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Intravoxel incoherent motion MRI to assess feto-placental diffusion and perfusion properties in small fetuses. 体内非相干运动核磁共振成像评估小胎儿的胎盘弥散和灌注特性。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-14 DOI: 10.1007/s11547-024-01918-4
Giada Ercolani, Silvia Capuani, Veronica Celli, Sandra Ciulla, Roberta Ninkova, Marco Gennarini, Valentina Miceli, Robert Grimm, Daniele Di Mascio, Maria Grazia Porpora, Antonella Giancotti, Carlo Catalano, Lucia Manganaro

Objectives: To investigate the use of intravoxel incoherent motion (IVIM) to study microperfusion and microstructural characteristics of lungs, brain, and placenta in normal and small fetuses.

Methods: We retrospectively enrolled 30 small fetuses and 82 normal pregnancies who underwent a 1.5-T MRI examination using an IVIM-DWI. Small fetuses were distinguished in small for gestational age (SGA) and "true" fetal growth restriction (FGR). ROIs were placed on the brain parenchyma, lungs, and fetal/maternal placental sides. Differences in perfusion fraction f, diffusion coefficient D, and pseudo-diffusion coefficient D* and their correlation with gestational age (GA) and birth weight (BW) were investigated.

Results: LUNG: f showed significantly lower values (p = 2·10-7) in small fetuses (SGA + FGR); f discriminates SGA and FGR from normal (p = 0.001; p = 1·10-6). f increases with GA (p < 0.0001) in the control group; a positive correlation was also obtained in small fetuses, although less significant.

Placenta: FGR showed lower f values than normal ones, in both the fetal (p = 1.4·10-7) and maternal side (p = 0.001); f discriminates between SGA and FGR (p = 0.03). In small fetuses (SGA + FGR), f correlates positively with BW.

Brain: D values in supratentorial white matter (WM) were significantly higher compared to other regions, in both normal and small fetuses. Small fetuses showed higher D values in occipital WM and pons (p = 0.041; p = 0.027) than in normal. D correlates negatively with GA in the healthy group. No correlation between D and GA was found in SGA + FGR group.

Conclusions: In our study, IVIM-MRI allowed us to detect microstructural and microperfusion changes in the placenta, brain, and lung of small fetuses, noninvasively.

目的:研究正常胎儿和小胎儿肺、脑和胎盘的微灌注和微结构特征:研究利用体细胞内非相干运动(IVIM)研究正常胎儿和小胎儿肺、脑和胎盘的微灌注和微结构特征:我们回顾性地选取了30名小胎儿和82名正常孕妇,使用IVIM-DWI进行了1.5T磁共振成像检查。矮小胎儿分为小胎龄(SGA)和 "真正的 "胎儿生长受限(FGR)。在脑实质、肺部和胎儿/母体胎盘侧放置 ROI。研究了灌注分数 f、扩散系数 D 和假扩散系数 D* 的差异及其与胎龄(GA)和出生体重(BW)的相关性:肺:小胎儿(SGA + FGR)的 f 值明显较低(p = 2-10-7);f 能区分 SGA 和 FGR 与正常胎儿(p = 0.001;p = 1-10-6):在胎儿(p = 1.4-10-7)和母体(p = 0.001)两侧,FGR 的 f 值均低于正常胎儿(p = 1.4-10-7);f 可区分 SGA 和 FGR(p = 0.03)。在矮小胎儿(SGA + FGR)中,f 与 BW.Brain.D 值呈正相关:正常胎儿和矮小胎儿脑室上白质(WM)的 D 值均显著高于其他区域。矮小胎儿枕叶白质和脑桥的 D 值(p = 0.041;p = 0.027)高于正常胎儿。在健康组中,D 与 GA 呈负相关。结论:在我们的研究中,IVIM-MRI 使我们能够无创检测小胎儿胎盘、大脑和肺部的微结构和微灌注变化。
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引用次数: 0
BPE on contrast-enhanced mammography: relationship with breast density, age and menopausal status. 造影剂增强乳腺 X 光造影的 BPE:与乳腺密度、年龄和绝经状态的关系。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-13 DOI: 10.1007/s11547-024-01912-w
Giuliana Moffa, Francesca Galati, Alessandra Spagnoli, Elena Fabrizi, Roberto Maroncelli, Sara Coppola, Veronica Rizzo, Federica Pediconi

Purpose: This retrospective study aimed to evaluate the relationship between BPE on CEM and breast density, age and menopausal status.

Material and methods: Our analysis included all women eligible for CEM as a second-level examination in the diagnostic phase in a 12-month period. CEM were performed on a dedicated low-dose digital mammography unit after the injection of 1.5 ml/kg body weight Iohexol 350 mgI/ml. Both breast composition and BPE were assessed independently by two breast radiologists according to the CEM supplement to the 2013 ACR BI-RADS Mammography. A two-stage ordered probit regression model was fitted to evaluate the relationship between BPE and the other factors considered.

Results: 49 patients were included (median age = 55 years, 28.6% premenopausal and 71.4% postmenopausal). Breast composition was classified as ACR BI-RADS a in 4.1%, ACR BI-RADS b in 36.7%, ACR BI-RADS c in 46.9%, and ACR BI-RADS d in 12.2% of cases, by both Readers. A BPE 1 category was assigned in 53.1-55.1% of patients (by Reader 1 and 2, respectively), BPE 2 in 22.4%, BPE 3 in 18.4-12.2%, and BPE 4 in 6.1-10.2%. Higher breast density was strongly associated with higher levels of BPE, while BPE was not directly associated with age, both in fertile and postmenopausal patients. No significant differences were observed between the two Readers.

Conclusion: Increased BPE is associated with a well-established breast cancer risk factor as high breast density, while it was not directly dependent on the other non-modifiable factors considered.

