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Biomaterials based on nanosized forms of polyconjugated systems 基于纳米多共轭体系的生物材料
Pub Date : 2021-09-27 DOI: 10.18332/pht/142042
Y. Mezhuev, O. Sizova, M. Stenkina, R. Alekperov, A. Varankin, I. Vorobev, Y. Korshak, ‪M. Shtilman
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引用次数: 0
Synergy of antibacterial effect of copper and silver nanoparticles with different functionalizations 不同官能化铜和银纳米粒子抑菌效果的协同作用
Pub Date : 2021-09-27 DOI: 10.18332/pht/142325
G. Vasiliev, Akane Kubo, O. Bondarenko
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引用次数: 0
Polyelectrolyte multilayer capsules modified with antitumor cytokine DR5-B and loaded with doxorubicin for targeted drug delivery to tumor cells 用抗肿瘤细胞因子DR5-B修饰的多电解质多层胶囊,负载多柔比星靶向给药到肿瘤细胞
Pub Date : 2021-09-27 DOI: 10.18332/pht/142136
A. Gileva, A. V. Yagolovich, M. Gasparian, L. Kurbanova, D. Trushina, E. Markvicheva
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引用次数: 0
Acceptance and concerns regarding COVID-19 vaccine in Kerala, India 印度喀拉拉邦对COVID-19疫苗的接受程度和担忧
Pub Date : 2021-09-15 DOI: 10.18332/pht/141976
Anamika Anil, Sulthana Sharafudeen, A. Krishna, R. Rajendran, J. James, Suneesh Kuruvilla, S. Ramanarayanan
INTRODUCTION The current global pandemic of COVID-19 is an international threat. A safe and effective vaccine for COVID-19 infection has been on the wish list of healthcare agencies across the globe since the onset of the pandemic. As the process of development of vaccine demands clinical trials across various phases for multiple checks concerning its safety, potency, and efficacy, there is an inherent delay in its launch. Considering the immediate need for global vaccination, the currently administered vaccines have been developed with a short period of testing and hence is a matter of concern among the population. Thus, this study was conducted to assess the acceptance and concerns regarding the vaccinations in the Indian state of Kerala. METHODS The study was a cross-sectional questionnairebased survey conducted online. The target population was individuals aged ≥18 years. The questionnaire was divided into two parts. The first part consisted of questions on personal data such as age, gender, education level, and occupation. The second part consisted of 10 questions to assess the willingness and concerns regarding vaccination for COVID-19 infection. RESULTS The final sample size comprised 314 participants. Over 92% indicated that they were aware of the vaccination guidelines. About 42% reported to have received knowledge about vaccination through printed media and 55% through social media. Among the 84% who were willing to take vaccination or already vaccinated, 39% expressed their willingness to get vaccinated due to their trust in the government’s awareness campaigns. Among 16% unwilling to take the vaccine, 86% were anxious about the side effects/ adverse reactions of the vaccine, and 56% were anxious regarding the effectiveness of the vaccine. CONCLUSIONS The study reveals a good level of acceptance regarding vaccination acceptance among the population studied. The predominant concerns regarding the vaccine included adverse reactions and efficacy. The study population demonstrated a positive attitude towards vaccination.
