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Psychopharmacologia最新文献

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Lithium and the transfer rate of sodium across the blood-brain barrier 锂离子和钠离子通过血脑屏障的传输速率
Psychopharmacologia
Pub Date : 2004-01-01 DOI: 10.1007/BF00403777
A. Amdisen, M. Schou
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引用次数: 1
Morphine-induced inhibition of different pain responses in relation to the regional turnover of rat brain noradrenaline and dopamine 吗啡诱导的不同疼痛反应的抑制与大鼠脑去甲肾上腺素和多巴胺的区域转换有关
Psychopharmacologia
Pub Date : 2004-01-01 DOI: 10.1007/BF00426204
G. Paalzow, L. Paalzow
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引用次数: 15
Behavioral effects of intracerebrally administered catecholamines in mice and their modifications by some adrenergic blocking agents 脑内给药儿茶酚胺对小鼠行为的影响及其被一些肾上腺素能阻断剂所改变
Psychopharmacologia
Pub Date : 2004-01-01 DOI: 10.1007/BF00426214
B. Pellegrini Quarantotti, A. S. Carolis, V. Longo
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引用次数: 0
A comparison of the analgetic potency of some analgesics as measured by the “flinch-jump” procedure 用“退缩-跳跃”方法测定的几种镇痛药的镇痛效力的比较
Psychopharmacologia
Pub Date : 2004-01-01 DOI: 10.1007/BF00413106
W. O. Evans
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引用次数: 5
Pharmacological dissociation between vocalization and biting produced in rats by the combination of imipramine and isocarboxazid 丙咪嗪和异嘧唑嗪联合用药对大鼠发声和咬伤的药理学分离作用
Psychopharmacologia
Pub Date : 2004-01-01 DOI: 10.1007/BF00426212
G. Zetler, B. HÄuer
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引用次数: 0
Metabolism of 5-hydroxytryptophan-14c after intracisternal injection with and without the influence of drugs in the rat brain 5-羟色氨酸-14c在有和无药物影响的大鼠脑内注射后的代谢
Psychopharmacologia
Pub Date : 2004-01-01 DOI: 10.1007/BF00426207
P. Baumann
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引用次数: 2
The effect of psychotropic drugs on food reinforced behaviour and on food consumption 精神药物对食物强化行为和食物消费的影响
Psychopharmacologia
Pub Date : 2004-01-01 DOI: 10.1007/BF00403774
J. Bainbridge
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引用次数: 25
Critical flicker frequency (CFF) and psychotropic drugs in normal human subjects-a review. 临界闪烁频率(CFF)与正常人的精神药物研究进展。
Psychopharmacologia
Pub Date : 1976-05-28 DOI: 10.1007/BF00735818
J M Smith, H Misiak

This literature review presents summary methodological and statistical data on 33 studies in which critical flicker frequency (CFF) thresholds were used to evaluate the effects of acute oral doses of single psychotropic drugs in normal human subjects. In all, 96 drug-dose-study combinations are represented. CFF was found to be altered to a statistically significant degree (P is less than 0.05) in 51 (65%) of the 79 instances in which inferential statistical methods were used to evaluate the results. As expected, stimulants increased CFF while hypnotics decreased it. There is also a discussion of important methodological considerations in the design of psychopharmacological studies employing CFF. While many studies have shown CFF to be sensitive to the effects of psychotropic drugs, there have not always been adequate controls for extraneous factors (especially, set and suggestion, changes in pupillary diameter, and the presence of other commonly used drugs). Finally, consideration is given to the attempts to increase the sensitivity of the CFF test to drug effects.

本文综述了33项研究的方法学和统计学数据，这些研究使用临界闪烁频率(CFF)阈值来评估急性口服单一精神药物对正常人的影响。总共有96种药物剂量研究组合。在采用推理统计方法评价结果的79例病例中，有51例(65%)的CFF发生了统计学显著性改变(P < 0.05)。正如预期的那样，兴奋剂增加了CFF，而催眠药则降低了它。本文还讨论了采用CFF设计精神药理学研究时的重要方法学考虑。虽然许多研究表明CFF对精神药物的影响很敏感，但对于外部因素(特别是set和suggestion，瞳孔直径的变化，以及其他常用药物的存在)并不总是有足够的控制。最后，考虑到试图提高CFF试验对药物效应的敏感性。
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引用次数: 108
Effect of doxepin on uptake and efflux of serotonin human blood patelets in vitro. 多虑平对体外人血小板5 -羟色胺摄取和排出的影响。
Psychopharmacologia
Pub Date : 1976-05-28 DOI: 10.1007/BF00735819
O Lingjaerde

It is shown that the tricyclic antidepressant drug doxepin (comprising 15% of the cis- and 85% of the trans-isomer) is a moderately potent competitive inhibitor of serotonin uptake in human blood platelets in vitro, with an inhibitory constant Ki of about 2 X 10(-7) M. The inhibitory effect was 6 times stronger in an artificial, protein-free medium than in diluted plasma, corresponding to about 85% protein binding. The efflux of serotonin from platelets preloaded with 14C-serotonin was not affected by doxepin in concentrations up to 10(-6) M, but increased rapidly at concentrations above 10(-4) M.

研究表明，三环抗抑郁药物doxepin(包含15%的顺式异构体和85%的反式异构体)是一种中等强效的体外人血小板血清素摄取竞争性抑制剂，其抑制常数Ki约为2 × 10(-7) M.在人工无蛋白培养基中抑制效果比稀释血浆强6倍，相当于约85%的蛋白质结合。在10(-6)M浓度下，预载14c - 5 -羟色胺的血小板的血清素外排不受多虑平的影响，但在10(-4)M浓度以上时，血清素外排迅速增加。
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引用次数: 2
Abolition of the hippocampal theta activity and drug-learning dissociation. 海马θ波活动的消除和药物学习解离。
Psychopharmacologia
Pub Date : 1976-05-28 DOI: 10.1007/BF00735823
N Irisawa, S Iwahara, S Fukuda

Rats were trained to escape electric shock by running into one arm of a T-maze on 10-trial daily sessions with pentobarbital (10 mg/kg), and to the opposite arm of the maze on other sessions with saline, the drug and saline sessions being alternated. This drug-learning dissociation or state-dependent learning was achieved by rats with medial septal lesions, abolishing hippocampal theta activity, as efficiently as rats with cortical lesions and intact rats. The suggested relationship between drug-learning dissociation and the suppression of hippocampal theta waves, produced by the drug, was not evidenced.

大鼠被训练成通过每天10次的戊巴比妥(10毫克/公斤)跑进t型迷宫的一只手臂来逃避电击，并在其他阶段用生理盐水跑到迷宫的另一只手臂，药物和生理盐水交替使用。这种药物学习分离或状态依赖学习是由内侧间隔损伤的大鼠实现的，海马theta活动消失，与皮质损伤的大鼠和完好的大鼠一样有效。药物学习分离与药物产生的海马θ波抑制之间的关系尚未得到证实。
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引用次数: 0
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