目的:这项回顾性研究旨在评估 CEM 的 BPE 与乳腺密度、年龄和绝经状态之间的关系:我们的分析包括 12 个月内所有符合 CEM 作为诊断阶段二级检查条件的女性。在注射 1.5 毫升/千克体重的碘海醇(Iohexol)350 毫克/毫升后,在专用的低剂量数字乳腺 X 光机上进行 CEM 检查。乳房成分和 BPE 均由两名乳腺放射科医生根据 2013 年 ACR BI-RADS 乳房 X 线照相术 CEM 补充标准进行独立评估。采用两阶段有序 probit 回归模型评估 BPE 与其他考虑因素之间的关系:共纳入 49 名患者(中位年龄 = 55 岁,28.6% 为绝经前,71.4% 为绝经后)。两种阅读器将 4.1% 的乳腺组织分为 ACR BI-RADS a、36.7% 的乳腺组织分为 ACR BI-RADS b、46.9% 的乳腺组织分为 ACR BI-RADS c、12.2% 的乳腺组织分为 ACR BI-RADS d。53.1%-55.1%的患者属于 BPE 1 类(分别由阅读器 1 和阅读器 2 评定),22.4%的患者属于 BPE 2 类,18.4%-12.2%的患者属于 BPE 3 类,6.1%-10.2%的患者属于 BPE 4 类。在生育期和绝经后患者中,乳腺密度越高与 BPE 水平越高密切相关,而 BPE 与年龄没有直接关系。结论:BPE的增加与高乳腺密度这一公认的乳腺癌风险因素有关,而与其他非可变因素没有直接关系。
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引用次数: 0
Metastasis-directed ablation of hepatocellular carcinoma with pulmonary oligometastases: a long-term multicenter study. 转移灶定向消融治疗伴肺部寡转移的肝癌:一项长期多中心研究。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-12 DOI: 10.1007/s11547-024-01907-7
Qunfang Zhou, Ruixia Li, Songsong Wu, Yanyang Zhang, Wei Wang, Kangshun Zhu, Murong Wang, Zhimei Huang, Feng Duan

Purpose: Ablation is a promising approach for eliminating intrathoracic metastases. We compared the effectiveness of a combination of metastasis-directed ablation and systemic therapy with that of systemic therapy alone for patients with hepatocellular carcinoma (HCC) having pulmonary oligometastases.

Materials and methods: We analyzed 679 patients with HCC and pulmonary oligometastases from seven tertiary hospitals. A total of 372 patients received systemic therapy (System group), whereas 307 patients received the combination therapy of pulmonary oligometastases ablation and systemic therapy (Ablation + System group).

Results: The median progression-free survival (PFS) was 9.7 ± 0.6 and 11.5 ± 0.6 months in the System and Ablation + System groups, respectively. The Ablation + System group exhibited significantly better PFS (hazard ratio [HR], 0.71; 95% confidence interval [CI] 0.60-0.85; P < 0.001) and overall survival (OS) (HR, 0.65; 95% CI 0.52-0.81; P < 0.001) than the System group. The subgroup analysis revealed that OS (HR, 0.91; 95% CI 0.65-1.28; P = 0.590) and PFS (HR, 0.81; 95% CI 0.62-1.05; P = 0.100) did not differ between tyrosine kinase inhibitor (TKI) and TKI plus programmed cell death protein-1 (PD-1) inhibitor therapies in the Ablation + system group. In addition, PFS (HR, 0.53; 95% CI 0.38-0.74; P < 0.001) and OS (HR, 0.66; 95% CI 52-0.84; P < 0.001) showed obviously different for intrahepatic tumors with partial response (PR) status.

Conclusion: The application of a combination of ablation of pulmonary oligometastases and systemic therapy resulted in longer PFS and OS than systemic therapy alone.

目的:消融术是消除胸腔内转移灶的一种很有前景的方法。我们比较了转移灶定向消融术和全身治疗相结合与单纯全身治疗对伴有肺寡转移灶的肝细胞癌(HCC)患者的疗效:我们分析了来自七家三级医院的 679 例 HCC 和肺寡转移患者。共有372名患者接受了系统治疗(系统组),307名患者接受了肺寡转移灶消融和系统治疗的联合治疗(消融+系统组):系统组和消融+系统组的中位无进展生存期(PFS)分别为(9.7±0.6)个月和(11.5±0.6)个月。消融+系统组的无进展生存期明显更好(危险比[HR],0.71;95%置信区间[CI],0.60-0.85;P联合应用肺寡转移灶消融术和全身治疗比单独使用全身治疗的PFS和OS更长。
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引用次数: 0
Interictal EEG spikes increase perfusion in low-grade epilepsy-associated tumors: a pediatric arterial spin labeling study. 发作间期脑电图尖峰增加低度癫痫相关肿瘤的灌注:一项儿科动脉自旋标记研究。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-12 DOI: 10.1007/s11547-024-01923-7
Antonio Giulio Gennari, Giulio Bicciato, Santo Pietro Lo Biundo, Raimund Kottke, Dorottya Cserpan, Ruth Tuura O'Gorman, Georgia Ramantani

Purpose: Arterial spin labeling (ASL), a noninvasive magnetic resonance (MRI) perfusion sequence, holds promise in the presurgical evaluation of pediatric lesional epilepsy patients, including those with low-grade epilepsy-associated tumors (LEATs). The interpretation of ASL-derived perfusion patterns, however, presents challenges. Our study aims to elucidate these perfusion changes in children with LEATs, exploring their correlations with clinical, electroencephalography (EEG), and anatomical MRI findings.

