首页 > 最新文献

Radiologia Medica最新文献

英文 中文
Exploring kappa statistics considerations between two raters. 探索两个评分者之间的卡帕统计考虑因素。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 Epub Date: 2024-06-25 DOI: 10.1007/s11547-024-01836-5
Tianfei Yu, Siyuan Qian, Ming Li
{"title":"Exploring kappa statistics considerations between two raters.","authors":"Tianfei Yu, Siyuan Qian, Ming Li","doi":"10.1007/s11547-024-01836-5","DOIUrl":"10.1007/s11547-024-01836-5","url":null,"abstract":"","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":null,"pages":null},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac MRI in heart failure with preserved ejection fraction. 射血分数保留型心力衰竭的心脏磁共振成像。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.1007/s11547-024-01874-z
Agostino Meduri, Alessio Perazzolo, Riccardo Marano, Massimo Muciaccia, Francesco Lauriero, Giuseppe Rovere, Lorenzo Giarletta, Eleonora Moliterno, Luigi Natale

Patients who have heart failure with preserved ejection fraction (HFpEF) have signs and symptoms of heart failure, yet their ejection fraction remains greater than or equal to 50 percent. Understanding the underlying cause of HFpEF is crucial for accurate diagnosis and effective treatment. This condition can be caused by multiple factors, including ischemic or nonischemic myocardial diseases. HFpEF is often associated with diastolic dysfunction. Cardiac magnetic resonance (CMR) allows for a precise examination of the functional and structural alterations associated with HFpEF through the measurement of volumes and mass, the assessment of systolic and diastolic function, and the analysis of tissue characteristics. We will discuss CMR imaging indicators that are specific to patients with HFpEF and their relation to the disease. These markers can be acquired through both established and emerging methods.

射血分数保留型心力衰竭(HFpEF)患者有心力衰竭的体征和症状,但其射血分数仍大于或等于 50%。了解 HFpEF 的潜在病因对于准确诊断和有效治疗至关重要。这种情况可由多种因素引起,包括缺血性或非缺血性心肌疾病。HFpEF 常伴有舒张功能障碍。心脏磁共振(CMR)可通过测量容积和质量、评估收缩和舒张功能以及分析组织特征,精确检查与 HFpEF 相关的功能和结构改变。我们将讨论 HFpEF 患者特有的 CMR 成像指标及其与疾病的关系。这些指标可通过既有方法和新兴方法获得。
{"title":"Cardiac MRI in heart failure with preserved ejection fraction.","authors":"Agostino Meduri, Alessio Perazzolo, Riccardo Marano, Massimo Muciaccia, Francesco Lauriero, Giuseppe Rovere, Lorenzo Giarletta, Eleonora Moliterno, Luigi Natale","doi":"10.1007/s11547-024-01874-z","DOIUrl":"10.1007/s11547-024-01874-z","url":null,"abstract":"<p><p>Patients who have heart failure with preserved ejection fraction (HFpEF) have signs and symptoms of heart failure, yet their ejection fraction remains greater than or equal to 50 percent. Understanding the underlying cause of HFpEF is crucial for accurate diagnosis and effective treatment. This condition can be caused by multiple factors, including ischemic or nonischemic myocardial diseases. HFpEF is often associated with diastolic dysfunction. Cardiac magnetic resonance (CMR) allows for a precise examination of the functional and structural alterations associated with HFpEF through the measurement of volumes and mass, the assessment of systolic and diastolic function, and the analysis of tissue characteristics. We will discuss CMR imaging indicators that are specific to patients with HFpEF and their relation to the disease. These markers can be acquired through both established and emerging methods.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":null,"pages":null},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interventional radiology in the 3rd millennium: past, present and future perspectives. 第三个千年的介入放射学:过去、现在和未来展望。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 Epub Date: 2024-10-03 DOI: 10.1007/s11547-024-01894-9
Francesco Giurazza, Raffaella Niola
{"title":"Interventional radiology in the 3rd millennium: past, present and future perspectives.","authors":"Francesco Giurazza, Raffaella Niola","doi":"10.1007/s11547-024-01894-9","DOIUrl":"10.1007/s11547-024-01894-9","url":null,"abstract":"","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":null,"pages":null},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of ultrasound-guided vacuum-assisted breast biopsy in the management of radiologic-pathologic discordance: a retrospective single-centre study. 超声引导下真空辅助乳腺活检在处理放射学与病理学不一致中的作用:一项回顾性单中心研究。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 Epub Date: 2024-08-05 DOI: 10.1007/s11547-024-01864-1
Giulia Vatteroni, Giulia Pinna, Rubina Manuela Trimboli, Riccardo Levi, Isabella Bolengo, Francesco Patrone, Daria Volpe, Bethania Fernandes, Daniela Bernardi

Purpose: To evaluate the efficacy of US-guided vacuum-assisted biopsy (US-VAB) in radiologic-pathologic (rad-path) discordance in women with suspicious breast lesions.

Methods: Two thousand three hundred and sixty patients with 2385 BI-RADS category 4 and 5 lesions underwent percutaneous US-guided CNB. Thirty-six lesions were classified as discordant benign and underwent second-line US-VAB. A 14-gauge needle was utilized for CNB and 10-gauge for US-VAB. Final pathology was the reference standard for women who underwent surgery, imaging follow-up in other cases. Rates of malignancy for US-VAB and subsequent surgery were evaluated. Lesions with upgrade and no upgrade to second-line VAB were compared in terms of patient's age, lesion type and characteristics, size and BI-RADS category. Positive predictive value (PPV), negative predictive value (NPV) for BI-RADS categories and diagnostic performance for second-line US-VAB were calculated. p value < 0.05 was considered statistically significant (t-test, Mann-Whitney, χ2).