当前COVID-19全球大流行是一项国际威胁。自大流行爆发以来,安全有效的COVID-19感染疫苗一直是全球卫生保健机构的愿望清单。由于疫苗的开发过程需要在各个阶段进行临床试验,对其安全性、效力和有效性进行多次检查,因此其上市存在固有的延迟。考虑到全球疫苗接种的迫切需要,目前接种的疫苗是在短时间内试验开发的,因此是人口关注的问题。因此,本研究旨在评估印度喀拉拉邦对疫苗接种的接受程度和关注程度。方法采用横断面在线问卷调查方法。目标人群为年龄≥18岁的个体。问卷分为两部分。第一部分包括有关年龄、性别、教育程度和职业等个人资料的问题。第二部分包括10个问题,以评估对COVID-19感染接种疫苗的意愿和担忧。结果最终样本量为314名参与者。92%以上的人表示他们了解疫苗接种指南。约42%的人报告通过印刷媒体获得了疫苗接种知识,55%的人通过社交媒体获得了疫苗接种知识。在84%愿意接种疫苗或已经接种疫苗的人中,39%表示愿意接种疫苗,因为他们相信政府的宣传活动。在不愿接种疫苗的16%中,86%的人担心疫苗的副作用/不良反应,56%的人担心疫苗的有效性。结论:该研究揭示了在研究人群中接受疫苗接种的良好水平。对疫苗的主要关注包括不良反应和疗效。研究人群对疫苗接种持积极态度。
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引用次数: 5
Methodological considerations for the design and implementation of reliable and valid web surveys 设计和实施可靠和有效的网络调查的方法学考虑
Pub Date : 2021-09-14 DOI: 10.18332/pht/141977
I. Agaku
This article examines practical epidemiology principles related to the design and implementation of web surveys. Six practice-oriented items are critically examined: 1) The study question; 2) The target population; 3) Study population needed; 4) Sampling or selecting the participants in a representative manner; 5) Sending the survey invitations in a manner that is efficient, safe, and mitigates bias; and 6) Assessing and enhancing the external validity of collected data. Clearly articulating the study’s purpose (including whether there is an intent to create generalizable knowledge) influences the sampling approach: probabilistic or non-probabilistic. Similarly, properly defining the study population (people, place and time) prevents overgeneralization of study findings. Adjustments to sample size may be needed to address different real-world complexities, including multi-purpose surveys with different (possibly un-related outcomes), multiple target populations, subgroup analyses, and cluster sampling. When the sample is being drawn from a sampling frame, efforts must be made to ensure that the frame is complete, current, and correct to reduce under-sampling. The choice of environment in which data collection is hosted is critical; practical considerations include data volume, variety, vulnerability, and the software’s capabilities and cost. Although web surveys, in general, are becoming increasingly easier to conduct, good web surveys in contrast are becoming increasingly harder to undertake. Careful consideration should be given to sampling and nonsampling sources of error when designing web surveys to ensure validity and reliability.
本文探讨了与网络调查的设计和实施有关的实用流行病学原则。六个面向实践的项目被严格审查:1)研究问题;2)目标人群;3)所需研究人群;4)抽样或选择具有代表性的参与者;5)以有效、安全、减少偏见的方式发送调查邀请;6)评估和增强所收集数据的外部有效性。清楚地阐明研究的目的(包括是否有意创造可概括的知识)影响抽样方法:概率或非概率。同样,适当地定义研究人群(人、地点和时间)可以防止研究结果的过度概括。可能需要调整样本量以解决不同的现实世界复杂性,包括具有不同(可能不相关的结果)的多目的调查、多目标人群、亚组分析和聚类抽样。当从采样帧中提取样本时,必须努力确保帧是完整的、当前的和正确的,以减少欠采样。选择托管数据收集的环境是至关重要的;实际的考虑因素包括数据量、种类、漏洞以及软件的功能和成本。总的来说,虽然网络调查越来越容易进行,但相比之下,好的网络调查却越来越难以进行。在设计网络调查时,应仔细考虑抽样和非抽样的误差来源,以确保有效性和可靠性。
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引用次数: 1
Biotransformation of phthalates by basidiomycete fungi from different ecophysiological groups 不同生态生理类群的担子菌真菌对邻苯二甲酸酯的生物转化
Pub Date : 2021-09-08 DOI: 10.18332/pht/142008
T. Fedorova, K. Moiseenko, O. Savinova, O. Glazunova, S. Eremin
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引用次数: 1
Eating habits and body ideals from the Renaissance period to the present: Perspectives from paintings onnutrition and body image 从文艺复兴时期到现在的饮食习惯和身体理想:从绘画的角度看营养和身体形象
Pub Date : 2021-08-04 DOI: 10.18332/pht/139905
Alexandros Karampetsos, D. Efthymiou, Effrosyni Griva, C. Mesiari, Andrey V. Severin, E. Vassilopoulou