Material and methods: Our cohort included 15 children with LEAT-associated focal lesional epilepsy who underwent single-delay pseudo-continuous ASL imaging; eight were imaged under sedation. We assessed perfusion images both qualitatively and quantitatively, focusing on LEAT-related perfusion changes, as indicated by the asymmetry index (AI) and regional cerebral blood flow (rCBF).

Results: ASL revealed LEAT-related perfusion changes in all but two patients: 12 LEATs were hypoperfused and one was hyperperfused relative to the contralateral brain parenchyma (CBP). LEATs showed significantly lower perfusion compared to CBP (median: 38.7 vs. 59.1 mL/100 g/min for LEAT and CBP, respectively; p value = 0.004, Wilcoxon-Mann-Whitney), regardless of sedation. Notably, elevated AI and rCBF values correlated with interictal spikes on EEG (median: -0.008 and 0.84 vs -0.27 and 0.58, respectively), but not to other clinical, EEG, or MRI variables (p value = 0.036, Wilcoxon-Mann-Whitney).

Conclusions: By highlighting the connection between LEAT and brain perfusion, and by correlating perfusion characteristics and epileptogenicity, our research enhanced our understanding of pediatric epilepsy associated with LEATs. Also, by proving the robustness of these findings to sedation we confirmed the importance of adding ASL to epilepsy protocols to as a valuable tool to supplement anatomical imaging.

目的:动脉自旋标记(ASL)是一种无创磁共振(MRI)灌注序列,有望用于小儿病灶性癫痫患者(包括低级别癫痫相关肿瘤(LEATs)患者)的术前评估。然而,ASL衍生灌注模式的解释却面临挑战。我们的研究旨在阐明LEATs患儿的这些灌注变化,探讨它们与临床、脑电图(EEG)和解剖磁共振成像结果的相关性:我们的队列包括15名接受单延时伪连续ASL成像的LEAT相关局灶性病变癫痫患儿;其中8名患儿是在镇静状态下接受成像的。我们对灌注图像进行了定性和定量评估,重点关注LEAT相关的灌注变化,如不对称指数(AI)和区域脑血流(rCBF)所示:除两名患者外,其他所有患者的 ASL 均显示出与 LEAT 相关的灌注变化:相对于对侧脑实质(CBP),12 例 LEAT 脑灌注不足,1 例高灌注。与 CBP 相比,LEAT 的灌注量明显较低(中位数为 38.7,而 CBP 为 59.1):无论镇静与否,LEAT 和 CBP 的灌注量分别为 38.7 mL/100 g/min 和 59.1 mL/100 g/min;P 值 = 0.004,Wilcoxon-Mann-Whitney)。值得注意的是,AI和rCBF值的升高与脑电图上的发作间期尖峰相关(中位数:分别为-0.008和0.84 vs -0.27和0.58),但与其他临床、脑电图或磁共振成像变量无关(P值=0.036,Wilcoxon-Mann-Whitney):通过强调LEAT与脑灌注之间的联系以及灌注特征与致痫性之间的相关性,我们的研究增进了我们对与LEAT相关的小儿癫痫的了解。此外,通过证明这些发现对镇静剂的稳健性,我们证实了在癫痫治疗方案中加入 ASL 的重要性,它是补充解剖成像的重要工具。
{"title":"Interictal EEG spikes increase perfusion in low-grade epilepsy-associated tumors: a pediatric arterial spin labeling study.","authors":"Antonio Giulio Gennari, Giulio Bicciato, Santo Pietro Lo Biundo, Raimund Kottke, Dorottya Cserpan, Ruth Tuura O'Gorman, Georgia Ramantani","doi":"10.1007/s11547-024-01923-7","DOIUrl":"https://doi.org/10.1007/s11547-024-01923-7","url":null,"abstract":"<p><strong>Purpose: </strong>Arterial spin labeling (ASL), a noninvasive magnetic resonance (MRI) perfusion sequence, holds promise in the presurgical evaluation of pediatric lesional epilepsy patients, including those with low-grade epilepsy-associated tumors (LEATs). The interpretation of ASL-derived perfusion patterns, however, presents challenges. Our study aims to elucidate these perfusion changes in children with LEATs, exploring their correlations with clinical, electroencephalography (EEG), and anatomical MRI findings.</p><p><strong>Material and methods: </strong>Our cohort included 15 children with LEAT-associated focal lesional epilepsy who underwent single-delay pseudo-continuous ASL imaging; eight were imaged under sedation. We assessed perfusion images both qualitatively and quantitatively, focusing on LEAT-related perfusion changes, as indicated by the asymmetry index (AI) and regional cerebral blood flow (rCBF).</p><p><strong>Results: </strong>ASL revealed LEAT-related perfusion changes in all but two patients: 12 LEATs were hypoperfused and one was hyperperfused relative to the contralateral brain parenchyma (CBP). LEATs showed significantly lower perfusion compared to CBP (median: 38.7 vs. 59.1 mL/100 g/min for LEAT and CBP, respectively; p value = 0.004, Wilcoxon-Mann-Whitney), regardless of sedation. Notably, elevated AI and rCBF values correlated with interictal spikes on EEG (median: -0.008 and 0.84 vs -0.27 and 0.58, respectively), but not to other clinical, EEG, or MRI variables (p value = 0.036, Wilcoxon-Mann-Whitney).</p><p><strong>Conclusions: </strong>By highlighting the connection between LEAT and brain perfusion, and by correlating perfusion characteristics and epileptogenicity, our research enhanced our understanding of pediatric epilepsy associated with LEATs. Also, by proving the robustness of these findings to sedation we confirmed the importance of adding ASL to epilepsy protocols to as a valuable tool to supplement anatomical imaging.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging in sensorineural and conductive hearing loss-an educational review. 感音神经性和传导性听力损失的成像--教育综述。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-12 DOI: 10.1007/s11547-024-01922-8
Edith Vassallo, Andre-Stefan Gatt, Reuben Grech, Serena Capasso, Ferdinando Caranci, Lorenzo Ugga