Results: US-VAB identified 10 B2, 9 B3 and 17 B5 lesions with upgrade to malignancy of 47.2% (17/36). There were 8 invasive no special type, 7 ductal in situ, 1 invasive lobular carcinoma and 1 angiosarcoma, and their distribution among BI-RADS categories was: 2/2 in BI-RADS 5 (100%), 12/18 in BI-RADS 4C (67%) and 3/16 in BI-RADS 4B lesions (19%) (p = 0.006). Of the remaining 19 lesions, 6 underwent surgery and 2 were upgraded to ductal carcinoma in situ; 13 underwent radiological follow-up and one resulted malignant. False-negative rate for US-VAB was 15.8% (3/19) with final upgrade to malignancy of 55% (20/36). The univariate analysis revealed mass shape (p = 0.008) and BI-RADS categories (p = 0.006) to be associated with upgrade to malignancy. Sensitivity, specificity, PPV, NPV and accuracy for US-VAB were 85, 100, 100, 84 and 92%, respectively.

Conclusions: US-VAB identified almost 50% of cancers missed by CNB, avoiding surgical biopsies and validating as an effective mini-invasive approach in rad-path discordance.

目的:评估 US 引导下真空辅助活检(US-VAB)对患有可疑乳腺病变的女性放射病理(rad-path)不一致的疗效:2385 名 BI-RADS 4 类和 5 类病变患者接受了经皮 US 引导的 CNB。有 36 个病灶被归类为不一致的良性病灶,并接受了二线 US-VAB。CNB 使用 14 号针头,US-VAB 使用 10 号针头。接受手术的女性以最终病理结果为参考标准,其他病例则以影像学随访结果为参考标准。对 US-VAB 和后续手术的恶变率进行了评估。根据患者的年龄、病变类型和特征、大小和 BI-RADS 类别,对升级和未升级为二线 VAB 的病变进行了比较。计算了 BI-RADS 类别的阳性预测值(PPV)、阴性预测值(NPV)和二线 US-VAB 的诊断性能:US-VAB 发现了 10 个 B2、9 个 B3 和 17 个 B5 病变,升级为恶性肿瘤的比例为 47.2%(17/36)。其中无特殊类型的浸润性病变 8 例,原位导管癌 7 例,浸润性小叶癌 1 例,血管肉瘤 1 例,它们在 BI-RADS 分类中的分布为:2/2 例 BI-RADS 5(100%),12/18 例 BI-RADS 4C(67%),3/16 例 BI-RADS 4B 病变(19%)(P = 0.006)。在剩余的 19 个病灶中,6 个接受了手术,2 个升级为导管原位癌;13 个接受了放射学随访,1 个结果为恶性。US-VAB的假阴性率为15.8%(3/19),最终升级为恶性的比例为55%(20/36)。单变量分析显示,肿块形状(p = 0.008)和 BI-RADS 类别(p = 0.006)与升级为恶性肿瘤有关。US-VAB的敏感性、特异性、PPV、NPV和准确性分别为85%、100%、100%、84%和92%:结论:US-VAB发现了CNB漏诊的近50%的癌症,避免了手术活检,是放射路径不一致情况下有效的微创方法。
{"title":"Role of ultrasound-guided vacuum-assisted breast biopsy in the management of radiologic-pathologic discordance: a retrospective single-centre study.","authors":"Giulia Vatteroni, Giulia Pinna, Rubina Manuela Trimboli, Riccardo Levi, Isabella Bolengo, Francesco Patrone, Daria Volpe, Bethania Fernandes, Daniela Bernardi","doi":"10.1007/s11547-024-01864-1","DOIUrl":"10.1007/s11547-024-01864-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of US-guided vacuum-assisted biopsy (US-VAB) in radiologic-pathologic (rad-path) discordance in women with suspicious breast lesions.</p><p><strong>Methods: </strong>Two thousand three hundred and sixty patients with 2385 BI-RADS category 4 and 5 lesions underwent percutaneous US-guided CNB. Thirty-six lesions were classified as discordant benign and underwent second-line US-VAB. A 14-gauge needle was utilized for CNB and 10-gauge for US-VAB. Final pathology was the reference standard for women who underwent surgery, imaging follow-up in other cases. Rates of malignancy for US-VAB and subsequent surgery were evaluated. Lesions with upgrade and no upgrade to second-line VAB were compared in terms of patient's age, lesion type and characteristics, size and BI-RADS category. Positive predictive value (PPV), negative predictive value (NPV) for BI-RADS categories and diagnostic performance for second-line US-VAB were calculated. p value < 0.05 was considered statistically significant (t-test, Mann-Whitney, χ<sup>2</sup>).</p><p><strong>Results: </strong>US-VAB identified 10 B2, 9 B3 and 17 B5 lesions with upgrade to malignancy of 47.2% (17/36). There were 8 invasive no special type, 7 ductal in situ, 1 invasive lobular carcinoma and 1 angiosarcoma, and their distribution among BI-RADS categories was: 2/2 in BI-RADS 5 (100%), 12/18 in BI-RADS 4C (67%) and 3/16 in BI-RADS 4B lesions (19%) (p = 0.006). Of the remaining 19 lesions, 6 underwent surgery and 2 were upgraded to ductal carcinoma in situ; 13 underwent radiological follow-up and one resulted malignant. False-negative rate for US-VAB was 15.8% (3/19) with final upgrade to malignancy of 55% (20/36). The univariate analysis revealed mass shape (p = 0.008) and BI-RADS categories (p = 0.006) to be associated with upgrade to malignancy. Sensitivity, specificity, PPV, NPV and accuracy for US-VAB were 85, 100, 100, 84 and 92%, respectively.</p><p><strong>Conclusions: </strong>US-VAB identified almost 50% of cancers missed by CNB, avoiding surgical biopsies and validating as an effective mini-invasive approach in rad-path discordance.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":null,"pages":null},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ischemic core detection threshold of computed tomography perfusion (CTP) in acute stroke. 急性中风时计算机断层扫描灌注(CTP)的缺血核心检测阈值。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1007/s11547-024-01868-x
Luigi Asmundo, Moreno Zanardo, Massimo Cressoni, Federico Ambrogi, Luciano Bet, Fabio Giatsidis, Giovanni Di Leo, Francesco Sardanelli, Paolo Vitali