INTRODUCTION Obesity, unhealthy eating habits and disordered eating behavior affect physiology and mental Visual arts, such as painting, have been shown beneficial in psychotherapy and stress-related disease management. Their impact on shaping eating habits and body image, and their possible use as a tool in health education for young people has not been thoroughly researched. METHODS In this review, significant paintings from the 15th century until the present, depicting eating habits and body image through the centuries are presented in the light of their capacity to transfer information about the shaping of eating habits and body ideals. The current review was performed under the auspices of the Hellenic Center of Education & Treatment of Eating Disorders (KEADD). RESULTS Paintings constitute a useful vehicle for capturing the changing eating habits according to the sociopolitical status of each era and the perceptions/emotions related to foods. Therein, the foods may be recognized as healthy or unhealthy, rich or poor, and the body shape perceived as beautiful, attractive, or ugly, as the concepts of beauty change over time. CONCLUSIONS The art of painting is a promising nutritional educational tool, serving as an agent for the promotion of a healthy body image. It can be utilized in imaginative school health education projects.
肥胖、不健康的饮食习惯和紊乱的饮食行为会影响生理和心理。视觉艺术,如绘画,已被证明对心理治疗和压力相关疾病管理有益。它们对塑造饮食习惯和身体形象的影响,以及它们作为年轻人健康教育工具的可能用途,尚未得到彻底的研究。在这篇综述中,从15世纪到现在的重要绘画,描绘了几个世纪以来的饮食习惯和身体形象,并根据它们传递有关饮食习惯和身体理想塑造信息的能力进行了展示。目前的审查是在希腊饮食失调教育与治疗中心(KEADD)的主持下进行的。结果绘画是一种有用的工具,可以根据每个时代的社会政治地位和与食物相关的感知/情绪来捕捉不断变化的饮食习惯。其中,食物可能被认为是健康的或不健康的,富裕的或贫穷的,身体形状被认为是美丽的,有吸引力的或丑陋的,因为美的概念随着时间的推移而变化。结论绘画艺术是一种很有前途的营养教育工具,可以促进健康的身体形象。它可用于富有想象力的学校健康教育项目。
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引用次数: 1
Announcing the launching of the new journal Public Health and Toxicology 宣布新一期《公共卫生与毒理学》创刊
Pub Date : 2021-05-28 DOI: 10.18332/pht/137797
A. Tsatsakis, A. Vardavas
We are proud to announce the creation of the new journal Public Health and Toxicology. Public Health and Toxicology is a new double-blind peer-reviewed, open access, online journal that welcomes integrated epidemiological, clinical, animal and cellular biological research to provide the scientific foundation in support of hazard identification and risk assessment today. Here at Public Health and Toxicology, we focus on publishing innovative international peer-reviewed research on all aspects of toxicology that can affect directly and indirectly the public from exposure to chemical and/or biological agents (environmental toxicology) and actions to protect public health and the environment through subsequent recommendations to reduce any resulting health effects (regulatory toxicology), including populationbased research and the evaluation of environmental risk throughout the lifespan including prenatal and postnatal development, childhood, adulthood and high-risk groups, and the impact on biological systems and the causes underlying the variability in susceptibility of people to exposures. Most importantly, Public Health and Toxicology is also highly interested in the recent real life risk simulation (RLRS) concept that plays a key role in chronic exposure paradigms. Public Health and Toxicology is published by European Publishing, an Open Access publishing firm supported by the European Union Regional Development Fund, Smart Specialization strategy (RIS3) and based within the Science and Technology Park of Crete, Greece. The journal adheres to the COPE Code of Conduct and Best-Practice Guidelines for Journal Editors, and the ICMJE’s Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals. Due to recent public health emergencies, the journal also welcomes research on public health emergency preparedness related to environmental accidents and epidemics, such as the ongoing COVID-19 pandemic, including natural and man-made disasters, that assesses this exposure and outcome associations, from a public health toxicology perspective. The need to enhance and further develop methods and approaches for evaluating toxicology issues cannot be overstated. Therefore, we welcome relevant manuscripts to Public Health and Toxicology that broaden these views and further enhance the discipline of Public Health and Toxicologgy.