Hearing loss is the most common sensory impairment globally and can affect all ages. It can be classified into two categories, conductive and sensorineural, though both conditions may coexist. Various causes may be responsible for hearing loss including congenital, infectious, inflammatory and neoplastic. Imaging will help detect or exclude such causes and in combination with the medical history and clinical findings, enable the necessary treatment to be initiated. Imaging also provides an accurate pre-operative anatomical road map for the surgeons to ensure the best possible surgical outcomes. The aim of this educational review is to present a range of common and rare diseases causing hearing loss and provide a brief explanation of the best imaging modalities for each. It also discusses briefly some important anatomical variants which the radiologists should highlight in their report to help prevent inadvertent post-operative complications.

听力损失是全球最常见的感官障碍,可影响所有年龄段的人。听力损失可分为传导性听力损失和感音神经性听力损失两类,但两种情况可能同时存在。导致听力损失的原因多种多样,包括先天性、感染性、炎症性和肿瘤性。成像检查有助于发现或排除这些病因,并结合病史和临床发现,启动必要的治疗。成像还能为外科医生提供准确的术前解剖路线图,以确保最佳的手术效果。本教育综述旨在介绍一系列导致听力损失的常见和罕见疾病,并简要说明每种疾病的最佳成像模式。它还简要讨论了一些重要的解剖变异,放射科医生应在报告中强调这些变异,以帮助防止术后并发症的发生。
{"title":"Imaging in sensorineural and conductive hearing loss-an educational review.","authors":"Edith Vassallo, Andre-Stefan Gatt, Reuben Grech, Serena Capasso, Ferdinando Caranci, Lorenzo Ugga","doi":"10.1007/s11547-024-01922-8","DOIUrl":"https://doi.org/10.1007/s11547-024-01922-8","url":null,"abstract":"<p><p>Hearing loss is the most common sensory impairment globally and can affect all ages. It can be classified into two categories, conductive and sensorineural, though both conditions may coexist. Various causes may be responsible for hearing loss including congenital, infectious, inflammatory and neoplastic. Imaging will help detect or exclude such causes and in combination with the medical history and clinical findings, enable the necessary treatment to be initiated. Imaging also provides an accurate pre-operative anatomical road map for the surgeons to ensure the best possible surgical outcomes. The aim of this educational review is to present a range of common and rare diseases causing hearing loss and provide a brief explanation of the best imaging modalities for each. It also discusses briefly some important anatomical variants which the radiologists should highlight in their report to help prevent inadvertent post-operative complications.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between nova volume flow rate and TOF signal intensity ratio: value in unilateral internal carotid artery occlusion. Nova 容积流速与 TOF 信号强度比之间的相关性:在单侧颈内动脉闭塞中的价值。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-12 DOI: 10.1007/s11547-024-01917-5
Fabian Wolf, Elisa Colombo, Tilman Schubert, Lara Maria Höbner, Susanne Wegener, Jorn Fierstra, Martina Sebök, Bas van Niftrik, Andreas Luft, Luca Regli, Giuseppe Esposito

Background and purposes: Non-invasive optimal vessel analysis quantitative magnetic resonance angiography (NOVA-QMRA) has emerged as a valuable tool to characterize cerebral hemodynamics in intracranial atherosclerotic disease (ICAD). Our aim was to explore the eventual correlation between volume flow rate (VFR) measured via NOVA-QMRA and signal intensity ratio (SIR) of time-of-flight (TOF) MRA in M1- and P2-segments bilaterally in patients with unilateral internal carotid artery (ICA) occlusion.

Materials and methods: Patients with acute, subacute or chronic unilaterall ICA occlusion receiving NOVA-QMRA between June 2019 and June 2021 were retrospectively included. In bilateral M1- and P2-segments VFR was assessed by means of NOVA-QMRA and a region of interest (ROI) was selected to measure TOF SIR. A correlation between TOF SIR and VFR was tested by means of Pearson correlation coefficient. Mean difference of TOF SIR and VFR between ipsilateral (to occluded ICA) and contralateral M1- and P2-segments was analyzed using a two-sided Welch's t test.

Results: Fifty-five patients with unilateral ICA occlusion were included (acute: 28; subacute: 8; chronic: 19). Both ipsilateral (r = 0.536, p < 0.001) and contralateral (r = 0.757, p < 0.001) TOF SIR correlated significantly with NOVA VFR. This observation proved especially true for patients with chronic ICA occlusion. Both VFR (165.18 vs 110.60, p < 0.001) and TOF SIR (4.96 vs 2.70, p < 0.001) were higher in contralateral than ipsilateral M1-segments; whereas, the contrary was observed for P2-segments (VFR 72.35 vs 102.12, p < 0.001, TOF SIR 2.87 vs 3.39, p = 0.016).

Conclusion: The study results showed that TOF SIR significantly correlated with phase-contrast derived flow volume in patients with symptomatic ICA occlusion. This correlation remains the same regardless of the stage of the ischemic stroke (acute vs subacute vs chronic). Furthermore, significantly high VFR and TOF SIR in ipsilateral P2-segments may provide evidence of leptomeningeal collateralization in acute patients. Standardly performed TOF SIR Sequences might be of help for a qualitative evaluation of the flow in M1- and P2-segments in patients with unilateral ICA occlusions. NOVA QMRA allows precise quantitative measurements of the flow in cerebral vessels.

