in a dose dependent manner. Ethylacetate fraction (EtyAc) showed the highest antiulcer activity. Elevated MDA and decreased levels of SOD, GSH, CAT, Vitamin A, C and E observed in ulcer control groups were significantly decreased and increased respectively in the EtyAc fraction treated groups. Antiulcer activity of the EtyAc fraction was blocked upon coadministration with glibenclamide; a KATP channel blocker. The stem bark extract of Lannea acida possess antiulcerogenic activity and the mechanisms seems to involve antioxidant activity and KATP channel opening.","PeriodicalId":20668,"journal":{"name":"Progress in Chemical and Biochemical Research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81106174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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