Purpose: This study aimed to determine the accuracy of detecting ischemic core volume using computed tomography perfusion (CTP) in patients with suspected acute ischemic stroke compared to diffusion-weighted magnetic resonance imaging (DW-MRI) as the reference standard.

Methods: This retrospective monocentric study included patients who underwent CTP and DW-MRI for suspected acute ischemic stroke. The ischemic core size was measured at DW-MRI. The detectability threshold volume was defined as the lowest volume detected by each method. Clinical data on revascularization therapy, along with the clinical decision that influenced the choice, were collected. Volumes of the ischemic cores were compared using the Mann-Whitney U test.

Results: Of 83 patients who underwent CTP, 52 patients (median age 73 years, IQR 63-80, 36 men) also had DW-MRI and were included, with a total of 70 ischemic cores. Regarding ischemic cores, only 18/70 (26%) were detected by both CTP and DW-MRI, while 52/70 (74%) were detected only by DW-MRI. The median volume of the 52 ischemic cores undetected on CTP (0.6 mL, IQR 0.2-1.3 mL) was significantly lower (p < 0.001) than that of the 18 ischemic cores detected on CTP (14.2 mL, IQR 7.0-18.4 mL). The smallest ischemic core detected on CTP had a volume of 5.0 mL. Among the 20 patients with undetected ischemic core on CTP, only 10% (2/20) received thrombolysis treatment.

Conclusions: CTP maps failed in detecting ischemic cores smaller than 5 mL. DW-MRI remains essential for suspected small ischemic brain lesions to guide a correct treatment decision-making.

目的:本研究旨在确定与作为参考标准的弥散加权磁共振成像(DW-MRI)相比,在疑似急性缺血性卒中患者中使用计算机断层扫描灌注(CTP)检测缺血核心体积的准确性:这项回顾性单中心研究纳入了接受 CTP 和 DW-MRI 检查的疑似急性缺血性脑卒中患者。DW-MRI 测量了缺血核心的大小。可检测阈值体积定义为每种方法检测到的最小体积。收集了血管重建疗法的临床数据以及影响选择的临床决定。使用 Mann-Whitney U 检验比较缺血核心的体积:在 83 名接受 CTP 的患者中,有 52 名患者(中位年龄 73 岁,IQR 63-80,36 名男性)也接受了 DW-MRI 检查,共纳入了 70 个缺血核。在缺血核方面,只有 18/70 例(26%)同时通过 CTP 和 DW-MRI 检测到缺血核,而 52/70 例(74%)仅通过 DW-MRI 检测到缺血核。CTP 未检测到的 52 个缺血核心的中位体积(0.6 mL,IQR 0.2-1.3 mL)明显低于 DW-MRI 检测到的缺血核心(p 结论:DW-MRI 检测到的缺血核心的中位体积为 0.6 mL,IQR 0.2-1.3 mL):CTP 图未能检测到小于 5 毫升的缺血核心。DW-MRI对疑似小面积脑缺血病变仍然至关重要,可指导正确的治疗决策。
{"title":"Ischemic core detection threshold of computed tomography perfusion (CTP) in acute stroke.","authors":"Luigi Asmundo, Moreno Zanardo, Massimo Cressoni, Federico Ambrogi, Luciano Bet, Fabio Giatsidis, Giovanni Di Leo, Francesco Sardanelli, Paolo Vitali","doi":"10.1007/s11547-024-01868-x","DOIUrl":"10.1007/s11547-024-01868-x","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to determine the accuracy of detecting ischemic core volume using computed tomography perfusion (CTP) in patients with suspected acute ischemic stroke compared to diffusion-weighted magnetic resonance imaging (DW-MRI) as the reference standard.</p><p><strong>Methods: </strong>This retrospective monocentric study included patients who underwent CTP and DW-MRI for suspected acute ischemic stroke. The ischemic core size was measured at DW-MRI. The detectability threshold volume was defined as the lowest volume detected by each method. Clinical data on revascularization therapy, along with the clinical decision that influenced the choice, were collected. Volumes of the ischemic cores were compared using the Mann-Whitney U test.</p><p><strong>Results: </strong>Of 83 patients who underwent CTP, 52 patients (median age 73 years, IQR 63-80, 36 men) also had DW-MRI and were included, with a total of 70 ischemic cores. Regarding ischemic cores, only 18/70 (26%) were detected by both CTP and DW-MRI, while 52/70 (74%) were detected only by DW-MRI. The median volume of the 52 ischemic cores undetected on CTP (0.6 mL, IQR 0.2-1.3 mL) was significantly lower (p < 0.001) than that of the 18 ischemic cores detected on CTP (14.2 mL, IQR 7.0-18.4 mL). The smallest ischemic core detected on CTP had a volume of 5.0 mL. Among the 20 patients with undetected ischemic core on CTP, only 10% (2/20) received thrombolysis treatment.</p><p><strong>Conclusions: </strong>CTP maps failed in detecting ischemic cores smaller than 5 mL. DW-MRI remains essential for suspected small ischemic brain lesions to guide a correct treatment decision-making.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":null,"pages":null},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance of two different artificial intelligence (AI) methods for assessing carpal bone age compared to the standard Greulich and Pyle method. 评估腕骨年龄的两种不同人工智能(AI)方法与标准 Greulich 和 Pyle 方法的性能比较。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1007/s11547-024-01871-2
Davide Alaimo, Maria Chiara Terranova, Ettore Palizzolo, Manfredi De Angelis, Vittorio Avella, Giuseppe Paviglianiti, Giuseppe Lo Re, Domenica Matranga, Sergio Salerno