背景和目的:无创最佳血管分析定量磁共振血管造影(NOVA-QMRA)已成为描述颅内动脉粥样硬化性疾病(ICAD)脑血流动力学特征的重要工具。我们的目的是探讨单侧颈内动脉(ICA)闭塞患者通过 NOVA-QMRA 测量的体积流量(VFR)与飞行时间(TOF)MRA 在双侧 M1 和 P2 区段的信号强度比(SIR)之间的最终相关性:回顾性纳入2019年6月至2021年6月期间接受NOVA-QMRA检查的急性、亚急性或慢性单侧颈内动脉闭塞患者。通过 NOVA-QMRA 评估双侧 M1 和 P2 节段的 VFR,并选择感兴趣区 (ROI) 测量 TOF SIR。通过皮尔逊相关系数检验 TOF SIR 与 VFR 之间的相关性。采用双侧韦尔奇 t 检验分析同侧(闭塞的 ICA)与对侧 M1 和 P2 节段的 TOF SIR 和 VFR 的平均差异:共纳入 55 名单侧 ICA 闭塞患者(急性:28 人;亚急性:8 人;慢性:19 人)。同侧(r = 0.536,p研究结果表明,TOF SIR 与相位对比得出的有症状的 ICA 闭塞患者的血流量有明显的相关性。无论缺血性卒中处于哪个阶段(急性 vs 亚急性 vs 慢性),这种相关性都是一样的。此外,同侧 P2 区段明显较高的 VFR 和 TOF SIR 可为急性患者提供侧膜侧支的证据。标准的 TOF SIR 序列可能有助于对单侧 ICA 闭塞患者 M1 和 P2 节段的血流进行定性评估。NOVA QMRA 可以对脑血管的血流进行精确的定量测量。
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引用次数: 0
Prediction of tumor response to neoadjuvant chemotherapy in high-grade osteosarcoma using clustering-based analysis of magnetic resonance imaging: an exploratory study. 利用基于聚类的磁共振成像分析预测高级别骨肉瘤对新辅助化疗的肿瘤反应:一项探索性研究。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-11 DOI: 10.1007/s11547-024-01921-9
Giovanni Benvenuti, Simona Marzi, Antonello Vidiri, Jacopo Baldi, Serena Ceddia, Federica Riva, Renato Covello, Irene Terrenato, Vincenzo Anelli

Purpose: To evaluate the ability of magnetic resonance imaging (MRI)-based clustering analysis to predict the pathological response to neoadjuvant chemotherapy (NACT) in patients with primary high-grade osteosarcoma.

Materials and methods: Twenty-two patients were included in this retrospective study. All patients underwent MRIs before and after NACT. The entire tumor volume was manually delineated on post-contrast T1-weighted images and subsegmented into three clusters using the K-means algorithm. Histogram-based parameters were calculated for each lesion. The response to NACT was obtained from the histopathological assessment of the tumor necrosis rate following resection. The Mann-Whitney test was used to compare poor and fair-to-good responders. The receiver operating characteristic curve was used to evaluate the diagnostic performance of the optimal parameters.

Results: At baseline, poor responders showed a significantly larger volume of cluster1 (Vol1) than fair-to-good responders (p = 0.038). After NACT, they exhibited a lower 10th percentile (P10) and kurtosis (p = 0.038 and 0.002, respectively). Vol1 at baseline and P10 after NACT had an AUC of 77% (95% CI 56-98%). The kurtosis after NACT had the best discriminative power, with an AUC of 89.7% (95% CI 75-100%).

Conclusion: The MRI-based histogram and clustering analysis provided a good ability to differentiate between poor and fair-to-good responders before and after NACT. Further investigations using larger datasets are required to corroborate our findings.

目的:评估基于磁共振成像(MRI)的聚类分析预测原发性高级别骨肉瘤患者对新辅助化疗(NACT)病理反应的能力:这项回顾性研究共纳入22名患者。所有患者在新辅助化疗前后均接受了核磁共振成像检查。在对比后 T1 加权图像上手动划定整个肿瘤体积,并使用 K-means 算法将其细分为三个簇。计算每个病灶的直方图参数。根据切除后肿瘤坏死率的组织病理学评估得出对 NACT 的反应。Mann-Whitney 检验用于比较反应较差者和反应尚可者。接受者操作特征曲线用于评估最佳参数的诊断性能:结果:基线时,反应差者的簇1体积(Vol1)明显大于反应尚可者(p = 0.038)。在 NACT 之后,他们的第 10 百分位数(P10)和峰度(p = 0.038 和 0.002)均有所下降。基线时的 Vol1 和 NACT 后的 P10 的 AUC 为 77% (95% CI 56-98%)。NACT后的峰度具有最好的鉴别力,AUC为89.7%(95% CI 75-100%):结论:基于 MRI 的直方图和聚类分析能够很好地区分 NACT 前后反应差和反应尚可的患者。需要使用更大的数据集进行进一步研究,以证实我们的发现。
{"title":"Prediction of tumor response to neoadjuvant chemotherapy in high-grade osteosarcoma using clustering-based analysis of magnetic resonance imaging: an exploratory study.","authors":"Giovanni Benvenuti, Simona Marzi, Antonello Vidiri, Jacopo Baldi, Serena Ceddia, Federica Riva, Renato Covello, Irene Terrenato, Vincenzo Anelli","doi":"10.1007/s11547-024-01921-9","DOIUrl":"https://doi.org/10.1007/s11547-024-01921-9","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the ability of magnetic resonance imaging (MRI)-based clustering analysis to predict the pathological response to neoadjuvant chemotherapy (NACT) in patients with primary high-grade osteosarcoma.</p><p><strong>Materials and methods: </strong>Twenty-two patients were included in this retrospective study. All patients underwent MRIs before and after NACT. The entire tumor volume was manually delineated on post-contrast T1-weighted images and subsegmented into three clusters using the K-means algorithm. Histogram-based parameters were calculated for each lesion. The response to NACT was obtained from the histopathological assessment of the tumor necrosis rate following resection. The Mann-Whitney test was used to compare poor and fair-to-good responders. The receiver operating characteristic curve was used to evaluate the diagnostic performance of the optimal parameters.</p><p><strong>Results: </strong>At baseline, poor responders showed a significantly larger volume of cluster1 (Vol1) than fair-to-good responders (p = 0.038). After NACT, they exhibited a lower 10th percentile (P10) and kurtosis (p = 0.038 and 0.002, respectively). Vol1 at baseline and P10 after NACT had an AUC of 77% (95% CI 56-98%). The kurtosis after NACT had the best discriminative power, with an AUC of 89.7% (95% CI 75-100%).</p><p><strong>Conclusion: </strong>The MRI-based histogram and clustering analysis provided a good ability to differentiate between poor and fair-to-good responders before and after NACT. Further investigations using larger datasets are required to corroborate our findings.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors of interobserver variability in prostate tumor MRI delineation: impact of PI-QUAL score. 前列腺肿瘤 MRI 划线的观察者间差异因素:PI-QUAL 评分的影响。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-08 DOI: 10.1007/s11547-024-01920-w
Emile Salgues, Thibaut Jeganathan, Ulrike Schick, Truong An Nguyen, Valentin Tissot, Georges Fournier, Antoine Valéri, Vincent Bourbonne

