Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.pa502
Khalil Bahri, S. Mhamdi, S. Daboussi, Asma Riahi, Imen Yousfi, I. Mejri, C. Aichaouia, Ziad Moatamri, M. Khadhraoui
{"title":"Covid-19 and pulmonary embolism : A heterogeneous association","authors":"Khalil Bahri, S. Mhamdi, S. Daboussi, Asma Riahi, Imen Yousfi, I. Mejri, C. Aichaouia, Ziad Moatamri, M. Khadhraoui","doi":"10.1183/13993003.congress-2021.pa502","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.pa502","url":null,"abstract":"","PeriodicalId":20797,"journal":{"name":"Pulmonary embolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77729796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.pa510
Asiye Büşra Çimen, A. F. Kalpaklioglu
{"title":"Comparison of acute phase reactant pentraksin-3 and inflammatory parameters in acute and stable pulmonary embolism","authors":"Asiye Büşra Çimen, A. F. Kalpaklioglu","doi":"10.1183/13993003.congress-2021.pa510","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.pa510","url":null,"abstract":"","PeriodicalId":20797,"journal":{"name":"Pulmonary embolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85882938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.oa2591
K. Bartziokas, C. Kyriakopoulos, A. Gogali, Dimitrios Potonos, K. Exarchos, C. Chronis, K. Kostikas
{"title":"The role of uric acid to creatinine ratio as predictor marker during pulmonary embolism","authors":"K. Bartziokas, C. Kyriakopoulos, A. Gogali, Dimitrios Potonos, K. Exarchos, C. Chronis, K. Kostikas","doi":"10.1183/13993003.congress-2021.oa2591","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.oa2591","url":null,"abstract":"","PeriodicalId":20797,"journal":{"name":"Pulmonary embolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79688649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.pa500
S. Meitei, S. Tale, A. Negi, R. Dua, R. Walia, S. Saxena
{"title":"Prevalence and characteristics of venous thromboembolism in severe exacerbation of COPD in a tertiary care hospital in India","authors":"S. Meitei, S. Tale, A. Negi, R. Dua, R. Walia, S. Saxena","doi":"10.1183/13993003.congress-2021.pa500","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.pa500","url":null,"abstract":"","PeriodicalId":20797,"journal":{"name":"Pulmonary embolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84927587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.pa504
C. Kyriakopoulos, K. Bartziokas, A. Gogali, K. Tatsis, C. Chronis, Dimitrios Potonos, G. Gkrepi, K. Kostikas
{"title":"Biomarkers model for prediction of hospitalisation duration and pulmonary embolism outcome","authors":"C. Kyriakopoulos, K. Bartziokas, A. Gogali, K. Tatsis, C. Chronis, Dimitrios Potonos, G. Gkrepi, K. Kostikas","doi":"10.1183/13993003.congress-2021.pa504","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.pa504","url":null,"abstract":"","PeriodicalId":20797,"journal":{"name":"Pulmonary embolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83763177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-07DOI: 10.1183/13993003.congress-2020.4976
S. Toor, H. McAuley, R. Spriggs, E. Bailie, N. Parmar, N. Greening
Background: Despite routine use of the Wells score and D-Dimers (DD), high proportions of CTPAs are negative, increasing unnecessary exposure to the risks of CT contrast and radiation. Variable presentation and high perceived risk of missed PEs makes risk stratification complex. The YEARS algorithm offers a more specific tool to reduce the number of CTPAs performed without increased risk. Methods: This audit applied the YEARS algorithm to ambulatory patients who had undergone CTPA for suspected PE, treated based on Wells score and DD. Patients were stratified as either high or low risk by the presence of any one of the YEARS items: clinical signs of DVT, PE the most likely diagnosis, haemoptysis. DD cut offs for ruling out PE were applied: ≤500 ng/mL for high risk and ≤1000 ng/mL for low risk. The outcome measures were the number of positive CTPAs missed and the number of CTPAs avoided. Results: 1527 events were reviewed with 485 (32%) included in our analysis. Detailed findings are shown in figure 1. Two CTPAs (0.4% of scans) were positive for PE, which may not have been performed using the YEARS algorithm (one sub-segmental PE and one PE with atypical history and borderline DD of 990 ng/mL). Application of the YEARS algorithm would have avoided 121 (25%) of all CTPAs. Conclusion: In this audit, application of the YEARS algorithm potentially reduced CTPAs by 25% without significant increased risk.