Purpose: Evaluate the agreement between bone age assessments conducted by two distinct machine learning system and standard Greulich and Pyle method.

Materials and methods: Carpal radiographs of 225 patients (mean age 8 years and 10 months, SD = 3 years and 1 month) were retrospectively analysed at two separate institutions (October 2018 and May 2022) by both expert radiologists and radiologists in training as well as by two distinct AI software programmes, 16-bit AItm and BoneXpert® in a blinded manner.

Results: The bone age range estimated by the 16-bit AItm system in our sample varied between 1 year and 1 month and 15 years and 8 months (mean bone age 9 years and 5 months SD = 3 years and 3 months). BoneXpert® estimated bone age ranged between 8 months and 15 years and 7 months (mean bone age 8 years and 11 months SD = 3 years and 3 months). The average bone age estimated by the Greulich and Pyle method was between 11 months and 14 years, 9 months (mean bone age 8 years and 4 months SD = 3 years and 3 months). Radiologists' assessments using the Greulich and Pyle method were significantly correlated (Pearson's r > 0.80, p < 0.001). There was no statistical difference between BoneXpert® and 16-bit AItm (mean difference = - 0.19, 95%CI = (- 0.45; 0.08)), and the agreement between two measurements varies between - 3.45 (95%CI = (- 3.95; - 3.03) and 3.07 (95%CI - 3.03; 3.57).

Conclusions: Both AI methods and GP provide correlated results, although the measurements made by AI were closer to each other compared to the GP method.

目的:评估两种不同的机器学习系统与标准Greulich和Pyle方法进行的骨龄评估之间的一致性:在两家不同的机构(2018 年 10 月和 2022 年 5 月),由放射科专家和正在接受培训的放射科专家对 225 名患者(平均年龄 8 岁 10 个月,SD = 3 岁 1 个月)的腕骨X光片进行了回顾性分析,并由 16 位 AItm 和 BoneXpert® 两款不同的人工智能软件进行了盲法分析:结果:在我们的样本中,16 位 AItm 系统估计的骨龄范围在 1 岁 1 个月到 15 岁 8 个月之间(平均骨龄为 9 岁 5 个月 SD = 3 岁 3 个月)。BoneXpert® 估计的骨龄介于 8 个月到 15 岁零 7 个月之间(平均骨龄为 8 岁零 11 个月 SD = 3 岁零 3 个月)。用 Greulich 和 Pyle 方法估计的平均骨龄为 11 个月至 14 岁零 9 个月(平均骨龄为 8 岁零 4 个月 SD = 3 岁零 3 个月)。放射科医生使用 Greulich 和 Pyle 方法进行的评估具有显著相关性(Pearson's r > 0.80,p tm(平均差异 = - 0.19,95%CI = (- 0.45; 0.08)),两次测量的一致性介于 - 3.45 (95%CI = (- 3.95; - 3.03) 和 3.07 (95%CI - 3.03; 3.57) 之间:AI方法和GP方法都能提供相关的结果,但与GP方法相比,AI方法的测量结果更为接近。
{"title":"Performance of two different artificial intelligence (AI) methods for assessing carpal bone age compared to the standard Greulich and Pyle method.","authors":"Davide Alaimo, Maria Chiara Terranova, Ettore Palizzolo, Manfredi De Angelis, Vittorio Avella, Giuseppe Paviglianiti, Giuseppe Lo Re, Domenica Matranga, Sergio Salerno","doi":"10.1007/s11547-024-01871-2","DOIUrl":"10.1007/s11547-024-01871-2","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluate the agreement between bone age assessments conducted by two distinct machine learning system and standard Greulich and Pyle method.</p><p><strong>Materials and methods: </strong>Carpal radiographs of 225 patients (mean age 8 years and 10 months, SD = 3 years and 1 month) were retrospectively analysed at two separate institutions (October 2018 and May 2022) by both expert radiologists and radiologists in training as well as by two distinct AI software programmes, 16-bit AI<sup>tm</sup> and BoneXpert® in a blinded manner.</p><p><strong>Results: </strong>The bone age range estimated by the 16-bit AI<sup>tm</sup> system in our sample varied between 1 year and 1 month and 15 years and 8 months (mean bone age 9 years and 5 months SD = 3 years and 3 months). BoneXpert® estimated bone age ranged between 8 months and 15 years and 7 months (mean bone age 8 years and 11 months SD = 3 years and 3 months). The average bone age estimated by the Greulich and Pyle method was between 11 months and 14 years, 9 months (mean bone age 8 years and 4 months SD = 3 years and 3 months). Radiologists' assessments using the Greulich and Pyle method were significantly correlated (Pearson's r > 0.80, p < 0.001). There was no statistical difference between BoneXpert® and 16-bit AI<sup>tm</sup> (mean difference = - 0.19, 95%CI = (- 0.45; 0.08)), and the agreement between two measurements varies between - 3.45 (95%CI = (- 3.95; - 3.03) and 3.07 (95%CI - 3.03; 3.57).</p><p><strong>Conclusions: </strong>Both AI methods and GP provide correlated results, although the measurements made by AI were closer to each other compared to the GP method.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":null,"pages":null},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11480116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical value of sequential circulating tumor DNA analysis using next-generation sequencing and epigenetic modifications for guiding thermal ablation for colorectal cancer metastases: a prospective study. 利用新一代测序和表观遗传学修饰进行循环肿瘤DNA序列分析以指导结直肠癌转移灶热消融的临床价值:一项前瞻性研究。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 Epub Date: 2024-08-25 DOI: 10.1007/s11547-024-01865-0
Tom Boeken, Olivier Pellerin, Camille Bourreau, Juliette Palle, Claire Gallois, Aziz Zaanan, Julien Taieb, Widad Lahlou, Alessandro Di Gaeta, Marc Al Ahmar, Xavier Guerra, Carole Dean, Pierre Laurent Puig, Marc Sapoval, Helena Pereira, Hélène Blons