Background: Prostate cancer ranks as the second most common cancer in men worldwide. Dose escalation to the tumor and/or the prostate improves biochemical recurrence-free survival. However, interobserver variability in lesion contouring poses a significant limitation to such therapeutic approaches. Therefore, a study of factors influencing this variability is necessary.

Materials and methods: Three independent readers delineated the index prostate lesion (DIL) using T2w and ADC sequences for each patient. Clinical data were retrospectively collected for all participants. Logistic regression analysis was employed to examine the correlation between clinical features and a mean DICE coefficient > 0.7. Features exhibiting a p value < 0.05 on univariate analysis were subjected to multivariate analysis.

Results: The study comprised 68 patients, with a median DICE coefficient of 0.69 (95% CI 0.65-0.71), wherein 42.6% (29/68) attained a mean DICE > 0.7. Univariate analysis identified the PI-QUAL score, maximum diameter of DIL, and mean DIL volume as significant (p < 0.05) predictors. In multivariate analysis, only the PI-QUAL score (p = 0.008) remained statistically associated with a DICE coefficient > 0.7.

Conclusion: The PI-QUAL score emerges as the primary predictive factor for minimizing inter-reader variability in intraprostatic dominant lesion segmentation. These findings underscore the importance of considering PI-QUAL scores when devising focal treatment plans. Adoption of a multi-reader approach involving diverse medical specialists (radiologists, radiotherapists, urologists) is advocated, particularly for MRIs with low PI-QUAL scores.

Clinical relevance statement: Radiotherapy is a major treatment for patients with localized prostate cancer. Dose escalation to the tumor leads to improved cancer control. Precise delineation of the dominant intraprostatic lesion (DIL) remains a limitation to focal treatments. Features influencing inter-reader variability were never evaluated. In this study, we identified that the PI-QUAL score was the sole predictor of the inter-reader delineation variability of the DIL.

背景:前列腺癌是全球第二大男性常见癌症。对肿瘤和/或前列腺进行剂量升级可提高无生化复发生存率。然而,病灶轮廓的观察者间变异性严重限制了此类治疗方法。因此,有必要对影响这种变异性的因素进行研究:三名独立阅读者使用 T2w 和 ADC 序列为每位患者划定前列腺病变指数(DIL)。回顾性收集了所有参与者的临床数据。采用逻辑回归分析研究临床特征与平均 DICE 系数 > 0.7 之间的相关性。结果该研究包括 68 名患者,DICE 系数中位数为 0.69(95% CI 0.65-0.71),其中 42.6%(29/68)的平均 DICE 系数大于 0.7。单变量分析表明,PI-QUAL 评分、DIL 最大直径和平均 DIL 容量具有显著性(P 0.7):结论:PI-QUAL 评分是最大程度减少泌尿系统前列腺内占位性病变分割中阅片人员之间差异的主要预测因素。这些发现强调了在制定病灶治疗计划时考虑 PI-QUAL 评分的重要性。建议采用由不同医学专家(放射科医师、放射治疗医师、泌尿科医师)参与的多阅片方法,尤其是对于 PI-QUAL 分数较低的 MRI:放疗是局部前列腺癌患者的主要治疗方法。针对肿瘤的剂量升级可提高癌症控制率。前列腺内主要病灶(DIL)的精确划分仍然是病灶治疗的一个限制因素。影响读片者之间差异的特征从未被评估过。在这项研究中,我们发现 PI-QUAL 评分是唯一能预测阅片师之间对 DIL 划线差异的因素。
{"title":"Factors of interobserver variability in prostate tumor MRI delineation: impact of PI-QUAL score.","authors":"Emile Salgues, Thibaut Jeganathan, Ulrike Schick, Truong An Nguyen, Valentin Tissot, Georges Fournier, Antoine Valéri, Vincent Bourbonne","doi":"10.1007/s11547-024-01920-w","DOIUrl":"https://doi.org/10.1007/s11547-024-01920-w","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer ranks as the second most common cancer in men worldwide. Dose escalation to the tumor and/or the prostate improves biochemical recurrence-free survival. However, interobserver variability in lesion contouring poses a significant limitation to such therapeutic approaches. Therefore, a study of factors influencing this variability is necessary.</p><p><strong>Materials and methods: </strong>Three independent readers delineated the index prostate lesion (DIL) using T2w and ADC sequences for each patient. Clinical data were retrospectively collected for all participants. Logistic regression analysis was employed to examine the correlation between clinical features and a mean DICE coefficient > 0.7. Features exhibiting a p value < 0.05 on univariate analysis were subjected to multivariate analysis.</p><p><strong>Results: </strong>The study comprised 68 patients, with a median DICE coefficient of 0.69 (95% CI 0.65-0.71), wherein 42.6% (29/68) attained a mean DICE > 0.7. Univariate analysis identified the PI-QUAL score, maximum diameter of DIL, and mean DIL volume as significant (p < 0.05) predictors. In multivariate analysis, only the PI-QUAL score (p = 0.008) remained statistically associated with a DICE coefficient > 0.7.</p><p><strong>Conclusion: </strong>The PI-QUAL score emerges as the primary predictive factor for minimizing inter-reader variability in intraprostatic dominant lesion segmentation. These findings underscore the importance of considering PI-QUAL scores when devising focal treatment plans. Adoption of a multi-reader approach involving diverse medical specialists (radiologists, radiotherapists, urologists) is advocated, particularly for MRIs with low PI-QUAL scores.</p><p><strong>Clinical relevance statement: </strong>Radiotherapy is a major treatment for patients with localized prostate cancer. Dose escalation to the tumor leads to improved cancer control. Precise delineation of the dominant intraprostatic lesion (DIL) remains a limitation to focal treatments. Features influencing inter-reader variability were never evaluated. In this study, we identified that the PI-QUAL score was the sole predictor of the inter-reader delineation variability of the DIL.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percutaneous microwave ablation of HCC: comparison between 100 and 150 W technology systems. 经皮微波消融治疗肝癌:100 W 和 150 W 技术系统的比较。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-08 DOI: 10.1007/s11547-024-01927-3
Carolina Lanza, Salvatore Alessio Angileri, Pierpaolo Biondetti, Andrea Coppola, Francesco Ricapito, Velio Ascenti, Gaetano Amato, Giuseppe Pellegrino, Lucilla Violetta Sciacqua, Andrea Vanzulli, Serena Carriero, Massimo Venturini, Anna Maria Ierardi, Gianpaolo Carrafiello