{"title":"Retrospective application of the YEARS algorithm to an ambulatory PE clinic cohort","authors":"S. Toor, H. McAuley, R. Spriggs, E. Bailie, N. Parmar, N. Greening","doi":"10.1183/13993003.congress-2020.4976","DOIUrl":"https://doi.org/10.1183/13993003.congress-2020.4976","url":null,"abstract":"Background: Despite routine use of the Wells score and D-Dimers (DD), high proportions of CTPAs are negative, increasing unnecessary exposure to the risks of CT contrast and radiation. Variable presentation and high perceived risk of missed PEs makes risk stratification complex. The YEARS algorithm offers a more specific tool to reduce the number of CTPAs performed without increased risk. Methods: This audit applied the YEARS algorithm to ambulatory patients who had undergone CTPA for suspected PE, treated based on Wells score and DD. Patients were stratified as either high or low risk by the presence of any one of the YEARS items: clinical signs of DVT, PE the most likely diagnosis, haemoptysis. DD cut offs for ruling out PE were applied: ≤500 ng/mL for high risk and ≤1000 ng/mL for low risk. The outcome measures were the number of positive CTPAs missed and the number of CTPAs avoided. Results: 1527 events were reviewed with 485 (32%) included in our analysis. Detailed findings are shown in figure 1. Two CTPAs (0.4% of scans) were positive for PE, which may not have been performed using the YEARS algorithm (one sub-segmental PE and one PE with atypical history and borderline DD of 990 ng/mL). Application of the YEARS algorithm would have avoided 121 (25%) of all CTPAs. Conclusion: In this audit, application of the YEARS algorithm potentially reduced CTPAs by 25% without significant increased risk.","PeriodicalId":20797,"journal":{"name":"Pulmonary embolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83621038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-01DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6045
Anna Francesca Mulles, Amraphel Nicolas, H. H. Chiu, R. E. Villalobos
Background: Venous thromboembolism (VTE) is a serious complication among cancer patients necessitating hospitalization. Current guidelines recommend anticoagulation using low molecular weight heparins (LMWH) for prevention of VTE. Recent studies have also demonstrated the efficacy of direct oral anticoagulants (DOACs) in the prevention of VTE among cancer patients. We aimed to assess the efficacy of DOACs and LMWH in primary prevention of VTE among cancer patients, and evaluate the risks of bleeding. Methods: Electronic databases were searched for randomized trials evaluating LMWH and DOACs versus placebo as primary prevention for VTE among cancer patients. The primary outcomes were VTE events and incidence of major and minor bleeding. Studies were assessed using the Cochrane Handbook for Systematic Reviews of Interventions. Results were calculated via RevMan Version 5.3 using fixed-effect modelling. Results: Seven randomized trials (two on DOACs; five on LMWHs) with 7073 patients were included. Both DOACs [RR 0.57; 95% CI 0.38, 0.84, p = 0.004] and LMWH [RR 0.49; CI 95% 0.36, 0.65, p Conclusion: Both DOACs and LMWH are effective in the prevention of VTE among cancer patients without an increase in risk for major bleeding. Compared to LMWH, DOAC may be associated with decreased risk of major bleeding.
背景:静脉血栓栓塞(VTE)是癌症患者中一种严重的并发症，需要住院治疗。目前的指南推荐使用低分子肝素(LMWH)抗凝来预防静脉血栓栓塞。最近的研究也证明了直接口服抗凝剂(DOACs)在预防癌症患者静脉血栓栓塞(VTE)方面的疗效。我们的目的是评估DOACs和低分子肝素在癌症患者静脉血栓栓塞一级预防中的疗效，并评估出血风险。方法:在电子数据库中检索评估低分子肝素和DOACs与安慰剂作为癌症患者静脉血栓栓塞一级预防的随机试验。主要结局是静脉血栓栓塞事件和大出血和小出血的发生率。使用Cochrane干预措施系统评价手册对研究进行评估。结果通过RevMan Version 5.3使用固定效应建模计算。结果:7项随机试验(2项针对DOACs;5例LMWHs)，共7073例患者。两个DOACs [RR 0.57;95% CI 0.38, 0.84, p = 0.004]和低分子肝素[RR 0.49;结论:DOACs和低分子肝素均可有效预防肿瘤患者静脉血栓栓塞，且未增加大出血风险。与低分子肝素相比，DOAC可能与大出血风险降低有关。
{"title":"Direct oral anticoagulants and low-molecular weight heparin for primary prevention of venous thromboembolism in cancer patients: a meta-analysis","authors":"Anna Francesca Mulles, Amraphel Nicolas, H. H. Chiu, R. E. Villalobos","doi":"10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6045","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6045","url":null,"abstract":"Background: Venous thromboembolism (VTE) is a serious complication among cancer patients necessitating hospitalization. Current guidelines recommend anticoagulation using low molecular weight heparins (LMWH) for prevention of VTE. Recent studies have also demonstrated the efficacy of direct oral anticoagulants (DOACs) in the prevention of VTE among cancer patients. We aimed to assess the efficacy of DOACs and LMWH in primary prevention of VTE among cancer patients, and evaluate the risks of bleeding. Methods: Electronic databases were searched for randomized trials evaluating LMWH and DOACs versus placebo as primary prevention for VTE among cancer patients. The primary outcomes were VTE events and incidence of major and minor bleeding. Studies were assessed using the Cochrane Handbook for Systematic Reviews of Interventions. Results were calculated via RevMan Version 5.3 using fixed-effect modelling. Results: Seven randomized trials (two on DOACs; five on LMWHs) with 7073 patients were included. Both DOACs [RR 0.57; 95% CI 0.38, 0.84, p = 0.004] and LMWH [RR 0.49; CI 95% 0.36, 0.65, p Conclusion: Both DOACs and LMWH are effective in the prevention of VTE among cancer patients without an increase in risk for major bleeding. Compared to LMWH, DOAC may be associated with decreased risk of major bleeding.","PeriodicalId":20797,"journal":{"name":"Pulmonary embolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83130479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1007/978-3-030-51736-6_7
P. Guichet, A. Sista
{"title":"Endovascular Techniques in the Treatment of Acute PE","authors":"P. Guichet, A. Sista","doi":"10.1007/978-3-030-51736-6_7","DOIUrl":"https://doi.org/10.1007/978-3-030-51736-6_7","url":null,"abstract":"","PeriodicalId":20797,"journal":{"name":"Pulmonary embolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76923609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1007/978-3-030-51736-6
B. Rivera-Lebron, G. Heresi
{"title":"Pulmonary Embolism: From Acute PE to Chronic Complications","authors":"B. Rivera-Lebron, G. Heresi","doi":"10.1007/978-3-030-51736-6","DOIUrl":"https://doi.org/10.1007/978-3-030-51736-6","url":null,"abstract":"","PeriodicalId":20797,"journal":{"name":"Pulmonary embolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78773003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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