Introduction: While thermal ablation is now a standard treatment option for oligometastatic colorectal cancer patients, selecting those who will benefit most from locoregional therapies remains challenging. This proof-of-concept study is the first to assess the feasibility of routine testing of ctDNA before and after thermal ablation with curative intent, analyzed by next-generation sequencing (NGS) and methylation specific digital droplet PCR (ddPCR). Our prospective study primary objective was to assess the prognostic value of ctDNA before thermal ablation.

Methods: This single-center prospective study from November 2021 to June 2022 included colorectal cancer patients referred for curative-intent thermal ablation. Cell-free DNA was tested at different time points by next-generation sequencing and detection of WIF1 and NPY genes hypermethylation using ddPCR. The ctDNA was considered positive if either a tumor mutation or hypermethylation was detected; recurrence-free survival was used as the primary endpoint.

Results: The study enrolled 15 patients, and a total of 60 samples were analyzed. The median follow-up after ablation was 316 days, and median recurrence-free survival was 250 days. CtDNA was positive for 33% of the samples collected during the first 24 h. The hazard ratio for progression according to the presence of baseline circulating tumor DNA was estimated at 0.14 (CI 95%: 0.03-0.65, p = 0.019). The dynamics are provided, and patients with no recurrence were all negative at H24 for ctDNA.

Discussion: This study shows the feasibility of routine testing of ctDNA before and after thermal ablation with curative intent. We report that circulating tumor DNA is detectable in patients with low tumor burden using 2 techniques. This study emphasizes the potential of ctDNA for discerning patients who are likely to benefit from thermal ablation from those who may not, which could shape future referrals. The dynamics of ctDNA before and after ablation shed light on the need for further research and larger studies.