Purpose: To evaluate the differences in efficacy and safety between the 100 and 150 W percutaneous microwave ablation (MWA) systems in the treatment of hepatocellular carcinoma (HCC).

Methods: We retrospectively reviewed all patients who underwent percutaneous MWA (Emprint™ HP Ablation System, Medtronic) between January 2021 and May 2023. We divided the cohort into two groups: Group 1, treated with MWA at 100 W power system, and Group 2, treated with 150 W one. Effectiveness was defined as the absence of residual disease at 1-month CT follow-up; safety was defined as the absence of grade II-VI complications.

Results: A total of 135 HCC nodules were treated with MWA in 87 patients with a median age of 66 ± 10 years: 76 procedures in 42 patients were carried out in group 1, while 59 procedures in 45 patients in group 2. Cases treated with 150 W had a shorter ablation time (p: 0.002; mean 227.37 ± 92.5 vs 180.51 ± 75.6 s (100 vs 150 W)) and a larger ablation volume (p 0.008; mean 13,920.0 ± 10,723.2 vs 21,241.4 ± 18,374.7 mm3 (100 vs 150 W)), and a major effectiveness at 1-month CT follow-up (p: 0.013). A higher rate of complications (grade II and III) was observed in Group 2 (p < 0.001).

Conclusions: In conclusion, these preliminary results showed a good correlation between intended-to-treat area and ablation volume and intended-to-treat area and ablation time for both Groups. A minor ablation time, and major ablation volume, but also a higher incidence of complications was observed in 150 W Group.