我们很自豪地宣布新期刊《公共卫生与毒理学》的创刊。《公共卫生与毒理学》是一本新的双盲同行评议、开放获取的在线期刊,欢迎流行病学、临床、动物和细胞生物学综合研究,为支持当今的危害识别和风险评估提供科学基础。在《公共卫生与毒理学》,我们专注于发表关于毒理学所有方面的创新国际同行评议研究,这些研究可能直接或间接地影响公众接触化学和/或生物制剂(环境毒理学),以及通过随后提出减少由此产生的任何健康影响的建议来保护公众健康和环境的行动(监管毒理学)。包括以人口为基础的研究和评估整个生命周期的环境风险,包括产前和产后发育、童年、成年和高风险群体,以及对生物系统的影响和人们对暴露的易感性变化的潜在原因。最重要的是,公共卫生和毒理学也对最近在慢性暴露范式中起关键作用的现实生活风险模拟(RLRS)概念非常感兴趣。《公共卫生与毒理学》由欧洲出版公司出版,欧洲出版公司是一家开放获取出版公司,由欧洲联盟区域发展基金、智能专业化战略(RIS3)支持,总部设在希腊克里特岛科技园。该杂志遵守COPE的行为准则和期刊编辑最佳实践指南,以及ICMJE关于医学期刊学术工作的行为、报告、编辑和出版的建议。鉴于最近发生的突发公共卫生事件,本杂志还欢迎开展与环境事故和流行病(如正在进行的COVID-19大流行)(包括自然灾害和人为灾害)相关的公共卫生应急准备研究,从公共卫生毒理学角度评估这种暴露和结果关联。加强和进一步发展评价毒理学问题的方法和途径的必要性再怎么强调也不为过。因此,我们欢迎相关稿件到公共卫生与毒理学,拓宽这些观点,进一步加强公共卫生与毒理学的学科。
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引用次数: 0
The growing anthropogenic immune deficit and the COVID-19 pandemic 日益严重的人为免疫缺陷和COVID-19大流行
Pub Date : 2021-04-19 DOI: 10.18332/pht/135057
D. Petrakis, T. Nikolouzakis, V. Karzi, A. Vardavas, C. Vardavas, A. Tsatsakis
The last 10 years, despite global scientific and technological progress, there has been an outbreak of chronic diseases, viral epidemics and pandemics, with a significant number of deaths, depletion of health systems and rising healthcare costs, leading to devastating economic, political and social consequences. Here, we describe briefly the human defence system, how environmental factors and mechanisms interfere with it, and the correlation with chronic exposure to environmentally toxic mixtures. Also, we examine the technologies that can increase viral aggression, focusing on the recent COVID-19 pandemic of the SARS-CoV-2 virus.
过去10年,尽管全球科学和技术取得了进步,但慢性病、病毒性流行病和大流行病爆发,造成大量死亡,卫生系统枯竭,卫生保健费用上升,导致毁灭性的经济、政治和社会后果。在这里,我们简要地描述了人类防御系统,环境因素和机制如何干扰它,以及与长期暴露于环境有毒混合物的关系。此外,我们还研究了可能增加病毒侵袭的技术,重点是最近的COVID-19大流行的SARS-CoV-2病毒。
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引用次数: 0
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Public Health Toxicology
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