导言:虽然热消融现已成为寡转移性结直肠癌患者的标准治疗方案,但选择从局部治疗中获益最多的患者仍具有挑战性。这项概念验证研究首次评估了通过新一代测序(NGS)和甲基化特异性数字液滴 PCR(ddPCR)分析治疗性热消融前后常规检测ctDNA的可行性。我们的前瞻性研究的主要目的是评估热消融前ctDNA的预后价值:这项单中心前瞻性研究的研究时间为 2021 年 11 月至 2022 年 6 月,研究对象包括转诊接受根治性热消融术的结直肠癌患者。在不同时间点通过新一代测序检测无细胞DNA,并使用ddPCR检测WIF1和NPY基因的高甲基化。如果检测到肿瘤突变或高甲基化,则认为ctDNA呈阳性;无复发生存期作为主要终点:研究共招募了 15 名患者,分析了 60 份样本。消融术后的中位随访时间为316天,中位无复发生存期为250天。在最初 24 小时内采集的样本中,有 33% 的样本 CtDNA 呈阳性。根据基线循环肿瘤 DNA 的存在,病情进展的危险比估计为 0.14(CI 95%:0.03-0.65,P = 0.019)。动态数据显示,没有复发的患者在H24时ctDNA均为阴性:讨论:这项研究表明,在以治愈为目的的热消融前后对ctDNA进行常规检测是可行的。我们报告说,使用两种技术可在肿瘤负荷较低的患者中检测到循环肿瘤 DNA。这项研究强调了ctDNA在鉴别可能从热消融中获益的患者和可能无法获益的患者方面的潜力,这可能会影响未来的转诊。消融前后ctDNA的动态变化揭示了进一步研究和更大规模研究的必要性。
{"title":"Clinical value of sequential circulating tumor DNA analysis using next-generation sequencing and epigenetic modifications for guiding thermal ablation for colorectal cancer metastases: a prospective study.","authors":"Tom Boeken, Olivier Pellerin, Camille Bourreau, Juliette Palle, Claire Gallois, Aziz Zaanan, Julien Taieb, Widad Lahlou, Alessandro Di Gaeta, Marc Al Ahmar, Xavier Guerra, Carole Dean, Pierre Laurent Puig, Marc Sapoval, Helena Pereira, Hélène Blons","doi":"10.1007/s11547-024-01865-0","DOIUrl":"10.1007/s11547-024-01865-0","url":null,"abstract":"<p><strong>Introduction: </strong>While thermal ablation is now a standard treatment option for oligometastatic colorectal cancer patients, selecting those who will benefit most from locoregional therapies remains challenging. This proof-of-concept study is the first to assess the feasibility of routine testing of ctDNA before and after thermal ablation with curative intent, analyzed by next-generation sequencing (NGS) and methylation specific digital droplet PCR (ddPCR). Our prospective study primary objective was to assess the prognostic value of ctDNA before thermal ablation.</p><p><strong>Methods: </strong>This single-center prospective study from November 2021 to June 2022 included colorectal cancer patients referred for curative-intent thermal ablation. Cell-free DNA was tested at different time points by next-generation sequencing and detection of WIF1 and NPY genes hypermethylation using ddPCR. The ctDNA was considered positive if either a tumor mutation or hypermethylation was detected; recurrence-free survival was used as the primary endpoint.</p><p><strong>Results: </strong>The study enrolled 15 patients, and a total of 60 samples were analyzed. The median follow-up after ablation was 316 days, and median recurrence-free survival was 250 days. CtDNA was positive for 33% of the samples collected during the first 24 h. The hazard ratio for progression according to the presence of baseline circulating tumor DNA was estimated at 0.14 (CI 95%: 0.03-0.65, p = 0.019). The dynamics are provided, and patients with no recurrence were all negative at H24 for ctDNA.</p><p><strong>Discussion: </strong>This study shows the feasibility of routine testing of ctDNA before and after thermal ablation with curative intent. We report that circulating tumor DNA is detectable in patients with low tumor burden using 2 techniques. This study emphasizes the potential of ctDNA for discerning patients who are likely to benefit from thermal ablation from those who may not, which could shape future referrals. The dynamics of ctDNA before and after ablation shed light on the need for further research and larger studies.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":null,"pages":null},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fundamental misunderstandings and methodological flaws in "exploring kappa statistics considerations between two raters" by Yu et al. Yu 等人在 "探讨两个评分者之间的 kappa 统计考虑因素 "一文中的基本误解和方法论缺陷。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1007/s11547-024-01873-0
Riccardo Picasso, Andrea Cozzi, Virginia Picasso, Federico Zaottini, Federico Pistoia, Sara Perissi, Carlo Martinoli
{"title":"Fundamental misunderstandings and methodological flaws in \"exploring kappa statistics considerations between two raters\" by Yu et al.","authors":"Riccardo Picasso, Andrea Cozzi, Virginia Picasso, Federico Zaottini, Federico Pistoia, Sara Perissi, Carlo Martinoli","doi":"10.1007/s11547-024-01873-0","DOIUrl":"10.1007/s11547-024-01873-0","url":null,"abstract":"","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":null,"pages":null},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy and time efficiency of a novel deep learning algorithm for Intracranial Hemorrhage detection in CT Scans. 用于 CT 扫描颅内出血检测的新型深度学习算法的准确性和时间效率。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 Epub Date: 2024-08-09 DOI: 10.1007/s11547-024-01867-y
Tommaso D'Angelo, Giuseppe M Bucolo, Tarek Kamareddine, Ibrahim Yel, Vitali Koch, Leon D Gruenewald, Simon Martin, Leona S Alizadeh, Silvio Mazziotti, Alfredo Blandino, Thomas J Vogl, Christian Booz

Purpose: To evaluate a deep learning-based pipeline using a Dense-UNet architecture for the assessment of acute intracranial hemorrhage (ICH) on non-contrast computed tomography (NCCT) head scans after traumatic brain injury (TBI).

Materials and methods: This retrospective study was conducted using a prototype algorithm that evaluated 502 NCCT head scans with ICH in context of TBI. Four board-certified radiologists evaluated in consensus the CT scans to establish the standard of reference for hemorrhage presence and type of ICH. Consequently, all CT scans were independently analyzed by the algorithm and a board-certified radiologist to assess the presence and type of ICH. Additionally, the time to diagnosis was measured for both methods.

Results: A total of 405/502 patients presented ICH classified in the following types: intraparenchymal (n = 172); intraventricular (n = 26); subarachnoid (n = 163); subdural (n = 178); and epidural (n = 15). The algorithm showed high diagnostic accuracy (91.24%) for the assessment of ICH with a sensitivity of 90.37% and specificity of 94.85%. To distinguish the different ICH types, the algorithm had a sensitivity of 93.47% and a specificity of 99.79%, with an accuracy of 98.54%. To detect midline shift, the algorithm had a sensitivity of 100%. In terms of processing time, the algorithm was significantly faster compared to the radiologist's time to first diagnosis (15.37 ± 1.85 vs 277 ± 14 s, p < 0.001).