目的:评估 100 W 和 150 W 经皮微波消融(MWA)系统在治疗肝细胞癌(HCC)方面的疗效和安全性差异:我们对2021年1月至2023年5月期间接受经皮微波消融术(Emprint™ HP消融系统,美敦力公司)的所有患者进行了回顾性研究。我们将患者分为两组:第 1 组使用功率为 100 W 的 MWA 系统进行治疗,第 2 组使用功率为 150 W 的 MWA 系统进行治疗。疗效的定义是在1个月的CT随访中无残留病灶;安全性的定义是无II-VI级并发症:87名患者共135个HCC结节接受了MWA治疗,中位年龄为66±10岁:第一组有42名患者接受了76次治疗,第二组有45名患者接受了59次治疗。使用 150 瓦功率治疗的病例消融时间较短(P:消融体积更大(P:0.008;平均 13,920.0 ± 10,723.2 vs 21,241.4 ± 18,374.7 mm3(100 W vs 150 W)),CT 随访 1 个月时疗效显著(P:0.013)。第 2 组的并发症(II 级和 III 级)发生率较高(P:0.013):总之,这些初步结果表明,两组的预定治疗面积和消融量以及预定治疗面积和消融时间之间存在良好的相关性。150 瓦组的消融时间较短,消融量较大,但并发症发生率较高。
{"title":"Percutaneous microwave ablation of HCC: comparison between 100 and 150 W technology systems.","authors":"Carolina Lanza, Salvatore Alessio Angileri, Pierpaolo Biondetti, Andrea Coppola, Francesco Ricapito, Velio Ascenti, Gaetano Amato, Giuseppe Pellegrino, Lucilla Violetta Sciacqua, Andrea Vanzulli, Serena Carriero, Massimo Venturini, Anna Maria Ierardi, Gianpaolo Carrafiello","doi":"10.1007/s11547-024-01927-3","DOIUrl":"https://doi.org/10.1007/s11547-024-01927-3","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the differences in efficacy and safety between the 100 and 150 W percutaneous microwave ablation (MWA) systems in the treatment of hepatocellular carcinoma (HCC).</p><p><strong>Methods: </strong>We retrospectively reviewed all patients who underwent percutaneous MWA (Emprint™ HP Ablation System, Medtronic) between January 2021 and May 2023. We divided the cohort into two groups: Group 1, treated with MWA at 100 W power system, and Group 2, treated with 150 W one. Effectiveness was defined as the absence of residual disease at 1-month CT follow-up; safety was defined as the absence of grade II-VI complications.</p><p><strong>Results: </strong>A total of 135 HCC nodules were treated with MWA in 87 patients with a median age of 66 ± 10 years: 76 procedures in 42 patients were carried out in group 1, while 59 procedures in 45 patients in group 2. Cases treated with 150 W had a shorter ablation time (p: 0.002; mean 227.37 ± 92.5 vs 180.51 ± 75.6 s (100 vs 150 W)) and a larger ablation volume (p 0.008; mean 13,920.0 ± 10,723.2 vs 21,241.4 ± 18,374.7 mm<sup>3</sup> (100 vs 150 W)), and a major effectiveness at 1-month CT follow-up (p: 0.013). A higher rate of complications (grade II and III) was observed in Group 2 (p < 0.001).</p><p><strong>Conclusions: </strong>In conclusion, these preliminary results showed a good correlation between intended-to-treat area and ablation volume and intended-to-treat area and ablation time for both Groups. A minor ablation time, and major ablation volume, but also a higher incidence of complications was observed in 150 W Group.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective study on the strength of magnetic resonance signs for predicting breast implant rupture: assessing the impact of radiologist expertise at a breast cancer referral center. 磁共振征象预测乳房植入物破裂强度的回顾性研究:评估乳腺癌转诊中心放射科医生专业知识的影响。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-08 DOI: 10.1007/s11547-024-01926-4
Filippo Pesapane, Anna Rotili, Giulia Signorelli, Valeria Dominelli, Luca Mazzocconi, Adriana Sorce, Ottavia Battaglia, Giovanni Cugliari, Sara Gandini, Luca Nicosia, Silvia Penco, Maria Pizzamiglio, Francesca De Lorenzi, Enrico Cassano

Objective: This study evaluates the diagnostic criteria of MRI for breast implant rupture and examines the influence of radiologist experience on the accuracy of rupture detection.

Methods: A retrospective study was conducted in a single center, involving patients who underwent implant replacement surgery between March 2019 and October 2022. MRI evaluations by four radiologists of varying experience levels were compared with surgical outcomes.

Results: The study included 118 explanted prostheses, with 25 identified as ruptured. Expert radiologists demonstrated near-perfect agreement (κ = 0.94) in identifying rupture signs, with high PPV and NPV, whereas non-experts showed only moderate agreement (κ = 0.44). Indicators such as the linguine sign, subcapsular line, and keyhole sign were identified with high accuracy by experts, contrasting with non-experts' lower detection rates.

Conclusions: Expertise in radiology significantly impacts the accurate diagnosis of breast implant ruptures. This study supports updating radiological guidelines and underscores the importance of specialized training and experience in improving diagnostic outcomes in breast implant assessments.

目的本研究评估了核磁共振成像对乳房假体破裂的诊断标准,并探讨了放射科医生经验对破裂检测准确性的影响:在一个中心开展了一项回顾性研究,涉及在 2019 年 3 月至 2022 年 10 月期间接受假体置换手术的患者。将四位不同经验水平的放射科医生的 MRI 评估结果与手术结果进行比较:研究包括 118 个取出的假体,其中 25 个被确定为破裂。放射科专家在识别破裂征象方面几乎完全一致(κ = 0.94),具有较高的PPV和NPV,而非专家仅表现出中等程度的一致(κ = 0.44)。专家对舌状征、囊下线和锁孔征等指标的识别准确率较高,而非专家的检出率较低:结论:放射学专家对乳房假体破裂的准确诊断有很大影响。这项研究支持更新放射学指南,并强调了专业培训和经验对提高乳房植入物评估诊断结果的重要性。
{"title":"Retrospective study on the strength of magnetic resonance signs for predicting breast implant rupture: assessing the impact of radiologist expertise at a breast cancer referral center.","authors":"Filippo Pesapane, Anna Rotili, Giulia Signorelli, Valeria Dominelli, Luca Mazzocconi, Adriana Sorce, Ottavia Battaglia, Giovanni Cugliari, Sara Gandini, Luca Nicosia, Silvia Penco, Maria Pizzamiglio, Francesca De Lorenzi, Enrico Cassano","doi":"10.1007/s11547-024-01926-4","DOIUrl":"https://doi.org/10.1007/s11547-024-01926-4","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates the diagnostic criteria of MRI for breast implant rupture and examines the influence of radiologist experience on the accuracy of rupture detection.</p><p><strong>Methods: </strong>A retrospective study was conducted in a single center, involving patients who underwent implant replacement surgery between March 2019 and October 2022. MRI evaluations by four radiologists of varying experience levels were compared with surgical outcomes.</p><p><strong>Results: </strong>The study included 118 explanted prostheses, with 25 identified as ruptured. Expert radiologists demonstrated near-perfect agreement (κ = 0.94) in identifying rupture signs, with high PPV and NPV, whereas non-experts showed only moderate agreement (κ = 0.44). Indicators such as the linguine sign, subcapsular line, and keyhole sign were identified with high accuracy by experts, contrasting with non-experts' lower detection rates.</p><p><strong>Conclusions: </strong>Expertise in radiology significantly impacts the accurate diagnosis of breast implant ruptures. This study supports updating radiological guidelines and underscores the importance of specialized training and experience in improving diagnostic outcomes in breast implant assessments.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Radiologia Medica
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