Conclusion: A novel deep learning algorithm can provide high diagnostic accuracy for the identification and classification of ICH from unenhanced CT scans, combined with short processing times. This has the potential to assist and improve radiologists' ICH assessment in NCCT scans, especially in emergency scenarios, when time efficiency is needed.

目的:评估一种基于深度学习的管道,该管道采用 Dense-UNet 架构,用于评估创伤性脑损伤(TBI)后非对比计算机断层扫描(NCCT)头部扫描中的急性颅内出血(ICH):这项回顾性研究采用一种原型算法,评估了 502 例创伤性脑损伤后有 ICH 的 NCCT 头部扫描结果。四位经委员会认证的放射科专家对 CT 扫描进行了一致评估,以确定出血存在和 ICH 类型的参考标准。因此,所有 CT 扫描均由该算法和一名经委员会认证的放射科医生进行独立分析,以评估是否存在 ICH 及其类型。此外,两种方法都对诊断时间进行了测量:共有 405/502 例患者出现了 ICH,分为以下类型:实质内(n = 172);脑室内(n = 26);蛛网膜下腔(n = 163);硬膜下(n = 178);硬膜外(n = 15)。该算法评估 ICH 的诊断准确率很高(91.24%),灵敏度为 90.37%,特异度为 94.85%。在区分不同类型的 ICH 时,该算法的灵敏度为 93.47%,特异度为 99.79%,准确率为 98.54%。在检测中线移位方面,该算法的灵敏度为 100%。在处理时间方面,该算法明显快于放射科医生的首次诊断时间(15.37 ± 1.85 vs 277 ± 14 s,p 结论:新颖的深度学习算法可在较短的处理时间内,从未增强 CT 扫描中对 ICH 进行高诊断准确性的识别和分类。这有可能帮助并改善放射科医生对 NCCT 扫描中的 ICH 评估,尤其是在需要提高时间效率的紧急情况下。
{"title":"Accuracy and time efficiency of a novel deep learning algorithm for Intracranial Hemorrhage detection in CT Scans.","authors":"Tommaso D'Angelo, Giuseppe M Bucolo, Tarek Kamareddine, Ibrahim Yel, Vitali Koch, Leon D Gruenewald, Simon Martin, Leona S Alizadeh, Silvio Mazziotti, Alfredo Blandino, Thomas J Vogl, Christian Booz","doi":"10.1007/s11547-024-01867-y","DOIUrl":"10.1007/s11547-024-01867-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate a deep learning-based pipeline using a Dense-UNet architecture for the assessment of acute intracranial hemorrhage (ICH) on non-contrast computed tomography (NCCT) head scans after traumatic brain injury (TBI).</p><p><strong>Materials and methods: </strong>This retrospective study was conducted using a prototype algorithm that evaluated 502 NCCT head scans with ICH in context of TBI. Four board-certified radiologists evaluated in consensus the CT scans to establish the standard of reference for hemorrhage presence and type of ICH. Consequently, all CT scans were independently analyzed by the algorithm and a board-certified radiologist to assess the presence and type of ICH. Additionally, the time to diagnosis was measured for both methods.</p><p><strong>Results: </strong>A total of 405/502 patients presented ICH classified in the following types: intraparenchymal (n = 172); intraventricular (n = 26); subarachnoid (n = 163); subdural (n = 178); and epidural (n = 15). The algorithm showed high diagnostic accuracy (91.24%) for the assessment of ICH with a sensitivity of 90.37% and specificity of 94.85%. To distinguish the different ICH types, the algorithm had a sensitivity of 93.47% and a specificity of 99.79%, with an accuracy of 98.54%. To detect midline shift, the algorithm had a sensitivity of 100%. In terms of processing time, the algorithm was significantly faster compared to the radiologist's time to first diagnosis (15.37 ± 1.85 vs 277 ± 14 s, p < 0.001).</p><p><strong>Conclusion: </strong>A novel deep learning algorithm can provide high diagnostic accuracy for the identification and classification of ICH from unenhanced CT scans, combined with short processing times. This has the potential to assist and improve radiologists' ICH assessment in NCCT scans, especially in emergency scenarios, when time efficiency is needed.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":null,"pages":null},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11480174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Background parenchymal enhancement on contrast-enhanced mammography: associations with breast density and patient's characteristics. 对比增强乳腺 X 射线造影术的背景实质增强:与乳腺密度和患者特征的关系。
IF 9.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.1007/s11547-024-01860-5
Veronica Magni, Andrea Cozzi, Giulia Muscogiuri, Adrienn Benedek, Gabriele Rossini, Marianna Fanizza, Giuseppe Di Giulio, Francesco Sardanelli

Purpose: To evaluate if background parenchymal enhancement (BPE) on contrast-enhanced mammography (CEM), graded according to the 2022 CEM-dedicated Breast Imaging Reporting and Data System (BI-RADS) lexicon, is associated with breast density, menopausal status, and age.

Methods: This bicentric retrospective analysis included CEM examinations performed for the work-up of suspicious mammographic findings. Three readers independently and blindly evaluated BPE on recombined CEM images and breast density on low-energy CEM images. Inter-reader reliability was estimated using Fleiss κ. Multivariable binary logistic regression was performed, dichotomising breast density and BPE as low (a/b BI-RADS categories, minimal/mild BPE) and high (c/d BI-RADS categories, moderate/marked BPE).

Results: A total of 200 women (median age 56.8 years, interquartile range 50.5-65.6, 140/200 in menopause) were included. Breast density was classified as a in 27/200 patients (13.5%), as b in 110/200 (55.0%), as c in 52/200 (26.0%), and as d in 11/200 (5.5%), with moderate inter-reader reliability (κ = 0.536; 95% confidence interval [CI] 0.482-0.590). BPE was minimal in 95/200 patients (47.5%), mild in 64/200 (32.0%), moderate in 25/200 (12.5%), marked in 16/200 (8.0%), with substantial inter-reader reliability (κ = 0.634; 95% CI 0.581-0.686). At multivariable logistic regression, premenopausal status and breast density were significant positive predictors of high BPE, with adjusted odds ratios of 6.120 (95% CI 1.847-20.281, p = 0.003) and 2.416 (95% CI 1.095-5.332, p = 0.029) respectively.

Conclusion: BPE on CEM is associated with well-established breast cancer risk factors, being higher in women with higher breast density and premenopausal status.

目的:评估造影剂增强乳腺 X 线摄影(CEM)的背景实质增强(BPE)是否与乳腺密度、绝经状态和年龄有关(根据 2022 年 CEM 专用的乳腺成像报告和数据系统(BI-RADS)词典进行分级):这项双中心回顾性分析包括对可疑乳腺 X 线造影结果进行的 CEM 检查。三名读片员独立、盲法评估重组 CEM 图像上的 BPE 和低能量 CEM 图像上的乳腺密度。读片者之间的可靠性使用 Fleiss κ 进行估算。进行多变量二元逻辑回归,将乳腺密度和BPE二分为低(a/b BI-RADS类别,最小/轻度BPE)和高(c/d BI-RADS类别,中度/标记BPE):共纳入 200 名妇女(中位年龄 56.8 岁,四分位数范围 50.5-65.6,140/200 名妇女处于绝经期)。有 27/200 名患者(13.5%)的乳腺密度被划分为 a,110/200 名患者(55.0%)的乳腺密度被划分为 b,52/200 名患者(26.0%)的乳腺密度被划分为 c,11/200 名患者(5.5%)的乳腺密度被划分为 d。95/200(47.5%)例患者的 BPE 为轻度,64/200(32.0%)例患者为轻度,25/200(12.5%)例患者为中度,16/200(8.0%)例患者为重度,读数间可靠性相当高(κ = 0.634;95% 置信区间 [CI] 0.581-0.686)。在多变量逻辑回归中,绝经前状态和乳腺密度是高 BPE 的显著正向预测因素,调整后的几率比分别为 6.120 (95% CI 1.847-20.281, p = 0.003) 和 2.416 (95% CI 1.095-5.332, p = 0.029):结论:CEM上的BPE与已确定的乳腺癌风险因素有关,乳腺密度较高和绝经前的妇女BPE更高。
{"title":"Background parenchymal enhancement on contrast-enhanced mammography: associations with breast density and patient's characteristics.","authors":"Veronica Magni, Andrea Cozzi, Giulia Muscogiuri, Adrienn Benedek, Gabriele Rossini, Marianna Fanizza, Giuseppe Di Giulio, Francesco Sardanelli","doi":"10.1007/s11547-024-01860-5","DOIUrl":"10.1007/s11547-024-01860-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate if background parenchymal enhancement (BPE) on contrast-enhanced mammography (CEM), graded according to the 2022 CEM-dedicated Breast Imaging Reporting and Data System (BI-RADS) lexicon, is associated with breast density, menopausal status, and age.</p><p><strong>Methods: </strong>This bicentric retrospective analysis included CEM examinations performed for the work-up of suspicious mammographic findings. Three readers independently and blindly evaluated BPE on recombined CEM images and breast density on low-energy CEM images. Inter-reader reliability was estimated using Fleiss κ. Multivariable binary logistic regression was performed, dichotomising breast density and BPE as low (a/b BI-RADS categories, minimal/mild BPE) and high (c/d BI-RADS categories, moderate/marked BPE).</p><p><strong>Results: </strong>A total of 200 women (median age 56.8 years, interquartile range 50.5-65.6, 140/200 in menopause) were included. Breast density was classified as a in 27/200 patients (13.5%), as b in 110/200 (55.0%), as c in 52/200 (26.0%), and as d in 11/200 (5.5%), with moderate inter-reader reliability (κ = 0.536; 95% confidence interval [CI] 0.482-0.590). BPE was minimal in 95/200 patients (47.5%), mild in 64/200 (32.0%), moderate in 25/200 (12.5%), marked in 16/200 (8.0%), with substantial inter-reader reliability (κ = 0.634; 95% CI 0.581-0.686). At multivariable logistic regression, premenopausal status and breast density were significant positive predictors of high BPE, with adjusted odds ratios of 6.120 (95% CI 1.847-20.281, p = 0.003) and 2.416 (95% CI 1.095-5.332, p = 0.029) respectively.</p><p><strong>Conclusion: </strong>BPE on CEM is associated with well-established breast cancer risk factors, being higher in women with higher breast density and premenopausal status.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":null,"pages":null},"PeriodicalIF":9.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Radiologia Medica
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1